Urticaria (DBCOND0013538)

Identifiers

Synonyms

Hives / Urticaria NOS / Hive / Urticarias / Urticaria, unspecified / Urtication / Urticated rash / Urticarial rash / Rash urticarial / Urticaria (morphologic abnormality) / Urticaria (disorder) / Unspecified urticaria / Wheal (disorder) / Nettle rash / Wheals / Welts

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Bendazac	A non-steroidal anti-inflammatory drug (NSAID) available as an eye drop for the treatment of cataracts and as a topical cream for the treatment of dermatitis, eczema, hives, skin ulcers and other inflammatory skin conditions.	Free radicalstarget Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target
Carbinoxamine	A first generation antihistamine used to treat allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis, allergic reactions, and mild allergic reactions.	Histamine H1 receptortarget alpha1-acid glycoproteincarrier
Chlorpheniramine	A histamine-H1 receptor antagonist indicated for the management of symptoms associated with upper respiratory allergies.	Histamine H1 receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 2D6enzyme Sodium-dependent serotonin transportertarget Sodium-dependent noradrenaline transportertarget Sodium-dependent dopamine transportertarget Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Solute carrier family 22 member 2transporter Solute carrier family 22 member 1transporter
Chlorphenoxamine	An antihistamine used as an antipruritic.	No drug targets
Clemastine	An antihistamine with sedative and anticholinergic effects used to treat the symptoms of allergic rhinitis.	Histamine H1 receptortarget Cytochrome P450 2D6enzyme
Dexchlorpheniramine	A chlorpheniramine enantiomer antihistamine indicated in the treatment of sunburns, insect bites, and allergic reactions of the skin.	Cytochrome P450 2D6enzyme
Dexchlorpheniramine maleate	A first generation antihistamine used to treat allergic and vasomotor rhinitis, allergic conjunctivitis, and mild urticaria and angioedema.	Cytochrome P450 2D6enzyme Histamine H1 receptortarget Solute carrier family 22 member 1carrier Solute carrier family 22 member 2carrier Cytochrome P450 3A4enzyme
Dexpanthenol	An alcoholic analogue of D-pantothenic acid that is used as a supplement or application to support a healthy epithelium and is also used to prevent vitamin deficiency in patients receiving total parenteral nutrition (TPN).	No drug targets
Diphenhydramine	A H1 receptor antihistamine used in the treatment of seasonal allergies, and various allergic reactions including sneezing, runny nose, itchy/watery eyes, itching of nose or throat, pruritus, urticaria, insect bites/stings, and allergic rashes.	Histamine H1 receptortarget Cytochrome P450 2D6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Solute carrier family 22 member 2transporter Organic cation/carnitine transporter 2transporter Prostaglandin G/H synthase 1enzyme Muscarinic acetylcholine receptor M2target Histamine N-methyltransferasetarget
Epinephrine	A hormone and neurotransmitter used to treat allergic reactions, to restore cardiac rhythm, and to control mucosal congestion, glaucoma, and asthma.	Alpha-1A adrenergic receptortarget Beta-1 adrenergic receptortarget Beta-2 adrenergic receptortarget Solute carrier family 22 member 2transporter Solute carrier family 22 member 1transporter Cytochrome P450 2C9enzyme Cytochrome P450 3A4enzyme Alpha-1B adrenergic receptortarget Alpha-1D adrenergic receptortarget Alpha-2A adrenergic receptortarget Alpha-2B adrenergic receptortarget Tumor necrosis factortarget Catechol O-methyltransferaseenzyme Monoamine oxidaseenzyme
Guaifenesin	An expectorant commonly found in OTC products for the symptomatic relief from congested chests and coughs associated with cold, bronchitis, and/or other breathing illnesses.	NMDA receptortarget
Mepyramine	An antihistamine agent used for the symptomatic treatment of allergy, hypersensitivity reactions, and pruritic skin disorders.	Cytochrome P450 2D6enzyme Histamine H1 receptortarget Solute carrier family 22 member 4transporter Organic cation/carnitine transporter 2transporter
Mizolastine	A second-generation non-sedating antihistamine used to treat symptoms of allergic rhinoconjunctivitis and urticaria.	Cytochrome P450 2D6enzyme Histamine H1 receptortarget
Pheniramine	An antihistamine used to treat allergic rhinitis and pruritus.	Histamine H1 receptortarget Nuclear receptor subfamily 1 group I member 3target Histamine H4 receptortarget
Rupatadine	A selective histamine H1 receptor antagonist and platelet activating factor (PAF) antagonist used to treat allergic rhinitis.	Cytochrome P450 3A4enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2D6enzyme Platelet-activating factor receptortarget Histamine H1 receptortarget
Triamcinolone	A glucocorticoid used to treat a wide variety of inflammatory conditions of organ systems and tissues.	Corticosteroid-binding globulincarrier Glucocorticoid receptortarget Cytochrome P450 3A4enzyme Prostaglandin G/H synthase 2enzyme Cholinesteraseenzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Albumincarrier

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01371877	The Role of Vitamin D in Chronic Urticaria and Angioedema Treatment	No drug interventions	treatment	Not Available	completed
NCT03968562	Assessment of Suppression of Cutaneous Allergic Responses and Pruritus by Topical Doxycycline	No drug interventions	treatment	2	unknown_status
NCT05936567	Study Evaluating the Efficacy and Safety of Povorcitinib in Adults With Chronic Spontaneous Urticaria	No drug interventions	treatment	2	recruiting
NCT02873364	High Dose Vitamin D Supplementation in Chronic Spontaneous Urticaria	No drug interventions	treatment	3	unknown_status
NCT06210698	Angioedema Biomarker Research Study	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT00724698	Evaluation of Desloratadine When Used in Patients With Either Allergic Rhinitis or Chronic Idiopathic Urticaria	No drug interventions	Not Available	Not Available	completed
NCT02742805	Sustained Effect of Urticaria Remission With Relatively High Dose Vitamin D Supplementation After Omalizumab Discontinuation	Omalizumab	treatment	4	withdrawn
NCT00762983	Observation of Use of Claritin (Loratadine) Tablet, RediTabs, and Dry Syrup in Children (Study P05834)(COMPLETED)	No drug interventions	Not Available	Not Available	completed
NCT02824393	Experimental Autologous Mesenchymal Stem Cell Therapy in Treatment of Chronic Autoimmune Urticaria	No drug interventions	treatment	0	completed
NCT01759693	Platelet Activation in Chronic Inflammatory Skin Diseases	No drug interventions	Not Available	Not Available	unknown_status
NCT00189878	A Study of the Use of Methotrexate in the Treatment of Chronic Idiopathic Urticaria	Methotrexate	treatment	2	terminated
NCT05461456	Bioavailability and Tolerability of Fexofenadine Hydrochloride Topical Lotion 1%	Fexofenadine	treatment	1	completed
NCT00129415	Ultraviolet (UVA and UVB) Light Therapy in the Treatment of Inflammatory Skin Conditions	No drug interventions	treatment	1 / 2	terminated
NCT05330637	Study on the Influence of Climatic and Environmental Factors on Respiratory Diseases in Sanya, Hainan Province, China.	No drug interventions	Not Available	Not Available	recruiting
NCT00723736	Safety of Aerius Syrup in Pediatric Patients Aged 1-5 Years Old With Allergic Rhinitis or Chronic Idiopathic Urticaria (Study P04446AM1)(COMPLETED)	No drug interventions	Not Available	Not Available	completed
NCT00751218	A Comparative Double-Blind, Double- Dummy Study of Desloratadine (DL) 5 MG Once Daily, Cetirizine 10 MG Once Daily, and Placebo Once Daily in Patients With Chronic Idiopathic Urticaria (Study P03735)	No drug interventions	treatment	4	completed
NCT02576041	Effects of Bilastine on F1 Simulator Driving Performance in Patients Affected by Allergic Rhinitis and/or Urticaria	Bilastine	supportive_care	4	completed
NCT00130234	Effect of Anti-IgE in Chronic Urticaria	Omalizumab	treatment	2	completed
NCT01444196	Desloratadine 5, 10 and 20mg in Patients With Cold Urticaria	Desloratadine	treatment	4	completed
NCT05497596	The Association Between Human Microbiome and Vitamin D in Chronic Urticaria	No drug interventions	treatment	Not Available	recruiting
NCT03296358	Adding a Short Burst of Corticosteroid to the Conventional Treatment of H1 Antihistamines in Emergency Department.	Dexamethasone Prednisolone Prednisolone phosphate	treatment	Not Available	completed
NCT00795158	How Desloratadine (Clarinex, Aerius) Affects Quality of Life in Patients With Chronic Idiopathic Urticaria (Have Had Hives for 6 Weeks or Longer)(Study P02988)	No drug interventions	treatment	3	completed
NCT05496465	Safety and Efficacy of Intranasal Epinephrine After Administration of ARS -1 in Subjects With Frequent Urticaria Flares	No drug interventions	treatment	2	completed
NCT02550080	Clinical Utility Of Genetic Screening For HLA-B*1301, On Susceptibility To Dapsone Hypersensitivity Syndrome	Dapsone	treatment	4	unknown_status
NCT00069329	Anakinra to Treat Patients With Neonatal Onset Multisystem Inflammatory Disease	Anakinra	treatment	1 / 2	terminated
NCT01008592	The Effect of Levocetirizine on Inflammatory Mediators in Dermatographism	No drug interventions	Not Available	Not Available	terminated
NCT00876369	Vitamin D Levels in Subjects With Chronic Urticaria and Angioedema	No drug interventions	Not Available	Not Available	completed
NCT00541255	A Long-Term Examination of Asthma From Childhood Through Adolescence	No drug interventions	Not Available	Not Available	completed
NCT00368823	A Trial of Point of Care Information in Ambulatory Pediatrics	No drug interventions	treatment	3	completed
NCT00199238	Efficacy of Rupatadine 5, 10 and 20 mg in Chronic Idiopathic Urticaria	Rupatadine	treatment	2	terminated
NCT03545464	COrticosteroids in acUte uRticAria in emerGency dEpartment	No drug interventions	treatment	3	recruiting
NCT02866864	Animal Allergy in Korean Veterinary Researcher	No drug interventions	Not Available	Not Available	completed
NCT01091402	Autologous Serum Skin Test and Serum IL-18 Levels in Chronic Idiopathic Urticaria and Respiratory Allergic Diseases	No drug interventions	Not Available	Not Available	completed
NCT00783354	A Comparison of Aerius Continuous Treatment Versus Aerius PRN for Chronic Idiopathic Urticaria (Study P03147)	No drug interventions	treatment	4	completed
NCT00199251	Efficacy and Safety of Rupatadine 10 and 20 Mg in Chronic Idiopathic Urticaria	Rupatadine	treatment	3	terminated
NCT01987947	A Study of Quilizumab Versus Placebo in Patients With Refractory Chronic Spontaneous Urticaria	No drug interventions	treatment	2	completed
NCT03991845	A Trial to Evaluate the Effect of Vitamin D Supplementation in Patients With Chronic Urticaria	No drug interventions	treatment	4	unknown_status
NCT01897428	PK Comparisons of Bepotastine Besilate 10 mg and Bepotastine Salicylate 9.64 mg	No drug interventions	Not Available	1	completed
NCT01940393	Evaluation of the Inhibitory Effect of 5 Anti-Histamines in Urticaria	No drug interventions	treatment	4	completed
NCT00421109	Efficacy Study for the Symptomatic Treatment of Chronic Idiopathic Urticaria	No drug interventions	treatment	3	completed
NCT04938700	Study on the Correlation Between Intestinal Microecology and Allergic Diseases in Children	No drug interventions	treatment	4	unknown_status
NCT02424799	Study to Investigate Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of GSK2646264	No drug interventions	treatment	1	completed
NCT02671006	Monitoring Chronic Urticaria Basophil Irritability by Cytometry	No drug interventions	Not Available	Not Available	completed
NCT00346606	The Efficacy and Safety of Desloratadine With Levocetirizine in Treatment of Chronic Idiopathic Urticaria	No drug interventions	treatment	4	unknown_status
NCT02238249	Study to Investigate the Safety and Efficacy of Alesion® in Japanese Paediatric Patients With Urticaria	No drug interventions	Not Available	Not Available	completed
NCT01170936	Ilaris® in Urticarial Vasculitis - Investigation of Treatment Responses	No drug interventions	treatment	2	completed
NCT05115136	Using Doxepin for Urticaria	No drug interventions	treatment	3	unknown_status
NCT00868036	Evaluating for Contact Allergies in Patients With Chronic Urticaria	No drug interventions	Not Available	Not Available	completed
NCT03101618	Animal Allergy in Korean Pet Owners, Pet-related Industry Workers, and Laboratory Animal Reseachers	No drug interventions	Not Available	Not Available	completed
NCT02392624	A Study of the Efficacy and Safety of Omalizumab Through 48 Weeks in Participants With Chronic Idiopathic Urticaria	No drug interventions	treatment	4	completed
NCT01805635	PF and FeNO and Clinical Characteristics in Children Being Diagnosed Due to Suspicion of Allergic Diseases	No drug interventions	Not Available	Not Available	unknown_status
NCT00163839	The Efficacy of a Pseudoallergen-Free Diet in the Treatment of Chronic Idiopathic Urticaria and/or Angioedema	No drug interventions	treatment	Not Available	unknown_status
NCT00795522	An Open-Label Study of the Effects of Desloratadine (Aerius.) Treatment on the Quality of Life of Patients With Chronic Idiopathic Urticaria (Study P02540)	No drug interventions	treatment	4	completed
NCT03693625	A Study to Evaluate the Long-term Safety and Efficacy of Fenebrutinib in Participants Previously Enrolled in a Fenebrutinib Chronic Spontaneous Urticaria (CSU) Study	No drug interventions	treatment	2	terminated
NCT00751166	A Comparative Double-blind, Double-dummy Study of Desloratadine (DL) 5 mg Once Daily, Cetirizine 10 mg Once Daily, and Placebo Once Daily in Patients With Chronic Idiopathic Urticaria (Study P03736)	No drug interventions	treatment	4	terminated
NCT00525382	Study to Compare the Efficacy and Safety Between Levocetirizine and Loratadine for Chronic Idiopathic Urticaria	No drug interventions	treatment	3	completed
NCT00761527	Observation of Side Effects and Effectiveness of Desloratadine (Aerius) Syrup in Filipino Children (Study P05634)	No drug interventions	Not Available	Not Available	completed
NCT00216762	Safety Study of Rituximab (Rituxan®) in Chronic Urticaria	Rituximab	treatment	1 / 2	terminated
NCT02382562	Brief Behavioral Activation Intervention for Depressed Asthma and Urticaria Patients	No drug interventions	treatment	Not Available	terminated
NCT01916967	An Efficacy and Safety Study of Desloratadine (MK-4117) in Japanese Participants With Chronic Urticaria (MK-4117-201)	No drug interventions	treatment	3	completed
NCT00385372	Significance of an Elimination and Provocation Diet in Patients With Chronic Urticaria	No drug interventions	Not Available	Not Available	completed
NCT02191072	Efficacy and Safety of Omalizumab in Patients With Severe Acute Urticaria	No drug interventions	treatment	Not Available	unknown_status
NCT03137069	A Study of GDC-0853 in Participants With Refractory Chronic Spontaneous Urticaria (CSU).	No drug interventions	treatment	2	completed
NCT03069495	Role of Circulating Innate Lymphoid Cells in Allergic Disorders	No drug interventions	Not Available	Not Available	terminated
NCT00886795	Safety and Efficacy of Abatacept in Subjects With Chronic Urticaria Who Have Had an Inadequate Response to Anti-histamine Therapy	No drug interventions	treatment	1 / 2	completed
NCT00001150	Induction of Suction Blisters in Patients With Urticaria, Blistering Diseases, Inflammatory Dermatoses and Neoplastic Disorders, and in Normal Volunteers	No drug interventions	Not Available	Not Available	completed