Fluphenazine is a phenothiazine used to treat patients requiring long-term neuroleptic therapy. Its properties and uses are generally similar to those of chlorpromazine.
- Mechanism
- Curator reviewed
Fluphenazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.
- Primary indication
- For management of manifestations of psychotic disorders.Curator reviewed · 5 structured indications
- Formula / weight
- C22H26F3N3OS · 437.522 g/mol (avg)
- First approval
- Canada, 1999 · United States, 1987
- Also known as
- Fluorfenazine · Fluorophenazine · Fluorphenazine · Triflumethazine
- Code names
- SQ 10733 · Squibb 16144
Resolves to
Clinical / RWD
Structure
InChIKey
PLDUPXSUYLZYBN-UHFFFAOYSA-NSMILESOCCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1Transporters
What you can answer from here — as of September 23, 2026
7Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
1TransporterSubstrate / inhibitor direction, not just membershipListed above
Which drugs share a target with Fluphenazine, and which of those have an active Phase 3 trial?
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