Flurbiprofen is an NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity.
- Mechanism
- Curator reviewed
Similar to other NSAIAs, the anti-inflammatory effect of flurbiprofen occurs via reversible inhibition of cyclooxygenase (COX), the enzyme responsible for the conversion of arachidonic acid to prostaglandin G2 (PGG2) and PGG2 to prostaglandin H2 (PGH2) in the prostaglandin synthesis pathway. This effectively decreases the concentration of prostaglandins involved in inflammation, pain, swelling and fever. Flurbiprofen is a non-selective COX inhibitor and inhibits the activity of both COX-1 and -2. It is also one of the most potent NSAIAs in terms of prostaglandin inhibitory activity.
- Primary indication
- Flurbiprofen tablets are indicated for the acute or long-term symptomatic treatment of rheumatoid arthritis, osteorarthritis and anklosing spondylitis.Curator reviewed · 24 structured indications
- Formula / weight
- C15H13FO2 · 244.2609 g/mol (avg)
- First approval
- Canada, 1998 · United States, 1987
- Code names
- BTS 18 322 · FP 70 · FP 83 · U-27,182
- Brand names
Resolves to
SYTBZMRGLBWNTM-UHFFFAOYSA-NSMILESCC(C(O)=O)C1=CC(F)=C(C=C1)C1=CC=CC=C1What you can answer from here — as of September 23, 2026
Which drugs share a target with Flurbiprofen, and which of those have an active Phase 3 trial?
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