Dietary and Nutritional Therapies (DBCOND0077565)

Identifiers

Synonyms

Supplementation therapy / Dietary and nutritional therapies

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Alanyl glutamine	A dipeptide consisting of alanine and glutamine used for supplementation.	No drug targets
Fish oil	A source of essential fatty acids used as a source of calories in parenteral nutrition and as a dietary supplement.	Diacylglycerol O-acyltransferase 2target Prostaglandin G/H synthase 2target Free fatty acid receptor 4target Voltage gated L-type calcium channeltarget Sodium channel proteintarget Free radicalstarget Nuclear factor NF-kappa-Btarget Sterol regulatory element-binding protein 1target Peroxisome proliferator-activated receptor alphatarget Peroxisome proliferator-activated receptor gammatarget Peroxisome proliferator-activated receptor deltatarget Cytochrome P450 3A4enzyme
Ginseng	A herbal supplement used in many health products.	Interleukin-6target Prostaglandin G/H synthase 2target Aryl hydrocarbon receptortarget
Icosapent	A polyunsaturated fatty acid, usually found in fish oils, that is used in many supplements.	Prostaglandin G/H synthase 2target Prostaglandin G/H synthase 1target Free fatty acid receptor 1target Acyl-CoA (8-3)-desaturasetarget Long-chain-fatty-acid--CoA ligase 4target Sodium/calcium exchanger 1target Peroxisome proliferator-activated receptor gammatarget Peroxisome proliferator-activated receptor deltatarget Transient receptor potential cation channel subfamily V member 1target Peroxisome proliferator-activated receptor alphatarget Albumincarrier Fatty acid-binding protein, braintarget Polyunsaturated fatty acid 5-lipoxygenasetarget
Lipoic acid	For nutritional supplementation, also for treating dietary shortage or imbalance.	Lipoyl amidotransferase LIPT1, mitochondrialtarget Sodium-dependent multivitamin transportertarget Lipoyl synthase, mitochondrialtarget NADPH--cytochrome P450 reductaseenzyme
Manganese gluconate	An ingredient found in a variety of supplements and vitamins.	No drug targets
N-Acetylmethionine	An amino acid used as a peritoneal dialysis treatment in patients with renal failure and nutritional therapy in patients with nutritional deficiency or post-infection weakness.	o-succinylbenzoate synthasetarget Rhodopsintarget
Nicotinamide	An ingredient found in a variety of cosmetic products.	NAD-dependent protein deacylase sirtuin-5, mitochondrialtarget ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2target Exotoxin Atarget L-lactate dehydrogenase A chaintarget Poly [ADP-ribose] polymerase 1target Cytochrome P450 2D6enzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A4enzyme
Riboflavin	A vitamin used to correct vitamin B2 deficiency.	Flavin reductase (NADPH)target Riboflavin kinasetarget Riboflavin synthasetarget Amine oxidase [flavin-containing] Aenzyme Methylenetetrahydrofolate reductase (NADPH)enzyme Solute carrier family 22 member 6transporter
Tryptophan	An amino acid commonly found as a component of total parenteral nutrition.	Tryptophan--tRNA ligase, cytoplasmictarget Tryptophan--tRNA ligasetarget Tryptophan--tRNA ligase, mitochondrialtarget Tryptophan 2,3-dioxygenaseenzyme Aromatic-L-amino-acid decarboxylaseenzyme Monocarboxylate transporter 8transporter Monocarboxylate transporter 10transporter Tryptophan--tRNA ligaseenzyme Tryptophan--tRNA ligase, mitochondrialenzyme Tryptophan 5-hydroxylase 1enzyme Tryptophan 5-hydroxylase 2enzyme Tryptophan--tRNA ligase, cytoplasmicenzyme Indoleamine 2,3-dioxygenase 1enzyme Indoleamine 2,3-dioxygenase 1target
Zinc	An essential element commonly used for the treatment of patients with documented zinc deficiency.	B1 bradykinin receptortarget Methylated-DNA--protein-cysteine methyltransferasetarget Fructose-bisphosphate aldolase Atarget Elongation factor 1-alpha 1target Alpha-enolasetarget Glyceraldehyde-3-phosphate dehydrogenase, testis-specifictarget Nucleoside diphosphate kinase Atarget Protein disulfide-isomerasetarget Protein disulfide-isomerase A3target Peroxiredoxin-1target Phosphoserine phosphatasetarget Triosephosphate isomerasetarget Elongation factor Tu, mitochondrialtarget Estrogen receptortarget Interleukin-3target Metallothionein-2target Copper chaperone for superoxide dismutasetarget Histone deacetylase 1target Histone deacetylase 4target DNA-3-methyladenine glycosylasetarget Semenogelin-1target Superoxide dismutase [Cu-Zn]target Histone deacetylase 8target Apoptosis regulatory protein Sivatarget Glycine receptor subunit alpha-1target E3 ubiquitin-protein ligase Mdm2target Insulintarget Utrophintarget Aspartoacylasetarget Protein S100-A8target Protein S100-A9target Matrix metalloproteinase-9target Tumor protein p73target Protein S100-A2target Cellular tumor antigen p53target Metallothionein-3target Programmed cell death protein 6target DAN domain family member 5target Metallothionein-1Atarget Alpha-1B-glycoproteintarget Alpha-2-macroglobulintarget Angiotensinogentarget Alpha-2-HS-glycoproteintarget Serum amyloid P-componenttarget Apolipoprotein A-Itarget Apolipoprotein A-IItarget Apolipoprotein A-IVtarget Apolipoprotein B receptortarget Apolipoprotein Etarget Apolipoprotein L1target Complement C1q subcomponent subunit Btarget Complement C1q subcomponent subunit Ctarget Complement C1r subcomponenttarget Complement C1s subcomponenttarget Complement C3target Complement C4-Btarget C4b-binding protein alpha chaintarget C4b-binding protein beta chaintarget Complement C5target Lys-63-specific deubiquitinase BRCC36target Complement component C8 alpha chaintarget Complement component C8 beta chaintarget Complement component C8 gamma chaintarget Complement factor Btarget Complement factor Htarget Complement factor Itarget Clusterintarget Ceruloplasmintarget Carboxypeptidase N catalytic chaintarget Carboxypeptidase N subunit 2target Dermcidintarget Desmoplakintarget Coagulation factor XIItarget Coagulation factor XIII B chaintarget Prothrombintarget Ficolin-3target Fibrinogen alpha chaintarget Fibronectintarget Gelsolintarget Hemoglobin subunit alphatarget Hemoglobin subunit betatarget Haptoglobin-related proteintarget Hornerintarget Insulin-like growth factor-binding protein complex acid labile subunittarget Immunoglobulin heavy constant alpha 1target Immunoglobulin heavy constant mutarget Immunoglobulin kappa variable 1-17target Immunoglobulin kappa variable 3-20target Immunoglobulin lambda variable 3-21target Inter-alpha-trypsin inhibitor heavy chain H1target Inter-alpha-trypsin inhibitor heavy chain H2target Inter-alpha-trypsin inhibitor heavy chain H3target Inter-alpha-trypsin inhibitor heavy chain H4target Immunoglobulin J chaintarget Junction plakoglobintarget Plasma kallikreintarget Kininogen-1target Keratin, type II cytoskeletal 1target Keratin, type I cytoskeletal 10target Keratin, type I cytoskeletal 14target Keratin, type I cytoskeletal 16target Keratin, type II cytoskeletal 2 epidermaltarget Keratin, type II cytoskeletal 5target Keratin, type II cytoskeletal 6Atarget Keratin, type I cytoskeletal 9target Alpha-1-acid glycoprotein 2target N-acetylmuramoyl-L-alanine amidasetarget Serum paraoxonase/arylesterase 1target Pregnancy zone proteintarget Protein S100-A7target Selenoprotein Ptarget Alpha-1-antitrypsintarget Alpha-1-antichymotrypsintarget Kallistatintarget Corticosteroid-binding globulintarget Heparin cofactor 2target Sex hormone-binding globulintarget Serotransferrintarget Transthyretintarget Vitronectintarget Amyloid beta precursor like protein 1target Amyloid beta precursor like protein 2target Amyloid-beta precursor proteintarget Poly [ADP-ribose] polymerase 1target Carbonic anhydrase 1enzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT02539316	Pilot Study: Hepatoprotective Role of SMOFlipid® Used in Short-term Parenteral Nutrition in an Onco-Hematology Pediatric Population	Fish oil Medium-chain triglycerides Olive oil Soybean oil	supportive_care	4	completed