Alanyl glutamine

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Alanyl glutamine is a dipeptide consisting of alanine and glutamine used for supplementation.

Generic Name
Alanyl glutamine
DrugBank Accession Number
DB11876
Background

Alanyl Glutamine is under investigation in clinical trial NCT00338221 (Clinical Trial of Alanyl-Glutamine or Glycine in Children With Persistent Diarrhea or Malnutrition).

Type
Small Molecule
Groups
Investigational
Structure
Weight
Average: 217.225
Monoisotopic: 217.106255975
Chemical Formula
C8H15N3O4
Synonyms
  • Alanyl glutamine
  • Alanyl-glutamine dipeptide
  • Alanylglutamine
  • L-Alanyl-L-glutamine
  • N(2)-L-Alanyl-L-glutamine
External IDs
  • FEMA NO. 4712

Pharmacology

Indication

Not Available

Reduce drug development failure rates
Build, train, & validate machine-learning models
with evidence-based and structured datasets.
See how
Build, train, & validate predictive machine-learning models with structured datasets.
See how
Associated Therapies
Contraindications & Blackbox Warnings
Prevent Adverse Drug Events Today
Tap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.
Learn more
Avoid life-threatening adverse drug events with our Clinical API
Learn more
Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Improve decision support & research outcomes
With structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!
See the data
Improve decision support & research outcomes with our structured adverse effects data.
See a data sample
Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

Drug product information from 10+ global regions
Our datasets provide approved product information including:
dosage, form, labeller, route of administration, and marketing period.
Access now
Access drug product information from over 10 global regions.
Access now
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
DIPEPTIVEN 100 ML SOLUSYONAlanyl glutamine (100 ml)SolutionIntravenousFRESENİUS KABİ İLAÇ SAN. VE TİC. LTD. ŞTİ.2013-01-292024-01-23Turkey flag

Categories

ATC Codes
B05XB02 — Alanyl glutamine
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as peptides. These are compounds containing an amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Sub Class
Amino acids, peptides, and analogues
Direct Parent
Peptides
Alternative Parents
N-acyl-alpha amino acids / Fatty acids and conjugates / Amino acids / Propargyl-type 1,3-dipolar organic compounds / Monocarboxylic acids and derivatives / Carboxylic acids / Carboximidic acids / Organopnictogen compounds / Organic oxides / Monoalkylamines
show 2 more
Substituents
Aliphatic acyclic compound / Alpha peptide / Alpha-amino acid or derivatives / Amine / Amino acid / Amino acid or derivatives / Carbonyl group / Carboximidic acid / Carboximidic acid derivative / Carboxylic acid
show 15 more
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
dipeptide (CHEBI:73788)
Affected organisms
Not Available

Chemical Identifiers

UNII
U5JDO2770Z
CAS number
39537-23-0
InChI Key
HJCMDXDYPOUFDY-WHFBIAKZSA-N
InChI
InChI=1S/C8H15N3O4/c1-4(9)7(13)11-5(8(14)15)2-3-6(10)12/h4-5H,2-3,9H2,1H3,(H2,10,12)(H,11,13)(H,14,15)/t4-,5-/m0/s1
IUPAC Name
(2S)-2-[(2S)-2-aminopropanamido]-4-carbamoylbutanoic acid
SMILES
C[C@H](N)C(=O)N[C@@H](CCC(N)=O)C(O)=O

References

General References
  1. ilacaBak: Glutaviven (l-alanyl-l-glutamine) intravenous solution [Link]
  2. AIFA Product Information: Dipeptiven (L-Alanyl-L-glutamine) concentrate for solution for infusion [Link]
Human Metabolome Database
HMDB0028685
PubChem Compound
123935
PubChem Substance
347828213
ChemSpider
110464
RxNav
1359422
ChEBI
73788
ChEMBL
CHEMBL3707366
ZINC
ZINC000002504612

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedOtherSurgical Infants Requiring Total Parenteral Nutrition1
4CompletedTreatmentComatose / Traumatic Brain Injury (TBI)1
4CompletedTreatmentGastric Cancer / Pancreatic Cancer1
4CompletedTreatmentGastrointestinal Surgery1
4TerminatedTreatmentICU Patients1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
InjectionParenteral20 %
Injection, solution, concentrateIntravenous
SolutionIntravenous200 mg/1ml
SolutionIntravenous100 ml
Injection, solution, concentrateIntravenous200 mg/ml
InjectionIntravenous20 g/100ml
Injection, solutionIntravenous
SolutionIntravenous20 g/100ml
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility12.7 mg/mLALOGPS
logP-3.2ALOGPS
logP-4.5Chemaxon
logS-1.2ALOGPS
pKa (Strongest Acidic)3.57Chemaxon
pKa (Strongest Basic)8.39Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count5Chemaxon
Hydrogen Donor Count4Chemaxon
Polar Surface Area135.51 Å2Chemaxon
Rotatable Bond Count6Chemaxon
Refractivity50.41 m3·mol-1Chemaxon
Polarizability20.97 Å3Chemaxon
Number of Rings0Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSsplash10-0006-9000000000-1cfb741cc8542dd66faa
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-014j-0690000000-5c966f0bef66b4acf114
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-000t-7920000000-719aff4ddd931f3f7dff
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0ftf-0920000000-ddf77680824e93b663d5
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-001l-9100000000-43ef5b1e110f229b9617
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0007-8900000000-f15873467bf09c7b9ef8
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0006-9100000000-74978d690d367e4ab3ce
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-152.8731185
predicted
DarkChem Lite v0.1.0
[M-H]-150.27228
predicted
DeepCCS 1.0 (2019)
[M+H]+152.3561185
predicted
DarkChem Lite v0.1.0
[M+H]+152.6303
predicted
DeepCCS 1.0 (2019)
[M+Na]+151.8527185
predicted
DarkChem Lite v0.1.0
[M+Na]+158.72353
predicted
DeepCCS 1.0 (2019)

Drug created at October 20, 2016 20:56 / Updated at April 07, 2023 13:12