Adjuvants, Anesthesia

Name
Adjuvants, Anesthesia
Accession Number
DBCAT000730
Description

Agents that are administered in association with anesthetics to increase effectiveness, improve delivery, or decrease required dosage.

Drugs
DrugDrug Description
HyoscyamineAn anticholinergic indicated to treat functional gastrointestinal disorders, biliary and renal colic, and acute rhinitis.
ChlordiazepoxideA benzodiazepine used to treat the withdrawal symptoms of acute alcoholism, to treat preoperative anxiety, and to treat anxiety over a short term period.
MidazolamA short-acting benzodiazepine with rapid onset that is commonly used in seizures, anesthesia and anxiety disorders.
SufentanilAn opioid used to induce and maintain anesthesia, to act as an analgesic in labor and delivery, and to treat severe, acute pain.
ScopolamineA belladonna alkaloid with anticholinergic effects indicated for the treatment of nausea and vomiting associated with motion sickness and postoperative nausea and vomiting (PONV).
FentanylAn opioid analgesic used in anesthesia, for breakthrough cancer pain, or round the clock pain management.
DiazepamA long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures.
TriazolamA benzodiazepine used for short term treatment of insomnia.
GlycopyrroniumAn anticholinergic agent used to treat hyperhidrosis, severe drooling, COPD, used with other medications to treat ulcers, and used in anesthesia.
PentobarbitalA barbiturate drug used to induce sleep, cause sedation, and control certain types of seizures.
SecobarbitalA barbiturate used for the short-term treatment of insomnia.
DroperidolA butyrophenone derivative and dopamine antagonist used to prevent and treat postoperative nausea and vomiting.
MeperidineAn opioid agonist with analgesic and sedative properties used to manage severe pain.
AtropineA muscarinic antagonist used to treat poisoning by muscarinic agents, including organophosphates and other drugs.
PentazocineAn analgesic used to treat moderate to severe pain.
TrimethaphanFor the controlled reduction of blood pressure during surgery and in the treatment of hypertensive emergencies.
OxymorphoneAn opioid analgesic used in the management of moderate-to-severe pain and for analgesic therapies.
gamma-Hydroxybutyric acidUsed as a general anesthetic, to treat conditions such as insomnia, clinical depression, narcolepsy, and alcoholism, and to improve athletic performance.
Sodium oxybateA central nervous system depressant used to treat cataplexy and excessive daytime sleepiness (EDS) associated with narcolepsy.
AlcuroniumA non-depolarizing skeletal muscle relaxant similar to tubocurarine. It is used as an anesthesia adjuvant.
Drugs & Drug Targets
DrugTargetType
HyoscyamineMuscarinic acetylcholine receptor M1target
HyoscyamineMuscarinic acetylcholine receptor M2target
HyoscyamineMuscarinic acetylcholine receptor M3target
HyoscyamineMuscarinic acetylcholine receptor M4target
HyoscyamineAdenylate cyclase type 1target
ChlordiazepoxideGABA(A) Receptortarget
ChlordiazepoxideGABA(A) Receptor Benzodiazepine Binding Sitetarget
ChlordiazepoxideCytochrome P450 3A4enzyme
MidazolamCytochrome P450 3A4enzyme
MidazolamCytochrome P450 3A5enzyme
MidazolamUDP-glucuronosyltransferase 1-4enzyme
MidazolamCytochrome P450 3A7enzyme
MidazolamGABA(A) Receptortarget
MidazolamGABA(A) Receptor Benzodiazepine Binding Sitetarget
MidazolamP-glycoprotein 1transporter
MidazolamSerum albumincarrier
MidazolamAlpha-1-acid glycoprotein 1carrier
MidazolamAdenosine receptor A2atarget
MidazolamExcitatory amino acid transporter 2transporter
MidazolamUDP-glucuronosyltransferase 2B7enzyme
MidazolamUDP-glucuronosyltransferase 2B4enzyme
SufentanilMu-type opioid receptortarget
SufentanilDelta-type opioid receptortarget
SufentanilKappa-type opioid receptortarget
SufentanilCytochrome P450 3A4enzyme
ScopolamineMuscarinic acetylcholine receptor M1target
ScopolamineSucrase-isomaltase, intestinaltarget
ScopolamineMuscarinic acetylcholine receptor M2target
ScopolamineMuscarinic acetylcholine receptor M3target
ScopolamineMuscarinic acetylcholine receptor M4target
ScopolamineMuscarinic acetylcholine receptor M5target
ScopolamineNeuronal acetylcholine receptor subunit alpha-4target
ScopolamineNeuronal acetylcholine receptor subunit beta-2target
ScopolamineCytochrome P450 3A4enzyme
FentanylMu-type opioid receptortarget
FentanylDelta-type opioid receptortarget
FentanylCytochrome P450 3A4enzyme
FentanylCytochrome P450 3A7enzyme
FentanylP-glycoprotein 1transporter
FentanylKappa-type opioid receptortarget
FentanylP-glycoprotein 1target
FentanylSerum albumincarrier
Fentanylalpha1-acid glycoproteincarrier
DiazepamCytochrome P450 3A4enzyme
DiazepamSerum albumincarrier
DiazepamCytochrome P450 2C9enzyme
DiazepamCytochrome P450 2C19enzyme
DiazepamCytochrome P450 3A5enzyme
DiazepamCytochrome P450 3A7enzyme
DiazepamP-glycoprotein 1transporter
DiazepamCytochrome P450 2B6enzyme
DiazepamProstaglandin G/H synthase 1enzyme
DiazepamCytochrome P450 2C18enzyme
DiazepamCytochrome P450 2C8enzyme
DiazepamGABA(A) Receptortarget
DiazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
TriazolamCytochrome P450 3A4enzyme
TriazolamCytochrome P450 3A5enzyme
TriazolamCytochrome P450 3A7enzyme
TriazolamCytochrome P450 2C8enzyme
TriazolamGABA(A) Receptor Benzodiazepine Binding Sitetarget
TriazolamGABA(A) Receptortarget
GlycopyrroniumMuscarinic acetylcholine receptor M1target
GlycopyrroniumMuscarinic acetylcholine receptor M3target
GlycopyrroniumMuscarinic acetylcholine receptor M2target
GlycopyrroniumCytochrome P450 2D6enzyme
GlycopyrroniumCytochrome P450 1A2enzyme
GlycopyrroniumCytochrome P450 2B6enzyme
GlycopyrroniumCytochrome P450 2C9enzyme
GlycopyrroniumCytochrome P450 2C18enzyme
GlycopyrroniumCytochrome P450 2C19enzyme
GlycopyrroniumCytochrome P450 3A4enzyme
GlycopyrroniumSolute carrier family 22 member 2transporter
GlycopyrroniumMultidrug and toxin extrusion protein 1transporter
GlycopyrroniumMuscarinic acetylcholine receptor M4target
GlycopyrroniumMuscarinic acetylcholine receptor M5target
GlycopyrroniumSerum albumincarrier
Glycopyrroniumalpha1-acid glycoproteincarrier
PentobarbitalGamma-aminobutyric acid receptor subunit alpha-1target
PentobarbitalCytochrome P450 3A4enzyme
PentobarbitalGamma-aminobutyric acid receptor subunit alpha-4target
PentobarbitalGamma-aminobutyric acid receptor subunit alpha-6target
PentobarbitalGamma-aminobutyric acid receptor subunit alpha-2target
PentobarbitalGamma-aminobutyric acid receptor subunit alpha-3target
PentobarbitalGamma-aminobutyric acid receptor subunit alpha-5target
PentobarbitalNeuronal acetylcholine receptor subunit alpha-4target
PentobarbitalNeuronal acetylcholine receptor subunit alpha-7target
PentobarbitalGlutamate receptor 2target
PentobarbitalGlutamate receptor ionotropic, kainate 2target
PentobarbitalCytochrome P450 2C19enzyme
PentobarbitalCytochrome P450 2A6enzyme
PentobarbitalGABA(A) Receptortarget
PentobarbitalNMDA receptortarget
PentobarbitalNuclear receptor subfamily 1 group I member 2target
SecobarbitalGamma-aminobutyric acid receptor subunit alpha-1target
SecobarbitalCytochrome P450 2C8enzyme
SecobarbitalCytochrome P450 2C9enzyme
SecobarbitalGamma-aminobutyric acid receptor subunit alpha-2target
SecobarbitalGamma-aminobutyric acid receptor subunit alpha-3target
SecobarbitalGamma-aminobutyric acid receptor subunit alpha-4target
SecobarbitalGamma-aminobutyric acid receptor subunit alpha-5target
SecobarbitalGamma-aminobutyric acid receptor subunit alpha-6target
SecobarbitalNeuronal acetylcholine receptor subunit alpha-4target
SecobarbitalNeuronal acetylcholine receptor subunit alpha-7target
SecobarbitalGlutamate receptor 2target
SecobarbitalGlutamate receptor ionotropic, kainate 2target
SecobarbitalCytochrome P450 1A2enzyme
SecobarbitalNMDA receptortarget
SecobarbitalCytochrome P450 2C19enzyme
DroperidolDopamine D2 receptortarget
DroperidolAlpha-1A adrenergic receptortarget
MeperidineKappa-type opioid receptortarget
MeperidineCytochrome P450 2D6enzyme
MeperidineCytochrome P450 2B6enzyme
MeperidineGlutamate receptor ionotropic, NMDA 1target
MeperidineGlutamate receptor ionotropic, NMDA 2Btarget
MeperidineGlutamate receptor ionotropic, NMDA 2Atarget
MeperidineGlutamate receptor ionotropic, NMDA 2Ctarget
MeperidineGlutamate receptor ionotropic, NMDA 2Dtarget
MeperidineCytochrome P450 2C19enzyme
MeperidineCytochrome P450 3A4enzyme
MeperidineSerum albumincarrier
MeperidineAlpha-1-acid glycoprotein 1carrier
MeperidineMuscarinic acetylcholine receptortarget
MeperidineMu-type opioid receptortarget
MeperidineSodium-dependent dopamine transportertarget
MeperidineSodium-dependent noradrenaline transportertarget
MeperidineSodium-dependent serotonin transportertarget
MeperidineLiver carboxylesterase 1target
MeperidineCytochrome P450 1A2enzyme
MeperidineP-glycoprotein 1transporter
AtropineMuscarinic acetylcholine receptor M2target
AtropineMuscarinic acetylcholine receptor M1target
AtropineMuscarinic acetylcholine receptor M4target
AtropineMuscarinic acetylcholine receptor M5target
AtropineMuscarinic acetylcholine receptor M3target
AtropineGlycine receptor subunit alpha-1target
AtropineNeuronal acetylcholine receptor subunit alpha-4target
AtropineNeuronal acetylcholine receptor subunit beta-2target
AtropineBile salt export pumptransporter
AtropineAlpha-1-acid glycoprotein 1carrier
PentazocineMu-type opioid receptortarget
PentazocineKappa-type opioid receptortarget
PentazocineSigma non-opioid intracellular receptor 1target
PentazocineP-glycoprotein 1transporter
TrimethaphanNeuronal acetylcholine receptor subunit alpha-10target
TrimethaphanCholinesteraseenzyme
OxymorphoneMu-type opioid receptortarget
OxymorphoneCytochrome P450 2D6enzyme
OxymorphoneDelta-type opioid receptortarget
OxymorphoneCytochrome P450 3A4enzyme
gamma-Hydroxybutyric acidMonocarboxylate transporter 2transporter
gamma-Hydroxybutyric acidMonocarboxylate transporter 1transporter
gamma-Hydroxybutyric acidMonocarboxylate transporter 4transporter
gamma-Hydroxybutyric acidGamma-hydroxybutyrate (GHB) receptortarget
gamma-Hydroxybutyric acidGamma-aminobutyric acid receptor subunit beta-1target
Sodium oxybateSuccinate-semialdehyde dehydrogenase, mitochondrialenzyme
Sodium oxybateHydroxyacid-oxoacid transhydrogenase, mitochondrialenzyme
Sodium oxybateGABA(B) Receptortarget
Sodium oxybateGamma-hydroxybutyrate (GHB) receptortarget
Sodium oxybateNAD(P) transhydrogenase, mitochondrialenzyme