Organic anion transporter 3

BE0003645ProteinHumansSLC22A8

Functions as an organic anion/dicarboxylate exchanger that couples organic anion uptake indirectly to the sodium gradient (PubMed:14586168, PubMed:15644426, PubMed:15846473, PubMed:16455804, PubMed:31553721). It is acted on by 195 drugs in DrugBank.

Gene name
SLC22A8
UniProtKB entry
Q8TCC7Swiss-Prot
Cellular location
Basolateral cell membrane
Residues / weight
542 residues · 59,856 Da
Also known as
hOAT3 · OAT3 · Organic anion/dicarboxylate exchanger · Solute carrier family 22 member 8

Resolves to

Protein
UniProtQ8TCC7UniProt nameS22A8_HUMAN
Gene
HGNCHGNC:10972NCBI Gene9376GenBank4378059GeneCardsSLC22A8
Pharmacology
IUPHAR/GtoPdb1027KEGGhsa:9376
Drugs

What you can answer from here — as of September 03, 2024

195DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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360+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Organic anion transporter 3, how selective are they, and which programs against it are still in active trials?

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