Carbamates

Name
Carbamates
Accession Number
DBCAT000800
Description

Derivatives of carbamic acid, H2NC(=O)OH. Included under this heading are N-substituted and O-substituted carbamic acids. In general carbamate esters are referred to as urethanes, and polymers that include repeating units of carbamate are referred to as POLYURETHANES. Note however that polyurethanes are derived from the polymerization of ISOCYANATES and the singular term URETHANE refers to the ethyl ester of carbamic acid.

ATC Classification
Drugs
DrugDrug Description
MeprobamateAn anxiolytic drug used for the short-term management of anxiety symptoms.
CarisoprodolA centrally acting muscle relaxant used to relieve the discomfort associated with various musculoskeletal conditions.
MethocarbamolA CNS depressant indicated with rest, physical therapy and other treatments to control the discomfort associated with various acute musculoskeletal conditions.
AlbendazoleA benzimidazole anthelmintic used to treat parenchymal neurocysticercosis and other helminth infections.
MebendazoleA benzimidazole anthelmintic used to treat helminth infections.
DiethylcarbamazineAn anthelmintic used to treat filarial infections like Wuchereria bancrofti and Loa loa.
DarunavirA HIV protease inhibitor used in the treatment of human immunodeficiency virus (HIV) infection in patients with history of prior antiretroviral therapies.
UrethaneUrethane, formerly marketed as an inactive ingredient in Profenil injection, was determined to be carcinogenic and was removed from the Canadian, US, and UK markets in 1963.
FenbendazoleFenbendazole is a benzimidazole that presents a wide spectrum anthelmintic effect. It is used against a number of gastrointestinal parasites including giardia, roundworms, hookworms, whipworms, the Taenia genus of tapeworms,...
MebutamateMebutamate is a sedative and anxiolytic drug with anti-hypertensive (blood pressure lowering) effects comparable to those of other barbiturates but is only around 1/3rd the potency of secobarbital as a...
EmylcamateNot Annotated
BethanecholA muscarinic agonist used to treat postoperative and postpartum nonobstructive functional urinary retention and neurogenic atony of the bladder with retention.
CobicistatA CYP3A inhibitor used to increase the systemic exposure of atazanavir or darunavir in combination with other antiretroviral agents in the treatment of HIV-1 infection.
CarbarylA medication used in shampoo to remove lice.
TolnaftateAn antifungal agent used to treat various skin infections caused by fungi.
ZafirlukastA leukotriene receptor antagonist used for prophylaxis and chronic treatment of asthma.
DisulfiramA carbamate derivative used to treat alcohol addiction.
FelbamateAn anticonvulsant used to treat severe epilepsy.
PhysostigmineA cholinesterase inhibitor used to treat glaucoma and anticholinergic toxicity.
RivastigmineA cholinesterase inhibitor used to treat mild to moderate dementia in Alzheimer's and Parkinson's.
DitiocarbA chelating agent that has been used to mobilize toxic metals from the tissues of man and experimental animals. It is the main metabolite of DISULFIRAM.
Ethyl N-methylcarbamateNot Available
PhenserineFor the treatment of Alzheimer's disease (AD).
NOX-700Investigated for use/treatment in diabetes mellitus (type 2).
GanstigmineInvestigated for use/treatment in alzheimer's disease.
FlubendazoleFlubendazole is an anthelmintic that is used to treat worm infection in humans. It is available OTC in Europe.
ThiramThiram may be used in dermatology as a scabicide . Thiram is mainly used as a fungicide for plants and treatment for seeds, however, this use is being investigated for...
TolciclateNot Annotated
Albendazole oxideNot Annotated
Tetramethylthiuram monosulfideNot Annotated
Ditiocarb zincDitiocarb Zinc is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6...
Zinc dibutyldithiocarbamateZinc dibutyldithiocarbamate is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6...
PosiphenPosiphen is under investigation in clinical trial NCT02925650 (Safety, Tolerability, PK and PD of Posiphen® in Subjects With Early Alzheimer's Disease).
Drugs & Drug Targets
DrugTargetType
MeprobamateGamma-aminobutyric acid receptor subunit alpha-1target
MeprobamateGamma-aminobutyric acid receptor subunit alpha-2target
MeprobamateGamma-aminobutyric acid receptor subunit alpha-3target
MeprobamateGamma-aminobutyric acid receptor subunit alpha-4target
MeprobamateGamma-aminobutyric acid receptor subunit alpha-5target
MeprobamateGamma-aminobutyric acid receptor subunit alpha-6target
MeprobamateGABA(A) Receptortarget
CarisoprodolCytochrome P450 2C19enzyme
CarisoprodolGamma-aminobutyric acid receptor subunit alpha-1target
CarisoprodolGamma-aminobutyric acid receptor subunit beta-2target
CarisoprodolGamma-aminobutyric acid receptor subunit gamma-2target
CarisoprodolGamma-aminobutyric acid receptor subunit alpha-5target
CarisoprodolGamma-aminobutyric acid receptor subunit alpha-3target
MethocarbamolCarbonic anhydrase 1target
AlbendazoleTubulin alpha-1A chaintarget
AlbendazoleTubulin beta-4B chaintarget
AlbendazoleCytochrome P450 3A4enzyme
AlbendazoleFumarate reductase flavoprotein subunittarget
AlbendazoleCytochrome P450 1A1enzyme
AlbendazoleCytochrome P450 1A2enzyme
AlbendazoleTubulin beta-2 chaintarget
AlbendazoleCytochrome P450 2C19enzyme
AlbendazoleP-glycoprotein 1transporter
MebendazoleTubulin alpha-1A chaintarget
MebendazoleTubulin beta-4B chaintarget
MebendazoleCytochrome P450 1A1enzyme
MebendazoleCytochrome P450 3A Subfamilyenzyme
DiethylcarbamazineArachidonate 5-lipoxygenasetarget
DiethylcarbamazineProstaglandin G/H synthase 1target
DiethylcarbamazineCholinesteraseenzyme
DarunavirHuman immunodeficiency virus type 1 proteasetarget
DarunavirCytochrome P450 3A4enzyme
DarunavirSolute carrier organic anion transporter family member 1B1transporter
DarunavirP-glycoprotein 1transporter
DarunavirSerum albumincarrier
DarunavirAlpha-1-acid glycoprotein 1carrier
DarunavirCytochrome P450 2D6enzyme
UrethaneCytosolic phospholipase A2enzyme
UrethaneMyeloperoxidaseenzyme
UrethaneAldehyde oxidaseenzyme
BethanecholMuscarinic acetylcholine receptor M2target
BethanecholMuscarinic acetylcholine receptor M1target
BethanecholMuscarinic acetylcholine receptor M3target
BethanecholMuscarinic acetylcholine receptor M4target
BethanecholMuscarinic acetylcholine receptor M5target
CobicistatCytochrome P450 2D6enzyme
CobicistatP-glycoprotein 1transporter
CobicistatATP-binding cassette sub-family G member 2transporter
CobicistatCytochrome P450 3A4enzyme
CobicistatCytochrome P450 3A5enzyme
CobicistatCytochrome P450 3A7enzyme
CobicistatCytochrome P450 3A43enzyme
CobicistatSolute carrier organic anion transporter family member 1B1transporter
CobicistatSolute carrier organic anion transporter family member 1B3transporter
TolnaftateSqualene monooxygenasetarget
ZafirlukastCysteinyl leukotriene receptor 1target
ZafirlukastCytochrome P450 2C9enzyme
ZafirlukastCytochrome P450 2C8enzyme
ZafirlukastProstaglandin G/H synthase 1enzyme
ZafirlukastCytochrome P450 3A4enzyme
ZafirlukastCytochrome P450 1A2enzyme
ZafirlukastCytochrome P450 2C19enzyme
ZafirlukastATP-binding cassette sub-family G member 2transporter
ZafirlukastCytochrome P450 2D6enzyme
DisulfiramAldehyde dehydrogenase, mitochondrialtarget
DisulfiramCytochrome P450 2E1enzyme
DisulfiramDopamine beta-hydroxylasetarget
DisulfiramCytochrome P450 3A4enzyme
DisulfiramCytochrome P450 3A5enzyme
DisulfiramBile salt export pumptransporter
FelbamateGlutamate receptor ionotropic, NMDA 2Btarget
FelbamateGlutamate receptor ionotropic, NMDA 2Atarget
FelbamateCytochrome P450 2C19enzyme
FelbamateCytochrome P450 3A4enzyme
FelbamateCytochrome P450 2E1enzyme
FelbamateCytochrome P450 2C9enzyme
PhysostigmineAcetylcholinesterasetarget
PhysostigmineNeuronal acetylcholine receptor subunit alpha-4target
PhysostigmineNeuronal acetylcholine receptor subunit beta-2target
RivastigmineAcetylcholinesterasetarget
RivastigmineCholinesterasetarget
DitiocarbCytochrome P450 2E1enzyme
DitiocarbCytochrome P450 3A4enzyme
DitiocarbCytochrome P450 3A5enzyme
Ethyl N-methylcarbamateShiga-like toxin 1 subunit Btarget
PhenserineAcetylcholinesterasetarget
PhenserineCholinesterasetarget
PhenserineAmyloid beta A4 proteintarget
NOX-700Nuclear factor NF-kappa-B p100 subunittarget
NOX-700Nuclear factor NF-kappa-B p105 subunittarget
GanstigmineAcetylcholinesterasetarget