This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Perazine is a phenothiazine antipsychotic used in the acute and chronic treatment of psychotic disorders.
- Generic Name
- Perazine
- DrugBank Accession Number
- DB12710
- Background
Perazine has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders, among others.
- Type
- Small Molecule
- Groups
- Approved, Investigational
- Structure
Structure for Perazine (DB12710)
- Weight
- Average: 339.5
Monoisotopic: 339.176918991 - Chemical Formula
- C20H25N3S
- Synonyms
- Not Available
Pharmacology
- Indication
Not Available
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Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Treatment of Acute psychotic symptoms •••••••••••• ••••••• •••• •••••• Management of Chronic psychosis •••••••••••• ••••••• •••• •••••• Treatment of Psychomotor agitation •••••••••••• ••••••• •••• •••••• Treatment of Catatonic reaction •••••••••••• ••••••• •••• •••••• - Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your software1,2-Benzodiazepine The risk or severity of CNS depression can be increased when 1,2-Benzodiazepine is combined with Perazine. Acebutolol The serum concentration of Acebutolol can be increased when it is combined with Perazine. Acetazolamide The risk or severity of CNS depression can be increased when Acetazolamide is combined with Perazine. Acetohexamide The therapeutic efficacy of Acetohexamide can be decreased when used in combination with Perazine. Acetophenazine The risk or severity of CNS depression can be increased when Acetophenazine is combined with Perazine. - Food Interactions
- Not Available
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
Categories
- ATC Codes
- N05AB10 — Perazine
- Drug Categories
- Antipsychotic Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Dopamine Agents
- Dopamine Antagonists
- Heterocyclic Compounds, Fused-Ring
- Nervous System
- Neurotoxic agents
- Neurotransmitter Agents
- Phenothiazines
- Phenothiazines With Piperazine Structure
- Psycholeptics
- Psychotropic Drugs
- Sulfur Compounds
- Tranquilizing Agents
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as phenothiazines. These are polycyclic aromatic compounds containing a phenothiazine moiety, which is a linear tricyclic system that consists of a two benzene rings joined by a para-thiazine ring.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Benzothiazines
- Sub Class
- Phenothiazines
- Direct Parent
- Phenothiazines
- Alternative Parents
- Alkyldiarylamines / Diarylthioethers / N-methylpiperazines / Benzenoids / 1,4-thiazines / Trialkylamines / Azacyclic compounds / Organopnictogen compounds / Hydrocarbon derivatives
- Substituents
- 1,4-diazinane / Alkyldiarylamine / Amine / Aromatic heteropolycyclic compound / Aryl thioether / Azacycle / Benzenoid / Diarylthioether / Hydrocarbon derivative / N-alkylpiperazine
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- phenothiazines, N-alkylpiperazine, N-methylpiperazine (CHEBI:59118)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 8915147A2B
- CAS number
- 84-97-9
- InChI Key
- WEYVCQFUGFRXOM-UHFFFAOYSA-N
- InChI
- InChI=1S/C20H25N3S/c1-21-13-15-22(16-14-21)11-6-12-23-17-7-2-4-9-19(17)24-20-10-5-3-8-18(20)23/h2-5,7-10H,6,11-16H2,1H3
- IUPAC Name
- 10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine
- SMILES
- CN1CCN(CCCN2C3=CC=CC=C3SC3=CC=CC=C23)CC1
References
- General References
- DIMDI Drug Product Information: Perazin-neuraxpharm (perazine) film-coated tablets [Link]
- External Links
- KEGG Compound
- C16903
- PubChem Compound
- 4744
- PubChem Substance
- 347828908
- ChemSpider
- 4582
- BindingDB
- 260166
- 8042
- ChEBI
- 59118
- ChEMBL
- CHEMBL1697766
- ZINC
- ZINC000019362664
- PharmGKB
- PA162565876
- Wikipedia
- Perazine
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Treatment Schizoaffective Disorders / Schizophrenia / Schizophrenia and Disorders With Psychotic Features 1 3 Terminated Treatment Anxiety Disorders / Dementia / Depression / Psychosomatic Disorders / Schizophrenia 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Tablet, film coated Oral 100 MG Tablet, film coated Oral 200 MG Tablet, film coated Oral 25 MG Tablet, coated Oral 25 MG - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0601 mg/mL ALOGPS logP 4.19 ALOGPS logP 3.78 Chemaxon logS -3.8 ALOGPS pKa (Strongest Basic) 8.41 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 9.72 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 105 m3·mol-1 Chemaxon Polarizability 39.53 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 191.7732622 predictedDarkChem Lite v0.1.0 [M-H]- 175.22598 predictedDeepCCS 1.0 (2019) [M+H]+ 192.5505622 predictedDarkChem Lite v0.1.0 [M+H]+ 177.58398 predictedDeepCCS 1.0 (2019) [M+Na]+ 192.3751622 predictedDarkChem Lite v0.1.0 [M+Na]+ 183.67711 predictedDeepCCS 1.0 (2019)
Drug created at October 20, 2016 23:43 / Updated at June 08, 2021 11:32