Name
Nitriles
Accession Number
DBCAT000545
Description

Organic compounds containing the -CN radical. The concept is distinguished from CYANIDES, which denotes inorganic salts of HYDROGEN CYANIDE.

Drugs
DrugDrug Description
CitalopramA selective serotonin reuptake inhibitor (SSRI) used in the treatment of depression.
EscitalopramA selective serotonin re-uptake inhibitor used in the treatment of major depressive disorder (MDD), generalized anxiety disorder (GAD), and other select psychiatric disorders such as obsessive-compulsive disorder (OCD).
RilpivirineA non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with other antiretrovirals to specifically treat human immunodeficiency virus type 1 (HIV-1).
IsoaminileIsoaminile, an antitussive drug with a structure similar to methadone, is also an anticholinergic with both antimuscarinic and antinicotinic properties.
Technetium Tc-99m sestamibiA radiopharmaceutical diagnostic agent used in nuclear medicine imaging tests to detect coronary artery disease and evaluate myocardial function.
2-octyl cyanoacrylateDermabond has been investigated for the basic science of Wound Healing.
EnbucrilateEnbucrilate is under investigation in clinical trial NCT02468206 (Secondary Prophylaxis of Gastric Variceal Bleed).
LetrazurilLetrazuril has been used in trials studying the treatment of HIV Infections and Cryptosporidiosis.
LetrozoleAn aromatase inhibitor used to treat breast cancer in postmenopausal women.
AnastrozoleA competitive, selective, non-steroidal aromatase inhibitor used as adjuvant therapy for the treatment of hormone receptor-positive breast cancer in postmenopausal women.
VildagliptinA once-daily dipeptidyl peptidase 4 (DPP-4) inhibitor used in the management of type 2 diabetes mellitus.
OcrylateOcrylate is under investigation in clinical trial NCT01918059 (Cosmetic Outcome Study of Lid Laceration Repair With Suture Versus Tissue Adhesive).
Drugs & Drug Targets
DrugTargetType
CitalopramSodium-dependent serotonin transportertarget
CitalopramCytochrome P450 2C19enzyme
CitalopramCytochrome P450 2D6enzyme
CitalopramCytochrome P450 3A4enzyme
CitalopramP-glycoprotein 1transporter
CitalopramCytochrome P450 1A2enzyme
CitalopramHistamine H1 receptortarget
EscitalopramSodium-dependent serotonin transportertarget
EscitalopramCytochrome P450 3A4enzyme
EscitalopramCytochrome P450 2D6enzyme
EscitalopramSodium-dependent dopamine transportertarget
EscitalopramSodium-dependent noradrenaline transportertarget
EscitalopramMuscarinic acetylcholine receptor M1target
EscitalopramHistamine H1 receptortarget
EscitalopramCytochrome P450 2C19enzyme
EscitalopramMonoamine oxidaseenzyme
EscitalopramP-glycoprotein 1transporter
Escitalopram5-hydroxytryptamine receptor 1Atarget
Escitalopram5-hydroxytryptamine receptor 2Atarget
Escitalopram5-hydroxytryptamine receptor 2Ctarget
EscitalopramAlpha-1 adrenergic receptorstarget
EscitalopramAlpha-2 adrenergic receptorstarget
EscitalopramDopamine D2 receptortarget
RilpivirineCytochrome P450 3A4enzyme
RilpivirineReverse transcriptase/RNaseHtarget
RilpivirineNuclear receptor subfamily 1 group I member 2target
RilpivirineCytochrome P450 2C19enzyme
RilpivirineCytochrome P450 2B6enzyme
RilpivirineP-glycoprotein 1transporter
RilpivirineATP-binding cassette sub-family G member 2transporter
RilpivirineSolute carrier organic anion transporter family member 1B1transporter
RilpivirineSolute carrier organic anion transporter family member 1B3transporter
RilpivirineSerum albumincarrier
RilpivirineCytochrome P450 2D6enzyme
RilpivirineCytochrome P450 2C9enzyme
RilpivirineCytochrome P450 2C8enzyme
RilpivirineCytochrome P450 2E1enzyme
Technetium Tc-99m sestamibiP-glycoprotein 1transporter
Technetium Tc-99m sestamibiMultidrug resistance-associated protein 1transporter
LetrozoleCytochrome P450 19A1target
LetrozoleCytochrome P450 3A4enzyme
LetrozoleCytochrome P450 2A6enzyme
LetrozoleCytochrome P450 19A1enzyme
LetrozoleCytochrome P450 2C19enzyme
LetrozoleUDP-glucuronosyltransferase 2B7enzyme
LetrozoleSerum albumincarrier
LetrozoleP-glycoprotein 1transporter
AnastrozoleCytochrome P450 19A1target
AnastrozoleP-glycoprotein 1transporter
AnastrozoleCytochrome P450 3A4enzyme
AnastrozoleCytochrome P450 3A5enzyme
AnastrozoleCytochrome P450 2C8enzyme
AnastrozoleUDP-glucuronosyltransferase 1-4enzyme
AnastrozoleUDP-glucuronosyltransferase 1-3enzyme
AnastrozoleUDP-glucuronosyltransferase 2B7enzyme
AnastrozoleCytochrome P450 1A2enzyme
AnastrozoleCytochrome P450 2C9enzyme
VildagliptinDipeptidyl peptidase 4target
VildagliptinP-glycoprotein 1transporter