Complicated Intra-Abdominal Infections (cIAIs) (DBCOND0079243)

Identifiers

Synonyms

Complicated Intra-abdominal Infection (cIAI) / Complicated Intra-Abdominal Infections, cIAIs / Complicated Intraabdominal Infections / Intra Abdominal Infections Complicated / Complicated Intra Abdominal Infections / Complicated Intra-Abdominal Infection / Complicated Intra-Abdominal Infections / Abdominal infection / Infectious disease of abdomen (disorder) / Intra-abdominal infection / Intraabdominal Infections

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Avibactam	A non-β-lactam β-lactamase inhibitor used in combination with ceftazidime for the treatment of complicated intra-abdominal infections, complicated urinary tract infections, and hospital or ventilator-acquired pneumonia.	ATP-binding cassette sub-family C member 2transporter Organic anion transporter 3transporter Beta-lactamase TEMtarget Beta-lactamase CTX-Mtarget Beta-lactamasetarget Beta-lactamase SHV-1target Beta-lactamase SHV-2target Beta-lactamase SHV-1target Class D OXA-48 carbapenemasetarget Carbapenem-hydrolyzing beta-lactamase KPCtarget Beta-lactamase UOE-1target Extended-spectrum beta-lactamase PER-1target
Cefepime	A fourth-generation cephalosporin antibiotic used in the treatment of infections caused by susceptible bacteria, such as pneumonia, urinary tract infections, and skin infections.	Organic cation/carnitine transporter 2transporter Solute carrier family 15 member 1transporter Solute carrier family 15 member 2transporter Penicillin-binding protein 2target Peptidoglycan synthase FtsItarget Cell division proteintarget Penicillin-binding protein 2target Penicillin-binding protein 1Atarget Penicillin-binding protein 1Btarget Penicillin-binding protein 1Btarget
Ceftazidime	An injected broad-spectrum third-generation cephalosporin beta-lactam antibiotic used to treat or prevent a variety of bacterial infections, including pneumonia, gynecological infections, bone and joint infections, and septicemia, among others.	Solute carrier family 22 member 6transporter Peptidoglycan synthase FtsItarget Penicillin-binding protein 1Atarget Penicillin-binding protein 1Btarget Penicillin-binding protein 2target Albumincarrier Beta-lactamase Toho-1target
Cilastatin	A renal dehydropeptidase inhibitor used to prevent degradation of imipenem. Both medications are used together to treat a variety of infections.	Dipeptidase 1target Solute carrier family 22 member 6transporter Organic anion transporter 3transporter
Ciprofloxacin	A second generation fluoroquinolone used to treat various susceptible bacterial infections.	DNA gyrase subunit Atarget DNA topoisomerase 4 subunit Atarget DNA topoisomerase 2-alphatarget Cytochrome P450 1A2enzyme Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter Voltage-gated inwardly rectifying potassium channel KCNH2target DNA gyrase subunit Atarget DNA topoisomerase 4 subunit Atarget DNA topoisomerase 4 subunit Btarget DNA gyrase subunit Atarget Multidrug resistance protein MdtKtarget Gyrase Atarget DNA gyrase subunit Atarget Multidrug and toxin extrusion protein 1transporter Multidrug and toxin extrusion protein 2transporter Albumincarrier Thymidylate synthasetarget DNA gyrase subunit Btarget
Doripenem	An antibiotic of the penem class used to treat complicated intra-abdominal and urinary tract infections.	Dipeptidase 1enzyme Penicillin-binding protein 1Atarget Penicillin-binding protein 1Btarget Penicillin-binding protein 2target Cell division proteintarget Penicillin-binding protein 4target Organic anion transporter 3transporter Dihydropteroate synthasetarget
Meropenem	A carbapenem antibiotic used to treat a wide variety of infections in the body.	D-alanyl-D-alanine carboxypeptidase DacBtarget Beta-lactamase OXA-10enzyme Dipeptidase 1enzyme
Relebactam	A beta-lactamase inhibitor used to prevent hydrolysis of beta-lactam antibiotics, leading to increased effectiveness.	Organic anion transporter 3transporter Solute carrier family 22 member 11transporter Multidrug and toxin extrusion protein 1transporter Multidrug and toxin extrusion protein 2transporter Beta-lactamase TEMtarget Beta-lactamase SHV-1target Beta-lactamase CTX-Mtarget Beta-lactamasetarget Beta-lactamasetarget Beta-lactamasetarget
Tigecycline	A glycylcycline antibiotic used to treat a number of susceptible bacterial infections.	30S ribosomal protein S9target 16S ribosomal RNAtarget 30S ribosomal protein S14target 30S ribosomal protein S13target 30S ribosomal protein S19target 30S ribosomal protein S12target
Trovafloxacin	An antibiotic used to treat gonorrhea and chlamydia.	DNA gyrase subunit Atarget DNA topoisomerase 4 subunit Atarget DNA topoisomerase 2-alphatarget Cytochrome P450 1A2enzyme DNA gyrase subunit Atarget DNA gyrase subunit Btarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT04335539	A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses of Cefiderocol in Hospitalized Pediatric Participants	Cefiderocol	treatment	2	completed
NCT02655419	Determine the PK and Safety and Tolerability of ATM-AVI for the Treatment of cIAIs in Hospitalized Adults (REJUVENATE)	Metronidazole	treatment	2	completed
NCT03265834	CABI: Antibiotic Duration for Complicated Intra-ABdominal Infection	No drug interventions	treatment	2	completed
NCT05487586	Real-World Study of Ceftazidime Avibactam in China	Avibactam Ceftazidime	Not Available	Not Available	terminated
NCT01994993	Antibiotic Safety (SCAMP)	Ampicillin Clindamycin Gentamicin Metronidazole Piperacillin Tazobactam	treatment	2 / 3	completed
NCT03217136	MK-7625A Plus Metronidazole Versus Meropenem in Pediatric Participants With Complicated Intra-Abdominal Infection (cIAI) (MK-7625A-035)	Ceftolozane Meropenem Metronidazole Tazobactam	treatment	2	completed
NCT01602874	Study Evaluating Tigecycline Versus Ceftriaxone In Complicated Intra-Abdominal Infections & Community Acquired Pneumonia	Ceftriaxone Clarithromycin Metronidazole Tigecycline	treatment	3	withdrawn
NCT01147640	Safety and Efficacy Study to Compare IV CXA 101/Tazobactam and Metronidazole With Meropenem in Complicated Intraabdominal Infections	Ceftolozane Metronidazole Tazobactam	treatment	2	completed
NCT05733104	A Study to Learn About the Study Medicine Zavicefta After it is Released Into the Markets in Korea	No drug interventions	Not Available	Not Available	recruiting
NCT01499290	Compare Ceftazidime-Avibactam + Metronidazole Versus Meropenem for Hospitalized Adults With Complicated Intra-Abdominal Infections	Ceftazidime Meropenem Metronidazole	treatment	3	completed
NCT05148702	EXTENDed Antibiotic Durations Compared to Standard Durations for Patients With Complicated Intra-abdominal Infection.	No drug interventions	treatment	3	recruiting
NCT01265784	Study to Compare TP-434 and Ertapenem in Community-acquired Complicated Intra-abdominal Infections	Eravacycline Ertapenem	treatment	2	completed
NCT00157898	A Study to Evaluate Ertapenem Versus It's Comparator in the Treatment of Complicated Intra-abdominal Infections in Adults (0826-050)(COMPLETED)	Ceftriaxone Ertapenem Metronidazole	treatment	4	completed
NCT02739997	Study of Ceftolozane/Tazobactam (MK-7625A) in Combination With Metronidazole in Japanese Participants With Complicated Intra-abdominal Infection (MK-7625A-013)	Ceftolozane Metronidazole Tazobactam	treatment	3	completed
NCT01445678	Study Comparing the Safety and Efficacy of Intravenous CXA-201 and Intravenous Meropenem in Complicated Intraabdominal Infections	Meropenem Metronidazole	treatment	3	completed
NCT00914888	Study Evaluating Tigecycline Versus Ceftriaxone In Complicated Intra-Abdominal Infections & Community Acquired Pneumonia	Ceftriaxone Clarithromycin Metronidazole Tigecycline	treatment	3	withdrawn
NCT03293485	Efficacy and Safety of Imipenem+Cilastatin/Relebactam (MK-7655A) in Japanese Participants With Complicated Intra-abdominal Infection or Complicated Urinary Tract Infection (MK-7655A-017)	Cilastatin Imipenem Relebactam	treatment	3	completed
NCT03329092	A Study to Determine the Efficacy, Safety and Tolerability of Aztreonam-Avibactam (ATM-AVI) ± Metronidazole (MTZ) Versus Meropenem (MER) ± Colistin (COL) for the Treatment of Serious Infections Due to Gram Negative Bacteria.	No drug interventions	treatment	3	completed
NCT04927312	Study to Assess Efficacy and Safety of PF-06947386 in Japanese Adult Patients With Complicated Intra-abdominal Infection	Metronidazole	treatment	3	completed
NCT05905055	P3 Study to Assess Efficacy and Safety of Cefepime/Nacubactam and Aztreonam/Nacubactam Versus Best Available Therapy for Adults With Infection Due to Carbapenem Resistant Enterobacterales	Aztreonam Cefepime Nacubactam	treatment	3	recruiting
NCT01726023	Compare Ceftazidime-Avibactam + Metronidazole vs Meropenem for Hospitalized Adults With Complicated Intra-Abd Infections	Avibactam Ceftazidime Meropenem Metronidazole	treatment	3	completed
NCT01644643	Ceftazidime-Avibactam for the Treatment of Infections Due to Ceftazidime Resistant Pathogens	Avibactam Ceftazidime Metronidazole	treatment	3	completed
NCT00929643	Impact Of Bacterial Resistance On Healthcare Costs For Hospitalized Patients With Complicated Intra-Abdominal Infections	No drug interventions	Not Available	Not Available	completed
NCT01500239	A Study Comparing Ceftazidime-Avibactam+Metronidazole Versus Meropenem in Adults With Complicated Intra-abdominal Infections	Ceftazidime Meropenem Metronidazole	treatment	3	completed
NCT00860587	Antibiotic Resistant Bacteria Among Patients With Severe Intraabdominal Infections	No drug interventions	Not Available	Not Available	unknown_status
NCT03830333	Ceftolozane/Tazobactam (MK-7625A) Plus Metronidazole Versus Meropenem for Participants With Complicated Intra-abdominal Infection (MK-7625A-015)	Ceftolozane Meropenem Metronidazole Tazobactam	treatment	3	completed
NCT03678298	Italian Register for the Study of Complicated Intra-Abdominal Infections	No drug interventions	Not Available	Not Available	unknown_status
NCT01844856	Efficacy and Safety Study of Eravacycline Compared With Ertapenem in Complicated Intra-abdominal Infections	Eravacycline Ertapenem	treatment	3	completed
NCT01072539	Study Evaluating The Safety And Effectiveness In Subjects With Tigecycline Treatment	Tigecycline	Not Available	Not Available	completed
NCT00389987	Ertapenem Sodium vs. Piperacillin/Tazobactam in the Treatment of Complicated Intra-Abdominal Infections (0826-037)	Piperacillin Tazobactam	treatment	3	completed
NCT02475733	Evaluation of Safety,Pharmacokinetics and Efficacy of CAZ-AVI With Metronidazole in Children Aged 3 Months to 18 Years Old With Complicated Intra-abdominal Infections (cIAIs).	Avibactam Ceftazidime Meropenem Metronidazole	treatment	2	completed
NCT00683332	Post-Marketing Study Of The Safety Of Tygacil (Tigecycline)	Tigecycline	Not Available	Not Available	completed
NCT00752219	Prospective Multicenter Doubleblind Randomized Study of NXL104/Ceftazidime + Metronidazole vs. Meropenem in Treatment of Complicated Intra-abdominal Infections	Avibactam Ceftazidime Meropenem Metronidazole	treatment	2	completed
NCT02784704	Efficacy and Safety Study of Eravacycline Compared With Meropenem in Complicated Intra-abdominal Infections	Eravacycline Meropenem	treatment	3	completed