Cytochrome P-450 CYP2B6 Inhibitors
- Cytochrome P-450 CYP2B6 Inhibitors
- Accession Number
- DBCAT001285 (DBCAT004053)
Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP2B6.
Drug Drug Description Orphenadrine A muscarinic antagonist used as an adjunct for the symptomatic relief of musculoskeletal pain and discomfort. Clopidogrel An antiplatelet agent used to prevent blood clots in peripheral vascular disease, coronary artery disease, and cerebrovascular disease. Thiotepa An alkylating agent used to prevent graft rejection in stem cell transplantation and to treat a variety of malignancies including certain types of adenocarcinoma and superficial bladder carcinomas. Curcumin No approved therapeutic indications. Crisaborole A non-steroidal topical medication used for the treatment of mild-moderate atopic dermatitis. Manidipine A dihydropyridine calcium channel blocker used to treat hypertension. Piperaquine For the treatment of uncomplicated Plasmodium falciparum infection in adults, children, and infants aged 6 months and up weighing over 5 kg [FDA Label]. Used in combination with DB11638. Lopinavir An HIV-1 protease inhibitor used in combination with ritonavir to treat human immunodeficiency virus (HIV) infection. Crizotinib A receptor tyrosine kinase inhibitor used to treat metastatic non-small cell lung cancer (NSCLC) where the tumors have been confirmed to be anaplastic lymphoma kinase (ALK), or ROS1-positive. Sertraline A selective serotonin reuptake inhibitor (SSRI) indicated to treat major depressive disorder, social anxiety disorder and many other psychiatric conditions. Clotrimazole A topical broad-spectrum antifungal agent used for the treatment of a wide variety of dermatophyte infections and candidiasis. Itraconazole An antifungal agent used for the treatment of various fungal infections in immunocompromised and non-immunocompromised patients, such as pulmonary and extrapulmonary blastomycosis, histoplasmosis, and onychomycosis. Raloxifene A selective estrogen receptor modulator that is used to prevent and treat osteoporosis and reduce the risk of invasive breast cancer in high-risk postmenopausal women. Ritonavir An HIV protease inhibitor used in combination with other antivirals in the treatment of HIV infection. Memantine An NMDA receptor antagonist used to treat moderate to severe dementia in Alzheimer's. Tamoxifen A selective estrogen receptor modulator used to treat estrogen receptor positive breast cancer, reduce the risk of invasive breast cancer following surgery, or reduce the risk of breast cancer in high risk women. Ketoconazole A broad spectrum antifungal used to treat seborrheic dermatitis and fungal skin infections. Paroxetine A selective serotonin reuptake inhibitor used to treat major depressive disorder, panic disorder, OCD, social phobia, generalized anxiety disorder, the vasomotor symptoms of menopause, and premenstrual dysphoric disorder. Amprenavir A protease inhibitor used to treat HIV infection. Fluvoxamine A selective serotonin-reuptake inhibitor used to treat obsessive-compulsive disorder. Modafinil A stimulant used to improve wakefulness in patients with sleep apnea, narcolepsy, or shift work disorder. Methimazole A thionamide antithyroid agent that inhibits the actions of thyroid peroxidase, leading to a reduction in thyroid hormone synthesis and amelioration of hyperthyroidism. Rilpivirine A non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with other antiretrovirals to specifically treat human immunodeficiency virus type 1 (HIV-1). Sorafenib A kinase inhibitor used to treat unresectable liver carcinoma, advanced renal carcinoma, and differentiated thyroid carcinoma. Amlodipine A calcium channel blocker used to treat hypertension and angina. Simvastatin An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular events including myocardial infarction and stroke. Nelfinavir A viral protease inhibitor used in the treatment of HIV infection. Selegiline A monoamine oxidase inhibitor used to treat major depressive disorder and Parkinson's. Desipramine A tricyclic antidepressant used in the treatment of depression. Doxorubicin A medication used to treat various cancers, including AIDS-associated Kaposi's Sarcoma. Phencyclidine A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to ketamine in structure and in many of its effects. Like... Azelastine A histamine H1-receptor antagonist used intranasally to treat allergic and vasomotor rhinitis and in an ophthalmic solution to treat allergic conjunctivitis. Colchicine An alkaloid used in the symptomatic relief of pain in attacks of gout and to treat the inflammatory symptoms of Familial Mediterranean Fever (FMF). Ethanol For therapeutic neurolysis of nerves or ganglia for the relief of intractable chronic pain in such conditions as inoperable cancer and trigeminal neuralgia (tic douloureux), in patients for whom neurosurgical... Miconazole An azole antifungal with broad-spectrum activity used to treat fungal infections affecting the vagina, mouth and skin, including candidiasis. Quinidine A medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias. Roxithromycin An antibiotic used to treat a variety of susceptible bacterial infections. Sulfaphenazole For the treatment bacterial infections. Nitric Oxide A vasodilating agent used in the treatment of hypoxic respiratory failure in premature neonates. Cisplatin A platinum based chemotherapy agent used to treat various sarcomas, carcinomas, lymphomas, and germ cell tumors. Regorafenib A kinase inhibitor used to treat patients with metastatic colorectal cancer, unresectable, locally advanced, or metastatic gastrointestinal stromal tumors, and hepatocellular carcinoma. Enzalutamide A second-generation androgen receptor inhibitor used to treat castration-resistant prostate cancer and metastatic castration-sensitive prostate cancer. Quazepam A long-acting benzodiazepine used to manage insomnia. Enasidenib An isocitrate dehydrogenase-2 inhibitor used to treat relapsed or refractory acute myeloid leukemia with an isocitrate dehydrogenase-2 mutation. Voriconazole A triazole compound used to treat fungal infections. Lenvatinib A receptor tyrosine kinase inhibitor used for the treatment of metastatic thyroid cancer, advanced renal cell carcinoma in combination with everolimus, and unresectable hepatocellular carcinoma. Rifamycin An antibacterial used to treat traveler's diarrhea. Triclabendazole An anthelmintic drug used to treat fascioliasis. Ticlopidine A platelet aggregation inhibitor used in the prevention of conditions associated with thrombi, such as stroke and transient ischemic attacks (TIA). Pexidartinib An antitumor agent that is used for the treatment of rare disease tenosynovial giant cell tumors (TGCT) by inhibiting colony-stimulating factor 1 and its receptor. Curcumin sulfate No approved therapeutic indications. Abemaciclib A medication used to treat HR+ HER2- advanced or metastatic breast cancer. Elexacaftor A small molecule CFTR corrector used in combination with tezacaftor and ivacaftor for the treatment of cystic fibrosis patients with one F508del-CFTR mutation. Cenobamate A small molecule drug indicated to treat partial onset seizures in adults. Methylene blue An oxidation-reduction agent used for the treatment of pediatric and adult patients with acquired methemoglobinemia. Abametapir A pediculicide metalloproteinase used topically in the treatment of head lice infection. Clascoterone An androgen receptor antagonist used for the topical treatment of acne vulgaris in patients 12 years of age and older. Tirbanibulin A tyrosine kinase and tubulin inhibitor used to treat actinic keratosis on the face or scalp. Dabrafenib A kinase inhibitor used to treat patients with specific types of melanoma, non-small cell lung cancer, and thyroid cancer. Opicapone A catechol-O-methyltransferase inhibitor used as an adjunct treatment for Parkinson's Disease in adults currently receiving levodopa and a dopa decarboxylase inhibitor. Menadione The primary known function of vitamin K is to assist in the normal clotting of blood, but it may also play a role in normal bone calcification. Duloxetine A serotonin norepinephrine reuptake inhibitor used to treat generalized anxiety disorder, neuropathic pain, osteoarthritis, and stress incontinence. Viloxazine A selective norepinephrine reuptake inhibitor indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) in adults in children. Cannabidiol An active cannabinoid used as an adjunctive treatment for the management of seizures associated with Lennox-Gastaut syndrome or Dravet syndrome and symptomatic relief of moderate to severe neuropathic pain or other painful conditions, like cancer. Brincidofovir An oral lipid prodrug of cidofovir used in the treatment of human smallpox disease. Fexinidazole An orally bioavailable 2-substituted 5-nitroimidazole used to treat early- and late-stage human African trypanosomiasis caused by Trypanosoma brucei gambiense. Levoketoconazole One of two enantiomeric forms of racemic ketoconazole that strongly inhibits multiple steroidogenic enzymes and is used for the symptomatic treatment of endogenous Cushing's syndrome. Dronabinol A synthetic delta-9-THC used in the treatment of anorexia and weight loss in HIV patients as well as nausea and vomiting in cancer chemotherapy. Cannabinol Cannabinol (CBN) is a physiologically inactive constituent of Cannabis sativa. Medical Cannabis The use of the plant species Cannabis sativa and Cannabis indica, popularly known as marijuana, has gained popularity in recent years for the management of a wide variety of medical... Stiripentol An antiepileptic agent used in combination with other anticonvulsants to treat seizures associated with Dravet syndrome. Baloxavir marboxil A polymerase acidic endonuclease inhibitor used to treat uncomplicated influenza. Resveratrol Being investigated for the treatment of Herpes labialis infections (cold sores). Pirtobrutinib A kinase inhibitor used to treat relapsed or refractory mantle cell lymphoma (MCL) after at least two lines of systemic therapy.
- Drugs & Drug Targets