Cytochrome P-450 CYP3A4 Inhibitors (strong)
- Name
- Cytochrome P-450 CYP3A4 Inhibitors (strong)
- Accession Number
- DBCAT002647
- Description
Not Available
- Drugs
Drug Drug Description Voriconazole A triazole compound used to treat fungal infections. Telithromycin An ketolide used to treat community acquired pneumonia of mild to moderate severity. Ketoconazole A broad spectrum antifungal used to treat seborrheic dermatitis and fungal skin infections. Nefazodone An antidepressant used in the treatment of depression. Itraconazole A triazole antifungal agent used to treat various fungal infections, such as blastomycosis and onychomycosis. Clarithromycin A macrolide antibiotic used for the treatment of a wide variety of bacterial infections such as acute otitis, pharyngitis, tonsillitis, respiratory tract infections, uncomplicated skin infections, and helicobacter pylori infection. Saquinavir An HIV protease inhibitor used in combination with other antiretroviral agents for the treatment of HIV-1 with advanced immunodeficiency. Darunavir A HIV protease inhibitor used in the treatment of human immunodeficiency virus (HIV) infection in patients with history of prior antiretroviral therapies. Posaconazole A triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. Lopinavir An HIV-1 protease inhibitor used in combination with ritonavir to treat human immunodeficiency virus (HIV) infection. Telaprevir An NS3/4A viral protease inhibitor used in combination with other antivirals for the curative treatment of chronic Hepatitis C Virus infections. Idelalisib An antineoplastic kinase inhibitor used to treat chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). Stiripentol An antiepileptic agent used in combination with other anticonvulsants to treat seizures associated with Dravet syndrome. Curcumin No approved therapeutic indications. Ritonavir An HIV protease inhibitor used in combination with other antivirals in the treatment of HIV infection. Conivaptan An antidiuretic hormone inhibitor used to raise serum sodium levels. Troleandomycin For the treatment of bacterial infection. Efavirenz A non-nucleoside reverse transcriptase inhibitor used to treat HIV infection or prevent the spread of HIV. Atazanavir An antiviral protease inhibitor used in combination with other antiretrovirals for the treatment of HIV. Tipranavir A protease inhibitor used to treat HIV-1 resistant to more than 1 protease inhibitor. Nilotinib A kinase inhibitor used for the chronic phase treatment of Chronic Myeloid Leukemia (CML) that is Philadelphia chromosome positive and for the treatment of CML that is resistant to therapy containing imatinib. Delavirdine A non-nucleoside reverse transcriptase inhibitor used to treat HIV infection. Ribociclib A kinase inhibitor used to treat HR+, HER2- advanced or metastatic breast cancer. Danoprevir Danoprevir has been used in trials studying the treatment of Hepatitis C, Chronic. Elvitegravir An antiretroviral agent used in combination with other antiretrovirals for the treatment of HIV-1 infection in antiretroviral treatment-experienced adults. Midostaurin An antineoplastic agent used to treat high-risk acute myeloid leukemia (AML) with specific mutations, aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated hematologic neoplasm (SM-AHN), or mast cell leukemia (MCL). Terfenadine An antihistamine for the treatment of allergy symptoms. Ergotamine An alpha-1 selective adrenergic agonist vasoconstrictor used to treat migraines with or without aura and cluster headaches. Econazole A topical antifungal used to treat tinea pedis, tinea cruris, tinea corporis, cutaneous candidiasis and tinea versicolor. Ditiocarb A chelating agent that has been used to mobilize toxic metals from the tissues of man and experimental animals. It is the main metabolite of DISULFIRAM. Indinavir A protease inhibitor used to treat HIV infection. Nelfinavir A viral protease inhibitor used in the treatment of HIV infection. Methimazole A thionamide antithyroid agent that inhibits the actions of thyroid peroxidase, leading to a reduction in thyroid hormone synthesis and amelioration of hyperthyroidism. Boceprevir A hepatitis C virus NS3/4A protease inhibitor used in combination with other medications to treat chronic hepatitis C genotype 1 infection. Boceprevir is not indicated as monotherapy. Danazol A synthetic steroid and pituitary gonadotropin inhibitor used in the treatment of endometriosis and symptomatic treatment of severe pain and tenderness associated with benign fibrocystic breasts. Diltiazem A calcium channel blocker used to treat hypertension and to manage chronic stable angina. Lonafarnib A potent farnesyl transferase inhibitor used to reduce mortality associated with Hutchinson-Gilford progeria syndrome (HGPS) and other progeroid laminopathies. Amprenavir A protease inhibitor used to treat HIV infection. Amiodarone A class III antiarrhythmic indicated for the treatment of recurrent hemodynamically unstable ventricular tachycardia and recurrent ventricular fibrillation. Levoketoconazole One of two enantiomeric forms of racemic ketoconazole that strongly inhibits multiple steroidogenic enzymes and is used for the symptomatic treatment of endogenous Cushing's syndrome. - Drugs & Drug Targets