Edema of the cerebrum (DBCOND0024353)

Identifiers

Synonyms

Cerebral Edema / Oedema cerebral / Cerebral oedema / Cerebral edema (disorder) / Edema cerebral / Oedema brain / Brain oedema / Brain swelling / Brain edema / Edema brain

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Betamethasone	A systemic corticosteroid used to relieve inflammation in various conditions, including but not limited to allergic states, dermatologic disorders, gastrointestinal diseases, and hematological disorders.	Glucocorticoid receptortarget Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Aromataseenzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Cytochrome P450 2A6enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Albumincarrier Corticosteroid-binding globulincarrier
Bupivacaine	A local anesthetic used in a wide variety of superficial and invasive procedures.	Sodium channel protein type 10 subunit alphatarget Prostaglandin E2 receptor EP1 subtypetarget Cytochrome P450 3A4enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2D6enzyme
Dexamethasone	A glucocorticoid available in various modes of administration that is used for the treatment of various inflammatory conditions, including bronchial asthma, as well as endocrine and rheumatic disorders.	Glucocorticoid receptortarget Annexin A1target Nitric oxide synthase, inducibletarget Nuclear receptor subfamily 0 group B member 1target Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Bile salt export pumptransporter ATP-dependent translocase ABCB1transporter ATP-binding cassette sub-family C member 2transporter Solute carrier organic anion transporter family member 1A2transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Steroid 17-alpha-hydroxylase/17,20 lyaseenzyme Cytochrome P450 1A1enzyme Cytochrome P450 2A6enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A43enzyme Cytochrome P450 4A11enzyme Nuclear receptor subfamily 1 group I member 2target Cytochrome P450 11B1, mitochondrialenzyme Albumincarrier 11-beta-hydroxysteroid dehydrogenase type 2enzyme 11-beta-hydroxysteroid dehydrogenase 1enzyme Organic anion transporter 3transporter
Dextrose, unspecified form	A form of glucose used for caloric supply and the replenishment of fluid in total parenteral nutrition and other therapies as well as for the treatment of hypoglycemic episodes.	Hexokinase-4enzyme Hexokinase-1enzyme Solute carrier family 2, facilitated glucose transporter member 1transporter Solute carrier family 2, facilitated glucose transporter member 2transporter Solute carrier family 2, facilitated glucose transporter member 3transporter Solute carrier family 2, facilitated glucose transporter member 4transporter Solute carrier family 2, facilitated glucose transporter member 6transporter Solute carrier family 2, facilitated glucose transporter member 7transporter Solute carrier family 2, facilitated glucose transporter member 8transporter Solute carrier family 2, facilitated glucose transporter member 9transporter Solute carrier family 2, facilitated glucose transporter member 10transporter Solute carrier family 2, facilitated glucose transporter member 11transporter Solute carrier family 2, facilitated glucose transporter member 12transporter Sodium/glucose cotransporter 1transporter
Glycerin	It is used as a solvent, emollient, pharmaceutical agent, and sweetening agent.	Group IIE secretory phospholipase A2target Inositol-3-phosphate synthase 1target All-trans-retinol dehydrogenase [NAD(+)] ADH1Btarget Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1target Glycodelintarget Alpha-N-acetylgalactosaminidasetarget ADP-ribosylation factor 1target Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1target DNA mismatch repair protein MutLtarget Ribonucleoside-diphosphate reductase 1 subunit betatarget Adenine DNA glycosylasetarget tRNA (cytosine(38)-C(5))-methyltransferasetarget Cytochrome P450 2E1enzyme Aldehyde dehydrogenase 1A1enzyme Peroxisome proliferator-activated receptor deltatarget Maleylacetoacetate isomerasetarget Aquaporin-7transporter Aquaporin-9transporter Glycerol uptake facilitator proteintransporter
Hydrocortisone succinate	A corticosteroid used to treat severe allergic reactions, dermatologic diseases, endocrine disorders, gastrointestinal diseases, hematological disorders, neoplastic diseases, nervous system conditions, ophthalmic diseases, renal diseases, respiratory diseases, and rheumatic disorders.	Cytochrome P450 3A4enzyme Cytochrome P450 2C8enzyme Cytochrome P450 11B1, mitochondrialenzyme Cytochrome P450 11B2, mitochondrialenzyme
Mannitol	A sugar alcohol used to test for asthma, to reduce intracranial and intraocular pressure, to measure glomerular filtration rate, and to manage pulmonary symptoms associated with cystic fibrosis.	Mannitol dehydrogenaseenzyme
Methylprednisolone	A corticosteroid used to treat inflammation or immune reactions across a variety of organ systems, endocrine conditions, and neoplastic diseases.	Glucocorticoid receptortarget Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 3A Subfamilyenzyme Cytochrome P450 2A6enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Annexin A1target 20-ketosteroid reductase (20-hydroxysteroid dehydrogenase)enzyme 11beta-hydroxysteroid dehydrogenaseenzyme Albumincarrier
Methylprednisolone hemisuccinate	A water soluble corticosteroid used to treat severe allergic reactions, dermatologic diseases, endocrine disorders, gastrointestinal diseases, hematological disorders, neoplastic diseases, nervous system conditions, ophthalmic diseases, renal diseases, respiratory diseases, and rheumatic disorders.	Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme
Prednisolone	A glucocorticoid used to treat adrenocortical insufficiency, inflammatory conditions, and some cancers.	Corticosteroid-binding globulincarrier Cytochrome P450 3A4enzyme Glucocorticoid receptortarget Solute carrier organic anion transporter family member 1A2transporter ATP-dependent translocase ABCB1transporter Albumincarrier
Prednisone	A corticosteroid used to treat inflammation or immune-mediated reactions and to treat endocrine or neoplastic diseases.	Glucocorticoid receptortarget Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1A2transporter Cytochrome P450 2C19enzyme Albumincarrier Cytochrome P450 3A5enzyme Corticosteroid-binding globulincarrier Cytochrome P450 3A Subfamilyenzyme Cytochrome P450 2A6enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme 11-beta-hydroxysteroid dehydrogenase 1enzyme
Triamcinolone	A glucocorticoid used to treat a wide variety of inflammatory conditions of organ systems and tissues.	Corticosteroid-binding globulincarrier Glucocorticoid receptortarget Cytochrome P450 3A4enzyme Prostaglandin G/H synthase 2enzyme Cholinesteraseenzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Albumincarrier

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01954290	Study of Stroke Related Edema Treatments	Conivaptan Diacerein L-Acetylleucine Mannitol Sodium chloride	treatment	2	withdrawn
NCT03703284	Molecular Mechanisms of Malignant Cerebral Edema After LHI	No drug interventions	Not Available	Not Available	unknown_status
NCT06515145	High-volume Versus Standard Volume Plasma Exchange in Patients With Acute Liver Failure With Cerebral Edema	No drug interventions	treatment	Not Available	not_yet_recruiting
NCT03000283	Conivaptan for the Reduction of Cerebral Edema in Intracerebral Hemorrhage- A Safety and Tolerability Study	Conivaptan	treatment	1	completed
NCT01365793	Randomized Control Trial of Fluid Therapy for Pediatric Diabetic Ketoacidosis	No drug interventions	treatment	3	completed
NCT06096415	Safety and Efficacy of ABX-101 in Participants Aged 18 to 50 Years of Age With Moderate to Severe Traumatic Brain Injury	No drug interventions	treatment	2	not_yet_recruiting
NCT03409237	Coagulation Activation by Hyperosmolar Agents in Intracranial Hypertension	Mannitol	Not Available	Not Available	withdrawn
NCT05060159	Conventional Hemodialysis Versus Post-Dilution Hemofiltration in Incident RRT	No drug interventions	treatment	Not Available	completed
NCT05796349	Study on Data Acquisition and Image Characteristics of Brain Multifrequency EIT in Healthy People and Patients With Brain Diseases	No drug interventions	Not Available	Not Available	completed
NCT06009016	Inflammation and Coagulation Factors for Predicting Cerebral Edema After SAH	No drug interventions	Not Available	Not Available	recruiting
NCT03243539	Implementation of Neuro Lung Protective Ventilation	No drug interventions	treatment	Not Available	active_not_recruiting
NCT04088630	Fingolimod as a Treatment of Cerebral Edema After Intracerebral Hemorrhage	Fingolimod	treatment	0	completed
NCT01605357	Hypernatremia for the Prevention and Treatment of Cerebral Edema in Traumatic Brain Injury	Aloe vera leaf Ascorbic acid Glycerin Mannitol Nicotinamide Vitamin A	treatment	1 / 2	withdrawn
NCT02460874	Glyburide vs Placebo as Prophylaxis Against Cerebral Edema in Patients Receiving Radiosurgery for Brain Metastases (RAD 1502/UAB 1593)	Glyburide	treatment	1 / 2	terminated
NCT05725694	Acute Ischaemic STROKE: From LAboratory to the Patient's BED	No drug interventions	Not Available	Not Available	enrolling_by_invitation
NCT02142712	Histamine Glutamate Antagonism in Stroke	Acetazolamide Dextromethorphan Diphenhydramine Famotidine Pantoprazole	treatment	2	completed
NCT05170295	Noninvasive Monitoring of Cerebral Blood Flow Autoregulation	No drug interventions	Not Available	Not Available	completed
NCT04116138	Antisecretory Factor in Primary Glioblastoma 1	No drug interventions	treatment	1 / 2	completed
NCT06018545	AI Assisted Reader Evaluation in Acute Computed Tomography (CT) Head Interpretation	No drug interventions	Not Available	Not Available	active_not_recruiting
NCT05200728	The Tolerability, Safety, and PK Characteristics of SIM1910-09 in Healthy Chinese Volunteers	No drug interventions	treatment	1	completed
NCT04247659	Study on the Relationship Between Asymmetric Vascular Sign of Cortex and Prognosis in Massive Cerebral Infarction	Sodium aescinate	prevention	4	unknown_status
NCT02937441	Evaluation of the Cerebral Edema in Children Having Diabetic Ketoacidosis	No drug interventions	Not Available	Not Available	completed
NCT00243022	Dietary, Herbal and Alternative Medicine in Glioblastoma Multiforme	Indian frankincense	treatment	2	terminated
NCT04303065	Dexamethasone for the Treatment of Vasogenic Pericontusional Edema.	Dexamethasone	treatment	3	unknown_status
NCT03276494	Safety & Tolerability of Hypertonic Saline Administration Via Intraosseous Access	No drug interventions	treatment	2	completed
NCT03330704	Small-Volume, Patient-Specific, Balanced Hypertonic Fluid Protocol Validation	Sodium bicarbonate Sodium chloride	treatment	0	withdrawn
NCT01060969	Tadalafil and Acetazolamide Versus Acetazolamide in Acute Mountain Sickness Prevention	Acetazolamide Tadalafil	prevention	Not Available	completed
NCT05585255	Clinical Significance of DKK2 Protein in Cerebral Ischemia-reperfusion Injury	No drug interventions	Not Available	Not Available	recruiting