Solute carrier family 22 member 11

BE0000879ProteinHumansSLC22A11

Antiporter that mediates the transport of conjugated steroids and other specific organic anions at the basal membrane of syncytiotrophoblast and at the apical membrane of proximal tubule epithelial cells, in exchange for anionic compounds (PubMed:10660625,... It is acted on by 48 drugs in DrugBank.

Gene name
SLC22A11
UniProtKB entry
Q9NSA0Swiss-Prot
Cellular location
Cell membrane
Residues / weight
550 residues · 59,971 Da
Also known as
OAT4 · Organic anion transporter 4 · Organic anion:dicarboxylate exchanger OAT4

Resolves to

Protein
UniProtQ9NSA0UniProt nameS22AB_HUMAN
Gene
HGNCHGNC:18120NCBI Gene55867GenBank7707622GeneCardsSLC22A11
Pharmacology
IUPHAR/GtoPdb1030KEGGhsa:55867
Structure
PDB8WJHPDB9M9YPDB9U5A
Drugs

What you can answer from here — as of September 07, 2019

48DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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81+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Solute carrier family 22 member 11, how selective are they, and which programs against it are still in active trials?

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