Neurotrophic Keratopathy (DBCOND0077055)

Identifiers

Synonyms
Neurotrophic Keratitis / Neurotrophic keratopathy / Neurotrophic keratitis (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Cenegermin
A recombinant human nerve growth factor used to treat neurotrophic keratitis.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT04293549
An 8-week Follow-up to Evaluate the Renewal of Corneal Nerves Structure and Function in Patients With Neurotrophic Keratopathy Treated With Recombinant Human Nerve Growth Factor (rhNGF) EyedropsNot AvailableNot Availablecompleted
NCT06412718
Validation of Human Drugs Target of Repurposed Drugs and Novel TherapiesNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT04604834
Autologous Platelet-rich Plasma (APRP) in the Treatment of Neurotrophic KeratopathyNo drug interventionstreatmentNot Availablerecruiting
NCT04957758
Phase 2 Clinical Trial to Evaluate OC-01 Nasal Spray in Subjects With Neurotrophic Keratopathytreatment2completed
NCT02600429
Assessment of the Safety and Efficacy Study of RGN-259 Ophthalmic Solutions for Neurotrophic Keratopathy : SEER-1No drug interventionstreatment3terminated
NCT05555589
Assessment of the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of NK: SEER-2treatment3recruiting
NCT06411145
Open-label Trial to Evaluate Efficacy and Safety of rhNGF on Corneal Thickness Via AS-OCT in Neurotrophic Keratitistreatment4active_not_recruiting
NCT03084861
A Clinical Trial to Asses Efficacy and Safety of Cord Blood Eye Drops in Neurotrophic KeratopathyNo drug interventionstreatment1 / 2terminated
NCT06331910
Efficacy and Safety of Topical Insulin for Neurotrophic Corneal Ulcerstreatment4not_yet_recruiting
NCT04909450
Study to Evaluate the Safety and Efficacy of CSB-001 Ophthalmic Solution 0.1% in Neurotrophic Keratitis SubjectsNo drug interventionstreatment1 / 2completed
NCT05552261
DEFENDO Long Term Follow-up Study in Stage 1 NK PatientsNot AvailableNot Availablecompleted
NCT06597422
A Study of STSP-0902 Ophthalmic Solution in Healthy SubjectsNo drug interventionstreatment1not_yet_recruiting
NCT05758753
QST for Corneal Nerve FunctionNo drug interventionstreatmentNot Availableenrolling_by_invitation
NCT05927428
Assessment of the Initial Efficacy and Safety of BRM424 Ophthalmic Solutions in Patients With Neurotrophic Keratitistreatment2not_yet_recruiting
NCT01756456
Evaluation of Safety and Efficacy of rhNGF in Patients With Stage 2 and 3 Neurotrophic Keratitis.treatment1 / 2completed
NCT05566717
An Investigator-Initiated Study to Assess the Association of Diabetic Retinopathy Severity Scale (DRSS) With Level of Decreased Corneal SensitivityNo drug interventionsNot AvailableNot Availableunknown_status
NCT06364657
Differences in Corneal Structure and Function in Patients With Sjogrens vs. Non-Sjogrens Dry EyeNo drug interventionsNot AvailableNot Availablerecruiting
NCT05321251
Topical Insulin Drops for the Treatment of Neurotrophic Keratopathy.treatment2 / 3withdrawn
NCT02227147
Evaluation of Efficacy of 20 µg/ml rhNGF New Formulation (With Anti-oxidant) in Patients With Stage 2 and 3 NKtreatment2completed
NCT04573647
OCT Evaluation of Neurotrophic Ulcer Following Treatment With OxervateNot AvailableNot Availablerecruiting
NCT05809245
Corneal Neurotization as a Treatment for Neurotrophic KeratopathyNo drug interventionstreatmentNot Availableterminated
NCT04627571
Corneal Nerves After Treatment With CenegerminNot AvailableNot Availablerecruiting
NCT04276558
REC 0/0559 Eye Drops for Treatment of Moderate and Severe Neurotrophic Keratitis in Adult Patientstreatment2completed
NCT04552730
Nerve Growth Factor for the Treatment of Cornea DiseaseNot AvailableNot Availablecompleted
NCT02707120
Efficacy and Safety of Plasma Rich in Growth Factors (PRGF-Endoret) Eye-drops in the Treatment of Neurotrophic KeratitisNo drug interventionstreatment4unknown_status
NCT04485546
Study to Evaluate OXERVATE™ in Patients With Stage 1 Neurotrophic Keratitistreatment4completed
NCT04820010
Topical Insulin - Utility and Results in Neurotrophic Keratopathy in Stages 2 and 3Not AvailableNot Availablecompleted
NCT03037450
Miniinvasive Corneal Neurotization. A Pilot Study.No drug interventionstreatmentNot Availableterminated