Lipid Modifying Agents, Plain

Name
Lipid Modifying Agents, Plain
Accession Number
DBCAT002167
Description
Not Available
ATC Classification
Drugs
DrugDrug Description
ColestipolA bile acid sequestrant used as an adjunct to diet and exercise to reduce LDL-C cholesterol levels in patients with primary hypercholesterolemia.
CerivastatinA statin (or HMG CoA reductase inhibitor) used with dietary changes to decrease lipid levels and reduce the risk of cardiovascular events.
DextrothyroxineA thyroid hormone used to treat hyperlipidemia.
ClofibrateA fibric acid derivative used to treat hypertriglyceridemia and high cholesterol.
ColesevelamA bile acid sequestrant used to lower LDL-C in adults with hyperlipidemia and pediatric patients with heterozygous familial hypercholesterolemia, and to improve glycemic control in type 2 diabetes.
FluvastatinAn HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.
GemfibrozilA lipid regulator that is used in the reduction of serum triglyceride levels in high-risk patients with hyperlipidemia.
BezafibrateA lipid-lowering fibrate used in the management of primary and secondary hyperlipidaemia, when there is a lack of clinical improvement following lifestyle modifications or correction of the underlying disorder.
CholestyramineA bile acid sequestrant used as an adjunct in the reduction of elevated serum cholesterol in patients with primary hypercholesterolemia, and for the relief of pruritus associated with partial biliary obstruction.
ProbucolUsed to lower LDL and HDL cholesterol.
MipomersenAn oligonucleotide drug used for the treatment of homozygous familial hypercholesterolemia.
LomitapideA microsomal triglyceride transfer protein inhibitor used to lower cholesterol associated with homozygous familial hypercholesterolemia (HoFH), reducing risk of cardiovascular events such as myocardial infarction and stroke.
PitavastatinAn HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.
EtofibrateEtofibrate is a fibrate produced by the combination of clofibrate ester linked to niacin. These components separate in the body slowly allowing for pharmacokinetics similar to controlled-release formulations.
AcipimoxUsed in the treatment of hyperlipidemias (abnormally elevated levels of any or all lipids and/or lipoproteins in the blood).
CiprofibrateNot Annotated
EvolocumabA PCSK9 (proprotein convertase subtilisin kexin type 9) inhibitor antibody used as an adjunct to LDL cholesterol reducing therapies, aiding in the prevention of cardiovascular events and cardiovascular revascularization procedures.
TiadenolNot Annotated
NicofuranoseNot Annotated
SimfibrateNot Annotated
NiceritrolNot Annotated
RonifibrateNot Annotated
Alipogene tiparvovecNot Annotated
Aluminium nicotinateNot Annotated
Aluminium clofibrateNot Annotated
ClofibrideNot Annotated
Fenofibric acidA fibrate used to treat severe hypertriglyceridemia, primary hypercholesterolemia, or mixed dyslipidemia.
PravastatinAn HMG-CoA reductase inhibitor used to lower lipid levels and to reduce the risk of cardiovascular events, including myocardial infarction and stroke.
NiacinA B vitamin used to treat hypertriglyceridemia and pellagra.
SimvastatinAn HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular events including myocardial infarction and stroke.
EzetimibeA cholesterol absorption inhibitor used to lower total cholesterol, LDL-C, Apo-B, and non-HDL-C in primary hyperlipidemia and familial cholesterolemia.
FenofibrateA peroxisome proliferator receptor alpha activator used to lower LDL-C, total-C, triglycerides, and Apo B, while increasing HDL-C in hypercholesterolemia, dyslipidemia, and hypertriglyceridemia.
AtorvastatinAn HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.
RosuvastatinAn HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.
Nicotinyl alcoholA direct-acting peripheral vasodilator that causes flushing and may decrease blood pressure. It is used in vasospasm and threatened gangrene. [PubChem]
MeglutolAn antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as...
AlirocumabA PCSK9 inhibitor used as an adjunct to manage heterozygous familial hypercholesterolemia or clinical atherosclerotic cardiovascular disease in patients who require additional lowering of LDL-cholesterol (LDL-C).
Bempedoic acidA drug used in conjunction with lifestyle modification and/or other agents for the treatment of refractory hypercholesterolemia.
Drugs & Drug Targets
DrugTargetType
ColestipolBile acidstarget
Cerivastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
CerivastatinCytochrome P450 2C8enzyme
CerivastatinCytochrome P450 3A4enzyme
CerivastatinCytochrome P450 2D6enzyme
CerivastatinCytochrome P450 2C9enzyme
CerivastatinCytochrome P450 3A5enzyme
CerivastatinCytochrome P450 3A7enzyme
CerivastatinP-glycoprotein 1transporter
CerivastatinCanalicular multispecific organic anion transporter 1transporter
CerivastatinATP-binding cassette sub-family G member 2transporter
CerivastatinSolute carrier organic anion transporter family member 1B1transporter
CerivastatinCytochrome P450 2B6enzyme
CerivastatinUDP-glucuronosyltransferase 1-1enzyme
CerivastatinBile salt export pumptransporter
DextrothyroxineThyroid hormone receptor alphatarget
DextrothyroxineThyroid hormone receptor betatarget
DextrothyroxineThyroid peroxidasetarget
DextrothyroxineSolute carrier organic anion transporter family member 1B1transporter
DextrothyroxineSolute carrier organic anion transporter family member 1C1transporter
DextrothyroxineSolute carrier organic anion transporter family member 4A1transporter
DextrothyroxineSolute carrier organic anion transporter family member 4C1transporter
DextrothyroxineLarge neutral amino acids transporter small subunit 1transporter
ClofibratePeroxisome proliferator-activated receptor alphatarget
ClofibrateCytochrome P450 3A4enzyme
ClofibrateGlutathione S-transferase A2enzyme
ClofibrateCytochrome P450 2E1enzyme
ClofibrateCytochrome P450 1A1enzyme
ClofibrateCytochrome P450 4A11enzyme
ClofibrateThyroxine-binding globulincarrier
ColesevelamBile acidstarget
Fluvastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
FluvastatinCytochrome P450 2C9enzyme
FluvastatinCytochrome P450 3A4enzyme
FluvastatinCytochrome P450 2C8enzyme
FluvastatinCytochrome P450 2D6enzyme
FluvastatinCytochrome P450 2C19enzyme
FluvastatinCytochrome P450 1A1enzyme
FluvastatinSolute carrier organic anion transporter family member 1B1transporter
FluvastatinSolute carrier organic anion transporter family member 1B3transporter
FluvastatinSolute carrier organic anion transporter family member 2B1transporter
FluvastatinSolute carrier family 15 member 1transporter
FluvastatinCytochrome P450 3A5enzyme
FluvastatinUDP-glucuronosyltransferase 1-1enzyme
FluvastatinUDP-glucuronosyltransferase 1-3enzyme
FluvastatinUDP-glucuronosyltransferase 2B7enzyme
FluvastatinCanalicular multispecific organic anion transporter 1transporter
FluvastatinCytochrome P450 2B6enzyme
FluvastatinHistone deacetylase 2target
GemfibrozilPeroxisome proliferator-activated receptor alphatarget
GemfibrozilCytochrome P450 2C9enzyme
GemfibrozilCytochrome P450 2C8enzyme
GemfibrozilCytochrome P450 1A2enzyme
GemfibrozilCytochrome P450 2C19enzyme
GemfibrozilUDP-glucuronosyltransferase 1-1enzyme
GemfibrozilCytochrome P450 3A4enzyme
GemfibrozilUDP-glucuronosyltransferase 1-3enzyme
GemfibrozilSolute carrier organic anion transporter family member 1B1target
GemfibrozilUDP-glucuronosyltransferase 2B7enzyme
GemfibrozilUDP-glucuronosyltransferase 1-9enzyme
GemfibrozilUDP-glucuronosyltransferase 2B4enzyme
GemfibrozilUDP-glucuronosyltransferase 2B17enzyme
GemfibrozilSerum albumincarrier
GemfibrozilSolute carrier family 22 member 8target
GemfibrozilSolute carrier organic anion transporter family member 2B1target
GemfibrozilSolute carrier organic anion transporter family member 1B3target
BezafibratePeroxisome proliferator-activated receptor alphatarget
BezafibrateSolute carrier organic anion transporter family member 1B1transporter
BezafibratePeroxisome proliferator-activated receptor deltatarget
BezafibratePeroxisome proliferator-activated receptor gammatarget
BezafibrateCytochrome P450 1A1enzyme
BezafibrateCytochrome P450 2C8enzyme
BezafibrateCytochrome P450 3A4enzyme
BezafibrateNuclear receptor subfamily 1 group I member 2target
BezafibrateRetinoic acid receptor RXR-alphatarget
BezafibrateRetinoic acid receptor RXR-betatarget
BezafibrateRetinoic acid receptor RXR-gammatarget
CholestyramineBile acidstarget
ProbucolATP-binding cassette sub-family A member 1target
ProbucolLiver carboxylesterase 1target
MipomersenmRNA of ApoB-100target
LomitapideMicrosomal triglyceride transfer protein large subunittarget
LomitapideCytochrome P450 3A4enzyme
LomitapideP-glycoprotein 1transporter
PitavastatinSolute carrier organic anion transporter family member 1B1transporter
PitavastatinSolute carrier organic anion transporter family member 1B3transporter
PitavastatinUDP-glucuronosyltransferase 2B7enzyme
PitavastatinUDP-glucuronosyltransferase 1-3enzyme
PitavastatinCytochrome P450 2C9enzyme
PitavastatinCytochrome P450 2C8enzyme
Pitavastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
PitavastatinSolute carrier organic anion transporter family member 2B1transporter
PitavastatinSodium/bile acid cotransportertransporter
PitavastatinATP-binding cassette sub-family G member 2transporter
PitavastatinP-glycoprotein 1transporter
PitavastatinCanalicular multispecific organic anion transporter 1transporter
PitavastatinSerum albumincarrier
PitavastatinAlpha-1-acid glycoprotein 1carrier
PitavastatinBile salt export pumptransporter
PitavastatinIntegrin alpha-Ltarget
CiprofibratePeroxisome proliferator-activated receptor alphatarget
EvolocumabProprotein convertase subtilisin/kexin type 9enzyme
Fenofibric acidPeroxisome proliferator-activated receptor alphatarget
Fenofibric acidMatrix metalloproteinase-25target
Fenofibric acidPeroxisome proliferator-activated receptor gammatarget
Fenofibric acidPeroxisome proliferator-activated receptor deltatarget
Fenofibric acidNuclear receptor subfamily 1 group I member 2target
Pravastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
PravastatinSolute carrier organic anion transporter family member 2B1transporter
PravastatinP-glycoprotein 1transporter
PravastatinSolute carrier organic anion transporter family member 1A2transporter
PravastatinSolute carrier family 22 member 6transporter
PravastatinSolute carrier family 22 member 8transporter
PravastatinCanalicular multispecific organic anion transporter 1transporter
PravastatinSolute carrier family 22 member 11transporter
PravastatinATP-binding cassette sub-family G member 2transporter
PravastatinSolute carrier family 22 member 7transporter
PravastatinSolute carrier organic anion transporter family member 1B1transporter
PravastatinMonocarboxylate transporter 1transporter
PravastatinBile salt export pumptransporter
PravastatinSolute carrier organic anion transporter family member 1B3transporter
PravastatinHistone deacetylase 2target
NiacinHydroxycarboxylic acid receptor 2target
NiacinNicotinamide N-methyltransferasetarget
NiacinNicotinate-nucleotide pyrophosphorylase [carboxylating]target
NiacinHydroxycarboxylic acid receptor 3target
NiacinSolute carrier family 22 member 5transporter
NiacinSolute carrier organic anion transporter family member 2B1transporter
NiacinMonocarboxylate transporter 1transporter
NiacinCytochrome P450 2D6enzyme
NiacinSodium-coupled monocarboxylate transporter 1transporter
NiacinMonocarboxylate transporter 4transporter
NiacinThyroxine-binding globulincarrier
NiacinCytochrome P450 3A4enzyme
NiacinCytochrome P450 2E1enzyme
Simvastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
SimvastatinCytochrome P450 3A4enzyme
SimvastatinCytochrome P450 2C8enzyme
SimvastatinCytochrome P450 2C9enzyme
SimvastatinCytochrome P450 3A5enzyme
SimvastatinP-glycoprotein 1transporter
SimvastatinSolute carrier organic anion transporter family member 1A2transporter
SimvastatinSolute carrier organic anion transporter family member 1B1transporter
SimvastatinCytochrome P450 2B6enzyme
SimvastatinCytochrome P450 2D6enzyme
SimvastatinUDP-glucuronosyltransferase 1-1enzyme
SimvastatinUDP-glucuronosyltransferase 1-3enzyme
SimvastatinUDP-glucuronosyltransferase 2B7enzyme
SimvastatinCanalicular multispecific organic anion transporter 1transporter
SimvastatinIntegrin alpha-Ltarget
SimvastatinBile salt export pumptransporter
SimvastatinCytochrome P450 2C19enzyme
SimvastatinSolute carrier organic anion transporter family member 2B1transporter
SimvastatinSolute carrier organic anion transporter family member 1B3transporter
SimvastatinHistone deacetylase 2target
EzetimibeNiemann-Pick C1-like protein 1target
EzetimibeAminopeptidase Ntarget
EzetimibeSterol O-acyltransferase 1target
EzetimibeUDP-glucuronosyltransferase 1-1enzyme
EzetimibeUDP-glucuronosyltransferase 1-3enzyme
EzetimibeP-glycoprotein 1transporter
EzetimibeCanalicular multispecific organic anion transporter 1transporter
EzetimibeSolute carrier organic anion transporter family member 1B1transporter
EzetimibeUDP-glucuronosyltransferase 2B15enzyme
EzetimibeUDP-glucuronosyltransferase 2B7enzyme
EzetimibeCytochrome P450 3A4enzyme
EzetimibeCanalicular multispecific organic anion transporter 2transporter
EzetimibeATP-binding cassette sub-family G member 2transporter
EzetimibeCytochrome P450 2C8enzyme
EzetimibeBile salt export pumptransporter
FenofibratePeroxisome proliferator-activated receptor alphatarget
FenofibrateMatrix metalloproteinase-25target
FenofibrateCytochrome P450 2C8enzyme
FenofibrateCytochrome P450 2C9enzyme
FenofibrateNuclear receptor subfamily 1 group I member 2target
FenofibrateUDP-glucuronosyltransferase 1-9enzyme
FenofibrateBile salt export pumptransporter
FenofibrateSerum albumincarrier
FenofibrateCytochrome P450 2C19enzyme
FenofibrateCytochrome P450 2A6enzyme
FenofibrateLiver carboxylesterase 1enzyme
FenofibrateCarbonyl reductase [NADPH] 1enzyme
FenofibrateAldo-keto reductase family 1 member C1enzyme
FenofibrateAldo-keto reductase family 1 member C2enzyme
FenofibrateAldo-keto reductase family 1 member C3enzyme
FenofibrateAldose reductaseenzyme
Atorvastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
AtorvastatinCytochrome P450 3A4enzyme
AtorvastatinDipeptidyl peptidase 4target
AtorvastatinCytochrome P450 2D6enzyme
AtorvastatinCytochrome P450 2C9enzyme
AtorvastatinCytochrome P450 2C19enzyme
AtorvastatinCytochrome P450 3A5enzyme
AtorvastatinCytochrome P450 3A7enzyme
AtorvastatinP-glycoprotein 1transporter
AtorvastatinSolute carrier organic anion transporter family member 1A2transporter
AtorvastatinSolute carrier organic anion transporter family member 1B1transporter
AtorvastatinMultidrug resistance-associated protein 4transporter
AtorvastatinMultidrug resistance-associated protein 5transporter
AtorvastatinMultidrug resistance-associated protein 1transporter
AtorvastatinCytochrome P450 2B6enzyme
AtorvastatinCytochrome P450 2C8enzyme
AtorvastatinAryl hydrocarbon receptortarget
AtorvastatinSolute carrier organic anion transporter family member 2B1transporter
AtorvastatinSolute carrier organic anion transporter family member 1B3transporter
AtorvastatinUDP-glucuronosyltransferase 1-1enzyme
AtorvastatinUDP-glucuronosyltransferase 1-3enzyme
AtorvastatinCanalicular multispecific organic anion transporter 1transporter
AtorvastatinBile salt export pumptransporter
AtorvastatinSerum albumincarrier
AtorvastatinHistone deacetylase 2target
AtorvastatinNuclear receptor subfamily 1 group I member 3target
Rosuvastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
RosuvastatinCytochrome P450 2C9enzyme
RosuvastatinMultidrug resistance-associated protein 4transporter
RosuvastatinSolute carrier organic anion transporter family member 1A2transporter
RosuvastatinSolute carrier organic anion transporter family member 1B3transporter
RosuvastatinSolute carrier organic anion transporter family member 2B1transporter
RosuvastatinCystine/glutamate transportertransporter
RosuvastatinSolute carrier organic anion transporter family member 1B1transporter
RosuvastatinBile salt export pumptransporter
RosuvastatinATP-binding cassette sub-family G member 2transporter
RosuvastatinSerum albumincarrier
RosuvastatinCanalicular multispecific organic anion transporter 1transporter
RosuvastatinSolute carrier family 22 member 8transporter
RosuvastatinSodium/bile acid cotransportertransporter
RosuvastatinIntegrin alpha-Ltarget
Meglutol3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
AlirocumabProprotein convertase subtilisin/kexin type 9target
Bempedoic acidATP-citrate synthasetarget
Bempedoic acidVery long-chain acyl-CoA synthetaseenzyme
Bempedoic acidSolute carrier organic anion transporter family member 1B1transporter
Bempedoic acidCanalicular multispecific organic anion transporter 2transporter
Bempedoic acidSolute carrier organic anion transporter family member 1B3transporter
Bempedoic acidUDP-glucuronosyltransferase 2B7enzyme
Bempedoic acidAcetyl-coenzyme A synthetase, cytoplasmicenzyme
Bempedoic acidNUAK family SNF1-like kinase 2enzyme