Cytochrome P-450 CYP3A4 Inhibitors (strong)
- Cytochrome P-450 CYP3A4 Inhibitors (strong)
- Accession Number
Drug Drug Description Voriconazole A triazole compound used to treat fungal infections. Telithromycin An ketolide used to treat community acquired pneumonia of mild to moderate severity. Ketoconazole A broad spectrum antifungal used to treat seborrheic dermatitis and fungal skin infections. Nefazodone An antidepressant used in the treatment of depression. Itraconazole An antifungal agent used for the treatment of various fungal infections in immunocompromised and non-immunocompromised patients, such as pulmonary and extrapulmonary blastomycosis, histoplasmosis, and onychomycosis. Clarithromycin A macrolide antibiotic used for the treatment of a wide variety of bacterial infections such as acute otitis, pharyngitis, tonsillitis, respiratory tract infections, uncomplicated skin infections, and helicobacter pylori infection. Saquinavir An HIV protease inhibitor used in combination with other antiretroviral agents for the treatment of HIV-1 with advanced immunodeficiency. Darunavir A HIV protease inhibitor used in the treatment of human immunodeficiency virus (HIV) infection in patients with history of prior antiretroviral therapies. Posaconazole A triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. Lopinavir An HIV-1 protease inhibitor used in combination with ritonavir to treat human immunodeficiency virus (HIV) infection. Telaprevir An NS3/4A viral protease inhibitor used in combination with other antivirals for the curative treatment of chronic Hepatitis C Virus infections. Idelalisib An antineoplastic kinase inhibitor used to treat chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). Cobicistat A CYP3A inhibitor used to increase the systemic exposure of atazanavir or darunavir in combination with other antiretroviral agents in the treatment of HIV-1 infection. Stiripentol An anticonvulsant agent used with clobazam and valproate as an adjunct to treat refractory generalized tonic-clonic seizures in Dravet syndrome. Curcumin No approved therapeutic indications. Ritonavir An HIV protease inhibitor used in combination with other antivirals in the treatment of HIV infection. Conivaptan An antidiuretic hormone inhibitor used to raise serum sodium levels. Troleandomycin For the treatment of bacterial infection. Efavirenz A non-nucleoside reverse transcriptase inhibitor used to treat HIV infection or prevent the spread of HIV. Atazanavir An antiviral protease inhibitor used in combination with other antiretrovirals for the treatment of HIV. Tipranavir A protease inhibitor used to treat HIV-1 resistant to more than 1 protease inhibitor. Naloxone An opioid receptor antagonist used to rapidly reverse an opioid overdose. Also included in some drug formulations as an abuse deterrent to prevent injection. Nilotinib A kinase inhibitor used for the chronic phase treatment of Chronic Myeloid Leukemia (CML) that is Philadelphia chromosome positive and for the treatment of CML that is resistant to therapy containing imatinib. Delavirdine A non-nucleoside reverse transcriptase inhibitor used to treat HIV infection. Loperamide A long acting antidiarrheal used to control nonspecific diarrhea and chronic diarrhea caused by inflammatory bowel disease, or gastroenteritis. Ribociclib A kinase inhibitor used to treat HR+, HER2- advanced or metastatic breast cancer. Danoprevir Danoprevir has been used in trials studying the treatment of Hepatitis C, Chronic. Elvitegravir An antiretroviral agent used in combination with other antiretrovirals for the treatment of HIV-1 infection in antiretroviral treatment-experienced adults. Midostaurin An antineoplastic agent used to treat high-risk acute myeloid leukemia (AML) with specific mutations, aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated hematologic neoplasm (SM-AHN), or mast cell leukemia (MCL). Terfenadine An antihistamine for the treatment of allergy symptoms. Ergotamine An alpha-1 selective adrenergic agonist vasoconstrictor used to treat migraines with or without aura and cluster headaches. Econazole A topical antifungal used to treat tinea pedis, tinea cruris, tinea corporis, cutaneous candidiasis and tinea versicolor. Ditiocarb A chelating agent that has been used to mobilize toxic metals from the tissues of man and experimental animals. It is the main metabolite of DISULFIRAM. Indinavir A protease inhibitor used to treat HIV infection. Nelfinavir A viral protease inhibitor used in the treatment of HIV infection. Methimazole A thionamide antithyroid agent that inhibits the actions of thyroid peroxidase, leading to a reduction in thyroid hormone synthesis and amelioration of hyperthyroidism. Boceprevir A hepatitis C virus NS3/4A protease inhibitor used in combination with other medications to treat chronic hepatitis C genotype 1 infection. Boceprevir is not indicated as monotherapy. Danazol A synthetic steroid and pituitary gonadotropin inhibitor used in the treatment of endometriosis and symptomatic treatment of severe pain and tenderness associated with benign fibrocystic breasts. Diltiazem A calcium channel blocker used to treat hypertension and to manage chronic stable angina. Lonafarnib A potent farnesyl transferase inhibitor used to reduce mortality associated with Hutchinson-Gilford progeria syndrome (HGPS) and other progeroid laminopathies. Amprenavir A protease inhibitor used to treat HIV infection. Amiodarone A class III antiarrhythmic indicated for the treatment of recurrent hemodynamically unstable ventricular tachycardia and recurrent ventricular fibrillation. Levoketoconazole One of two enantiomeric forms of racemic ketoconazole that strongly inhibits multiple steroidogenic enzymes and is used for the symptomatic treatment of endogenous Cushing's syndrome.
- Drugs & Drug Targets