Acute Otitis Media (AOM) (DBCOND0124842)

Identifiers

Synonyms
AOM - Acute Otitis Media / Acute Otitis Media / Otitis media acute / Otitis media, unspecified / Acute otitis media (disorder) / Otitis media acute NOS

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Amoxicillin
A penicillin derivative used for the treatment of infections caused by gram-positive bacteria, in particular streptococcal bacteria causing upper respiratory tract infections.
Azithromycin
A macrolide antibiotic used to treat a variety of bacterial infections.
Cefpodoxime
A third-generation cephalosporin antibiotic used in the treatment of various bacterial infections, including gonorrhea, community acquired pneumonia, and sinusitis.
Ceftibuten
A third-generation cephalosporin antibiotic commonly used in the treatment of acute bacterial exacerbations of chronic bronchitis (ABECB), acute bacterial otitis media, pharyngitis, and tonsillitis.
Ciprofloxacin
A second generation fluoroquinolone used to treat various susceptible bacterial infections.
Dexamethasone
A glucocorticoid available in various modes of administration that is used for the treatment of various inflammatory conditions, including bronchial asthma, as well as endocrine and rheumatic disorders.
Fluocinolone acetonide
A corticosteroid used to treat skin conditions, eczematous otitis externa, diabetic macular edema, and non-infectious uveitis of the posterior segment of the eye.
Lidocaine
A local anesthetic used in a wide variety of superficial and invasive procedures.
Ofloxacin
An antibacterial agent used for the treatment of bacterial infections in many parts of the body, including the respiratory tract, kidney, skin, soft tissue, and urinary tract.
Polymyxin B
A polymyxin antibiotic used to treat a wide variety of infections in the body.
Sulfisoxazole
A sulfonamide antibiotic used with other antibiotics to prevent and treat a variety of bacterial infections.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT03197558
Adult Study to Evaluate Placement of Tympanostomy Tubes In-office (ADEPT)No drug interventionstreatment2completed
NCT05361239
Delayed Antibiotic Therapy in General PracticeNo drug interventionsNot AvailableNot Availablecompleted
NCT03323736
In-Office Tympanostomy Tube Placement in Children (OTTER)No drug interventionstreatment3completed
NCT04193215
V114 and Acute Otitis Media (V114-032/PNEU-ERA)prevention3active_not_recruiting
NCT06027593
Using Electronically Derived Automated Reports of Appropriate Antibiotic Use to Inform Stewardship InterventionsNo drug interventionsotherNot Availablecompleted
NCT01908803
Proof-of-Concept Study of a Single Application of an Investigational Otic Suspension in Treatment of Acute Otitis Media With Tympanostomy Tubestreatment2terminated
NCT00645203
Safety and Efficacy Study of Cefdinir Oral Suspension, in Pediatric Subjects to Treat Acute Otitis Mediatreatment2 / 3completed
NCT00714064
PneuMum: Pneumococcal Vaccination of Australian Indigenous Mothersprevention3completed
NCT01071902
Safety and Efficacy of Moxidex Otictreatment3terminated
NCT05651633
Analgesic Ear Drops for Children With Acute Otitis Mediatreatment3terminated
NCT02856633
Preliminary Testing of the Vitaliti CVSM Wearable, Vitaliti Spirotoscope, and Vitaliti IVD StationNo drug interventionsNot AvailableNot Availablecompleted
NCT02092454
Study to Assess the Safety and Efficacy of Benzocaine for Pain Relief in Children Presenting With Acute Otitis Mediatreatment2completed
NCT02345447
Herbal-Based Medication vs. Placebo in Preventing Acute Otitis Media in Children at High Risk of RecurrenceNo drug interventionsprevention3completed
NCT01800747
Clinical Trial for the Assessment of Delayed Antibiotic Treatment in Pediatric (DAP-Pediatrics)No drug interventionstreatment4completed
NCT02521597
Mobile Otoscopy - Efficacy of Residents to Diagnose Acute Otitis Media Using a Smartphone Otoscope AttachmentNo drug interventionsdiagnosticNot Availablecompleted
NCT01404611
Efficacy and Safety of DF289 Plus DF277 Otic Solution in the Treatment of Middle Ear Infections in Pediatric PatientsNo drug interventionstreatment3completed
NCT01202578
Evaluation of the Tympanostomy Tube Delivery SystemNo drug interventionstreatment2 / 3completed
NCT01511107
Efficacy of Short-Course Antimicrobial Treatment for Children With Acute Otitis Media and Impact on Resistancetreatment2terminated
NCT03818815
A Study to Assess the Safety, Tolerability and Efficacy of OP0201 as an Adjunct Treatment for Acute Otitis Media in Infants and Children Aged 6 to 24 Monthstreatment2completed
NCT01272999
Impact of Prevnar 13 on Ear Infections in ChildrenNo drug interventionsNot AvailableNot Availablecompleted
NCT00310349
PneuMum: Pneumococcal Vaccination of Australian Indigenous Mothers to See if it Protects Their Babies From Ear DiseaseNo drug interventionsprevention3unknown_status
NCT00622518
Ear Drops for Children With Otitis MediaNo drug interventionssupportive_careNot Availablecompleted
NCT02408796
Open-Label Study of OTO-201 for Treatment of AOMTNo drug interventionstreatment2completed
NCT02872558
Shared Decision Making in Parents of Children With Acute Otitis MediaNo drug interventionstreatmentNot Availablecompleted
NCT02567825
Efficacy of Tympanostomy Tubes for Children With Recurrent Acute Otitis MediatreatmentNot Availablecompleted
NCT01044030
Xylitol Syrup for the Prevention of Acute Otitis Media in Otitis-prone Childrenprevention3completed
NCT01395966
Clinical Study to Assess the Efficacy and Safety of DF289 Plus DF277 Otic Solution in the Treatment of Middle Ear Infections in Pediatric PatientsNo drug interventionstreatment3completed
NCT00578474
A Phase III Study of an Otic Formulation in Acute Otitis Media With Tympanostomy Tubestreatment3completed
NCT02935374
Effect of Antimicrobial Treatment of Acute Otitis Media on the Intestinal Microbiome in Childrenother4completed
NCT02918773
Pediatric Emergency Department Smartphone Otoscope Study (PED-Oto)No drug interventionshealth_services_researchNot Availablecompleted
NCT03766373
Evaluation of Safety and Reduction of Ear Pain in Adults With Acute Otitis Media and Reduction of Ear Pain in Adults With Acute Otitis MediaNo drug interventionsother1completed
NCT04588376
Improving Antibiotic Prescribing for Pediatric Respiratory Infections by Family Physicians With Peer ComparisonNo drug interventionsotherNot Availablecompleted
NCT01027494
Topical Treatment of Acute Otitis Media Through Tympanostomy Tubes (AOMT) and Its Effect on Microbial FloraNot AvailableNot Availablecompleted
NCT03055091
Xylitol for the Prevention of Acute Otitis Media Episodes in ChildrenNo drug interventionspreventionNot Availableunknown_status
NCT00579189
Phase III Study of an Otic Formulation in Acute Otitis Media With Tympanostomy Tubestreatment3completed
NCT02630992
Reduced Clavulanate Formulation of Amoxicillin-Clavulanate in Children 6-23 Months With Acute Otitis Mediaother3completed
NCT02549612
The Effect of Early Non-Surgical Treatment of Children With Middle Ear Effusion on the HearingNo drug interventionstreatmentNot Availableunknown_status
NCT00502450
Is There Hearing Loss After Acute MastoiditisNo drug interventionsNot AvailableNot Availablewithdrawn
NCT00368823
A Trial of Point of Care Information in Ambulatory PediatricsNo drug interventionstreatment3completed
NCT00644943
A Comparison of the Safety and Efficacy of Cefdinir Oral Suspension Versus Amoxicillin/Clavulanate in Pediatric Subjects With Acute Otitis Mediatreatment4completed
NCT04946084
Dynamic Change and Immune Response to Nasopharyngeal Carriage and Acute Otitis Media PathogensNo drug interventionsotherNot Availableactive_not_recruiting
NCT02742753
Impact of Pneumococcal Conjugate Vaccines on Otitis Media and Acute Otitis Media in Swedish ChildrenNo drug interventionsNot AvailableNot Availablecompleted
NCT02567747
Vaccination Impact Against Pneumococcal Disease on Acute Otitis Media Morbidity in Colombian Children < 5 Years of AgeNo drug interventionsNot AvailableNot Availablecompleted
NCT05608993
RELAX: Reducing Length of Antibiotics for Children With Ear InfectionsNo drug interventionshealth_services_researchNot Availablenot_yet_recruiting
NCT00941993
Anesthetic Effect of Lidocaine/Epinephrine Solution Delivered Via Iontophoresis to External Auditory ApparatusNo drug interventionsotherNot Availablecompleted
NCT02037893
Four Arm Safety & Efficacy With Antipyrine and Benzocaine Otic Solution in Children With Acute Otitis Mediatreatment2completed
NCT05915078
Evaluation of Outcomes Following In-office Tympanostomy Using the Tula® System: a Prospective, Multi-center RegistryNo drug interventionsNot AvailableNot Availablerecruiting
NCT02074007
Study to Compare Efficacy and Safety of AR01 to a Placebo Solution for Relief of Pain in Acute Otitis Media (AR01007)treatment3terminated
NCT03516409
Bio-Kult Infantis® in AAD Prevention in InfantsNo drug interventionstreatmentNot Availableunknown_status
NCT03315156
Taste Changes in Acute Otitis MediaNo drug interventionsNot AvailableNot Availableunknown_status
NCT02297815
Comparative Effectiveness of Antibiotics for Respiratory InfectionsNo drug interventionsNot AvailableNot Availablecompleted
NCT06005337
Supporting Parents to Choose WiselyNo drug interventionsotherNot Availableactive_not_recruiting
NCT03116737
Phase III Study Evaluating Topical Benzocaine for Treatment of Acute Otitis Media in Childrentreatment3completed
NCT02110732
Lactobacillus Rhamnosus GG in the Middle Ear and Adenoid TonsilNo drug interventionssupportive_careNot Availablecompleted
NCT03534219
Efficacy of the EarPopper Device in Children With Recurrent Otitis MediaNo drug interventionspreventionNot Availablewithdrawn
NCT02044341
Phase 3 Study to Compare the Efficacy and Safety of AR01 to a Placebo Solution for Relief of Pain in Acute Otitis Mediatreatment3completed
NCT03614117
Effect of a New Probiotic Strain on Recurrent Acute Otitis Media in Children (PROMAR)No drug interventionspreventionNot Availablecompleted
NCT00796224
Pharmacokinetics Of Azithromycin Immediate Release And Extended Release Formulation In Kids With Acute Otitis Mediatreatment2completed
NCT02719158
Dose Ranging Study of OTO-201 in AOMTtreatment2completed
NCT04296448
Evaluation of Cellphone Based Otoscopy in Pediatric PatientsNo drug interventionsdiagnosticNot Availablecompleted
NCT01031082
Study to Identify and Characterize Bacteria Causing Acute Otitis Media in South African ChildrenNo drug interventionsNot AvailableNot Availablecompleted
NCT00578773
A Phase II Study of an Otic Formulation in Treating Peri-Operative Tube Otorrheatreatment2completed
NCT01072227
Study to Identify and Characterize the Bacteria Causing Acute Otitis Media Episodes in Young Children in TaiwanNo drug interventionsNot AvailableNot Availableterminated
NCT00377260
Acute Otitis Media (AOM) Therapy Trial in Young Childrentreatment4completed
NCT04464291
An Epidemiological Survey to Establish the Spectrum of Circulating Serotypes of S. Pneumoniae, in Patients Older 18 YearsNo drug interventionsscreeningNot Availablecompleted
NCT00189462
A Pilot Study to Evaluate the Efficacy of Montelukast in the Treatment of Acute Otitis Media (AOM) in Childrenprevention4completed
NCT06034080
Interventions to De-implement Unnecessary Antibiotic Prescribing for Children With Ear InfectionsNo drug interventionshealth_services_researchNot Availablenot_yet_recruiting
NCT00643292
A Single, High-Dose Azithromycin Extended Release (60 mg/kg) Compared With 10 Days of High-Dose Amoxicillin Clavulanate in Children With Ear Infections at High Risk of Persistent/Recurrent Ear Infectionstreatment3completed
NCT00645112
A Comparison of Safety and Efficacy of Cefdinir Oral Suspension Versus Azithromycin in Pediatric Subjects With Acute Otitis Mediatreatment4completed
NCT01941381
Does Tympanometry Predict Antibiotic Usage in Acute Otitis Media?No drug interventionsNot AvailableNot Availablecompleted
NCT00299455
Amoxicillin Clavulanate in Treatment of Acute Otitis Mediatreatment4unknown_status
NCT01214538
Assessment of the Natural Antibody Response to Pneumococcal Surface Proteins During Acute Otitis Media in ChildrenNo drug interventionsNot AvailableNot Availableunknown_status
NCT05353569
Coherent Optical Detection of Middle Ear DiseaseNo drug interventionsdiagnosticNot Availablerecruiting
NCT04722770
Clinical Development of Deep Learning for the OtoSightNo drug interventionsNot AvailableNot Availablecompleted
NCT06285812
Otitis Treatment With OtoSight™ - Modification of Antibiotic Treatment Intervention in ChildrenNo drug interventionsNot AvailableNot Availablerecruiting