Hospital-Acquired Pneumonia (DBCOND0038730)

Identifiers

Synonyms
Pneumonia Hospital Acquired / Hospital Acquired Bacterial Pneumonia / Hospital-acquired Pneumonia (HAP) / Hospital-acquired bacterial pneumonia / Nosocomial Pneumonia (NP) / Pneumonia, Hospital-Acquired / Hospital Acquired Bacterial Pneumonia (HABP) / Hospital Acquired Pneumonia / Nosocomial Pneumonia / Hospital Acquired Pneumonia (HAP) / Hospital-acquired bacteral pneumonia / Pneumonia, Hospital Acquired / HAP - Hospital Acquired Pneumonia / Nosocomial pneumonia (disorder) / Healthcare associated pneumonia / Healthcare-Associated Pneumonia / Unspecified bacterial pneumonia / Pneumonia, Bacterial / Bacterial pneumonia (disorder) / Pneumonia bacterial / Bacterial pneumonia, unspecified / Pneumonia bacterial NOS / Pneumonia, unspecified organism / Lung inflammation / Pneumonia / Pneumonia (disorder) / Pneumonia NOS / Pulmonitis

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Amikacin
An aminoglycoside used to treat infections caused by more resistant strains of Gram negative bacteria and some Gram positive bacteria.
Avibactam
A non-β-lactam β-lactamase inhibitor used in combination with ceftazidime for the treatment of complicated intra-abdominal infections, complicated urinary tract infections, and hospital or ventilator-acquired pneumonia.
Cefiderocol
A cephalosporin antibiotic used in complicated urinary tract infections.
Ceftazidime
An injected broad-spectrum third-generation cephalosporin beta-lactam antibiotic used to treat or prevent a variety of bacterial infections, including pneumonia, gynecological infections, bone and joint infections, and septicemia, among others.
Ceftobiprole
A broad spectrum 5th-generation cephalosporin antibacterial indicated for certain kinds of pneumonia, bacteremia, and skin and skin structure infections, including those caused by MRSA.
Ceftolozane
A cephalosporin antibiotic used to treat complicated intra-abdominal infections in combination with metronidazole, complicated urinary tract infections, and hospital-acquired pneumonia.
Ciprofloxacin
A second generation fluoroquinolone used to treat various susceptible bacterial infections.
Piperacillin
A penicillin antibiotic combined with tazobactam to treat piperacillin-resistant, piperacillin/tazobactam­ susceptible, β-lactamase generating strains of several bacteria.
Sulbactam
An beta-lactamase inhibitor antibiotic combined with other antibiotics to treat a variety of susceptible bacterial infections.
Tazobactam
A beta lactamase inhibitor administered with antibiotics such as piperacillin and ceftolozane to prevent their degradation, resulting in increased efficacy.
Teicoplanin
A glycopeptide antibiotic with a similar mechanism of action and spectrum of activity to vancomycin used to treat various infections caused by gram-positive bacteria.
Telavancin
An antibacterial agent used in the treatment of complicated skin and skin structure infections and types of hospital-acquired bacterial pneumonia.
Trovafloxacin
An antibiotic used to treat gonorrhea and chlamydia.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT05214716
FilmArray Pneumonia Panel for Antimicrobial Treatment of HAP/VAP in Intensive Care UnitsNo drug interventionsdiagnosticNot Availableterminated
NCT06602934
Long-term Alterations of Host-microbiome Interactions and Cardiovascular and Respiratory Diseases Progression After PneumoniaNo drug interventionsotherNot Availablenot_yet_recruiting
NCT02714595
Study of Cefiderocol (S-649266) or Best Available Therapy for the Treatment of Severe Infections Caused by Carbapenem-resistant Gram-negative Pathogenstreatment3completed
NCT03439124
Ceftobiprole in the Treatment of Pediatric Patients With Pneumoniatreatment3completed
NCT04335539
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses of Cefiderocol in Hospitalized Pediatric Participantstreatment2completed
NCT03032380
Clinical Study of Cefiderocol (S-649266) for the Treatment of Nosocomial Pneumonia Caused by Gram-negative Pathogenstreatment3completed
NCT00842478
Effectiveness of Dental Brushing for Preventing Ventilator-Associated PneumoniaNo drug interventionsprevention2 / 3unknown_status
NCT03303937
Characteristics of Lower Respiratory Tract Escherichia Coli Isolates in Mechanically Ventilated Intensive Care PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT02413242
Advanced Understanding of Staphylococcus Aureus and Pseudomonas Aeruginosa Infections in EuRopE - ICUNo drug interventionsNot AvailableNot Availablecompleted
NCT06310941
Mechanical Insufflation-exsufflation and Hypertonic Saline in Nosocomial Bacterial Respiratory Tract InfectionNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT02793141
International Study on NoSocomial Pneumonia in Intensive CaRE (PneumoINSPIRE)No drug interventionsNot AvailableNot Availablecompleted
NCT00236834
A Study of the Safety and Effectiveness of Levofloxacin Compared With Imipenem/Cilastatin in Patients With Pneumonia Acquired During Hospitalizationtreatment3completed
NCT01431326
Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of CareNot AvailableNot Availablecompleted
NCT04279873
Use of Microscopy, Cultures and Molecular Biological Methods for Diagnosing Nosocomial PneumoniaNo drug interventionsNot AvailableNot Availablecompleted
NCT05928208
The Role of Point-of-care Polymerase Chain Reaction in Managing Nosocomial PneumoniaNo drug interventionsNot AvailableNot Availablecompleted
NCT01363271
Cost Study of Linezolid Versus Vancomycin Among Previously Hospitalized PatientsNot AvailableNot Availablecompleted
NCT02598609
SEPREVEN: a Stepped-wedge Randomised Controlled TrialNo drug interventionspreventionNot Availablecompleted
NCT04223752
Safety and Pharmacokinetics of Ceftolozane/Tazobactam in Pediatric Participants With Nosocomial Pneumonia (MK-7625A-036)treatment1active_not_recruiting
NCT00829842
Oral Hygiene With Chlorhexidine and Incidence of Ventilator-Associated Pneumonia in Children Submitted to Heart SurgeryNo drug interventionsprevention3completed
NCT01796717
Optimizing Dosing Regimen of Piperacillin/Tazobactam for Nosocomial PneumoniaNo drug interventionstreatment2 / 3unknown_status
NCT00610324
Effect of Oral Decontamination Using Chlorhexidine or Potassium Permanganate in ICU Patientsprevention4completed
NCT06261827
High-dose Inhaled NO Therapy for the pREvenvention of NP After Cardiac Surgery Under CPBpreventionNot Availablerecruiting
NCT01897792
Effect of Antioxidant Vitamins on Coagulopathy and Nosocomial Pneumonia After Severe TraumaNo drug interventionsprevention2terminated
NCT06170372
High-dose Inhalations of Nitric Oxide in the Treatment of PneumoniatreatmentNot Availablerecruiting
NCT04488510
Pathogens Involved in Secondary Infections During Severe Forms of Covid-19 Pneumonia:No drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT06162455
High-dose Inhaled NO Therapy for the Prevention of Nosocomial Pneumonia After Cardiac Surgery With CPBpreventionNot Availablecompleted
NCT04774094
Efficacy and Safety of Ceftazidime-Avibactam (CAZ-AVI) in Chinese Participants With HAP (Including VAP)treatment4completed
NCT05487586
Real-World Study of Ceftazidime Avibactam in ChinaNot AvailableNot Availableterminated
NCT04700202
Identifying Risk Factors for Gram-negative Resistance for HAP/VAP in the Intensive Care UnitNo drug interventionsNot AvailableNot Availablecompleted
NCT03006679
A Study of Meropenem-Vaborbactam Versus Piperacillin/Tazobactam in Participants With Hospital-Acquired and Ventilator-Associated Bacterial Pneumoniatreatment3withdrawn
NCT06028217
Chinese Hospital Acquired Pneumonia Collaboration Network: Epidemiology, Diagnosis and TreatmentNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT05785442
Use of Presepsin as a Marker for Immunotherapy Administration in Pneumoniatreatment2completed
NCT05060718
HOspital NEtwork STudy - Preparation for a Randomized Evaluation of Anti-Pneumonia StrategiesNo drug interventionsNot AvailableNot Availablecompleted
NCT04403971
0.12% Chlorhexidine Oral Care for the Prevention of Non-ventilator Hospital-acquired PneumoniapreventionNot Availablecompleted
NCT03361085
Modular Prevention Bundle for Non-ventilator-associated Hospital-acquired Pneumonia (nvHAP)No drug interventionspreventionNot Availableterminated
NCT04055922
Comparison of Solid Organ TransplantNo drug interventionsNot AvailableNot Availableunknown_status
NCT06269900
Dexamethasone for Treating Severe Hospital-acquired Pneumonia in Critically Ill Patients With a Proinflammatory Phenotypetreatment3not_yet_recruiting
NCT06134492
Acyclovir in Mechanically Ventilated Patients With Pneumonia and HSV-1 in BALtreatment3recruiting
NCT05979545
EaRly impAct theraPy With Ceftazidime-avibactam Via rapID DiagnosticsNo drug interventionstreatment4recruiting
NCT05663905
Efficacy of Intravenous Amboxol Hydrochloride as an Adjunct Therapy for Severe Pneumonia in Critically Ill Patientstreatment4completed
NCT05483309
Feasibility Study of Contemporary Diagnostics for Patients With Suspected Hospital-Acquired Pneumonia.No drug interventionsdiagnosticNot Availablecompleted
NCT04937075
Impact of Antimicrobial Stewardship on Outcomes of Patients With Hospital-acquired Pneumonia Due to Gram-negative Bacilli - A Before-after StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT04381247
Comprehensive Molecular Diagnosis and Management of Hospital- and Ventilator-associated Pneumonia in NorwayNo drug interventionsNot AvailableNot Availablerecruiting
NCT05624684
Diagnostic Performance and Impact of a Multiplex PCR Pneumonia Panel in ICU Patients With Severe Pneumonia.No drug interventionsNot AvailableNot Availablecompleted
NCT05914584
"Baricitinib for Treating Hospital-acquired Pneumonia in Critically Ill Patients With a Proinflammatory Phenotype.treatment2 / 3not_yet_recruiting
NCT01561469
Evaluation of Patients With Methicillin-Resistant Staphylococcus Aureus Hospital-Acquired Pneumonia Treated With Linezolid or VancomycinNot AvailableNot Availablecompleted
NCT00543608
Clinical Efficacy of Intravenous Iclaprim Versus Vancomycin in the Treatment of Hospital-Acquired, Ventilator-Associated, or Health-Care-Associated Pneumoniatreatment2terminated
NCT05733104
A Study to Learn About the Study Medicine Zavicefta After it is Released Into the Markets in KoreaNo drug interventionsNot AvailableNot Availablerecruiting
NCT01577862
Colistin and Rifampicin for MDR-Acinetobactertreatment3completed
NCT02203110
The Impact of Simultaneous Presence of Viral and Bacterial Pathogens on Therapy and Course of Severe PneumoniaNo drug interventionsNot AvailableNot Availableunknown_status
NCT02454114
HOME FIRST Pilot: a Study of Early Supported Discharge in Patients With Lower Respiratory Tract InfectionsNo drug interventionssupportive_careNot Availablecompleted
NCT03348579
Hospital-acquired Pneumonia in Intensive Care UnitNo drug interventionsNot AvailableNot Availablecompleted
NCT03039998
Validity of Biological Material Sampling in Patients With Hospital-acquired PneumoniaNo drug interventionsNot AvailableNot Availablecompleted
NCT04882085
Efficacy and Safety of CAZ-AVI in the Treatment of Infections Due to Carbapenem-resistant G- Pathogens in Chinese Adultstreatment4completed
NCT01769742
Early Mobility Bundle to Prevent Hospital Acquired Pneumonia (HAP) in Medical InpatientsNo drug interventionspreventionNot Availablecompleted
NCT06168734
Cefepime-taniborbactam vs Meropenem in Adults With VABP or Ventilated HABPtreatment3not_yet_recruiting
NCT04153682
Trial on a Strategy Combining Rapid Diagnostic Testing and Antimicrobial Stewardship to Improve Antibiotic Use in Patients With Hospital-acquired Pneumonia.No drug interventionsdiagnosticNot Availablerecruiting
NCT03496220
Effect of Angulus on Patient-elevation ComplianceNo drug interventionspreventionNot Availablecompleted
NCT05418517
Hospital Acquired Pneumonia in Temporary TracheostomyNo drug interventionsNot AvailableNot Availableunknown_status
NCT01940731
Efficacy and Safety of Colistimethate Sodium Injection Vial to Treat Hospital-acquired Pneumonia in Adultstreatment2unknown_status
NCT01266863
E Test Strips Applied to Bronchoalveolar Lavage for Suspicion of Hospital-acquired Pneumonia to Accelerate Antibiogram Analysis.No drug interventionsdiagnosticNot Availablecompleted
NCT02058004
Does Cricoid Pressure Reduce the Risk of Aspiration?No drug interventionspreventionNot Availablecompleted
NCT01883869
Targeting Platelet-Leukocyte Aggregates in Pneumonia With Ticagrelortreatment1completed
NCT04215991
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Cefiderocol in Hospitalized Pediatric Participantstreatment2recruiting
NCT02689531
CTTI Risk Factors for HABP/VABP StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT05405491
Impact of a Strategy Based on Bacterial DNA Detection to Optimize Antibiotics in Immunocompromised Patients With Hospital-acquired Pneumonia Requiring Mechanical VentilationNo drug interventionstreatmentNot Availablerecruiting
NCT02364284
Reporting Patterns and Results of Initial Antibiotic Treatment in Patients With cUTI, cIAI,NP Including VAPNo drug interventionsNot AvailableNot Availablecompleted
NCT01808092
A Study Comparing Ceftazidime-Avibactam Versus Meropenem in Hospitalized Adults With Nosocomial Pneumoniatreatment3completed
NCT06087536
A Clinical Trial to Assess the Safety and PK of OMN6 in HABP or VABP Caused by Acinetobacter Baumannii ComplexNo drug interventionstreatment2recruiting
NCT03583333
Imipenem/Cilastatin/Relebactam (MK-7655A) Versus Piperacillin/Tazobactam in Participants With Hospital-Acquired or Ventilator-Associated Bacterial Pneumonia (MK-7655A-016)treatment3completed
NCT03894046
Study to Evaluate the Efficacy and Safety of Intravenous Sulbactam-ETX2514 in the Treatment of Patients With Infections Caused by Acinetobacter Baumannii-calcoaceticus Complextreatment3completed
NCT05905055
P3 Study to Assess Efficacy and Safety of Cefepime/Nacubactam and Aztreonam/Nacubactam Versus Best Available Therapy for Adults With Infection Due to Carbapenem Resistant Enterobacteralestreatment3recruiting
NCT02168946
Efficacy, Safety, Tolerability of Vabomere Compared to Best Available Therapy in Treating Serious Infections in Adultstreatment3completed
NCT02288234
Telavancin Observational Use Registry (TOUR)Not AvailableNot Availablecompleted
NCT02420366
Study of Cases of Serious Infections Due to Carbapenem-Resistant EnterobacteriaceaeNo drug interventionsNot AvailableNot Availablecompleted
NCT03121690
The Applicability of Different Scoring Systems and Use of Steroids in the Treatment of Hospital Acquired Pneumoniatreatment4unknown_status
NCT06062862
Effect of Breather on Hospital Stay in Patients With Acquired PneumoniaNo drug interventionstreatmentNot Availablecompleted
NCT05952648
HAP/VAP Diagnosis in Critically Ill Septic Patients Using a Multiplex PCR ArrayNo drug interventionsdiagnosticNot Availablerecruiting