Alanyl glutamine

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Alanyl glutamine is a dipeptide consisting of alanine and glutamine used for supplementation.

Generic Name
Alanyl glutamine
DrugBank Accession Number
DB11876
Background

Alanyl Glutamine is under investigation in clinical trial NCT00338221 (Clinical Trial of Alanyl-Glutamine or Glycine in Children With Persistent Diarrhea or Malnutrition).

Type
Small Molecule
Groups
Investigational
Structure
Thumb
Weight
Average: 217.225
Monoisotopic: 217.106255975
Chemical Formula
C8H15N3O4
Synonyms
  • Alanyl glutamine
  • Alanylglutamine
  • L-Alanyl-L-glutamine
  • N(2)-L-Alanyl-L-glutamine
External IDs
  • FEMA NO. 4712

Pharmacology

Indication

Not Available

Pharmacology
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Associated Therapies
Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Medicalerrors
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
DIPEPTIVEN 100 ML SOLUSYONAlanyl glutamine (100 ml)SolutionIntravenousFRESENİUS KABİ İLAÇ SAN. VE TİC. LTD. ŞTİ.2020-08-14Not applicableTurkey flag

Categories

ATC Codes
B05XB02 — Alanyl glutamine
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as peptides. These are compounds containing an amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Sub Class
Amino acids, peptides, and analogues
Direct Parent
Peptides
Alternative Parents
N-acyl-alpha amino acids / Fatty acids and conjugates / Amino acids / Propargyl-type 1,3-dipolar organic compounds / Monocarboxylic acids and derivatives / Carboxylic acids / Carboximidic acids / Organopnictogen compounds / Organic oxides / Monoalkylamines
show 2 more
Substituents
Aliphatic acyclic compound / Alpha peptide / Alpha-amino acid or derivatives / Amine / Amino acid / Amino acid or derivatives / Carbonyl group / Carboximidic acid / Carboximidic acid derivative / Carboxylic acid
show 15 more
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
dipeptide (CHEBI:73788)
Affected organisms
Not Available

Chemical Identifiers

UNII
U5JDO2770Z
CAS number
39537-23-0
InChI Key
HJCMDXDYPOUFDY-WHFBIAKZSA-N
InChI
InChI=1S/C8H15N3O4/c1-4(9)7(13)11-5(8(14)15)2-3-6(10)12/h4-5H,2-3,9H2,1H3,(H2,10,12)(H,11,13)(H,14,15)/t4-,5-/m0/s1
IUPAC Name
(2S)-2-[(2S)-2-aminopropanamido]-4-carbamoylbutanoic acid
SMILES
C[C@H](N)C(=O)N[C@@H](CCC(N)=O)C(O)=O

References

General References
  1. ilacaBak: Glutaviven (l-alanyl-l-glutamine) intravenous solution [Link]
  2. AIFA Product Information: Dipeptiven (L-Alanyl-L-glutamine) concentrate for solution for infusion [Link]
PubChem Compound
123935
PubChem Substance
347828213
ChemSpider
110464
RxNav
1359422
ChEBI
74387
ChEMBL
CHEMBL3707366
ZINC
ZINC000002504612

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedTreatmentComatose / Traumatic Brain Injury (TBI)1
4CompletedTreatmentGastrointestinal Surgery1
4CompletedTreatmentMalignant Neoplasm of Pancreas / Malignant Neoplasm of Stomach1
4TerminatedTreatmentICU Patients1
4Unknown StatusNot AvailableSurgical Infants Requiring Total Parenteral Nutrition1
3CompletedTreatmentCoronary Artery Disease (CAD)1
3CompletedTreatmentCritically Ill Patients1
3RecruitingTreatmentCardiopulmonarybypass / Coronary Artery Bypass Grafting (CABG) / Coronary Artery Disease (CAD)1
3RecruitingTreatmentCoronavirus Disease 2019 (COVID‑19)1
3Unknown StatusTreatmentMyeloablative Allo-SCT1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
SolutionIntravenous200 mg/1ml
SolutionIntravenous
Injection, solution, concentrateIntravenous
Injection, solutionIntravenous
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility12.7 mg/mLALOGPS
logP-3.2ALOGPS
logP-4.5ChemAxon
logS-1.2ALOGPS
pKa (Strongest Acidic)3.57ChemAxon
pKa (Strongest Basic)8.39ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area135.51 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity50.41 m3·mol-1ChemAxon
Polarizability20.97 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Drug created on October 20, 2016 20:56 / Updated on May 14, 2021 01:06