Acute Sinusitis (DBCOND0061066)

Identifiers

Synonyms

Acute sinusitis / Acute empyema of nasal sinus (disorder) / Acute abscess of nasal sinus (disorder) / Acute sinusitis, unspecified / Sinusitis acute NOS / Acute sinusitis (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Cefpodoxime	A third-generation cephalosporin antibiotic used in the treatment of various bacterial infections, including gonorrhea, community acquired pneumonia, and sinusitis.	Peptidoglycan synthase FtsItarget
Ceftibuten	A third-generation cephalosporin antibiotic commonly used in the treatment of acute bacterial exacerbations of chronic bronchitis (ABECB), acute bacterial otitis media, pharyngitis, and tonsillitis.	Solute carrier family 15 member 1transporter Solute carrier family 15 member 2transporter Peptidoglycan synthase FtsItarget Penicillin-binding protein 1Atarget Penicillin-binding protein 1Btarget Penicillin-binding protein 2target Solute carrier family 22 member 6transporter Organic anion transporter 3transporter
Chlorobutanol	No approved therapeutic indications on its own.	Potassium voltage-gated channel subfamily H member 2target
Ciprofloxacin	A second generation fluoroquinolone used to treat various susceptible bacterial infections.	DNA gyrase subunit Atarget DNA topoisomerase 4 subunit Atarget DNA topoisomerase 2-alphatarget Cytochrome P450 1A2enzyme Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter Potassium voltage-gated channel subfamily H member 2target DNA gyrase subunit Atarget DNA topoisomerase 4 subunit Atarget DNA topoisomerase 4 subunit Btarget DNA gyrase subunit Atarget Multidrug resistance protein MdtKtarget Gyrase Atarget DNA gyrase subunit Atarget Multidrug and toxin extrusion protein 1transporter Multidrug and toxin extrusion protein 2transporter Albumincarrier Thymidylate synthasetarget DNA gyrase subunit Btarget
Dimetindene	A 1st generation selective H1 antagonist used topically as an antipruritic and orally to treat allergies.	Muscarinic acetylcholine receptor M2target Histamine H1 receptortarget
Sparfloxacin	A fluoroquinolone antibiotic used to treat bacterial respiratory infections and sinusitis.	DNA gyrase subunit Atarget DNA topoisomerase 4 subunit Atarget DNA topoisomerase 2-alphatarget Organic cation/carnitine transporter 2transporter ATP-binding cassette sub-family C member 2transporter ATP-dependent translocase ABCB1transporter Cytochrome P450 1A2enzyme DNA gyrase subunit Atarget DNA gyrase subunit Btarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05127161	Broad Implementation of Outpatient Stewardship	No drug interventions	health_services_research	Not Available	active_not_recruiting
NCT03431337	Treatment of Acute Sinusitis With High-Dose vs. Standard-Dose Amoxicillin/Clavulanate	Amoxicillin	treatment	4	terminated
NCT04241016	Endoscopic Sinus Surgery in Recurrent Acute Rhinosinusitis	No drug interventions	treatment	Not Available	recruiting
NCT03729258	Efficacy and Safety of Modified Release Cefpodoxime Formulation in the Treatment of Acute Sinusitis.	No drug interventions	treatment	3	recruiting
NCT01934231	Study to Assess the Efficacy and Safety of Potassium Clavulanate/Amoxicillin in Children With Acute Bacterial Rhinosinusitis	No drug interventions	treatment	3	completed
NCT00552773	Pilot Study to Determine Efficacy of Cyclamen Europaeum Extract Nasal Spray in Patients With Acute Sinusitis	No drug interventions	treatment	Not Available	completed
NCT04664803	Safety and Efficacy of Cefecin Tab. in Patients With Acute Sinusitis	No drug interventions	treatment	4	terminated
NCT01806103	Antimicrobial Stewardship for Primary Care Pediatricians	No drug interventions	treatment	Not Available	completed
NCT05924711	"Association of Peri-implantitis and Maxillary Sinusitis: a Case-control Study".	No drug interventions	Not Available	Not Available	recruiting
NCT02297815	Comparative Effectiveness of Antibiotics for Respiratory Infections	No drug interventions	Not Available	Not Available	completed
NCT01700725	Gulf War Illness Nasal Irrigation Study	No drug interventions	treatment	2	completed
NCT01018030	Dose Finding Study of Fluticasone Furoate Nasal Spray for Uncomplicated Acute Rhinosinusitis	No drug interventions	treatment	2	completed
NCT06076304	Nasal Steroids, Irrigation, Oral Antibiotics, and Subgroup Targeting for Effective Management of Sinusitis	No drug interventions	treatment	4	active_not_recruiting