Antidepressive Agents, Tricyclic
- Antidepressive Agents, Tricyclic
- Accession Number
Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system.
Drug Drug Description Amitriptyline A tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety. Protriptyline A tricyclic antidepressant that is indicated in the treatment of depression only under close clinical supervision. Imipramine A tricyclic antidepressant indicated for the treatment of depression and to reduce childhood enuresis. Nortriptyline A tricyclic antidepressant used in the treatment of depression. Trimipramine A tricyclic antidepressant used to treat depression. Doxepin A psychotropic agent used for the treatment of depression, anxiety, manic-depressive disorder, and insomnia. Desipramine A tricyclic antidepressant used in the treatment of depression. Clomipramine A tricyclic antidepressant used in the treatment of obsessive-compulsive disorder and disorders with an obsessive-compulsive component, such as depression, schizophrenia, and Tourette’s disorder. Butriptyline Butriptyline is a tricyclic antidepressant which has been used in Europe since 1974. It is the isobutyl side chain homologue of amitriptyline. Amitriptylinoxide A tricyclic antidepressant indicated in the treatment of depressive disorders. Melitracen A thioxanthene neuroleptic indicated in the treatment of anxiety, depression, and asthenia. Dimetacrine Dimetacrine is also known as dimethacrine or acripamine. It is marketed under the names Istonil, Istonyl, Linostil, and Miroistonil. Dimetacrine is a tricyclic antidepressant (TCA) with imipramine-like effects used in... Amineptine For the treatment of depression. Dosulepin A tricyclic antidepressant commonly used only in patients for whom alternative therapies are ineffective due to its toxicity potential. Tianeptine An atypical tricyclic antidepressant with antidepressant and anxiolytic effects primarily used to treat major depressive disorder. Opipramol A medication to treat general anxiety and somatoform disorders. Dibenzepin Dibenzepin is approved for use in Europe. Lofepramine Not Annotated Iprindole Not Annotated Amoxapine A tricyclic antidepressant used in the treatment of neurotic or reactive depressive disorders and endogenous or psychotic depression. Oxaprotiline Investigated for the treatment of depression. Quinupramine Quinupramine has been approved in France under the brand name Kinupril, as an antidepressant . Imipramine oxide Not Annotated
- Drugs & Drug Targets