Blepharoconjunctivitis (DBCOND0022572)

Identifiers

Synonyms

Blepharo Conjunctivitis / Rosacea Keratitis / Unspecified blepharoconjunctivitis / Blepharoconjunctivitis, unspecified / Blepharoconjunctivitis (disorder) / Rosacea keratitis (disorder) / Unspecified conjunctivitis / Conjunctivitis, unspecified / Conjunctivitis NOS / Conjunctivitis / Conjunctivitis (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Bacitracin	A cyclic polypeptide antibiotic used to prevent wound infections, treat pneumonia and empyema in infants, and to treat skin and eye infections.	Alpha-2-macroglobulintarget Insulin-degrading enzymetarget C55-isoprenyl pyrophosphatetarget Bacitracin transport ATP-binding protein BcrAtransporter Bacitracin transport permease protein BCRBtransporter Bacitracin transport permease protein BcrCtransporter
Betamethasone	A systemic corticosteroid used to relieve inflammation in various conditions, including but not limited to allergic states, dermatologic disorders, gastrointestinal diseases, and hematological disorders.	Glucocorticoid receptortarget Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Aromataseenzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Cytochrome P450 2A6enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Albumincarrier Corticosteroid-binding globulincarrier
Clobetasone	A corticosteroid used to treat dry eyes, eczema, and dermatitis.	Glucocorticoid receptortarget Cytochrome P450 3A4enzyme
Gentamicin	An aminoglycoside used to treat a wide variety of aerobic infections in the body.	30S ribosomal protein S12target 16S ribosomal RNAtarget NH(3)-dependent NAD(+) synthetasetarget Dihydrofolate reductasetarget 23S ribosomal RNAtarget Bacterial outer membranetarget Cytoplasmic membranetarget Low-density lipoprotein receptor-related protein 2transporter Solute carrier family 22 member 2transporter ATP-binding cassette sub-family C member 2transporter
Gramicidin D	A bactericidal antibiotic used in the treatment of dermatological and ophthalmic infections.	ATP-dependent translocase ABCB1transporter Dihydropteroate synthasetarget
Lomefloxacin	A fluoroquinolone used to prevent and treat a wide variety of infections in the body.	DNA gyrase subunit Atarget DNA topoisomerase 4 subunit Atarget DNA topoisomerase 2-alphatarget Cytochrome P450 1A2enzyme Organic cation/carnitine transporter 2transporter ATP-binding cassette sub-family C member 2transporter DNA topoisomerase 2-betatarget
Naphazoline	A sympathomimetic vasoconstrictor used for the symptomatic relief of redness and itching of the eye, and nasal congestion.	Alpha-1A adrenergic receptortarget Alpha-2A adrenergic receptortarget D(2) dopamine receptortarget
Tetryzoline	An alpha-adrenergic agonist used in the temporary symptomatic relief of discomfort and redness of the eyes due to minor irritations, as well as alleviate nasal congestion.	Alpha-1 adrenergic receptorstarget Alpha-2 adrenergic receptorstarget Alpha-2C adrenergic receptortarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT03975374	To Study Efficacy and Safety of Tobradex Eye Drop Suspension vs Tobramycin/Dexamethasone Ophthalmic Suspension	Dexamethasone Tobramycin	treatment	0	unknown_status
NCT00754949	Comparative Study of AzaSite Plus Compared to AzaSite Alone and Dexamethasone Alone to Treat Subjects With Blepharoconjunctivitis	Azithromycin Dexamethasone	treatment	3	withdrawn
NCT00578955	Comparative Study of AzaSite Plus Compared to AzaSite Alone and Dexamethasone Alone to Treat Subjects With Blepharoconjunctivitis	Azithromycin Dexamethasone	treatment	3	completed