Vasodilators Used in Cardiac Diseases

Vasodilators Used in Cardiac Diseases
Accession Number

Not Available

ATC Classification
DrugDrug Description
NitroglycerinA nitrate vasodilator used to treat or prevent angina, heart failure, hypertension, and anal fissures.
Isosorbide dinitrateA vasodilator used to treat angina in coronary artery disease.
Isosorbide mononitrateA nitrate used to prevent and treat angina and to treat angina caused by coronary artery disease.
Erythrityl tetranitrateFor the prevention of angina.
PrenylaminePrenylamine was withdrawn from the Canadian, US, and UK markets in 1988 due to concerns regarding cardiac arrhythmias.
NesiritideA recombinant natriuretic peptide used for the treatment of patients with acutely decompensated congestive heart failure who have dyspnea at rest or with minimal activity.
SerelaxinInvestigated for use/treatment in cardiovascular disorders, congestive heart failure, infertility, peripheral vascular disease, and scleroderma.
Pentaerythritol tetranitrateUsed for the treatment of angina pectoris .
NicorandilA vasodilatory drug that functions through potassium channels and intracellular cGMP concentrations commonly used to treat angina.
MolsidomineA long-acting vasodilator used to treat angina pectoris, including in association with left heart failure and acute myocardial infarction.
TrapidilUsed in the treatment of chronic stable angina .
ImolamineImolamine is indicated for the treatment of angina pectoris. The hydrochloride form is used as a local anesthetic.
FlosequinanFlosequinan was approved in the USA and the UK for a year prior to being withdrawn from the market due to increased mortality in chronic heart failure patients, found in...
Propatyl nitrateNot Annotated
HexobendineHexobendine is a medication used to cause vasodilation, to treat several conditions including angina pectoris. It has not been approved in the United States or the United Kingdom, but has...
BenziodaroneBenziodarone is a uricostatic and a uricosuric agent which is sold also under the name Amplivex-Labaz. It is used in the treatment of gout . It was withdrawn from France...
CarbocromenCarbocromen was marketed for use in Germany as a vasodilator, however, it has been discontinued due to the risk of arrhythmia development .
CloridarolCloridarol is an experimental medication in the treatment of heart disease, which acts through vasodilation. It was studied for the treatment of coronary insufficiency in Italy in the 1970s .
EfloxateNot Annotated
CinepazetNot Annotated
OxyfedrineNot Annotated
LinsidomineNot Annotated
Methylpropylpropanediol dinitrateNot Annotated
HeptaminolA cardiac stimulant and vasodilator indicated in the treatment of hemorrhoids and venolymphatic insufficiency.
Aminoethyl nitrateNot Annotated
TenitramineNot Annotated
DilazepNot Annotated
TrolnitrateNot Annotated
EtafenoneEtafenone is a vasodilator.
VericiguatA soluble guanylate cyclase stimulator used to reduce heart failure-related hospitalization and cardiovascular death in patients with chronic systolic heart failure.
Drugs & Drug Targets
NitroglycerinAtrial natriuretic peptide receptor 1target
NitroglycerinAldehyde dehydrogenase, mitochondrialenzyme
Isosorbide dinitrateAtrial natriuretic peptide receptor 1target
Isosorbide dinitrateCytochrome P450 2E1enzyme
Isosorbide mononitrateGuanylate cyclase soluble subunit alpha-2target
Isosorbide mononitrateGlutathione S-transferase Mu 1enzyme
Isosorbide mononitrateXanthine dehydrogenase/oxidaseenzyme
Isosorbide mononitrateAlcohol dehydrogenase class-3enzyme
Erythrityl tetranitrateAtrial natriuretic peptide receptor 1target
Erythrityl tetranitrateAtrial natriuretic peptide receptor 2target
PrenylamineMyosin light chain kinase 2, skeletal/cardiac muscletarget
PrenylamineCytochrome P450 3A4enzyme
NesiritideAtrial natriuretic peptide receptor 1target
NesiritideAtrial natriuretic peptide receptor 2target
NesiritideAtrial natriuretic peptide receptor 3target
Pentaerythritol tetranitrateHemoglobin subunit alphatarget
Pentaerythritol tetranitrateHemoglobin subunit betatarget
Pentaerythritol tetranitrateGuanylate cyclase soluble subunit alpha-2enzyme
Pentaerythritol tetranitrateFree radicalstarget
Pentaerythritol tetranitrateNitric oxide synthase, endothelialenzyme
Pentaerythritol tetranitrateAldehyde dehydrogenase, mitochondrialenzyme
NicorandilATP-binding cassette sub-family C member 9target
MolsidomineGuanylate cyclase soluble subunit alpha-2target
MolsidomineGuanylate cyclase soluble subunit alpha-2enzyme
MolsidominecGMP-specific 3',5'-cyclic phosphodiesteraseenzyme
TrapidilPlatelet-derived growth factor receptor betatarget
TrapidilCyclic nucleotide phosphodiesterasetarget
VericiguatUDP-glucuronosyltransferase 1-9enzyme
VericiguatUDP-glucuronosyltransferase 1-1enzyme
VericiguatP-glycoprotein 1transporter
VericiguatATP-binding cassette sub-family G member 2transporter
VericiguatSerum albumincarrier
VericiguatGuanylate cyclase soluble subunit beta-1target