Antibiotics, Antineoplastic

Name
Antibiotics, Antineoplastic
Accession Number
DBCAT000679
Description

Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms.

Drugs
DrugDrug Description
BleomycinA chemotherapy agent used to treat various malignancies, including head and neck malignancy, lymphoma, and testicular tumors, among others.
MitomycinAn antimetabolite used as an adjunct to ab externo (outside approach) eye surgeries for the treatment of glaucoma and used as a chemotherapeutic agent for various malignancies.
StreptozocinA nitrosourea antineoplastic agent used in the treatment of metastatic pancreatic islet cell carcinoma.
EpirubicinAn anthracycline topoisomerase II inhibitor used as an adjuvant to treating axillary node metastases in patients who have undergone surgical resection of primary breast cancer.
DaunorubicinAn anthracycline aminoglycoside used to induce remission of nonlymphocytic leukemia and acute lymphocytic leukemia.
SirolimusAn immunosuppressant used to prevent organ transplant rejections and to treat lymphangioleiomyomatosis.
DactinomycinAn actinomycin used to treat a wide variety of cancers.
DoxorubicinA medication used to treat various cancers and Kaposi's Sarcoma.
Mycophenolic acidAn immunosuppressant used to prevent organ transplant rejections.
IdarubicinAn anthracycline antineoplastic agent used to treat acute myeloid leukemia (AML) in adults.
HadacidinNot Available
GeldanamycinNot Available
TubercidinAn antibiotic purine ribonucleoside that readily substitutes for adenosine in the biological system, but its incorporation into DNA and RNA has an inhibitory effect on the metabolism of these nucleic...
UbenimexAn adjuvant therapy used for acute and chronic myelonous leukemia, lung cancer and nasopharyngeal cancer. It is also used to treat hypercholesterolaemia.
SparsomycinAn antitumor antibiotic produced by Streptomyces sparsogenes. It inhibits protein synthesis in 70S and 80S ribosomal systems. [PubChem]
ElsamitrucinInvestigated for use/treatment in lymphoma (non-hodgkin's).
AlanosineInvestigated for use/treatment in brain cancer and cancer/tumors (unspecified).
RomidepsinA histone deacetylase (HDAC) inhibitor used to treat cutaneous and peripheral T-cell lymphoma.
AnnamycinInvestigated for use/treatment in breast cancer and leukemia (unspecified).
PorfiromycinInvestigated for use/treatment in head and neck cancer.
PlicamycinFor the treatment of testicular cancer, as well as hypercalcemia and hypercalciuria associated with a variety of advanced forms of cancer.
AclarubicinNot Annotated
ZorubicinZorubicin is a drug of the anthracycline class - a class of medications that have historically demonstrated effective chemotherapy for a variety of cancer types.
IndirubinIndirubin is under investigation in clinical trial NCT01735864 (Dosage Determination Trial for Indigo Naturalis Extract in Oil Ointment).
MizoribineMizoribine has been investigated for the treatment of Rheumatoid Arthritis.
GusperimusGusperimus has been used in trials studying the treatment of Lupus Nephritis, Wegeners Granulomatosis, and Wegener's Granulomatosis.
DeoxyspergualinDeoxyspergualin has been used in trials studying the treatment of Lupus Nephritis, Chronic Rejection, and Diabetes Mellitus, Type 1.
Toyocamycin4-Amino-5-cyano-7-(D-ribofuranosyl)-7H- pyrrolo(2,3-d)pyrimidine. Antibiotic antimetabolite isolated from Streptomyces toyocaensis cultures. It is an analog of adenosine, blocks RNA synthesis and ribosome function, and is used mainly as a tool in biochemistry.
TNP-470O-(chloroacetylcarbamoyl)fumagillol (TNP-470) has been used in trials studying the treatment of HIV Infections, Sarcoma, Kaposi, and Pancreatic Neoplasms.
Mycophenolate mofetilAn inosine monophosphate dehydrogenase inhibitor used to prevent the rejection of kidney, heart, or liver transplants.
EchinomycinEchinomycin is a cytotoxic polypeptide quinoxaline antibiotic isolated from Streptomyces echinatus that binds to DNA and inhibits RNA synthesis.
DurvalumabAn antineoplastic monoclonal antibody used to treat urothelial carcinoma and locally advanced, unresectable non-small cell lung cancer.
Drugs & Drug Targets
DrugTargetType
BleomycinDNA ligase 3target
BleomycinDNA ligase 1target
BleomycinDNAtarget
BleomycinBleomycin hydrolaseenzyme
MitomycinDNAtarget
MitomycinNADPH--cytochrome P450 reductaseenzyme
StreptozocinDNAtarget
StreptozocinP-glycoprotein 1transporter
StreptozocinSolute carrier family 2, facilitated glucose transporter member 2target
StreptozocinO-GlcNAcase BT_4395target
StreptozocinCytochrome P450 1A1enzyme
StreptozocinCytochrome P450 1A2enzyme
StreptozocinCytochrome P450 2E1enzyme
StreptozocinBifunctional protein NCOATtarget
EpirubicinDNA topoisomerase 2-alphatarget
EpirubicinDNAtarget
EpirubicinMultidrug resistance-associated protein 1transporter
EpirubicinUDP-glucuronosyltransferase 2B7enzyme
EpirubicinCytosolic phospholipase A2enzyme
DaunorubicinDNAtarget
DaunorubicinXanthine dehydrogenase/oxidaseenzyme
DaunorubicinCytochrome P450 3A5enzyme
DaunorubicinNADPH--cytochrome P450 reductaseenzyme
DaunorubicinP-glycoprotein 1transporter
DaunorubicinMultidrug resistance-associated protein 1transporter
DaunorubicinCanalicular multispecific organic anion transporter 1transporter
DaunorubicinMultidrug resistance-associated protein 6transporter
DaunorubicinBile salt export pumptransporter
DaunorubicinMultidrug resistance-associated protein 7transporter
DaunorubicinATP-binding cassette sub-family G member 2transporter
DaunorubicinDNA topoisomerase 2-alphatarget
DaunorubicinDNA topoisomerase 2-betatarget
DaunorubicinCytochrome P450 1A1enzyme
DaunorubicinCytochrome P450 1B1enzyme
DaunorubicinCytochrome P450 3A4enzyme
SirolimusPeptidyl-prolyl cis-trans isomerase FKBP1Atarget
SirolimusCytochrome P450 3A4enzyme
SirolimusSerine/threonine-protein kinase mTORtarget
SirolimusFibroblast growth factor 2target
SirolimusCytochrome P450 3A5enzyme
SirolimusCytochrome P450 3A7enzyme
SirolimusP-glycoprotein 1transporter
SirolimusSolute carrier organic anion transporter family member 1B1transporter
SirolimusMultidrug and toxin extrusion protein 1transporter
DactinomycinDNAtarget
DactinomycinSolute carrier family 22 member 5transporter
DactinomycinP-glycoprotein 1transporter
DactinomycinMultidrug resistance-associated protein 6transporter
DactinomycinMultidrug resistance-associated protein 1transporter
DactinomycinATP-binding cassette sub-family G member 2transporter
DactinomycinDNA topoisomerase 2target
DoxorubicinDNA topoisomerase 2-alphatarget
DoxorubicinDNAtarget
DoxorubicinCytochrome P450 3A4enzyme
DoxorubicinCytochrome P450 2D6enzyme
DoxorubicinCytochrome P450 2B6enzyme
DoxorubicinP-glycoprotein 1transporter
DoxorubicinCanalicular multispecific organic anion transporter 2transporter
DoxorubicinMultidrug resistance-associated protein 6transporter
DoxorubicinMultidrug resistance-associated protein 1transporter
DoxorubicinMultidrug resistance-associated protein 7transporter
DoxorubicinATP-binding cassette sub-family G member 2transporter
DoxorubicinBile salt export pumptransporter
DoxorubicinSolute carrier family 22 member 16transporter
DoxorubicinATP-binding cassette sub-family B member 8, mitochondrialtransporter
DoxorubicinCytochrome P450 1B1enzyme
DoxorubicinCarbonyl reductase [NADPH] 1enzyme
DoxorubicinCarbonyl reductase [NADPH] 3enzyme
DoxorubicinAlcohol dehydrogenase [NADP(+)]enzyme
DoxorubicinAldo-keto reductase family 1 member C3enzyme
DoxorubicinNAD(P)H dehydrogenase [quinone] 1enzyme
DoxorubicinXanthine dehydrogenase/oxidaseenzyme
DoxorubicinNitric oxide synthase, endothelialenzyme
DoxorubicinNitric oxide synthase, inducibleenzyme
DoxorubicinNitric oxide synthase, brainenzyme
DoxorubicinNADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrialenzyme
DoxorubicinNADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialenzyme
DoxorubicinNADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialenzyme
DoxorubicinNADPH--cytochrome P450 reductaseenzyme
DoxorubicinRalA-binding protein 1transporter
DoxorubicinCanalicular multispecific organic anion transporter 1transporter
DoxorubicinSerum albumincarrier
DoxorubicinNucleolar and coiled-body phosphoprotein 1target
Mycophenolic acidInosine-5'-monophosphate dehydrogenase 2target
Mycophenolic acidInosine-5'-monophosphate dehydrogenase 1target
Mycophenolic acidUDP-glucuronosyltransferase 1-1enzyme
Mycophenolic acidUDP-glucuronosyltransferase 1-9enzyme
Mycophenolic acidUDP-glucuronosyltransferase 2B7enzyme
Mycophenolic acidUDP-glucuronosyltransferase 1-7enzyme
Mycophenolic acidUDP-glucuronosyltransferase 1-6enzyme
IdarubicinDNA topoisomerase 2-alphatarget
IdarubicinDNAtarget
IdarubicinMultidrug resistance-associated protein 1transporter
IdarubicinCytochrome P450 2C9enzyme
IdarubicinCytochrome P450 2D6enzyme
HadacidinAdenylosuccinate synthetasetarget
HadacidinAdenylosuccinate synthetase isozyme 1target
HadacidinAdenylosuccinate synthetasetarget
GeldanamycinHeat shock protein HSP 90-alphatarget
GeldanamycinHeat shock protein HSP 90-betatarget
GeldanamycinEndoplasmintarget
TubercidinPurine nucleoside phosphorylase DeoD-typetarget
UbenimexBacterial leucyl aminopeptidasetarget
UbenimexLeukotriene A-4 hydrolasetarget
UbenimexSolute carrier family 15 member 1transporter
UbenimexSolute carrier family 15 member 2transporter
ElsamitrucinDNAtarget
ElsamitrucinDNA topoisomerase 1target
ElsamitrucinDNA topoisomerase 2-alphatarget
AlanosineAspartate carbamoyltransferase catalytic chaintarget
AlanosineAdenylosuccinate synthetase isozyme 2target
AlanosineAdenylosuccinate synthetase isozyme 1target
AlanosineCystine/glutamate transportertransporter
RomidepsinCytochrome P450 3A4enzyme
RomidepsinCytochrome P450 3A5enzyme
RomidepsinP-glycoprotein 1transporter
RomidepsinSolute carrier organic anion transporter family member 1B3transporter
RomidepsinCytochrome P450 1A1enzyme
RomidepsinCytochrome P450 2B6enzyme
RomidepsinCytochrome P450 2C19enzyme
RomidepsinHistone deacetylase 1target
RomidepsinHistone deacetylase 2target
RomidepsinHistone deacetylase 4target
RomidepsinHistone deacetylase 6target
RomidepsinMultidrug resistance-associated protein 1target
AnnamycinDNA topoisomerase 2-alphatarget
AnnamycinDNAtarget
AnnamycinP-glycoprotein 1transporter
PorfiromycinXanthine dehydrogenase/oxidaseenzyme
PlicamycinDNAtarget
IndirubinCytochrome P450 1A1target
IndirubinAryl hydrocarbon receptortarget
TNP-470Methionine aminopeptidase 2target
Mycophenolate mofetilInosine-5'-monophosphate dehydrogenase 2target
Mycophenolate mofetilInosine-5'-monophosphate dehydrogenase 1target
Mycophenolate mofetilUDP-glucuronosyltransferase 1-1enzyme
Mycophenolate mofetilUDP-glucuronosyltransferase 1-7enzyme
Mycophenolate mofetilUDP-glucuronosyltransferase 1-6enzyme
Mycophenolate mofetilUDP-glucuronosyltransferase 1-9enzyme
Mycophenolate mofetilUDP-glucuronosyltransferase 2B7enzyme
Mycophenolate mofetilUDP-glucuronosyltransferase 1-8enzyme
Mycophenolate mofetilUDP-glucuronosyltransferase 1-10enzyme
Mycophenolate mofetilLiver carboxylesterase 1enzyme
Mycophenolate mofetilCytochrome P450 3A4enzyme
Mycophenolate mofetilCytochrome P450 3A5enzyme
Mycophenolate mofetilCytochrome P450 2C8enzyme
Mycophenolate mofetilSolute carrier organic anion transporter family member 1B1transporter
Mycophenolate mofetilSolute carrier organic anion transporter family member 1B3transporter
Mycophenolate mofetilATP-binding cassette sub-family G member 2transporter
Mycophenolate mofetilP-glycoprotein 1transporter
Mycophenolate mofetil6-pyruvoyl tetrahydrobiopterin synthasetarget
Mycophenolate mofetilCarboxylic ester hydrolaseenzyme
Mycophenolate mofetilCanalicular multispecific organic anion transporter 1transporter
DurvalumabProgrammed cell death 1 ligand 1target