Phenothiazines With Piperazine Structure

Name
Phenothiazines With Piperazine Structure
Accession Number
DBCAT002373
Description

Not Available

ATC Classification
Drugs
DrugDrug Description
ProchlorperazineA phenothiazine derivative used in the treatment of schizophrenia and anxiety and to relieve severe nausea and vomiting.
FluphenazineA phenothiazine used to treat patients requiring long-term neuroleptic therapy.
TrifluoperazineA phenothiazine used to treat depression, anxiety, and agitation.
PerphenazineA phenothiazine used to treat schizophrenia as well as nausea and vomiting.
AcetophenazineFor the treatment of disorganized and psychotic thinking. Also used to help treat false perceptions (e.g. hallucinations or delusions.)
ThioproperazineAn antipsychotic indicated for the management of acute and chronic schizophrenia, including cases that are refractory to more common neuroleptics. May also be used to treat manic syndromes.
PerazineA phenothiazine antipsychotic used in the acute and chronic treatment of psychotic disorders.
ButaperazineButaperazine was approved in 1967 , and possibly discontinued in the 1980s .
ThiopropazateNot Annotated
DixyrazineNot Annotated
Drugs & Drug Targets
DrugTargetType
ProchlorperazineDopamine D2 receptortarget
ProchlorperazineCytochrome P450 2D6enzyme
ProchlorperazineHistamine H1 receptortarget
ProchlorperazineAlpha-1 adrenergic receptorstarget
ProchlorperazineAlpha-2 adrenergic receptorstarget
FluphenazineDopamine D2 receptortarget
FluphenazineCalmodulintarget
FluphenazineDopamine D1 receptortarget
FluphenazineCytochrome P450 2D6enzyme
FluphenazineP-glycoprotein 1transporter
FluphenazineCytochrome P450 2E1enzyme
FluphenazineAndrogen receptortarget
Fluphenazine5-hydroxytryptamine receptor 2Atarget
Fluphenazine5-hydroxytryptamine receptor 2Ctarget
TrifluoperazineDopamine D2 receptortarget
TrifluoperazineAlpha-1A adrenergic receptortarget
TrifluoperazineNeuron-specific vesicular protein calcyontarget
TrifluoperazineXanthine dehydrogenase/oxidaseenzyme
TrifluoperazineUDP-glucuronosyltransferase 1-4enzyme
TrifluoperazineCytochrome P450 1A2enzyme
TrifluoperazineP-glycoprotein 1transporter
TrifluoperazineCalmodulintarget
TrifluoperazineTroponin C, slow skeletal and cardiac musclestarget
TrifluoperazineProtein S100-A4target
PerphenazineDopamine D1 receptortarget
PerphenazineDopamine D2 receptortarget
PerphenazineCalmodulintarget
PerphenazineCytochrome P450 2D6enzyme
PerphenazineCytochrome P450 1A2enzyme
PerphenazineCytochrome P450 2C18enzyme
PerphenazineCytochrome P450 2C19enzyme
PerphenazineCytochrome P450 2C8enzyme
PerphenazineCytochrome P450 2C9enzyme
PerphenazineCytochrome P450 3A4enzyme
AcetophenazineDopamine D2 receptortarget
AcetophenazineAndrogen receptortarget
ThioproperazineDopamine D2 receptortarget
ThioproperazineDopamine D1 receptortarget
ThioproperazineAlpha-1A adrenergic receptortarget
ThioproperazineAlpha-1B adrenergic receptortarget
ThioproperazineSerum albumincarrier