Folate deficiency (DBCOND0015758)

Identifiers

Synonyms

Deficiency of other specified B group vitamins / Folic acid deficiency / Folic acid deficiency (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
(6R)-Folinic acid	A drug used to treat and prevent iron and folic acid deficiency.	Serine hydroxymethyltransferasetarget Aminomethyltransferasetarget Bifunctional polymyxin resistance protein ArnAtarget Formimidoyltransferase-cyclodeaminasetarget Dimethylglycine oxidasetarget
Ascorbic acid	A vitamin used to correct vitamin C deficiency and to increase the intestinal absorption of iron.	Prolyl 4-hydroxylase subunit alpha-1target Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1target Hyaluronate lyasetarget DNAtarget Xylose isomerasetarget Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2target Phytanoyl-CoA dioxygenase, peroxisomaltarget Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3target Gamma-butyrobetaine dioxygenasetarget Dopamine beta-hydroxylasetarget Peptidyl-glycine alpha-amidating monooxygenasetarget Prolyl 3-hydroxylase 1target 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2target DNA oxidative demethylase ALKBH2target Prolyl 3-hydroxylase 2target Prolyl 3-hydroxylase 3target Prolyl 3-hydroxylase OGFOD1target Prolyl hydroxylase EGLN2target Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3target Lysine-specific demethylase 5Dtarget Egl nine homolog 1target Prolyl hydroxylase EGLN3target Trimethyllysine dioxygenase, mitochondrialtarget Transmembrane prolyl 4-hydroxylasetarget Solute carrier family 23 member 1transporter Solute carrier family 23 member 2transporter Solute carrier family 2, facilitated glucose transporter member 1transporter Solute carrier family 2, facilitated glucose transporter member 3transporter Solute carrier family 2, facilitated glucose transporter member 4transporter Albumincarrier Thioredoxin reductase 1, cytoplasmicenzyme Solute carrier family 23 member 2target Solute carrier family 23 member 1target
Calcium citrate	An ingredient found in a variety of supplements and vitamins.	Transient receptor potential cation channel subfamily V member 6transporter Calbindincarrier Protein S100-Gcarrier Sodium/calcium exchanger 1transporter Transient receptor potential cation channel subfamily V member 5transporter Extracellular calcium-sensing receptortarget Calreticulintarget Calcium and integrin-binding protein 1target Programmed cell death protein 6target Sorcintarget Calcineurin B homologous protein 1target SPARCtarget Calnexintarget Fibrillin-2target Protein S100-Btarget Calsequestrin-2target Regucalcintarget Peflintarget Protein S100-A6target Translationally-controlled tumor proteintarget Calcium and integrin-binding family member 2target Protein S100-A13target Calsequestrin-1target Nucleobindin-1target Nucleobindin-2target Fibrillin-3target Grancalcintarget Calcium-dependent secretion activator 1target Albumincarrier Calmodulin-2target Calmodulin-3target Protein S100-A16target Calretinintarget Calcyphosintarget Calcium-dependent secretion activator 2target Calreticulin-3target Ryanodine receptor 1transporter Ryanodine receptor 2transporter Polycystin-2-like protein 1transporter Neurexin-1target Neuronal calcium sensor 1target Ryanodine receptor 3transporter Polycystin-1-like protein 3transporter Cation channel sperm-associated protein 1transporter Voltage-dependent L-type calcium channeltransporter Voltage-dependent P/Q-type calcium channeltransporter Voltage-dependent T-type calcium channeltransporter Voltage-dependent R-type calcium channeltransporter Calmodulintarget
Cyanocobalamin	A vitamin available in many formulations to correct vitamin B12 deficiency.	Methionine synthase reductasetarget Methylmalonic aciduria type A protein, mitochondrialtarget Methylmalonyl-CoA mutase, mitochondrialtarget Cyanocobalamin reductase / alkylcobalamin dealkylasetarget Methionine synthasetarget Methylenetetrahydrofolate reductase (NADPH)target Protein amnionlesstransporter Transcobalamin-1transporter Transcobalamin-2transporter Corrinoid adenosyltransferase MMABenzyme Cobalamin binding intrinsic factortransporter Cubilintransporter Bifunctional adenosylcobalamin biosynthesis protein CobUenzyme Low-density lipoprotein receptor-related protein 2transporter Multidrug resistance-associated protein 1transporter Pancreatic proteasesenzyme
Ferrous gluconate	A medication used to treat iron-deficiency anemia.	Transferrin receptor protein 1target Egl nine homolog 1target Histone deacetylase 8target Alpha-hemoglobin-stabilizing proteintarget Hemoglobin subunit alphatarget Frataxin, mitochondrialtarget Ferritin heavy chaintarget Flap endonuclease 1target Endonuclease 8-like 1target Endonuclease 8-like 2target DNA polymerase betatarget Ceruloplasmintarget Serotransferrintarget
Ferrous sulfate anhydrous	An iron supplement used to prevent or treat iron deficiency anemia.	Natural resistance-associated macrophage protein 2transporter Ceruloplasminenzyme Hemoglobin subunit alphatarget Transferrin receptortarget Ferroportintransporter Hepcidinenzyme Serotransferrinenzyme Hephaestinenzyme Plasma membrane ascorbate-dependent reductase CYBRD1enzyme
Folic acid	A nutrient used to treat megaloblastic anemia and is found in many supplements.	Folate receptor gammatarget Folate receptor betatarget Methylenetetrahydrofolate reductase (NADPH)enzyme ATP-binding cassette sub-family C member 4transporter Solute carrier family 22 member 6transporter ATP-binding cassette sub-family C member 3transporter ATP-binding cassette sub-family C member 11transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Proton-coupled folate transportertransporter Solute carrier family 25 member 32transporter Gamma-glutamyl hydrolaseenzyme Folate receptor alphatarget Dihydrofolate reductaseenzyme Proton-coupled folate transportertarget Reduced folate transportertarget
Iron polymaltose	Not Annotated	No drug targets
Leucovorin	A folate analog used to treat the toxic effects of methotrexate and other folate antagonists, to treat megaloblastic anemia, and to provide palliative treatment of colorectal cancer.	Organic anion transporter 3transporter Proton-coupled folate transportertarget Dihydrofolate reductasetarget
Potassium Iodide	An oral antithyroid agent used for the prevention of radioactive iodine uptake into the thyroid gland during a nuclear radiation emergency.	Tyrosinetarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT06223854	Acceptability and Nutritional Impact of Double-fortified Salt Containing Iodine and Folic Acid	No drug interventions	prevention	Not Available	active_not_recruiting
NCT03089684	Correspondence of Folate Dietary Intake and Biomarker Data	No drug interventions	Not Available	Not Available	completed
NCT04632771	Nutritional Status and Bouillon Use in Northern Ghana	No drug interventions	Not Available	Not Available	completed
NCT04095052	Food and Alcohol Behavior Study: Meaningful Enhancement	No drug interventions	treatment	Not Available	active_not_recruiting
NCT05792241	Acceptability and Nutritional Impact of Double-fortified Salt Containing Iodine and Folic Acid - Phase 1	No drug interventions	Not Available	Not Available	completed
NCT04048330	Periconceptional Surveillance in India	No drug interventions	Not Available	Not Available	active_not_recruiting
NCT03853304	Quadruple Fortified Salt Trial in India	No drug interventions	prevention	Not Available	active_not_recruiting
NCT06100146	Effectiveness of Fortification With Folic Acid and Vitamin B12 Among Teenage Girls	No drug interventions	prevention	Not Available	recruiting
NCT03489538	Homocysteine After Laparoscopic Roux-enY Gastric Bypass	No drug interventions	Not Available	Not Available	completed
NCT03376490	Study of the Association of Muscle Strength, Balance and Other Factors With Vitamin Levels Among Elderly Diabetics	No drug interventions	Not Available	Not Available	completed
NCT05178407	Effect of Household Use of Multiple Micronutrient-fortified Bouillon on Micronutrient Status Among Women and Children in Two Districts in the Northern Region of Ghana	No drug interventions	other	Not Available	completed
NCT04694235	Egg Intervention During Pregnancy in Indonesia	No drug interventions	prevention	Not Available	active_not_recruiting
NCT05453708	Maternal Risk Factors for Autism Spectrum Disorders: A Case-Control Approach	No drug interventions	Not Available	Not Available	completed