Nalidixic acid

DB00779ApprovedWithdrawnSmall molecule

Nalidixic acid is a quinolone antibiotic used to treat urinary tract infections. Nalidixic acid is a synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum.

Chemical structure of Nalidixic acid
Mechanism
Curator reviewed
Primary indication
For the treatment of urinary tract infections caused by susceptible gram-negative microorganisms, including the majority of E.Curator reviewed · 1 structured indication
Formula / weight
C12H12N2O3 · 232.2353 g/mol (avg)
First approval
Canada, 2006 · United States, 1964
Code names
NSC-82174 · WIN-18320

Resolves to

Compound
UNII3B91HWA56MCAS389-08-2ChEMBLCHEMBL5ChEBI100147PubChem4421KEGGD00183
Clinical / RWD
RxNorm7240ATCJ01MB02PharmGKBPA164746384
Structure
InChIKeyMHWLWQUZZRMNGJ-UHFFFAOYSA-NSMILESCCN1C=C(C(O)=O)C(=O)C2=C1N=C(C)C=C2
Targets
P0AES4gyrAP0AES6gyrBQ02880TOP2BP11388TOP2A
Transporters
Q4U2R8SLC22A6

What you can answer from here — as of September 20, 2026

5Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
1TransporterSubstrate / inhibitor direction, not just membership
Listed above
1,065Drug interactionsStructured to mechanism, not free text
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1Clinical trialPhase, status and sponsor resolved per trial
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1Structured indicationCondition, population, route and combination as fields, not prose
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4ContraindicationsEach with its own population and attribute set
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44Marketed productsAcross 6 countries and 23 labellers
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1ATC codeIncluding every combination product, plus 23 drug categories
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12+ReferencesStructured and connected to the statements they support
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