Alanyl glutamine
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Alanyl glutamine is a dipeptide consisting of alanine and glutamine used for supplementation.
- Generic Name
- Alanyl glutamine
- DrugBank Accession Number
- DB11876
- Background
Alanyl Glutamine is under investigation in clinical trial NCT00338221 (Clinical Trial of Alanyl-Glutamine or Glycine in Children With Persistent Diarrhea or Malnutrition).
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 217.225
Monoisotopic: 217.106255975 - Chemical Formula
- C8H15N3O4
- Synonyms
- Alanyl glutamine
- Alanyl-glutamine dipeptide
- Alanylglutamine
- L-Alanyl-L-glutamine
- N(2)-L-Alanyl-L-glutamine
- External IDs
- FEMA NO. 4712
Pharmacology
- Indication
Not Available
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- Contraindications & Blackbox Warnings
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image DIPEPTIVEN 100 ML SOLUSYON Alanyl glutamine (100 ml) Solution Intravenous FRESENİUS KABİ İLAÇ SAN. VE TİC. LTD. ŞTİ. 2013-01-29 2024-01-23 Turkey
Categories
- ATC Codes
- B05XB02 — Alanyl glutamine
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as peptides. These are compounds containing an amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another.
- Kingdom
- Organic compounds
- Super Class
- Organic acids and derivatives
- Class
- Carboxylic acids and derivatives
- Sub Class
- Amino acids, peptides, and analogues
- Direct Parent
- Peptides
- Alternative Parents
- N-acyl-alpha amino acids / Fatty acids and conjugates / Amino acids / Propargyl-type 1,3-dipolar organic compounds / Monocarboxylic acids and derivatives / Carboxylic acids / Carboximidic acids / Organopnictogen compounds / Organic oxides / Monoalkylamines show 2 more
- Substituents
- Aliphatic acyclic compound / Alpha peptide / Alpha-amino acid or derivatives / Amine / Amino acid / Amino acid or derivatives / Carbonyl group / Carboximidic acid / Carboximidic acid derivative / Carboxylic acid show 15 more
- Molecular Framework
- Aliphatic acyclic compounds
- External Descriptors
- dipeptide (CHEBI:73788)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- U5JDO2770Z
- CAS number
- 39537-23-0
- InChI Key
- HJCMDXDYPOUFDY-WHFBIAKZSA-N
- InChI
- InChI=1S/C8H15N3O4/c1-4(9)7(13)11-5(8(14)15)2-3-6(10)12/h4-5H,2-3,9H2,1H3,(H2,10,12)(H,11,13)(H,14,15)/t4-,5-/m0/s1
- IUPAC Name
- (2S)-2-[(2S)-2-aminopropanamido]-4-carbamoylbutanoic acid
- SMILES
- C[C@H](N)C(=O)N[C@@H](CCC(N)=O)C(O)=O
References
- General References
- External Links
- Human Metabolome Database
- HMDB0028685
- PubChem Compound
- 123935
- PubChem Substance
- 347828213
- ChemSpider
- 110464
- 1359422
- ChEBI
- 73788
- ChEMBL
- CHEMBL3707366
- ZINC
- ZINC000002504612
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Other Surgical Infants Requiring Total Parenteral Nutrition 1 4 Completed Treatment Comatose / Traumatic Brain Injury (TBI) 1 4 Completed Treatment Gastric Cancer / Pancreatic Cancer 1 4 Completed Treatment Gastrointestinal Surgery 1 4 Terminated Treatment ICU Patients 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Injection Parenteral 20 % Injection, solution, concentrate Intravenous Solution Intravenous 200 mg/1ml Solution Intravenous 100 ml Injection, solution, concentrate Intravenous 200 mg/ml Injection Intravenous 20 g/100ml Injection, solution Intravenous Solution Intravenous 20 g/100ml - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 12.7 mg/mL ALOGPS logP -3.2 ALOGPS logP -4.5 Chemaxon logS -1.2 ALOGPS pKa (Strongest Acidic) 3.57 Chemaxon pKa (Strongest Basic) 8.39 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 4 Chemaxon Polar Surface Area 135.51 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 50.41 m3·mol-1 Chemaxon Polarizability 20.97 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS splash10-0006-9000000000-1cfb741cc8542dd66faa Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-014j-0690000000-5c966f0bef66b4acf114 Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-000t-7920000000-719aff4ddd931f3f7dff Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-0ftf-0920000000-ddf77680824e93b663d5 Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-001l-9100000000-43ef5b1e110f229b9617 Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-0007-8900000000-f15873467bf09c7b9ef8 Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-0006-9100000000-74978d690d367e4ab3ce Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 152.8731185 predictedDarkChem Lite v0.1.0 [M-H]- 150.27228 predictedDeepCCS 1.0 (2019) [M+H]+ 152.3561185 predictedDarkChem Lite v0.1.0 [M+H]+ 152.6303 predictedDeepCCS 1.0 (2019) [M+Na]+ 151.8527185 predictedDarkChem Lite v0.1.0 [M+Na]+ 158.72353 predictedDeepCCS 1.0 (2019)
Drug created at October 20, 2016 20:56 / Updated at April 07, 2023 13:12