Smoldering Multiple Myeloma (SMM) (DBCOND0074632)

Identifiers

Synonyms
Multiple Myeloma, Smoldering / Smoldering Multiple Myeloma / Smoldering Myeloma / Smoldering Plasma Cell Myeloma / Smoldering myeloma (disorder) / Multiple myeloma / Multiple myeloma not having achieved remission / Plasma cell myeloma (morphologic abnormality) / Plasma cell myelomas / Myelomatosis multiple / Peripheral plasma cell myeloma / Myelomatosis / Plasma cell myeloma / Myeloma / Multiple myeloma (disorder)

Associated Data

Indicated Drugs and Targets
Not Available
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT06055894
A Study of a Plant-Based Diet and Dietary Supplements in People With Smoldering Multiple Myeloma (SMM)No drug interventionspreventionNot Availablerecruiting
NCT00099047
Celecoxib in Preventing Multiple Myeloma in Patients With Monoclonal Gammopathy or Smoldering Myelomaprevention2completed
NCT05597345
Selinexor for the Treatment of Intermediate and High-Risk Smoldering Multiple Myelomatreatment2recruiting
NCT05469893
Immuno-PRISM (PRecision Intervention Smoldering Myeloma)treatment2recruiting
NCT02916771
Trial of Combination of Ixazomib and Lenalidomide and Dexamethasone in Smoldering Multiple Myelomatreatment2active_not_recruiting
NCT03289299
Aggressive Smoldering Curative Approach Evaluating Novel Therapies and Transplanttreatment2active_not_recruiting
NCT02415413
Carfilzomib in Treatment Patients Under 65 Years With High Risk Smoldering Multiple Myelomatreatment2active_not_recruiting
NCT00503763
Efficacy and Safety of Statin on the Course of Progressive Smoldering Multiple Myelomatreatment2withdrawn
NCT01222286
Study on the Anti-tumor Activity, Safety and Pharmacology of IPH2101 in Patients With Smoldering Multiple Myelomatreatment2completed
NCT01302886
Study of BHQ880 in Patients With High Risk Smoldering Multiple MyelomaNo drug interventionstreatment2completed
NCT03850522
PD-L1 Peptide Vaccination in High Risk Smoldering Multiple MyelomaNo drug interventionstreatment2terminated
NCT02886065
A Study of PVX-410, a Cancer Vaccine, and Citarinostat +/- Lenalidomide for Smoldering MMprevention1active_not_recruiting
NCT03301220
A Study of Subcutaneous Daratumumab Versus Active Monitoring in Participants With High-Risk Smoldering Multiple Myelomatreatment3active_not_recruiting
NCT01441973
Biomarker Study of Elotuzumab in High Risk Smoldering Myelomatreatment2completed
NCT01177527
Questionnaire and Tissue Banking For Multiple Myeloma, Waldenstrom Macroglobulinemia and Related DisordersNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT06365060
Screening for AL Amyloidosis in Smoldering Multiple MyelomaNo drug interventionsNot AvailableNot Availablerecruiting
NCT02279394
E-PRISM: Phase II Trial of Elotuzumab Lenalidomide and Dexamethasone in High-Risk Smoldering Multiple Myelomatreatment2completed
NCT03717844
Registry for Adults With Plasma Cell Disorders (PCD's)No drug interventionsNot AvailableNot Availablerecruiting
NCT00114101
Lenalidomide in Treating Patients With Multiple Myeloma Undergoing Autologous Stem Cell TransplantNo drug interventionstreatment3active_not_recruiting
NCT04615572
Screening to Improve Survival in AL AmyloidosisNo drug interventionsNot AvailableNot Availablecompleted
NCT04850846
Investigation of Metformin for the Prevention of Progression of Precursor Multiple MyelomaNo drug interventionstreatment2active_not_recruiting
NCT01955395
Genomic and Psychosocial Effects of the 3RP on Patients With MGUS and Smoldering Multiple MyelomaNo drug interventionssupportive_careNot Availablecompleted
NCT05841550
The TG01 Study With TG01/QS-21 Vaccine in Patients With High-risk Smouldering Multiple Myeloma and Multiple MyelomaNo drug interventionstreatment1 / 2recruiting
NCT06212323
Smoldering Myeloma High-Risk Patient Observation and Longitudinal Insight TrialNo drug interventionsNot AvailableNot Availablerecruiting
NCT06383143
Promoting Diagnosis and Management of AL in Italy (ProDigALIty)No drug interventionsNot AvailableNot Availablerecruiting
NCT06237803
European Myeloma Network (EMN) Sample ProjectNo drug interventionsNot AvailableNot Availablerecruiting
NCT04920084
A Study of a Plant-Based Diet in People With Monoclonal Gammopathy of Undetermined Significance (MGUS) or Smoldering Multiple Myeloma (SMM)No drug interventionspreventionNot Availableactive_not_recruiting
NCT03815279
A Nationwide Phase 2 Trial of Patients With Smoldering and Active Multiple Myeloma (MM)No drug interventionstreatment2enrolling_by_invitation
NCT04144387
Evaluation of the Impact of the Update SMM Criteria on the Natural History of SMM to Establish New Recommendations.No drug interventionsscreeningNot Availableactive_not_recruiting
NCT01237054
Imaging in MGUS, SMM and MMNo drug interventionsdiagnostic2completed
NCT00899353
Prevention of Disease Progression in Early Stage Indolent B Cell Malignancies. (SMM)No drug interventionstreatment2terminated
NCT03236428
Phase II Study of the CD38 Antibody Daratumumab in Patients With High-Risk MGUS and Low-Risk Smoldering Multiple MyelomaNo drug interventionstreatment2active_not_recruiting
NCT05283993
A Cohort Study of Plasma Cell Disorders (PCDs) in PKUFHNo drug interventionsNot AvailableNot Availablerecruiting
NCT06472778
A Real-world Study in Participants With Smoldering Multiple MyelomaNo drug interventionsNot AvailableNot Availablerecruiting
NCT01169337
Lenalidomide or Observation in Treating Patients With Asymptomatic High-Risk Smoldering Multiple MyelomaNo drug interventionstreatment3active_not_recruiting
NCT03839459
Denosumab for Smoldering Multiple MyelomaNo drug interventionstreatment2active_not_recruiting
NCT05767359
CAR- PRISM (PRecision Intervention Smoldering Myeloma)No drug interventionstreatment2recruiting
NCT01718899
Phase 1/2a Study of Cancer Vaccine to Treat Smoldering Multiple MyelomaNo drug interventionstreatment1completed
NCT05831358
Early Detection of Multiple Myeloma to Fight Cancer Disparities: A Screening and Patient Navigation ProgramNo drug interventionsscreeningNot Availablerecruiting
NCT01571726
Imaging Studies and the Development of Multiple MyelomaNo drug interventionsdiagnostic2withdrawn
NCT00112827
Melphalan and Radiation Therapy Followed By Lenalidomide in Treating Patients Who Are Undergoing Autologous Stem Cell Transplant for Stage I, Stage II, or Stage III Multiple MyelomaNo drug interventionstreatment1 / 2completed
NCT05361694
Two Biologically and Clinically Distinct Entities: Progressive Versus Stable Multiple Myeloma (MM) Precursor ConditionsNo drug interventionsNot AvailableNot Availablerecruiting
NCT04727294
MGUS, SMM, and MM Patient Experience With Coronavirus 19 (COVID-19) SurveyNo drug interventionsNot AvailableNot Availableunknown_status
NCT06183489
Use of Elranatamab in Patients With High-risk Smoldering Multiple MyelomaNo drug interventionstreatment2recruiting
NCT02269592
Study of MGUS, Smoldering Myeloma, Early MDS and CLL to Assess Molecular Events of Progression and Clinical OutcomeNo drug interventionsNot AvailableNot Availablerecruiting
NCT01838369
A Phase II Study of BI-505 in Smoldering Multiple MyelomaNo drug interventionstreatment2terminated
NCT02903381
A Phase II Trial If Nivolumab, Lenalidomide and Dexamethasone in High Risk Smoldering MyelomaNo drug interventionstreatment2completed
NCT01248455
A Phase II Trial of Anti-KIR in Smoldering Multiple MyelomaNo drug interventionstreatment2terminated
NCT00919139
S0309, Repository: Blood/Bone Marrow From Pts. With Myeloma, WM, Amyloidosis, or MGUS.No drug interventionsNot AvailableNot Availablecompleted
NCT01079429
Study of DNA Copy Numbers Variations and Gene Expression Profile of Bone Marrow Plasma Cells From MGUS and SMM.No drug interventionsNot AvailableNot Availableterminated
NCT01109407
Natural History Study of Monoclonal Gammopathy of Undetermined Significance (MGUS) and Smoldering Myeloma (SMM)No drug interventionsNot AvailableNot Availableterminated
NCT03591614
Dendritic Cell DKK1 Vaccine for Monoclonal Gammopathy and Stable or Smoldering MyelomaNo drug interventionstreatment0withdrawn
NCT05955508
A Proof-of-Concept Trial to Study the Safety and Activity of Linvoseltamab in Participants With Smoldering Multiple Myeloma at High Risk of Developing Multiple MyelomaNo drug interventionstreatment2recruiting
NCT02240537
Phase I Study of an Oncofetal Antigen Multi-Peptide Immunotherapy in Subjects With Hematologic CancerNo drug interventionstreatment1unknown_status
NCT06140524
A Proof-of-Concept Study to Learn Whether Linvoseltamab Can Eliminate Abnormal Plasma Cells That May Lead to Multiple Myeloma in Adult Patients With High-Risk Monoclonal Gammopathy of Undetermined Significance or Non-High-Risk Smoldering Multiple MyelomaNo drug interventionstreatment2recruiting
NCT04731844
Curcumin and Piperine in Patients on Surveillance for Monoclonal Gammopathy, Smoldering Myeloma or Prostate CancerNo drug interventionstreatment2recruiting
NCT04370483
Leflunomide for the Treatment of High-Risk Smoldering Multiple Myelomatreatment0active_not_recruiting
NCT04776395
Iberdomide Alone or in Combination With Dexamethasone for the Treatment of Intermediate- or High-Risk Smoldering Multiple MyelomaNo drug interventionstreatment2recruiting
NCT02726750
Observational Prospective Research Study In Monoclonal Gammopathies leadINg to MyelomaNo drug interventionsNot AvailableNot Availablerecruiting
NCT02492750
Lenalidomide and Dexamethasone With or Without Anakinra in Treating Patients With Early Stage Multiple MyelomaNo drug interventionstreatment1completed
NCT03631043
Personalized Vaccine in Treating Patients With Smoldering Multiple MyelomaNo drug interventionstreatment0active_not_recruiting
NCT02603887
Pembrolizumab in Treating Patients With Intermediate or High-Risk Smoldering Multiple MyelomaNo drug interventionstreatment0active_not_recruiting
NCT05136807
Quality of Life in Patients With Asymptomatic Monoclonal GammopathiesNo drug interventionsNot AvailableNot Availablerecruiting
NCT03952832
Leflunomide in Treating Patients With High-Risk Smoldering Multiple MyelomaNo drug interventionstreatment2withdrawn
NCT03937635
Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering MyelomaNo drug interventionstreatment3recruiting
NCT05288062
Immunomodulatory Drugs (Lenalidomide With or Without Pomalidomide) in Combination With a Corticosteroid Drug (Dexamethasone) for the Treatment of Multiple MyelomaNo drug interventionstreatment2active_not_recruiting
NCT02353572
Melphalan and Bortezomib Prior to Autologous Stem Cell Transplant in Treating Patients With Multiple MyelomaNo drug interventionstreatment1 / 2terminated
NCT05014646
Leflunomide for the Treatment of High-Risk Smoldering Multiple Myeloma in African-American and European-American PatientsNo drug interventionsprevention2recruiting
NCT02960555
Isatuximab With or Without Lenalidomide in Patients With High Risk Smoldering Multiple Myeloma (ISAMAR)No drug interventionstreatment2active_not_recruiting
NCT05312255
Non-chemotherapeutic Interventions for the Improvement of Quality of Life and Immune Function in Patients With Multiple MyelomaNo drug interventionstreatmentNot Availablerecruiting