Pyrrolidinones

Name
Pyrrolidinones
Accession Number
DBCAT000973
Description

A group of compounds that are derivatives of oxo-pyrrolidines. A member of this group is 2-oxo pyrrolidine, which is an intermediate in the manufacture of polyvinylpyrrolidone. (From Merck Index, 11th ed)

Drugs
DrugDrug Description
DoxapramA short acting respiratory stimulant used to treat acute respiratory insufficiency in COPD patients.
EthosuximideAn anticonvulsant used to treat petit mal seizures.
PhensuximideFor the treatment of epilepsy.
LevetiracetamA novel anticonvulsant agent used as an adjunct medication to manage partial onset, myoclonic, and generalized tonic-clonic seizures in patients with epilepsy.
RolipramA phosphodiesterase inhibitor with antidepressant properties.
Pidolic acidThere is currently no clinically approved and/or marketed medicine that relies upon pidolic acid as an active ingredient for any formal therapeutic indication. Although pidolic acid may be sold in...
MethsuximideA succinimide anticonvulsant that increases the seizure threshold. Primarily used for childhood absence seizures. Functions by suppressing paroxysmal spike-and-wave patterns associated with lapses of consciousness in absence seizures.
Povidone-iodineA topical antiseptic agent used for the treatment and prevention of infection in wounds.
RaltegravirAn antiretroviral agent used for the treatment of HIV infections in conjunction with other antiretrovirals.
PiracetamIndicated in adult patients suffering from myoclonus of cortical origin, irrespective of aetiology, and should be used in combination with other anti-myoclonic therapies .
PovidoneWhen in complex with iodine, indicated for inducing antisepsis for prevention of infection in minor cuts, scrapes, and burns.
PidotimodFor use as immunostimulant therapy for treatment of cell-mediated immunosuppression with respiratory or urinary infections .
EtiracetamEtiracetam is under investigation in clinical trial NCT01137110 (Comparison of Short Duration Levetiracetam to Extended Course for Seizure Prophylaxis After Subarachnoid Hemorrhage (SAH)).
Oxothiazolidinecarboxylic acidProcysteine has been used in trials studying the treatment of HIV Infections.
SuccinimideNot Annotated
Drugs & Drug Targets
DrugTargetType
DoxapramPotassium channel subfamily K member 3target
DoxapramPotassium channel subfamily K member 9target
EthosuximideVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
EthosuximideCytochrome P450 3A4enzyme
EthosuximideCytochrome P450 2E1enzyme
EthosuximideCytochrome P450 3A Subfamilyenzyme
LevetiracetamSynaptic vesicle glycoprotein 2Atarget
LevetiracetamP-glycoprotein 1transporter
LevetiracetamVoltage-dependent N-type calcium channel subunit alpha-1Btarget
RolipramcAMP-specific 3',5'-cyclic phosphodiesterase 4Dtarget
RolipramcAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
Pidolic acidAlpha-amylase 2Btarget
Pidolic acidVascular endothelial growth factor Atarget
Pidolic acidPancreatic alpha-amylasetarget
Pidolic acidIg lambda-1 chain C regionstarget
Pidolic acidIg lambda chain V-II region MGCtarget
Pidolic acidTrefoil factor 2target
Pidolic acidCytochrome c2target
Pidolic acidDisintegrin and metalloproteinase domain-containing protein 28target
Pidolic acidEndo-1,4-beta-xylanasetarget
Pidolic acidDissimilatory copper-containing nitrite reductasetarget
Pidolic acidKeratin-associated protein 5-2target
Pidolic acidOrexintarget
Pidolic acidC-C motif chemokine 8target
Pidolic acidCytochrome c'target
Pidolic acidPancreatic alpha-amylaseenzyme
MethsuximideCytochrome P450 2C19enzyme
MethsuximideVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
RaltegravirUDP-glucuronosyltransferase 1-1enzyme
RaltegravirIntegrasetarget