Ginseng

Identification

Summary

Ginseng is a herbal supplement used in many health products.

Generic Name
Ginseng
DrugBank Accession Number
DB01404
Background

Ginseng is promoted as an adaptogen (a product that increases the body's resistance to stress), one which can to a certain extent be supported with reference to its anticarcinogenic and antioxidant properties. Ginseng is also known to contain phytoestrogens.

Type
Biotech
Groups
Investigational, Nutraceutical
Synonyms
  • Aralia ginseng root
  • Asian ginseng root
  • Chinese ginseng root
  • Ginseng (panax ginseng)
  • Ginseng extract
  • Ginseng, asian
  • Hong shen root
  • Insam root
  • Korean ginseng
  • Korean ginseng root
  • Ninjin root
  • Panax ginseng
  • Panax ginseng root
  • Panax ginseng root extract
  • Panax schinseng root
  • Panax verus root
  • Red ginseng
  • Ren seng root
  • Ren shen
  • Ren shen root
  • True ginseng root
External IDs
  • B1673

Pharmacology

Indication

Not Available

Reduce drug development failure rates
Build, train, & validate machine-learning models
with evidence-based and structured datasets.
See how
Build, train, & validate predictive machine-learning models with structured datasets.
See how
Associated Therapies
Contraindications & Blackbox Warnings
Prevent Adverse Drug Events Today
Tap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.
Learn more
Avoid life-threatening adverse drug events with our Clinical API
Learn more
Pharmacodynamics

Not Available

Mechanism of action
TargetActionsOrganism
UAryl hydrocarbon receptor
agonist
Humans
UInterleukin-6
antagonist
Humans
UProstaglandin G/H synthase 2
inhibitor
Humans
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Improve decision support & research outcomes
With structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!
See the data
Improve decision support & research outcomes with our structured adverse effects data.
See a data sample
Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Ginseng.
MorphineThe therapeutic efficacy of Morphine can be decreased when used in combination with Ginseng.
WarfarinThe metabolism of Warfarin can be decreased when combined with Ginseng.
Food Interactions
No interactions found.

Products

Drug product information from 10+ global regions
Our datasets provide approved product information including:
dosage, form, labeller, route of administration, and marketing period.
Access now
Access drug product information from over 10 global regions.
Access now
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Baek Su Hee (joy 99 year life) (20ml)Liquid0.5 g/20mLOralMercylight2015-06-26Not applicableUS flag
Cheong-Kwan-Jang Korean HongSamPowder90 g/90gOralKorea Ginseng Corporation2010-10-08Not applicableUS flag
Cheong-Kwan-Jang Korean HongSamTablet500 mg/90000mgOralKorea Ginseng Corporation2011-02-24Not applicableUS flag
Cheong-Kwan-Jang Korean HongSamCapsule500 mg/500mgOralKorea Ginseng Corporation2010-11-15Not applicableUS flag
Cheong-Kwan-Jang Sliced Korean HongSamBar, chewable75 g/75gOralKorea Ginseng Corporation2011-05-31Not applicableUS flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Anti Fatigue Eye DropsGinseng (3 mg/15mL) + Cyanocobalamin (1.5 mg/15mL) + Lutein (3.75 mg/15mL) + Vitamin E (3 mg/15mL)LiquidIntraocularShantou Youjia E-Commerce Co., Ltd.2024-02-012024-12-31US flag
Ari Moms CareGinseng (1.2 g/100g) + Angelica dahurica root (0.8 g/100g) + Licorice (0.4 g/100g) + Orange (0.8 g/100g)Tablet, chewableOralBIOHERB Co,, Ltd.2020-01-012020-12-31US flag
Ari Moms CareGinseng (1.2 g/100g) + Angelica dahurica root (0.8 g/100g) + Licorice (0.4 g/100g) + Orange (0.8 g/100g)Tablet, chewableOralARI BIOTECHNOLOGY CO., LTD2019-03-132020-03-13US flag
BiO-LiFE Ginsomin Softgel CapsulesGinseng (50 mg) + Ascorbic acid (60 mg) + Beta carotene (6 mg) + Calcium phosphate, dibasic (255 mg) + Copper (2 mg) + Cyanocobalamin (2 µg) + Folic acid (200 µg) + Iron (15 mg) + Magnesium (4 mg) + Manganese cation (1 mg) + Nicotinamide (20 mg) + Calcium pantothenate (6 mg) + Potassium (3.5 µg) + Pyridoxine (2 mg) + Riboflavin (1.5 mg) + Selenium (35 µg) + Thiamine (1.5 mg) + Vitamin D (200 IU) + Vitamin E (15 IU) + Zinc (5 mg)CapsuleOralMEGA LIFESCIENCES SDN. BHD.2020-09-08Not applicableMalaysia flag
BiO-LiFE Premiton Soft CapsuleGinseng (100 mg) + Ascorbic acid (60 mg) + Calcium (104 mg) + Cholecalciferol (400 IU) + Copper (1 mg) + Cyanocobalamin (6 mcg) + Folic acid (400 mcg) + Lipoic acid (25 mg) + Magnesium (5 mg) + Manganese cation (1 mg) + Nicotinamide (20 mg) + Calcium pantothenate (10 mg) + Phosphorus (80 mg) + Potassium (4 mg) + Pyridoxine (2 mg) + Riboflavin (1.6 mg) + Rutin (20 mg) + Selenium (40 mcg) + Thiamine (1.5 mg) + Vitamin A (4000 IU) + Vitamin E (14.9 IU) + Zinc (1 mg)CapsuleOralBIO-LIFE MARKETING SDN. BHD.2020-09-08Not applicableMalaysia flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Ari Moms CareGinseng (1.2 g/100g) + Angelica dahurica root (0.8 g/100g) + Licorice (0.4 g/100g) + Orange (0.8 g/100g)Tablet, chewableOralBIOHERB Co,, Ltd.2020-01-012020-12-31US flag
Ari Moms CareGinseng (1.2 g/100g) + Angelica dahurica root (0.8 g/100g) + Licorice (0.4 g/100g) + Orange (0.8 g/100g)Tablet, chewableOralARI BIOTECHNOLOGY CO., LTD2019-03-132020-03-13US flag
Baek Su Hee (joy 99 year life) (20ml)Ginseng (0.5 g/20mL)LiquidOralMercylight2015-06-26Not applicableUS flag
Blood Care Honzo Seika Chinese Herbal Aroma OilGinseng (8.5 mg/100mL) + Angelica sinensis root (3 mg/100mL)OilTopicalPhytopia Co., Ltd.2016-04-01Not applicableUS flag
Blood Care Honzo Seika Chinese Herbal Aroma OilGinseng (8.5 mg/100mL) + Angelica sinensis root (3 mg/100mL)OilTopicalNic Co., Ltd.2016-04-01Not applicableUS flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
CUQ3A77YXI
CAS number
50647-08-0

References

Synthesis Reference

Iwao Hachiya, Keizo Mochizuki, Yukio Kuwada, "Method of preparing dried ginseng for drug." U.S. Patent US4446130, issued January, 1970.

US4446130
General References
  1. Lee YJ, Jin YR, Lim WC, Park WK, Cho JY, Jang S, Lee SK: Ginsenoside-Rb1 acts as a weak phytoestrogen in MCF-7 human breast cancer cells. Arch Pharm Res. 2003 Jan;26(1):58-63. [Article]
  2. Chan RY, Chen WF, Dong A, Guo D, Wong MS: Estrogen-like activity of ginsenoside Rg1 derived from Panax notoginseng. J Clin Endocrinol Metab. 2002 Aug;87(8):3691-5. [Article]
  3. Lee Y, Jin Y, Lim W, Ji S, Choi S, Jang S, Lee S: A ginsenoside-Rh1, a component of ginseng saponin, activates estrogen receptor in human breast carcinoma MCF-7 cells. J Steroid Biochem Mol Biol. 2003 Mar;84(4):463-8. [Article]
  4. McElhaney JE, Gravenstein S, Cole SK, Davidson E, O'neill D, Petitjean S, Rumble B, Shan JJ: A placebo-controlled trial of a proprietary extract of North American ginseng (CVT-E002) to prevent acute respiratory illness in institutionalized older adults. J Am Geriatr Soc. 2004 Jan;52(1):13-9. [Article]
  5. Lewis WH, Zenger VE, Lynch RG: No adaptogen response of mice to ginseng and Eleutherococcus infusions. J Ethnopharmacol. 1983 Aug;8(2):209-14. [Article]
PubChem Substance
46508934
RxNav
325526
PharmGKB
PA164781150
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Ginseng
MSDS
Download (73.2 KB)

Clinical Trials

Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package
PhaseStatusPurposeConditionsCountStart DateWhy Stopped100+ additional columns
4CompletedNot AvailableHealthy Volunteers (HV)1somestatusstop reasonjust information to hide
4CompletedTreatmentCold Hypersensitivity1somestatusstop reasonjust information to hide
4CompletedTreatmentFatigue1somestatusstop reasonjust information to hide
4CompletedTreatmentMen Infertility2somestatusstop reasonjust information to hide
3CompletedTreatmentPsychiatric Disorder NOS2somestatusstop reasonjust information to hide

Pharmacoeconomics

Manufacturers
Not Available
Packagers
  • Basic Drugs Inc.
  • Contract Pharm
  • CVS Pharmacy
  • Equaline Vitamins
  • Good Neighbour Pharmacy
  • Mason Distributors
  • Mckesson Corp.
  • National Vitamin Company
  • PharmAssure
  • Pharmavite
  • Rite Aid Corp.
  • Tyler Encapsulations
Dosage Forms
FormRouteStrength
LiquidIntraocular
Tablet, chewableOral
LiquidOral0.5 g/20mL
TabletOral40.000 mg
LiquidTopical
OilTopical
CapsuleOral500 mg/500mg
PowderOral90 g/90g
TabletOral500 mg/90000mg
Bar, chewableOral75 g/75g
CreamCutaneous5 g/80g
CreamDental
LiquidCutaneous
LiquidTopical24 g/100mL
GranuleOral
LiquidOral
Capsule, gelatin coatedOral
TabletOral100 mg / tab
SuspensionOral200 mg
CreamCutaneous
GelOral
LiquidCutaneous7.5 mg/30mg
SprayCutaneous
OilTopical46 mg/100mL
PlasterCutaneous
CapsuleTopical5 g/100mg
SolutionOral2500 mg
PatchCutaneous
CapsuleOral
CapsuleOral0.05 g/1
PasteTopical
LiquidOral1300 mg / mL
TabletOral3000 mg / tab
TabletOral0.125 g/1
TabletOral0.125 g/0.8g
TabletOral17.19 g/100g
PowderOral5.67 g/100g
PillOral0.0567 g/1g
OilTopical7 mg/100mL
LiquidTopical0.03 mg/1mL
SolutionTopical0.03 mg/1mL
GlobuleOral
LiquidTopical0.5 g/100mL
CreamTopical0.5 g/100mL
EmulsionTopical0.5 g/100mL
PatchTopical
LiquidTopical1 g/100mL
TabletOral
CapsuleOral100 mg
Prices
Unit descriptionCostUnit
V-r panax ginseng 300 mg capsule0.18USD capsule
Ra ginseng 100 mg softgel0.17USD softgel capsule
Eql ginseng 100 mg caplet0.15USD caplet
Eql ginseng 100 mg softgel0.15USD softgel capsule
Korean ginseng 1000 mg tablet0.14USD tablet
Siberian ginseng 250 mg capsule0.14USD capsule
CVS Pharmacy ginseng 200 mg softgel0.13USD softgel capsule
Korean ginseng 518 mg cap0.13USD capsule
Korean ginseng 350 mg capsule0.09USD capsule
Ginseng 8 gr capsule0.08USD capsule
Siberian root 1000 mg capsule0.08USD capsule
Ginseng 250 mg capsule0.07USD capsule
Ra siberian ginseng 410 mg0.05USD each
Gnp ginseng root 410 mg capsule0.04USD capsule
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available

Targets

Build, predict & validate machine-learning models
Use our structured and evidence-based datasets to unlock new
insights and accelerate drug research.
Learn more
Use our structured and evidence-based datasets to unlock new insights and accelerate drug research.
Learn more
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Agonist
General Function
Transcription regulatory region dna binding
Specific Function
Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes...
Gene Name
AHR
Uniprot ID
P35869
Uniprot Name
Aryl hydrocarbon receptor
Molecular Weight
96146.705 Da
References
  1. Wang Y, Ye X, Ma Z, Liang Q, Lu B, Tan H, Xiao C, Zhang B, Gao Y: Induction of cytochrome P450 1A1 expression by ginsenoside Rg1 and Rb1 in HepG2 cells. Eur J Pharmacol. 2008 Dec 28;601(1-3):73-8. doi: 10.1016/j.ejphar.2008.10.057. Epub 2008 Nov 11. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Antagonist
General Function
Interleukin-6 receptor binding
Specific Function
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Inv...
Gene Name
IL6
Uniprot ID
P05231
Uniprot Name
Interleukin-6
Molecular Weight
23717.965 Da
References
  1. Kim DH, Moon YS, Lee TH, Jung JS, Suh HW, Song DK: The inhibitory effect of ginseng saponins on the stress-induced plasma interleukin-6 level in mice. Neurosci Lett. 2003 Dec 15;353(1):13-6. [Article]
  2. Kim SJ, Jeong HJ, Yi BJ, Kang TH, An NH, Lee EH, Yang DC, Kim HM, Hong SH, Um JY: Transgenic Panax ginseng inhibits the production of TNF-alpha, IL-6, and IL-8 as well as COX-2 expression in human mast cells. Am J Chin Med. 2007;35(2):329-39. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Prostaglandin-endoperoxide synthase activity
Specific Function
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and...
Gene Name
PTGS2
Uniprot ID
P35354
Uniprot Name
Prostaglandin G/H synthase 2
Molecular Weight
68995.625 Da
References
  1. Yim HW, Jong HS, Kim TY, Choi HH, Kim SG, Song SH, Kim J, Ko SG, Lee JW, Kim TY, Bang YJ: Cyclooxygenase-2 inhibits novel ginseng metabolite-mediated apoptosis. Cancer Res. 2005 Mar 1;65(5):1952-60. [Article]
  2. Seo JY, Lee JH, Kim NW, Her E, Chang SH, Ko NY, Yoo YH, Kim JW, Seo DW, Han JW, Kim YM, Choi WS: Effect of a fermented ginseng extract, BST204, on the expression of cyclooxygenase-2 in murine macrophages. Int Immunopharmacol. 2005 May;5(5):929-36. [Article]
  3. Kim SJ, Jeong HJ, Yi BJ, Kang TH, An NH, Lee EH, Yang DC, Kim HM, Hong SH, Um JY: Transgenic Panax ginseng inhibits the production of TNF-alpha, IL-6, and IL-8 as well as COX-2 expression in human mast cells. Am J Chin Med. 2007;35(2):329-39. [Article]

Drug created at July 13, 2007 20:21 / Updated at July 19, 2024 07:26