Accession Number

Synthetic or naturally occurring substances related to coumarin, the delta-lactone of coumarinic acid.

DrugDrug Description
WarfarinA vitamin K antagonist used to treat venous thromboembolism, pulmonary embolism, thromboembolism with atrial fibrillation, thromboembolism with cardiac valve replacement, and thromboembolic events post myocardial infarction.
AcenocoumarolAn anticoagulant drug used in the prevention of thromboembolic diseases in infarction and transient ischemic attacks, as well as management of deep vein thrombosis and myocardial infarction.
TecarfarinTecarfarin has been used in trials studying the prevention of Thrombosis and Thromboembolism.
DicoumarolFor decreasing blood clotting. Often used along with heparin for treatment of deep vein thrombosis.
PhenprocoumonAn anticoagulant drug used for the prevention of thrombosis.
NovobiocinFor the treatment of infections due to staphylococci and other susceptible organisms
4-hydroxycoumarinNot Available
ClorobiocinClorobiocin is an aminocoumarin antibiotic, similar to novobiocin and coumermycin A1.
TrioxsalenA psoralen derivative that has been used in combination with UV light to treat vitiligo, but has been discontinued by its manufacturer.
Calanolide AFor use in combination treatment of HIV infection (AIDS).
HymecromoneA coumarin derivative that lacks anticoagulant properties but possesses choleretic and biliary antispasmodic activity.
Ethyl biscoumacetateEthyl biscoumacetate is a courmarin that is used as an anticoagulant. It has actions similar to those of Warfarin. (From Martindale, The Extra Pharmacopoeia, 30th ed, p226)
CoumaphosThis drug is a fat-soluble phosphorothioate agent that kills both insects and mites. It is non-volatile in nature and is well known by a variety of names as such a...
HaloxonNot Annotated
BergaptenBergapten is under investigation in clinical trial NCT00533195 (Comparison of UVA1 Phototherapy Versus Photochemotherapy for Patients With Severe Generalized Atopic Dermatitis).
EsculinAs medication, esculin is sometimes used as a vasoprotective agent. Esculin is also used in a microbiology laboratory to aid in the identification of bacterial species (especially Enterococci and Listeria),...
4-methylumbelliferyl beta-D-glucosideNot Annotated
CarbocromenCarbocromen was marketed for use in Germany as a vasodilator, however, it has been discontinued due to the risk of arrhythmia development .
CloricromenNot Annotated
Coumermycin A1Not Annotated
4-methyl-umbelliferyl-N-acetyl-chitobioseNot Available
3,4-DichloroisocoumarinNot Available
AmotosalenNot Available
PsoralenNot Annotated
Drugs & Drug Targets
WarfarinVitamin K epoxide reductase complex subunit 1target
WarfarinCytochrome P450 2C8enzyme
WarfarinCytochrome P450 1A2enzyme
WarfarinCytochrome P450 2C9enzyme
WarfarinAlpha-1-acid glycoprotein 1carrier
WarfarinSerum albumincarrier
WarfarinCytochrome P450 2C19enzyme
WarfarinCytochrome P450 3A4enzyme
WarfarinCytochrome P450 2C18enzyme
WarfarinNuclear receptor subfamily 1 group I member 2target
AcenocoumarolVitamin K epoxide reductase complex subunit 1target
AcenocoumarolCytochrome P450 2C9enzyme
AcenocoumarolCytochrome P450 1A2enzyme
AcenocoumarolSerum albumincarrier
AcenocoumarolAlpha-1-acid glycoprotein 1carrier
AcenocoumarolCytochrome P450 2C19enzyme
AcenocoumarolCytochrome P450 3A4enzyme
AcenocoumarolP-glycoprotein 1transporter
DicoumarolVitamin K epoxide reductase complex subunit 1target
DicoumarolNAD(P)H dehydrogenase [quinone] 1target
DicoumarolQuinone oxidoreductasetarget
DicoumarolCytochrome P450 2C9enzyme
DicoumarolSerum albumincarrier
DicoumarolCytochrome P450 2C6enzyme
DicoumarolCytochrome P450 2C11enzyme
PhenprocoumonVitamin K epoxide reductase complex subunit 1target
PhenprocoumonAlpha-1-acid glycoprotein 1carrier
PhenprocoumonSerum albumincarrier
PhenprocoumonCytochrome P450 2C9enzyme
PhenprocoumonCytochrome P450 3A4enzyme
PhenprocoumonCytochrome P450 2C8enzyme
NovobiocinDNA gyrase subunit Btarget
NovobiocinSolute carrier family 22 member 6transporter
NovobiocinSolute carrier family 22 member 8transporter
NovobiocinSolute carrier family 22 member 11transporter
NovobiocinATP-binding cassette sub-family G member 2transporter
NovobiocinDNA topoisomerase 1target
NovobiocinSolute carrier organic anion transporter family member 1B1transporter
NovobiocinSolute carrier organic anion transporter family member 1B3transporter
NovobiocinSolute carrier organic anion transporter family member 2B1transporter
4-hydroxycoumarinMajor NAD(P)H-flavin oxidoreductasetarget
ClorobiocinDNA gyrase subunit Btarget
Calanolide AGag-Pol polyproteintarget
Calanolide ACytochrome P450 3A4enzyme
HymecromoneArylsulfate sulfotransferasetarget
Ethyl biscoumacetateGlutamine synthetaseenzyme
Ethyl biscoumacetateCytochrome P450 3A4enzyme
EsculinGlutaminase kidney isoform, mitochondrialenzyme
EsculinAndrogen receptortarget
4-methyl-umbelliferyl-N-acetyl-chitobioseLysozyme Ctarget
3,4-DichloroisocoumarinComplement factor Dtarget