Cytochrome P-450 CYP2B6 Inhibitors (weak)

Cytochrome P-450 CYP2B6 Inhibitors (weak)
Accession Number
Not Available
DrugDrug Description
CrisaboroleA non-steroidal topical medication used for the treatment of mild-moderate atopic dermatitis.
ManidipineFor the treatment of hypertension.
PiperaquineFor the treatment of uncomplicated Plasmodium falciparum infection in adults, children, and infants aged 6 months and up weighing over 5 kg [FDA Label]. Used in combination with DB11638.
LopinavirAn HIV-1 protease inhibitor used in combination with ritonavir to treat human immunodeficiency virus (HIV) infection.
AmprenavirA protease inhibitor used to treat HIV infection.
SimvastatinAn HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular events including myocardial infarction and stroke.
ClascoteroneClascoterone is indicated for the topical treatment of acne vulgaris in patients 12 years of age and older.
Drugs & Drug Targets
CrisaborolecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
CrisaborolecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
CrisaborolecAMP-specific 3',5'-cyclic phosphodiesterase 4Ctarget
CrisaborolecAMP-specific 3',5'-cyclic phosphodiesterase 4Dtarget
CrisaboroleCytochrome P450 2B6enzyme
CrisaboroleCytochrome P450 2C8enzyme
CrisaboroleCytochrome P450 2C9enzyme
ManidipineVoltage-dependent L-type calcium channeltarget
ManidipineVoltage-dependent T-type calcium channeltarget
ManidipineCytochrome P450 2C9enzyme
ManidipineCytochrome P450 2D6enzyme
ManidipineCytochrome P450 1A1enzyme
ManidipineCytochrome P450 2B6enzyme
ManidipineCytochrome P450 2C19enzyme
ManidipineCytochrome P450 3A4enzyme
PiperaquineCytochrome P450 3A4enzyme
PiperaquineCytochrome P450 2C19enzyme
PiperaquineCytochrome P450 2C9enzyme
PiperaquineCytochrome P450 2B6enzyme
PiperaquineCytochrome P450 2E1enzyme
LopinavirHuman immunodeficiency virus type 1 proteasetarget
LopinavirCytochrome P450 3A4enzyme
LopinavirCytochrome P450 2D6enzyme
LopinavirCytochrome P450 2C19enzyme
LopinavirP-glycoprotein 1transporter
LopinavirCytochrome P450 2B6enzyme
LopinavirCytochrome P450 2C9enzyme
LopinavirCytochrome P450 3A Subfamilyenzyme
LopinavirSolute carrier organic anion transporter family member 1B1transporter
LopinavirSolute carrier organic anion transporter family member 1B3transporter
LopinavirBile salt export pumptransporter
LopinavirCytochrome P450 1A2enzyme
LopinavirAlpha-1-acid glycoprotein 1carrier
LopinavirSerum albumincarrier
AmprenavirHuman immunodeficiency virus type 1 proteasetarget
AmprenavirCytochrome P450 3A4enzyme
AmprenavirP-glycoprotein 1transporter
AmprenavirMultidrug resistance-associated protein 1transporter
AmprenavirCytochrome P450 2B6enzyme
AmprenavirCytochrome P450 2C19enzyme
AmprenavirCytochrome P450 2C9enzyme
AmprenavirCytochrome P450 2D6enzyme
AmprenavirCytochrome P450 3A5enzyme
AmprenavirSolute carrier organic anion transporter family member 1B1transporter
Simvastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
SimvastatinCytochrome P450 3A4enzyme
SimvastatinCytochrome P450 2C8enzyme
SimvastatinCytochrome P450 2C9enzyme
SimvastatinCytochrome P450 3A5enzyme
SimvastatinP-glycoprotein 1transporter
SimvastatinSolute carrier organic anion transporter family member 1A2transporter
SimvastatinSolute carrier organic anion transporter family member 1B1transporter
SimvastatinCytochrome P450 2B6enzyme
SimvastatinCytochrome P450 2D6enzyme
SimvastatinUDP-glucuronosyltransferase 1-1enzyme
SimvastatinUDP-glucuronosyltransferase 1-3enzyme
SimvastatinUDP-glucuronosyltransferase 2B7enzyme
SimvastatinCanalicular multispecific organic anion transporter 1transporter
SimvastatinIntegrin alpha-Ltarget
SimvastatinBile salt export pumptransporter
SimvastatinCytochrome P450 2C19enzyme
SimvastatinSolute carrier organic anion transporter family member 2B1transporter
SimvastatinSolute carrier organic anion transporter family member 1B3transporter
SimvastatinHistone deacetylase 2target
ClascoteroneAndrogen receptortarget
ClascoteroneCytochrome P450 1A2enzyme
ClascoteroneCytochrome P450 2B6enzyme
ClascoteroneCytochrome P450 2C8enzyme
ClascoteroneCytochrome P450 2C9enzyme
ClascoteroneCytochrome P450 2C19enzyme
ClascoteroneCytochrome P450 2D6enzyme
ClascoteroneCytochrome P450 2E1enzyme
ClascoteroneCytochrome P450 3A4enzyme