ATP-binding cassette sub-family C member 4

BE0001188ProteinHumansABCC4

ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells (PubMed:11856762, PubMed:12523936, PubMed:15364914, PubMed:38886124, PubMed:40138312). It is acted on by 54 drugs in DrugBank.

Gene name
ABCC4
UniProtKB entry
O15439Swiss-Prot
Cellular location
Basolateral cell membrane
Residues / weight
1,325 residues · 149,525 Da
Also known as
7.6.2.- · 7.6.2.2 · 7.6.2.3 · MOAT-B · MOATB

Resolves to

Protein
UniProtO15439UniProt nameMRP4_HUMAN
Gene
HGNCHGNC:55NCBI Gene10257GenBank3335173GeneCardsABCC4
Pharmacology
IUPHAR/GtoPdb782KEGGhsa:10257
Structure
PDB8BJFPDB8BWOPDB8BWP
Drugs

What you can answer from here — as of September 03, 2024

54DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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27GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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114+ReferencesStructured and connected to the statements they support
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Which approved drugs act on ATP-binding cassette sub-family C member 4, how selective are they, and which programs against it are still in active trials?

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