Hypokalemia (DBCOND0003942)

Identifiers

Synonyms

Low potassium / Hypokalaemia / All grades Hypokalemia / Hypokalemia (all grades) / Serum potassium level below reference range (finding) / Low potassium syndrome / Syndrome hypokalaemic / Hypokalaemic syndrome / Syndrome hypokalemic / Hypokalemic syndrome / Hypopotassaemia / Hypopotassemia / Hypokalemia (disorder) / Potassium Deficiency / K+ decreased

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Amiloride	A pyrizine compound used to treat hypertension and congestive heart failure.	Amiloride-sensitive sodium channel subunit betatarget Acid-sensing ion channel 1target Diamine oxidase [copper-containing]target Amiloride-sensitive sodium channel subunit alphatarget Amiloride-sensitive sodium channel subunit gammatarget Sodium/hydrogen exchanger 1target Acid-sensing ion channel 2target Amiloride-sensitive sodium channel subunit deltatarget Urokinase-type plasminogen activatortarget Solute carrier family 22 member 2transporter Solute carrier family 22 member 4transporter Diamine oxidase [copper-containing]enzyme Amiloride-sensitive amine oxidase [copper-containing]enzyme
Ammonium chloride	Expectorant in cough syrups. The ammonium ion (NH4+) in the body plays an important role in the maintenance of acid-base balance. The kidney uses ammonium (NH4+) in place of sodium...	No drug targets
Malic acid	Malic acid has been used in trials studying the treatment of Xerostomia, Depression, and Hypertension.	No drug targets
Potassium	A medication used to treat hypokalemic conditions and to clear the colon prior to colonoscopy.	Sodium/potassium-transporting ATPase subunit alpha-1target Sodium/potassium-transporting ATPase subunit alpha-1transporter Solute carrier family 12 member 1transporter
Potassium acetate	A medication used to treat hypokalemia.	Sodium/potassium-transporting ATPase subunit alpha-1target
Potassium aspartate	A potassium supplement used to treat hypokalemia or hyperammonemia.	No drug targets
Potassium bicarbonate	An ingredient used as an antacid or to treat hypokalemia.	Hydrogen ionstarget Solute carrier family 12 member 2transporter Solute carrier family 12 member 1transporter
Potassium chloride	A potassium salt used to treat hypokalemia.	Solute carrier family 12 member 2target Solute carrier family 12 member 1target Solute carrier family 12 member 5target Solute carrier family 12 member 6target Solute carrier family 12 member 7target Solute carrier family 12 member 4target Solute carrier family 12 member 2transporter Solute carrier family 12 member 1transporter Solute carrier family 12 member 5transporter Solute carrier family 12 member 6transporter Solute carrier family 12 member 7transporter Solute carrier family 12 member 4transporter
Potassium hydroxide	A disinfectant used to clean hands, skin, and surfaces.	No drug targets
Sodium chloride	An ingredient found in a variety of nutritional products as a source of electrolytes and water.	No drug targets

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05118022	Artificial Intelligence Identified Dyskalemia Using Electrocardiogram (AIDE)	No drug interventions	screening	Not Available	completed
NCT00605202	Effect of Licorice and Hydrochlorothiazide on Plasma Potassium	Hydrochlorothiazide	treatment	4	completed
NCT01572454	Comparison of Dexmedetomidine and Remifentanil Infusion During CABG	Dexmedetomidine Remifentanil	Not Available	Not Available	completed
NCT01431326	Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care	Alfentanil Amikacin Aminocaproic acid Bosentan Cefepime Cidofovir Ciprofloxacin Clozapine Fosfomycin Haloperidol Labetalol Lurasidone Methylprednisolone Molindone Nafcillin Nifedipine Oxycodone Pentobarbital Piperacillin Rocuronium Sevelamer Spironolactone Tazobactam Tobramycin Tranexamic acid Vancomycin Vecuronium Warfarin Ziprasidone Zolpidem	Not Available	Not Available	completed
NCT02709031	Cicletanine in Hypertension With Diabetes: Added Magnesium Preserves Potassium and Sodium	Cicletanine	treatment	1 / 2	unknown_status
NCT02926989	Intravenous Fluids in Hospitalised Children	D-glucose	treatment	4	completed
NCT02721095	Efficacy of KCl Plus 0.9%NaCl Compare With KCl Plus 0.45%NaCl	No drug interventions	treatment	4	unknown_status
NCT05184998	Description of the Clinical Outcomes of Hospitalized Patients With Heart Failure With Different Serum Potassium Levels	No drug interventions	Not Available	Not Available	completed
NCT02082717	The Impact of Neut During Potassium Chloride Replacement on Pain and Incidence of Phlebitis	Potassium chloride Sodium bicarbonate	supportive_care	4	terminated
NCT04428827	Outcome of Patients With Primary Aldosteronism	No drug interventions	Not Available	Not Available	unknown_status
NCT04426994	Hypomagnesemia Associated With Proton-Pump Inhibitor Use	No drug interventions	Not Available	Not Available	completed
NCT03833089	Targeted Potassium Levels for Prevention of ICD Therapy	Aloe vera leaf Ascorbic acid Glycerin Nicotinamide Potassium Vitamin A	prevention	4	unknown_status
NCT04278404	Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)	Abatacept Acetylsalicylic acid Aminocaproic acid Amiodarone Amphetamine Anakinra Azithromycin Bosentan Budesonide Canakinumab Cefdinir Cefepime Ceftazidime Clindamycin Clobazam Colchicine Dexamethasone Dexmedetomidine Fosfomycin Furosemide Gabapentin Guanfacine Hydrocortisone Infliximab Labetalol Lopinavir Meropenem Metformin Milrinone Nalbuphine Nicardipine Nifedipine Oseltamivir Oxycodone Remdesivir Ribavirin Risperidone Ritonavir Ruxolitinib Sarilumab Sertraline Sevelamer Spironolactone Terbutaline Tocilizumab Tranexamic acid Voriconazole Zolpidem	Not Available	Not Available	recruiting
NCT00718068	Safety of Continuous Potassium Chloride Infusion in Critical Care	Potassium chloride	treatment	4	completed