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Aklavine

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

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Identification

Generic Name
Aklavine
DrugBank Accession Number
DB19070
Background

Aklavine is under investigation in clinical trial NCT03026842 (Decitabine Versus Conventional Chemotherapy for Maintenance Therapy of Acute Myeloid Leukemia With T(8;21)).

Type
Small Molecule
Groups
Investigational
Structure
3D
Similar Structures
Weight
Average: 569.607
Monoisotopic: 569.226096331
Chemical Formula
C30H35NO10
Synonyms
  • 1-naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-((2,3,6-trideoxy-3-(dimethylamino)-.alpha.-l-lyxo-hexopyranosyl)oxy)-, methyl ester, (1r,2r,4s)-
  • Aclacinomycin
  • Aclacinomycin t
External IDs
  • MA-144T1
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
T87WN25BNW
CAS number
66676-88-8
InChI Key
LJZPVWKMAYDYAS-QKKPTTNWSA-N
InChI
InChI=1S/C30H35NO10/c1-6-30(38)12-19(41-20-11-17(31(3)4)25(33)13(2)40-20)22-15(24(30)29(37)39-5)10-16-23(28(22)36)27(35)21-14(26(16)34)8-7-9-18(21)32/h7-10,13,17,19-20,24-25,32-33,36,38H,6,11-12H2,1-5H3/t13-,17-,19-,20-,24-,25+,30-/m0/s1
IUPAC Name
SMILES
[H][C@@]1(C[C@@H]([C@H](O)[C@H](C)O1)N(C)C)O[C@H]1C[C@](O)(CC)[C@H](C(=O)OC)C2=CC3=C(C(O)=C12)C(=O)C1=C(O)C=CC=C1C3=O

References

General References
Not Available
KEGG Compound
C18634
ChemSpider
131997
ChEBI
74351
ChEMBL
CHEMBL3040622
ZINC
ZINC000003977735
PDBe Ligand
3VL

Clinical Trials

Clinical Trials
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PhaseStatusPurposeConditionsCountStart DateWhy Stopped100+ additional columns
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4Active Not RecruitingPreventionAcute Myeloid Leukemia1somestatusstop reasonjust information to hide
3RecruitingTreatmentRelapsed or Refractory Acute Myeloid Leukemia (AML)1somestatusstop reasonjust information to hide
2CompletedTreatmentAcute Myeloid Leukemia1somestatusstop reasonjust information to hide
2RecruitingTreatmentAcute Myeloid Leukemia1somestatusstop reasonjust information to hide
2RecruitingTreatmentRefractory/Relapse Acute Myeloid Leukemia1somestatusstop reasonjust information to hide

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at July 03, 2024 14:34 / Updated at July 04, 2024 03:36