Brucellosis (DBCOND0014686)

Identifiers

Synonyms

Brucellosis, unspecified / Mediterranean fever / Unspecified brucellosis / Brucella infections / Brucellosis (disorder) / Malta fever / Undulant fever

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Demeclocycline	A tetracycline antibiotic used to treat a wide variety of susceptible bacterial infections.	30S ribosomal proteintarget Vasopressin V2 receptortarget
Doxycycline	A tetracycline antibiotic used to treat a wide variety of bacterial infections.	Solute carrier family 22 member 6transporter Cytochrome P450 3A4enzyme ATP-binding cassette sub-family B member 5transporter Albumincarrier 30S ribosomal proteintarget
Minocycline	A tetracycline analog used to treat a wide variety of infections in the body.	30S ribosomal protein S4target 30S ribosomal protein S9target 16S ribosomal RNAtarget Interleukin-1 betatarget Polyunsaturated fatty acid 5-lipoxygenasetarget Matrix metalloproteinase-9target Vascular endothelial growth factor A, long formtarget Caspase-1target Caspase-3target Cytochrome ctarget Solute carrier family 22 member 6transporter Solute carrier family 22 member 7transporter Outer membrane protein Ftransporter Outer membrane porin Ctransporter Mitogen-activated Protein Kinasestarget Nitric oxide synthase, inducibletarget
Sulfamethoxazole	An oral sulfonamide antibiotic, given in combination with trimethoprim, used to treat a variety of infections of the urinary tract, respiratory system, and gastrointestinal tract.	Cytochrome P450 2C9enzyme Albumincarrier Arylamine N-acetyltransferase 1enzyme Arylamine N-acetyltransferase 2enzyme Dihydropteroate synthasetarget Cytochrome P450 3A4enzyme Bile salt export pumptransporter
Tetracycline	An antibiotic used to treat a wide variety of susceptible infections.	16S ribosomal RNAtarget Major prion proteintarget Albumincarrier Cytochrome P450 3A4enzyme Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Solute carrier family 22 member 11transporter Solute carrier family 22 member 7transporter 30S ribosomal protein S3target 30S ribosomal protein S8target 30S ribosomal protein S19target 30S ribosomal protein S14target 30S ribosomal protein S7target Multidrug translocase MdfAtarget Protein-arginine deiminase type-4target Solute carrier organic anion transporter family member 2B1transporter
Trimethoprim	An antifolate antibiotic often used in combination with sulfamethoxazole to treat a number of infections, including those of the urinary tract, respiratory tract, and gastrointestinal tract.	Dihydrofolate reductasetarget Cytochrome P450 2C8enzyme Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 2C9enzyme Cytochrome P450 1A2enzyme Multidrug and toxin extrusion protein 1transporter Multidrug and toxin extrusion protein 2transporter Dihydrofolate reductasetarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT04911283	Brucella Serology and History of Brucellosis in Patients With Modic Changes Type 1	No drug interventions	Not Available	Not Available	completed
NCT04717622	Investigation of Fever Suspected as a Zoonosis Using Advanced Diagnostic Technologies	No drug interventions	Not Available	Not Available	unknown_status
NCT01766830	Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever)	No drug interventions	diagnostic	Not Available	completed
NCT04301752	Cognitive Impairment and Neuropsychiatric Manifestations of Neurobrucellosis	No drug interventions	Not Available	Not Available	completed
NCT06007326	A Multicentre, Retrospective Study of Clinical Characteristics and Long-term Outcomes of Patients With Brucellosis	No drug interventions	Not Available	Not Available	completed