Mobilization of hematopoietic stem cells (DBCOND0023418)

Identifiers

Synonyms

Mobilization of Hematopoietic Stem Cells (HSC) to Peripheral Blood (PB) / Hematopoietic stem cell mobilisation / Stem Cell Mobilization / Hematopoietic Stem Cell Mobilization / Mobilization of hematopoietic stem cells therapy / Hematopoietic stem cell mobilization (procedure) / Haematopoietic stem cell mobilisation / Stem cell mobilisation / Stem cell mobilization (procedure)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Lenograstim	A granulocyte colony-stimulating factor indicated in the reduction of duration of neutropenia in bone marrow transplant and cytotoxic chemotherapy, as well as mobilizing hematopoietic stem cells in healthy donors.	Granulocyte colony-stimulating factor receptortarget
Motixafortide	A peptide inhibitor of CXCR4 used to mobilize hematopoietic stem cells prior to collection and autologous transplantation in multiple myeloma patients.	C-X-C chemokine receptor type 4target
Plerixafor	A CXCR4 antagonist used in combination with granulocyte-colony stimulating factor to mobilize hematopoietic stem cells to the peripheral blood for collection and autologous transplantation in patients with non-Hodgkin’s lymphoma and multiple myeloma.	C-X-C chemokine receptor type 4target

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT02073019	A Phase I Study Evaluating Safety, Tolerability, PK and PD of BL-8040 for Stem Cell Mobilization in Healthy Volunteers	Motixafortide	Not Available	1	completed
NCT01164345	Mozobil for Autologous Stem Cell Mobilization	Filgrastim Plerixafor	treatment	2	completed
NCT03388073	Evaluation of Plant-based Nutritional Products on Stem Cells	No drug interventions	basic_science	Not Available	unknown_status
NCT05409547	A Clinical Study of Autologous Peripheral Blood Stem Cell Mobilization for PEG-G-CSF	No drug interventions	treatment	4	not_yet_recruiting
NCT06520176	Comparison Study of EAP and CG Regimens for Mobilizing Hematopoietic Stem Cells in Multiple Myeloma Patients	Cyclophosphamide Cytarabine Etoposide Filgrastim Pegfilgrastim	treatment	3	recruiting
NCT03014102	Recombinant Human Thrombopoietin for Mobilization of Peripheral Blood Progenitor Cells for Autologous Transplantation	Recombinant Human Thrombopoietin	prevention	1 / 2	unknown_status
NCT01766934	Non-interventional, Long-term Safety Data Collection of Zarzio® / Filgrastim HEXAL® in Stem Cell Donors	No drug interventions	Not Available	Not Available	active_not_recruiting
NCT06520163	Comparison Study of EAP and Disease-Specific Chemotherapy Regimens in Hematopoietic Stem Cell Mobilization for Lymphoma	Cytarabine Etoposide Filgrastim	treatment	3	recruiting