Motion Sickness (DBCOND0035529)

Identifiers

Synonyms

Motion sickness / Motion sickness (disorder) / Travel sickness / Travel sickness NOS / Seasickness / Sea sickness symptom / Sea sickness (disorder) / Sea sickness / Airsickness / Air sickness (disorder) / Air sickness

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Chlorcyclizine	Chlorcyclizine is a first generation phenylpiperazine class antihistamine used to treat urticaria, rhinitis, pruritus, and other allergy symptoms. Chlorcyclizine also has some local anesthetic, anticholinergic, and antiserotonergic properties, and can...	Histamine H1 receptortarget Albumincarrier
Cinnarizine	A drug used for the management of labyrinthine disorder symptoms, including vertigo, tinnitus, nystagmus, nausea, and vomiting.	Histamine H1 receptortarget D(2) dopamine receptortarget Voltage-dependent T-type calcium channel subunit alpha-1Htarget Cytochrome P450 2D6enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 1A1enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2A6enzyme Voltage-dependent L-type calcium channel subunit alpha-1Ctarget Voltage-dependent L-type calcium channel subunit alpha-1Starget Voltage-dependent L-type calcium channel subunit alpha-1Ftarget Voltage-dependent L-type calcium channel subunit alpha-1Dtarget Voltage-dependent T-type calcium channel subunit alpha-1Gtarget Voltage-dependent T-type calcium channel subunit alpha-1Itarget D(1) dopamine receptortarget Muscarinic acetylcholine receptortarget Cytochrome P450 3A4enzyme Albumincarrier
Cyclizine	An antihistamine and antiemetic drug used for the prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness, and vertigo.	Histamine H1 receptortarget Sulfotransferase 1E1target Cytochrome P450 2C9enzyme Albumincarrier
Dimenhydrinate	A medication used to prevent and treat nausea, vomiting, vertigo, and motion sickness.	Histamine H1 receptortarget
Diphenhydramine	A H1 receptor antihistamine used in the treatment of seasonal allergies, and various allergic reactions including sneezing, runny nose, itchy/watery eyes, itching of nose or throat, pruritus, urticaria, insect bites/stings, and allergic rashes.	Histamine H1 receptortarget Cytochrome P450 2D6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Solute carrier family 22 member 2transporter Organic cation/carnitine transporter 2transporter Prostaglandin G/H synthase 1enzyme Muscarinic acetylcholine receptor M2target Histamine N-methyltransferasetarget
Meclizine	A histamine H1 antagonist used to treat nausea, vomiting, and dizziness associated with motion sickness.	Histamine H1 receptortarget Nuclear receptor subfamily 1 group I member 3target Cytochrome P450 2D6enzyme Albumincarrier
Promethazine	A first-generation antihistamine used for the treatment of allergic conditions, nausea and vomiting, and motion sickness.	D(2) dopamine receptortarget Histamine H1 receptortarget Muscarinic acetylcholine receptor M4target Muscarinic acetylcholine receptor M1target Muscarinic acetylcholine receptor M5target Muscarinic acetylcholine receptor M2target Muscarinic acetylcholine receptor M3target Cytochrome P450 2D6enzyme Cytochrome P450 2B6enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 2C9enzyme Histamine H2 receptortarget Alpha adrenergic receptortarget P2 Purinoceptorstarget Voltage-gated sodium channel alpha subunittarget Voltage-gated Potassium Channelstarget ATP-binding cassette sub-family C member 3transporter ATP-binding cassette sub-family C member 4transporter Albumincarrier Calmodulintarget
Pyridoxine	A vitamin used to correct vitamin B6 deficiency and to treat nausea during pregnancy.	Pyridoxal kinasetarget Cytochrome P450 1A1enzyme Albumincarrier Pyridoxal kinaseenzyme Chronophinenzyme Alkaline phosphatase, tissue-nonspecific isozymetransporter Alkaline phosphatase, tissue-nonspecific isozymeenzyme Aromatic-L-amino-acid decarboxylasetarget
Scopolamine	A belladonna alkaloid with anticholinergic effects indicated for the treatment of nausea and vomiting associated with motion sickness and postoperative nausea and vomiting (PONV).	Muscarinic acetylcholine receptor M1target Sucrase-isomaltase, intestinaltarget Muscarinic acetylcholine receptor M2target Muscarinic acetylcholine receptor M3target Muscarinic acetylcholine receptor M4target Muscarinic acetylcholine receptor M5target Neuronal acetylcholine receptor subunit alpha-4target Neuronal acetylcholine receptor subunit beta-2target Cytochrome P450 3A4enzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT06587386	The 90% Minimum Effective Concentration of Bupivacaine Liposomes for Preserving Motion Function	Bupivacaine	treatment	Not Available	not_yet_recruiting
NCT04196933	Analysis of Vestibular Compensation Following Clinical Intervention for Vestibular Schwannoma	No drug interventions	basic_science	Not Available	enrolling_by_invitation
NCT04327661	Motion Syros: A Study to Investigate the Efficacy of Tradipitant in Subjects Affected by Motion Sickness	Tradipitant	treatment	3	completed
NCT06232785	Gynecologic Endoscopic Surgery of Female Motion Sickness Patients	Ibuprofen Sufentanil	prevention	4	completed
NCT04184115	Nasal Gel for the Prevention and Treatment of Nausea Associated With Motion Sickness	Scopolamine	treatment	3	completed
NCT04420949	Sensory Training for Visual Motion Sickness	No drug interventions	treatment	Not Available	completed
NCT04999449	Nebulizer Delivery of Intranasal Scopolamine	Scopolamine	treatment	1	recruiting
NCT05004818	Galvanic Vestibular Stimulation as a Novel Treatment for Seasickness	No drug interventions	treatment	Not Available	completed
NCT02839135	A Comparative Bioavailability and Adhesion Performance Study, Comparing a New Scopolamine Transdermal Delivery System Formulation to the Currently Established Reference Transdermal Delivery System in Healthy Adult Participants.	Scopolamine	other	1	completed
NCT03988530	Prevention and Treatment of Nausea Associated With Motion Sickness in Senior Subjects	Scopolamine	treatment	3	completed
NCT05628220	Motion Sickness Desensitization Using VR	No drug interventions	treatment	Not Available	unknown_status
NCT05622344	StableEyes With Active Neurofeedback	No drug interventions	treatment	Not Available	recruiting
NCT03772340	Motion Sifnos: A Study to Investigate the Efficacy of Tradipitant in Subjects Affected by Motion Sickness	Tradipitant	treatment	2	completed
NCT05611814	Preliminary Evaluation of an Osteopathic Manipulative Treatment (OMT) to Prevent Motion Sickness Symptoms	No drug interventions	prevention	Not Available	completed
NCT04947423	Nasal Gel for the Prevention of Nausea and Vomiting Associated With Motion	Scopolamine	treatment	3	completed
NCT03986905	The Prevention and Treatment of Nausea Associated With Motion Sickness	Scopolamine	treatment	3	completed
NCT04331561	Sensory Training for Orientation and Balance	No drug interventions	treatment	Not Available	withdrawn
NCT00374478	Effects of Transdermal Scopolamine on Occupational Performance	Scopolamine	prevention	2	completed
NCT06128707	Vestibulo-Ocular Reflex Function in Individuals With Chronic Motion Sensitivity Cross-Sectional Study	No drug interventions	Not Available	Not Available	recruiting
NCT06354309	The Impact of Immersive Virtual Reality Training on Adult: Motion Sickness, and Ocular Surface: A Pilot Study	No drug interventions	other	Not Available	completed
NCT02155309	Pharmacokinetic and Efficacy Profile Intranasal Scopolamine Spray	Scopolamine	treatment	2 / 3	terminated
NCT06106256	Three-Axis Wearable Adaptive Vestibular Stimulator	No drug interventions	treatment	Not Available	recruiting
NCT05548270	Efficacy and Safety of DPI-386 Nasal Gel for the Prevention of Nausea and Vomiting Associated With Motion	Scopolamine	treatment	3	completed
NCT06138613	Motion Delos: An Open Label Safety and Efficacy of Tradipitant in Participants Affected by Motion Sickness	Tradipitant	treatment	3	recruiting
NCT05903924	Motion Serifos: A Study to Investigate the Efficacy of Tradipitant in Participants Affected by Motion Sickness	Tradipitant	treatment	3	recruiting
NCT03755596	Clinical Evaluation of the Use of Ginger Extract in the Management of Motion Sickness	No drug interventions	treatment	4	completed
NCT06056622	Motion Sickness Rehabilitation for Virtual Reality	No drug interventions	treatment	Not Available	completed
NCT04219982	DPI 386 Nasal Gel for the Prevention of Nausea Associated With Motion Sickness	Scopolamine	prevention	2 / 3	terminated
NCT05886660	Combination of Intranasal Scopolamine and Sensory Augmentation to Mitigate G-transition Induced Motion Sickness and Enhance Sensorimotor Performance	Scopolamine	treatment	2	recruiting
NCT02241629	Levo Phencynonate Hydrochloride for the Prevention of Seasickness	No drug interventions	prevention	2	completed
NCT04272255	Nasal Gel Under Military Operational Conditions for the Prevention of Nausea Associated With Motion Sickness	Scopolamine	treatment	3	unknown_status
NCT02986555	Research on Quantification of VR(Virtual Reality) Related Stress and Relaxation	No drug interventions	health_services_research	Not Available	unknown_status