Antiparasitic Agents
- Name
- Antiparasitic Agents
- Accession Number
- DBCAT000522
- Description
Drugs used to treat or prevent parasitic infections.
- Drugs
Drug Drug Description 5'-S-methyl-5'-thioadenosine Not Available Acedapsone Acedapsone is a small molecule drug. Acedapsone has a monoisotopic molecular weight of 332.08 Da. Albendazole A benzimidazole anthelmintic used to treat parenchymal neurocysticercosis and other helminth infections. Albendazole oxide Not Annotated Allopurinol riboside Allopurinol riboside is a nucleoside analogue of allopurinol with a beta-D-ribofuranosyl moiety at the 1-position. Amocarzine Amocarzine is a small molecule drug. Amocarzine has a monoisotopic molecular weight of 371.14 Da. Amodiaquine An antimalarial drug. Amoscanate Amoscanate is a small molecule drug. Amoscanate has a monoisotopic molecular weight of 271.04 Da. Amphotericin B An antifungal used to treat fungal infections in neutropenic patients, cryptococcal meningitis in HIV infection, fungal infections, and leishmaniasis. Amprolium Amprolium is a coccidiostat used in poultry. Andrographolide Investigated for use/treatment in ulcerative colitis. Anisomycin Anisomycin (sometimes known as flagecidin), is an antibiotic retrieved from the bacteria Streptomyces griseolus. This drug acts to inhibit bacterial protein and DNA synthesis. Antimony potassium tartrate Antimony potassium tartrate is a schistosomicide possibly useful against other parasites. It has irritant emetic properties and may cause lethal cardiac toxicity among other adverse effects. Arpraziquantel (R)-Praziquantel is under investigation in clinical trial NCT02271984 (Relative Bioavailability Trial of L-Praziquantel in Healthy Volunteers). Arprinocid Arprinocid is a small molecule drug. Arprinocid has a monoisotopic molecular weight of 277.05 Da. Artefenomel Artefenomel has been investigated for the treatment of Malaria. Arteflene Arteflene is a small molecule drug. Arteflene has a monoisotopic molecular weight of 408.12 Da. Artemether An antimalarial agent used in combination with lumefantrine for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum. Artemotil Artemotil, also known as β-arteether, is a semi-synthetic derivative of artemisinin and a fast acting blood schizonticide specifically indicated for the treatment of chloroquine-resistant Plasmodium falciparum malaria and cerebral malaria... Artenimol For the treatment of uncomplicated Plasmodium falciparum infection in adults, children, and infants aged 6 months and up weighing over 5 kg [FDA Label]. Used in combination with DB13941. Artesunate Artesunate is an artemesinin derivative indicated for the initial treatment of severe malaria. Atovaquone An antimicrobial indicated for the prevention and treatment of Pneumocystis jirovecii pneumonia (PCP) and for the prevention and treatment of Plasmodium falciparum malaria. Benzimidazole Not Available Benznidazole A trypanocidal agent used to treat Chagas disease. Bephenium Not Annotated Betulinic Acid Betulinic Acid has been used in trials studying the treatment of Dysplastic Nevus Syndrome. Bithionol Bithionol, formerly marketed as an active ingredient in various topical drug products, was shown to be a potent photosensitizer with the potential to cause serious skin disorders. Approvals of the... Bromofenofos Bromofenofos is a small molecule drug. Bromofenofos has a monoisotopic molecular weight of 577.68 Da. Bunamidine Bunamidine is a veterinary anti-platyhelmintic agent used for taenia infestations. Cambendazole Not Annotated Carbendazim Carbendazim has been used in trials studying the treatment of Lymphoma and Unspecified Adult Solid Tumor, Protocol Specific. Chloroquine An antimalarial drug used to treat susceptible infections with P. vivax, P. malariae, P. ovale, and P. falciparum. It is also used for second line treatment for rheumatoid arthritis. Chloroxylenol An antimicrobial used to treat cuts, bites, stings, abrasions, and used as an antiseptic hand cleaner. Chlorproguanil Chlorproguanil has been used in trials studying the treatment of MALARIA. It is a dichloro-derivative of chloroguanide. Chlortetracycline The first tetracycline antibiotic most commonly used for veterinary purposes. Ciclobendazole Not Annotated Clorsulon Not Annotated Coumaphos This drug is a fat-soluble phosphorothioate agent that kills both insects and mites. It is non-volatile in nature and is well known by a variety of names as such a... Cycloguanil Cycloguanil is the active metabolite of proguanil. Dapsone A sulfone drug used to treat acne vulgaris, Hansen's disease, and dermatitis herpetiformis. Decoquinate Decoquinate is used in veterinary to delay the growth and reproduction of coccidian parasites. Desaspidin Not Annotated Diamfenetide Diamfenetide is a small molecule drug. Diamfenetide has a monoisotopic molecular weight of 372.17 Da. Dichlorophen Dichlorophen is an antimicrobial agent shown to exert activity against cestodes, protozoa, fungi, and bacteria. It is often combined with toluene to remove parasites including ascarids, tapeworm, and hookworm from... Dichlorvos Dichlorvos or 2,2-dichlorovinyl dimethyl phosphate is a drug of the organophosphate class, frequently used as an insecticide for the control of indoor pests and for the protection of stored products... Diclazuril Diclazuril is a coccidiostat. Diethylcarbamazine An anthelmintic used to treat filarial infections like Wuchereria bancrofti and Loa loa. Diiodohydroxyquinoline Used in the treatment of amoebiasis. Diloxanide Diloxanide is used alone as a primary agent in the treatment of asymptomatic (cyst passers) intestinal amebiasis caused by Entamoeba histolytica. Diloxanide may also be used concurrently, or sequentially, with... Diloxanide furoate Diloxanide is used alone as a primary agent in the treatment of asymptomatic (cyst passers) intestinal amebiasis caused by Entamoeba histolytica. Diloxanide may also be used concurrently, or sequentially, with... Dimetridazole Dimetridazole is a small molecule drug. Dimetridazole has a monoisotopic molecular weight of 141.05 Da. Diminazene Diminazene, also known as Diminazine, 4,4'-(Diazoamino)benzamidine, 4,4'-(1-triazene-1,3-diyl)bis-benzenecarboximidamide, diminazine aceturate, or Diminazene aceturate, is a trypanocidal agent. Major brands of Diminazene are Berenil, Pirocide, Ganasag, and Azidin. This substance is a... Dithiazanine Dithiazanine is a highly potent anthelmintic, introduced in 1959 for the treatment of strongyloid worms and whipworms. However, its use is severely limited due to its toxicity. Dithiazanine iodide was... Doramectin Doramectin is a veterinary drug approved by the Food and Drug Administration for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in... Doxycycline A tetracycline antibiotic used to treat a wide variety of bacterial infections. Eflornithine An ornithine decarboxylase inhibitor used to prevent relapse of high-risk neuroblastoma in pediatric and adult patients Emetine Not Annotated Emodepside Emodepside is an anthelmintic drug that is effective against a number of gastrointestinal nematodes, is licensed for use in cats and belongs to the class of drugs known as the... Eprinomectin Not Annotated Etofamide Etofamide is used as an antiamoebic agent. Etofamide, under the brand name Kitnos, was marketed in Brazil by Pfizer but has been discontinued . Febantel Not Annotated Fenbendazole Fenbendazole is a benzimidazole that presents a wide spectrum anthelmintic effect. It is used against a number of gastrointestinal parasites including giardia, roundworms, hookworms, whipworms, the Taenia genus of tapeworms,... Flubendazole Flubendazole is an anthelmintic that is used to treat worm infection in humans. It is available OTC in Europe. Fumagillin Not Available Furazolidone A drug for the treatment of infectious diarrhea. Geneticin Geneticin (also known as G418) is an aminoglycoside antibiotic similar in structure to gentamicin B1, produced by Micromonospora rhodorangea. Geneticin blocks polypeptide synthesis by inhibiting the elongation step in both... Hachimycin Not Annotated Halofantrine An antimalarial used for the treatment of severe malaria. Halofuginone For the treatment of scleroderma, cancer, and restenosis. Hexylresorcinol An ingredient used to relieve irritation, pain, and prevent infection. Homidium Homidium is a group II compound with trypanocidal effects. Hycanthone Potentially toxic, but effective antischistosomal agent, it is a metabolite of LUCANTHONE. Hycanthone was approved by the FDA in 1975 but is no longer used. Hydroxychloroquine An antimalarial medication used to treat uncomplicated cases of malaria and for chemoprophylaxis in specific regions. Also a disease modifying anti-rheumatic drug (DMARD) indicated for treatment of rheumatoid arthritis and lupus erythematosus. Hygromycin B Hygromycin B is an aminoglycoside antibiotic produced by the bacterium Streptomyces hygroscopicus which kills bacteria, fungi and higher eukaryotic cells by inhibiting protein synthesis. Imidocarb Imidocarb is a urea derivative used in veterinary medicine as an antiprotozoal agent for the treatment of infection with Babesia and other parasites. Ivermectin An anti parasite medication used to treat head lice, onchocerciasis, strongyloidiasis, ascariasis, trichuriasis, and enterobiasis. Kainic acid Kainic acid is a small molecule drug. Kainic acid has a monoisotopic molecular weight of 213.1 Da. Lasalocid Lasalocid is an agent that presents antibacterial and coccidiostat activities. It is produced by strains of Streptomyces lasaliensis. Levamisole Levamisole is a nicotinic receptor agonist used to treat helminth infections and some skin infections. Lonidamine Investigated for use/treatment in benign prostatic hyperplasia, prostate disorders, and cancer/tumors (unspecified). Lotilaner An antiparasitic agent used to treat Demodex blepharitis. Lucanthone Intended for use as a radiation sensitizer in the treatment of brain cancer. Lumefantrine An antimalarial agent used in combination with artemether for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum. Mebendazole A benzimidazole anthelmintic used to treat helminth infections. Mefloquine An antimalarial agent used in the prophylaxis and treatment of malaria caused by Plasmodium falciparum and Plasmodium vivax. Meglumine antimoniate Not Annotated Melarsoprol Melarsoprol is under investigation in clinical trial NCT00330148 (Randomized Clinical Trial of Three Drug Combinations for Late-Stage Gambiense Human African Trypanosomiasis). Mepartricin A medication indicated in the treatment of benign prostatic hyperplasia, vaginal candidiasis, or trichomoniasis. Metrifonate Metrifonate or trichlorfon is an irreversible organophosphate acetylcholinesterase inhibitor. It is a prodrug which is activated non-enzymatically into 2,2-dichlorovinyl dimethyl phosphate. Metronidazole A nitroimidazole used to treat trichomoniasis, amebiasis, inflammatory lesions of rosacea, and bacterial infections, as well as prevent postoperative infections. Metyridine Metyridine is a small molecule drug. Metyridine has a monoisotopic molecular weight of 137.08 Da. Milbemycin oxime Not Annotated Miltefosine An antileishmanial agent used to treat leishmaniasis, a group of disease caused by parasites of the Leishmania type. Misonidazole Misonidazole is under investigation in clinical trial NCT00038038 (Assessment of Head and Neck Tumor Hypoxia Using 18F-Fluoromisonidazole). Mizoribine Mizoribine has been investigated for the treatment of Rheumatoid Arthritis. Monensin Monensin is a polyether isolated from Streptomyces cinnamonensis that presents antibiotic properties. It is widely used in ruminant animal feeds. Moxidectin Moxidectin is indicated for the treatment of river blindness, also called onchocerciasis, in patients aged 12 years and older. River blindness is caused by a parasitic worm Onchocerca volvulus and... Narasin Narasin is an agent with coccidiostatic and antibacterial properties. Netobimin Netobimin is a small molecule drug. Netobimin has a monoisotopic molecular weight of 420.08 Da. Nicarbazin Not Annotated Niclosamide An anthelmintic indicated in the treatment of beef, pork, fish, and dwarf tapeworm infections in adults and children. Nifuratel A nitrofuran derivative indicated in the treatment of leucorrhea, vulvovaginal infections, and urinary tract infections. Nifurtimox An antiparasitic drug used for the treatment of Chagas disease (Trypanosoma cruzi infection). Nimorazole Nimorazole has been used in trials studying the treatment of Hypoxia, Radiotherapy, Hypoxic Modification, Gene Profile, Gene Signature, and Head and Neck Squamous Cell Carcinoma, among others. Niridazole Not Annotated Nitazoxanide A thiazolide anti-infective used to treat infections by protozoa, helminths, anaerobic bacteria, microaerophilic bacteria, and viruses. Nitroxinil Nitroxinil is a small molecule drug. The usage of the INN stem '-nil' in the name indicates that Nitroxinil is a benzodiazepine receptor antagonist/agonist. Nitroxinil has a monoisotopic molecular weight... Oltipraz Oltipraz has been used in trials studying the treatment and prevention of Lung Cancer, Liver Fibrosis, Liver Cirrhosis, and Non-alcoholic Fatty Liver Disease. Ornidazole A nitroimidazole agent indicated in the treatment of infections such as trichomoniasis, amebiasis, and giardiasis. Oxamniquine For treatment of Schistosomiasis caused by Schistosoma mansoni Oxantel An antihelminthic indicated in the treatment of ascaris, trichocephaliasis, and oxyuriasis infections. Oxfendazole Oxfendazole is a sulfoxide metabolite of fenbendazole. This benzimidazole antihelminthic protects livestock from roundworm. strongyles, and pinworn. Oxibendazole Investigated for use/treatment in infectious and parasitic disease (unspecified) and pediatric indications. Oxyclozanide Oxyclozanide is a small molecule drug. Oxyclozanide has a monoisotopic molecular weight of 398.88 Da. Pafuramidine Investigated for use/treatment in pneumonia, trypanosomiasis, malaria, HIV infection, and infectious and parasitic disease (unspecified). Parbendazole Parbendazole is a small molecule drug. Parbendazole has a monoisotopic molecular weight of 247.13 Da. Paromomycin An aminoglycoside antibiotic used in the treatment of acute and chronic intestinal amebiasis, and as an adjunct for the management of hepatic coma. Pentamidine An antifungal agent used to treat Pneumocystis pneumonia in patients infected with HIV. Pepstatin Pepstatin is a small molecule drug. Pepstatin has a monoisotopic molecular weight of 685.46 Da. Phenothiazine Phenothiazine (PTZ) is an organic thiazine compound. Piperaquine For the treatment of uncomplicated Plasmodium falciparum infection in adults, children, and infants aged 6 months and up weighing over 5 kg [FDA Label]. Used in combination with DB11638. Piperazine A medication used to treat roundworm and pinworm. Plumbagin Plumbagin is a compound investigated for its anticancer activity. It has been found that it inactivates the Akt/NF-kB, MMP-9 and VEGF pathways. Posaconazole A triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. Praziquantel An anthelmintic medication used to treat parasitic worm infections such as schistosomiasis, clonorchiasis, and opisthorchiasis Primaquine An antimalarial indicated to prevent relapse of vivax malaria. Proguanil A medication indicated for prophylaxis and treatment of Plasmodium falciparum malaria. Propamidine Not Annotated Psoralen Not Annotated Puromycin Puromycin is an antibiotic that prevents bacterial protein translation. It is utilized as a selective agent in laboratory cell cultures. Puromycin is toxic to both prokaryotic and eukaryotic cells, resulting... Pyrantel An anthelmintic used to treat helminth infections. Pyrimethamine An antiparasitic drug used in the prevention and treatment of toxoplasmosis and malaria. Pyronaridine A benzonaphthyridine derivative indicated in the treatment of acute malaria caused by P. falciparum or P. vivax in area with low rates of infection and low resistance to artemisinin. Pyrvinium An anthelmintic agent used for the treatment of pinworm infestations. Quinacrine For the treatment of giardiasis and cutaneous leishmaniasis and the management of malignant effusions. Quinidine A medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias. Quinine An alkaloid used to treat uncomplicated Plasmodium falciparum malaria. Radicicol Not Available Rafoxanide Rafoxanide is a small molecule drug. Rafoxanide has a monoisotopic molecular weight of 624.82 Da. Robenidine Robenidine is identified as a coccidiostat drug, which slows both the growth and reproductive cycles of coccidian parasites. Robenidine is used to control coccidiosis, a lethal infection in poultry which... Ronidazole Ronidazole is a small molecule drug. The usage of the INN stem '-nidazole' in the name indicates that Ronidazole is a antiprotozoal and radiosensitizer, metronidazole derivative. Ronidazole has a monoisotopic... Roxarsone Roxarsone is an organoarsenic molecule added to poultry feed. The addition of this compound to poultry feed improves weight gain and feed efficiency as well as prevent the growth of... Salicylhydroxamic Acid Not Available Salinomycin Not Annotated Santonin Santonin is a anthelmintic drug that was previously approved in the US to treat certain parasitic infections. Secnidazole A nitroimidazole antibiotic used to treat bacterial vaginosis. Selamectin Selamectin is a topical parasiticide and antihelminthic used on dogs and cats to treat and prevent infections of heartworms, fleas, ear mites, sarcoptic mange, and certain types of ticks in... Sinefungin Sinefungin is a solid. This compound belongs to the purine nucleosides and analogues. These are compounds comprising a purine base attached to a sugar. The proteins that adenosyl-ornithine target include... Sodium stibogluconate For the treatment of various types of a protozoal infection called leishmaniasis, which may result from sandfly bites in tropical and temperate parts of the world. Also investigated for use/treatment... Spiramycin A macrolide antimicrobial agent used in the treatment of various bacterial infections. Spirogermanium Spirogermanium is a small molecule drug. Spirogermanium has a monoisotopic molecular weight of 342.21 Da. Stibophen Stibophen is used in the treatment of schistosomiasis, a disease of parasitic flatworms. Sulfadiazine A sulfonamide antibiotic used in a variety of infections, such as urinary tract infections, trachoma, and chancroid. Sulfadoxine A long acting sulfonamide used for the treatment or prevention of malaria. Sulfametopyrazine An antibiotic used in the treatment or prevention of bacterial infections and malaria. Sulfaquinoxaline Sulfaquinoxaline is a veterinary medicine which can be given to cattle and sheep to treat coccidiosis.It is available in Pakistan with Sanna Laboratories in combination with Amprolium and Vitamin K... Suramin For treatment of human sleeping sickness, onchocerciasis and other diseases caused by trypanosomes and worms. Tafenoquine An antiparasitic agent used for the treatment and prevention of relapse of Vivax malaria. Tetrandrine Not Annotated Thiabendazole A benzimidazole used in the treatment of strongyloides, cutaneous larva migrans, visceral larva migrans, and trichinosis infections. Tinidazole A nitroimidazole used to treat trichomoniasis, giardiasis, amebiasis, and bacterial vaginosis. Triclabendazole An anthelmintic drug used to treat fascioliasis. Zoalene Dinitolmide is a fodder additive for prophylaxis against coccidiosis infections in poultry. - Drugs & Drug Targets