TTD: Therapeutic Target Database.

Article Details

Citation

Chen X, Ji ZL, Chen YZ

TTD: Therapeutic Target Database.

Nucleic Acids Res. 2002 Jan 1;30(1):412-5.

PubMed ID
11752352 [ View in PubMed
]
Abstract

A number of proteins and nucleic acids have been explored as therapeutic targets. These targets are subjects of interest in different areas of biomedical and pharmaceutical research and in the development and evaluation of bioinformatics, molecular modeling, computer-aided drug design and analytical tools. A publicly accessible database that provides comprehensive information about these targets is therefore helpful to the relevant communities. The Therapeutic Target Database (TTD) is designed to provide information about the known therapeutic protein and nucleic acid targets described in the literature, the targeted disease conditions, the pathway information and the corresponding drugs/ligands directed at each of these targets. Cross-links to other databases are also introduced to facilitate the access of information about the sequence, 3D structure, function, nomenclature, drug/ligand binding properties, drug usage and effects, and related literature for each target. This database can be accessed at http://xin.cz3.nus.edu.sg/group/ttd/ttd.asp and it currently contains entries for 433 targets covering 125 disease conditions along with 809 drugs/ligands directed at each of these targets. Each entry can be retrieved through multiple methods including target name, disease name, drug/ligand name, drug/ligand function and drug therapeutic classification.

DrugBank Data that Cites this Article

Drugs
Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
(R)-RolipramcAMP-specific 3',5'-cyclic phosphodiesterase 4BProteinHumans
Unknown
Inhibitor
Details
(S)-RolipramcAMP-specific 3',5'-cyclic phosphodiesterase 4BProteinHumans
Unknown
Inhibitor
Details
1-Guanidinium-7-AminoheptaneDeoxyhypusine synthaseProteinHumans
Unknown
Inhibitor
Details
3-[4-(1-formylpiperazin-4-yl)-benzylidenyl]-2-indolinoneFibroblast growth factor receptor 2ProteinHumans
Unknown
Not AvailableDetails
3-MethylthiofentanylMu-type opioid receptorProteinHumans
Yes
Agonist
Details
AbataceptT-lymphocyte activation antigen CD80ProteinHumans
Yes
Antagonist
Details
AbataceptT-lymphocyte activation antigen CD86ProteinHumans
Yes
Antagonist
Details
AbciximabIntegrin beta-3ProteinHumans
Yes
Antagonist
Details
AcebutololBeta-1 adrenergic receptorProteinHumans
Yes
Partial agonist
Details
AcenocoumarolVitamin K epoxide reductase complex subunit 1ProteinHumans
Yes
Inhibitor
Details
AcepromazineDopamine D2 receptorProteinHumans
Yes
Antagonist
Details
AceprometazineHistamine H1 receptorProteinHumans
Yes
Antagonist
Details
AcetaminophenProstaglandin G/H synthase 1ProteinHumans
Yes
Inhibitor
Details
AcetaminophenProstaglandin G/H synthase 2ProteinHumans
Yes
Inhibitor
Details
Acetohydroxamic acidUrease subunit alphaProteinEnterobacter aerogenes
Yes
Inhibitor
Details
AcetophenazineDopamine D2 receptorProteinHumans
Yes
Antagonist
Details
AdenosineAdenosine receptor A3ProteinHumans
Yes
Agonist
Details
Adenosine phosphateAdenylate cyclase type 1ProteinHumans
Unknown
Product of
Details
Alanine4-aminobutyrate aminotransferase, mitochondrialProteinHumans
Unknown
Inhibitor
Details
AldesleukinInterleukin-2 receptor subunit alphaProteinHumans
Yes
Agonist
Modulator
Details
AldesleukinInterleukin-2 receptor subunit betaProteinHumans
Yes
Agonist
Modulator
Details
AlefaceptT-cell surface antigen CD2ProteinHumans
Yes
Inhibitor
Details
AlemtuzumabCAMPATH-1 antigenProteinHumans
Yes
Antibody
Details
Alendronic acidFarnesyl pyrophosphate synthaseProteinHumans
Yes
Inhibitor
Details
Alendronic acidReceptor-type tyrosine-protein phosphatase SProteinHumans
Unknown
Inhibitor
Details
AlfacalcidolVitamin D3 receptorProteinHumans
Yes
Agonist
Details
AlfentanilMu-type opioid receptorProteinHumans
Yes
Agonist
Details
AlimemazineHistamine H1 receptorProteinHumans
Yes
Antagonist
Details
AlitretinoinRetinoic acid receptor alphaProteinHumans
Yes
Agonist
Details
AllopurinolXanthine dehydrogenase/oxidaseProteinHumans
Yes
Inhibitor
Details
AlmitrineSodium/potassium-transporting ATPase subunit alpha-1ProteinHumans
Yes
Binder
Details
Almotriptan5-hydroxytryptamine receptor 1BProteinHumans
Unknown
Agonist
Details
Almotriptan5-hydroxytryptamine receptor 1DProteinHumans
Unknown
Agonist
Details
Alosetron5-hydroxytryptamine receptor 3AProteinHumans
Yes
Antagonist
Details
Alpha-1-proteinase inhibitorNeutrophil elastaseProteinHumans
Yes
Inhibitor
Details
AlprenololBeta-1 adrenergic receptorProteinHumans
Yes
Antagonist
Details
AlprostadilProstaglandin E2 receptor EP2 subtypeProteinHumans
Yes
Agonist
Details
AlsterpaulloneCyclin-dependent kinase 1ProteinHumans
Unknown
Inhibitor
Details
AlsterpaulloneCyclin-dependent kinase 5ProteinHumans
Unknown
Not AvailableDetails
AlteplasePlasminogenProteinHumans
Yes
Activator
Details
AluminiumSodium/potassium-transporting ATPase subunit alpha-1ProteinHumans
Unknown
Binder
Details
Aluminium monostearateTroponin C, slow skeletal and cardiac musclesProteinHumans
Unknown
Stimulator
Details
Aluminium phosphateSodium/potassium-transporting ATPase subunit alpha-1ProteinHumans
Unknown
Not AvailableDetails
Aluminum acetateSodium/potassium-transporting ATPase subunit alpha-1ProteinHumans
Unknown
Not AvailableDetails
AlvimopanMu-type opioid receptorProteinHumans
Yes
Antagonist
Details
AlvocidibCyclin-dependent kinase 1ProteinHumans
Unknown
Not AvailableDetails
AlvocidibCyclin-dependent kinase 2ProteinHumans
Unknown
Inhibitor
Details
AlvocidibCyclin-dependent kinase 4ProteinHumans
Unknown
Not AvailableDetails
AlvocidibCyclin-dependent kinase 5ProteinHumans
Unknown
Not AvailableDetails
AlvocidibCyclin-dependent kinase 6ProteinHumans
Unknown
Not AvailableDetails
AlvocidibCyclin-dependent kinase 7ProteinHumans
Unknown
Not AvailableDetails
AlvocidibCyclin-dependent kinase 8ProteinHumans
Unknown
Not AvailableDetails
AlvocidibCyclin-dependent kinase 9ProteinHumans
Unknown
Not AvailableDetails
AlvocidibEpidermal growth factor receptorProteinHumans
Unknown
Not AvailableDetails
AmbenoniumAcetylcholinesteraseProteinHumans
Yes
Inhibitor
Details
AmilorideAmiloride-sensitive sodium channel subunit alphaProteinHumans
Yes
Inhibitor
Details
AmilorideUrokinase-type plasminogen activatorProteinHumans
Unknown
Inhibitor
Details
Aminocaproic acidPlasminogenProteinHumans
Yes
Inhibitor
Details
AminoglutethimideCholesterol side-chain cleavage enzyme, mitochondrialProteinHumans
Yes
Inhibitor
Details
AminoglutethimideCytochrome P450 19A1ProteinHumans
Yes
Inhibitor
Details
Aminolevulinic acidDelta-aminolevulinic acid dehydrataseProteinHumans
Yes
Inducer
Details
AminophyllinecGMP-inhibited 3',5'-cyclic phosphodiesterase AProteinHumans
Yes
Inhibitor
Details
AmobarbitalGamma-aminobutyric acid receptor subunit alpha-1ProteinHumans
Yes
Potentiator
Details
AmodiaquineHistamine N-methyltransferaseProteinHumans
Unknown
Inhibitor
Details
AmrinonecGMP-inhibited 3',5'-cyclic phosphodiesterase AProteinHumans
Yes
Inhibitor
Details
AmsacrineDNA topoisomerase 2-alphaProteinHumans
Yes
Inhibitor
Details
AnakinraInterleukin-1 receptor type 1ProteinHumans
Yes
Antagonist
Details
AnileridineMu-type opioid receptorProteinHumans
Yes
Agonist
Details
AnisindioneVitamin K-dependent gamma-carboxylaseProteinHumans
Yes
Inhibitor
Details
AnistreplasePlasminogenProteinHumans
Yes
Activator
Details
Antithymocyte immunoglobulin (rabbit)T-cell surface glycoprotein CD1aProteinHumans
Unknown
Inhibitor
Details
AntrafenineProstaglandin G/H synthase 2ProteinHumans
Unknown
Inhibitor
Details
ApomorphineDopamine D1 receptorProteinHumans
Unknown
Agonist
Details
ApomorphineDopamine D2 receptorProteinHumans
Yes
Agonist
Details
ApomorphineDopamine D3 receptorProteinHumans
Yes
Agonist
Details
ApomorphineDopamine D4 receptorProteinHumans
Yes
Agonist
Details
ApomorphineDopamine D5 receptorProteinHumans
Unknown
Agonist
Details
AprepitantNeurokinin 1 receptorProteinHumans
Yes
Antagonist
Details
ArbaclofenGamma-aminobutyric acid type B receptor subunit 1ProteinHumans
Yes
Agonist
Details
Arbaclofen PlacarbilGamma-aminobutyric acid type B receptor subunit 1ProteinHumans
Yes
Agonist
Details
ArdeparinHeparin cofactor 2ProteinHumans
Yes
Agonist
Details
ArformoterolBeta-2 adrenergic receptorProteinHumans
Yes
Agonist
Details
ArgatrobanProthrombinProteinHumans
Yes
Inhibitor
Details
AripiprazoleDopamine D2 receptorProteinHumans
Yes
Antagonist
Partial agonist
Details
Aripiprazole lauroxilDopamine D2 receptorProteinHumans
Yes
Partial agonist
Details
Arsenic trioxideInhibitor of nuclear factor kappa-B kinase subunit betaProteinHumans
Yes
Inducer
Details
Ascorbic acidProcollagen-lysine,2-oxoglutarate 5-dioxygenase 1ProteinHumans
Unknown
Cofactor
Details
AstemizoleHistamine H1 receptorProteinHumans
Yes
Antagonist
Details
AtazanavirHuman immunodeficiency virus type 1 proteaseProteinHuman immunodeficiency virus 1
Yes
Inhibitor
Details
AtenololBeta-1 adrenergic receptorProteinHumans
Yes
Antagonist
Details
Atorvastatin3-hydroxy-3-methylglutaryl-coenzyme A reductaseProteinHumans
Yes
Inhibitor
Details
AtovaquoneDihydroorotate dehydrogenase (quinone), mitochondrialProteinHumans
Unknown
Inhibitor
Details
AtovaquoneDihydroorotate dehydrogenase (quinone), mitochondrialProteinPlasmodium falciparum (isolate 3D7)
Yes
Inhibitor
Details
ATPAbelson tyrosine-protein kinase 2ProteinHumans
Unknown
Inhibitor
Details
ATPTyrosine-protein kinase ABL1ProteinHumans
Unknown
Inhibitor
Details
AtropineMuscarinic acetylcholine receptor M5ProteinHumans
Yes
Antagonist
Details
AuranofinPeroxiredoxin-5, mitochondrialProteinHumans
Yes
Inhibitor
Details
AzacitidineDNA (cytosine-5)-methyltransferase 1ProteinHumans
Yes
Inhibitor
Details
AzatadineHistamine H1 receptorProteinHumans
Yes
Antagonist
Details
Azilsartan medoxomilType-1 angiotensin II receptorProteinHumans
Yes
Antagonist
Details
BacitracinInsulin-degrading enzymeProteinHumans
Yes
Inhibitor
Details
BalsalazideProstaglandin G/H synthase 1ProteinHumans
Yes
Inhibitor
Details
BambuterolBeta-2 adrenergic receptorProteinHumans
Yes
Agonist
Details
BasiliximabInterleukin-2 receptor subunit alphaProteinHumans
Yes
Antibody
Details
BasiliximabInterleukin-2 receptor subunit betaProteinHumans
Unknown
Antibody
Details
Bb-3497Peptide deformylase, mitochondrialProteinHumans
Unknown
Inhibitor
Details
BenazeprilAngiotensin-converting enzymeProteinHumans
Yes
Inhibitor
Details
BendroflumethiazideSolute carrier family 12 member 3ProteinHumans
Yes
Inhibitor
Details
BenzatropineMuscarinic acetylcholine receptor M1ProteinHumans
Yes
Antagonist
Details
BenzthiazideCarbonic anhydrase 2ProteinHumans
Unknown
Inhibitor
Details
Benzylpenicilloyl polylysineHigh affinity immunoglobulin epsilon receptor subunit alphaProteinHumans
Yes
Agonist
Details
Benzylpenicilloyl polylysineHigh affinity immunoglobulin epsilon receptor subunit gammaProteinHumans
Yes
Agonist
Details
BepotastineHistamine H1 receptorProteinHumans
Yes
Antagonist
Details
BetaxololBeta-1 adrenergic receptorProteinHumans
Yes
Antagonist
Details
BetazoleHistamine H2 receptorProteinHumans
Yes
Agonist
Details
BethanidineBeta adrenergic receptor (Protein Group)Protein groupHumans
Unknown
Antagonist
Details
BevacizumabVascular endothelial growth factor AProteinHumans
Yes
Not AvailableDetails
BezafibratePeroxisome proliferator-activated receptor alphaProteinHumans
Yes
Agonist
Details
BicalutamideAndrogen receptorProteinHumans
Yes
Antagonist
Details
BiperidenMuscarinic acetylcholine receptor M1ProteinHumans
Yes
Antagonist
Details
BisoprololBeta-1 adrenergic receptorProteinHumans
Yes
Antagonist
Details
BivalirudinProthrombinProteinHumans
Yes
Inhibitor
Details
Bopindolol5-hydroxytryptamine receptor 1AProteinHumans
Unknown
Not AvailableDetails
BopindololBeta-1 adrenergic receptorProteinHumans
Yes
Partial agonist
Details
BopindololBeta-2 adrenergic receptorProteinHumans
Unknown
Partial agonist
Details
BopindololBeta-3 adrenergic receptorProteinHumans
Unknown
Not AvailableDetails
BosentanEndothelin B receptorProteinHumans
Yes
Antagonist
Details
BosentanEndothelin-1 receptorProteinHumans
Yes
Antagonist
Details
Botulinum toxin type BVesicle-associated membrane protein 1ProteinHumans
Yes
Binder
Details
Botulinum toxin type BVesicle-associated membrane protein 2ProteinHumans
Yes
Binder
Details
BrimonidineAlpha-2A adrenergic receptorProteinHumans
Yes
Agonist
Details
BromfenacProstaglandin G/H synthase 1ProteinHumans
Unknown
Inhibitor
Details
BromocriptineDopamine D2 receptorProteinHumans
Yes
Agonist
Details
BromodiphenhydramineHistamine H1 receptorProteinHumans
Yes
Antagonist
Details
BrompheniramineHistamine H1 receptorProteinHumans
Yes
Antagonist
Details
BuclizineHistamine H1 receptorProteinHumans
Yes
Antagonist
Details
BudesonideGlucocorticoid receptorProteinHumans
Yes
Agonist
Details
BumetanideSolute carrier family 12 member 1ProteinHumans
Yes
Inhibitor
Details
BuprenorphineMu-type opioid receptorProteinHumans
Yes
Partial agonist
Details
BupropionSodium-dependent dopamine transporterProteinHumans
Yes
Inhibitor
Details
BupropionSodium-dependent noradrenaline transporterProteinHumans
Yes
Inhibitor
Details
Buspirone5-hydroxytryptamine receptor 1AProteinHumans
Yes
Partial agonist
Details
ButalbitalGamma-aminobutyric acid receptor subunit alpha-1ProteinHumans
Yes
Potentiator
Details
ButenafineSqualene monooxygenaseProteinHumans
Yes
Inhibitor
Details
ButobarbitalGamma-aminobutyric acid receptor subunit alpha-1ProteinHumans
Yes
Potentiator
Details
ButorphanolDelta-type opioid receptorProteinHumans
Yes
Agonist
Details
CabergolineDopamine D2 receptorProteinHumans
Yes
Agonist
Details
CaffeineAdenosine receptor A2aProteinHumans
Yes
Antagonist
Multitarget
Details
CalcifediolVitamin D3 receptorProteinHumans
Yes
Agonist
Details
CalcipotriolVitamin D3 receptorProteinHumans
Unknown
Antagonist
Details
CalcitriolVitamin D3 receptorProteinHumans
Yes
Antagonist
Details
CamptothecinDNA topoisomerase 1ProteinHumans
Unknown
Not AvailableDetails
CanalineOrnithine aminotransferase, mitochondrialProteinHumans
Unknown
Inhibitor
Details
CandesartanType-1 angiotensin II receptorProteinHumans
Yes
Antagonist
Details
Candesartan cilexetilType-1 angiotensin II receptorProteinHumans
Yes
Antagonist
Details
CandoxatrilNeprilysinProteinHumans
Yes
Inhibitor
Details
CapecitabineThymidylate synthaseProteinHumans
Yes
Inhibitor
Details
Capromab pendetideGlutamate carboxypeptidase 2ProteinHumans
Yes
Other/unknown
Details
CaptoprilAngiotensin-converting enzymeProteinHumans
Yes
Inhibitor
Details
CarbamoylcholineNeuronal acetylcholine receptor subunit alpha-2ProteinHumans
Yes
Agonist
Details
CarbenoxoloneCorticosteroid 11-beta-dehydrogenase isozyme 1ProteinHumans
Unknown
Inhibitor
Details
CarbetocinOxytocin receptorProteinHumans
Yes
Agonist
Details
CarbidopaAromatic-L-amino-acid decarboxylaseProteinHumans
Yes
Inhibitor
Details
CarbimazoleThyroid peroxidaseProteinHumans
Yes
Inhibitor
Details
CarbinoxamineHistamine H1 receptorProteinHumans
Yes
Antagonist
Details
CarphenazineDopamine D2 receptorProteinHumans
Yes
Antagonist
Details
CarprofenProstaglandin G/H synthase 2ProteinHumans
Yes
Inhibitor
Details
CarteololBeta-1 adrenergic receptorProteinHumans
Yes
Partial agonist
Details
CarteololBeta-2 adrenergic receptorProteinHumans
Yes
Antagonist
Details
Cerivastatin3-hydroxy-3-methylglutaryl-coenzyme A reductaseProteinHumans
Yes
Inhibitor
Details
CeruleninFatty acid synthaseProteinHumans
Yes
Inhibitor
Details
CetrorelixGonadotropin-releasing hormone receptorProteinHumans
Yes
Antagonist
Details
CetuximabEpidermal growth factor receptorProteinHumans
Yes
Binder
Details
CevimelineMuscarinic acetylcholine receptor M3ProteinHumans
Yes
Agonist
Details
ChlormerodrinSuccinate-semialdehyde dehydrogenase, mitochondrialProteinHumans
Unknown
Inhibitor
Details
ChlormezanoneTranslocator proteinProteinHumans
Yes
Agonist
Details
ChloroquineGlutathione S-transferase A2ProteinHumans
Unknown
Inhibitor
Details
ChlorothiazideCarbonic anhydrase 2ProteinHumans
Yes
Inhibitor
Details
ChlorotrianiseneEstrogen receptor alphaProteinHumans
Yes
Agonist
Details
ChlorpheniramineHistamine H1 receptorProteinHumans
Yes
Antagonist
Details
ChlorpromazineDopamine D2 receptorProteinHumans
Yes
Antagonist
Details
ChlorprothixeneDopamine D2 receptorProteinHumans
Yes
Antagonist
Details
ChlorthalidoneSolute carrier family 12 member 1ProteinHumans
Yes
Inhibitor
Details
CholecalciferolVitamin D3 receptorProteinHumans
Yes
Agonist
Details
Choriogonadotropin alfaFollicle-stimulating hormone receptorProteinHumans
Yes
Binder
Details
CilastatinDipeptidase 1ProteinHumans
Yes
Inhibitor
Details
CilazaprilAngiotensin-converting enzymeProteinHumans
Yes
Inhibitor
Details
CilazaprilatAngiotensin-converting enzymeProteinHumans
Yes
Not AvailableDetails
CilostazolcGMP-inhibited 3',5'-cyclic phosphodiesterase AProteinHumans
Yes
Inhibitor
Details
CimetidineHistamine H2 receptorProteinHumans
Yes
Antagonist
Details
CinacalcetExtracellular calcium-sensing receptorProteinHumans
Yes
Agonist
Details
CinalukastCysteinyl leukotriene receptor 1ProteinHumans
Yes
Antagonist
Details
CinchocaineSodium channel protein type 5 subunit alphaProteinHumans
Yes
Inhibitor
Details
CinnarizineHistamine H1 receptorProteinHumans
Yes
Antagonist
Details
CiprofloxacinDNA topoisomerase 2-alphaProteinHumans
Unknown
Inhibitor
Details
Cisapride5-hydroxytryptamine receptor 4ProteinHumans
Yes
Agonist
Details
ClemastineHistamine H1 receptorProteinHumans
Yes
Antagonist
Details
ClenbuterolBeta-2 adrenergic receptorProteinHumans
Yes
Agonist
Details
ClidiniumMuscarinic acetylcholine receptor M1ProteinHumans
Yes
Antagonist
Details
Clodronic acidADP/ATP translocase 1ProteinHumans
Yes
Inhibitor
Details
ClofedanolHistamine H1 receptorProteinHumans
Yes
Antagonist
Details
ClomifeneEstrogen receptor alphaProteinHumans
Yes
Antagonist
Agonist
Details
ClozapineDopamine D1 receptorProteinHumans
Unknown
Antagonist
Details
ClozapineDopamine D2 receptorProteinHumans
Yes
Antagonist
Details
ClozapineDopamine D4 receptorProteinHumans
Unknown
Antagonist
Details
ClozapineHistamine H1 receptorProteinHumans
No
Antagonist
Details
ClozapineHistamine H4 receptorProteinHumans
No
Antagonist
Details
ClozapineNeuron-specific vesicular protein calcyonProteinHumans
Unknown
Unknown
Details
Coagulation Factor IX (Recombinant)Coagulation factor XProteinHumans
Yes
Activator
Details
Coagulation Factor IX HumanCoagulation factor XProteinHumans
Yes
Activator
Details
ConivaptanVasopressin V1a receptorProteinHumans
Yes
Antagonist
Details
ConivaptanVasopressin V2 receptorProteinHumans
Yes
Antagonist
Details
CyclizineHistamine H1 receptorProteinHumans
Yes
Antagonist
Details
CycloserineD-alanine--D-alanine ligase AProteinEscherichia coli (strain K12)
Yes
Inhibitor
Details
CyclothiazideCarbonic anhydrase 2ProteinHumans
Unknown
Inhibitor
Details
CycrimineMuscarinic acetylcholine receptor M1ProteinHumans
Yes
Antagonist
Details
CyproheptadineHistamine H1 receptorProteinHumans
Yes
Antagonist
Details
D-SerineGlycine receptor subunit alpha-1ProteinHumans
Unknown
Not AvailableDetails
DaclizumabInterleukin-2 receptor subunit alphaProteinHumans
Yes
Antibody
Details
DaclizumabInterleukin-2 receptor subunit betaProteinHumans
Yes
Antibody
Details
DanazolEstrogen receptor alphaProteinHumans
Yes
Agonist
Details
DantroleneRyanodine receptor 1ProteinHumans
Yes
Antagonist
Details
Darbepoetin alfaErythropoietin receptorProteinHumans
Yes
Agonist
Details
DarifenacinMuscarinic acetylcholine receptor M3ProteinHumans
Yes
Antagonist
Details
DasatinibAbelson tyrosine-protein kinase 2ProteinHumans
Unknown
Multitarget
Details
DasatinibProto-oncogene tyrosine-protein kinase SrcProteinHumans
Yes
Multitarget
Details
DasatinibTyrosine-protein kinase ABL1ProteinHumans
Yes
Multitarget
Details
DasatinibTyrosine-protein kinase FynProteinHumans
Unknown
Multitarget
Details
DasatinibTyrosine-protein kinase LckProteinHumans
Yes
Multitarget
Details
DazoxibenThromboxane-A synthaseProteinHumans
Unknown
Inhibitor
Details
DecamethoniumNeuronal acetylcholine receptor subunit alpha-2ProteinHumans
Yes
Partial agonist
Details
DecitabineDNA (cytosine-5)-methyltransferase 1ProteinHumans
Yes
Inhibitor
Details
DemecariumAcetylcholinesteraseProteinHumans
Yes
Inhibitor
Details
Denileukin diftitoxInterleukin-2 receptor subunit betaProteinHumans
Yes
Agonist
Details
DesipramineSodium-dependent noradrenaline transporterProteinHumans
Yes
Inhibitor
Details
DeslanosideSodium/potassium-transporting ATPase subunit alpha-1ProteinHumans
Yes
Inhibitor
Details
DesloratadineHistamine H1 receptorProteinHumans
Yes
Antagonist
Details
DesmopressinVasopressin V2 receptorProteinHumans
Yes
Agonist
Details
DesogestrelProgesterone receptorProteinHumans
Yes
Agonist
Details
Desoxycorticosterone pivalateMineralocorticoid receptorProteinHumans
Yes
Agonist
Details
DexamethasoneGlucocorticoid receptorProteinHumans
Yes
Agonist
Details
DexamethasoneNitric oxide synthase, inducibleProteinHumans
Unknown
Negative modulator
Details
DexbrompheniramineHistamine H1 receptorProteinHumans
Yes
Antagonist
Details
DexmethylphenidateSodium-dependent dopamine transporterProteinHumans
Yes
Inhibitor
Details
DexrazoxaneDNA topoisomerase 2-alphaProteinHumans
Yes
Inhibitor
Details
DextroamphetamineAlpha-1B adrenergic receptorProteinHumans
Unknown
Antagonist
Details
DextromethorphanSigma non-opioid intracellular receptor 1ProteinHumans
Yes
Agonist
Details
DextropropoxypheneKappa-type opioid receptorProteinHumans
Yes
Antagonist
Details
DextropropoxypheneMu-type opioid receptorProteinHumans
Yes
Agonist
Details
DezocineKappa-type opioid receptorProteinHumans
Yes
Antagonist
Details
DiamorphineDelta-type opioid receptorProteinHumans
Unknown
Agonist
Details
DiclofenacProstaglandin G/H synthase 1ProteinHumans
Yes
Inhibitor
Details
DicoumarolVitamin K epoxide reductase complex subunit 1ProteinHumans
Yes
Inhibitor
Details
DicyclomineMuscarinic acetylcholine receptor M1ProteinHumans
Yes
Antagonist
Details
DienestrolEstrogen receptor alphaProteinHumans
Yes
Agonist
Details
DiethylcarbamazineArachidonate 5-lipoxygenaseProteinHumans
Yes
Inhibitor
Details
DiethylstilbestrolEstrogen receptor alphaProteinHumans
Yes
Agonist
Details
DiflunisalProstaglandin G/H synthase 2ProteinHumans
Yes
Inhibitor
Details
Dihomo-gamma-linolenic acidProstaglandin G/H synthase 1ProteinHumans
Yes
Inhibitor
Details
Dihydroergotamine5-hydroxytryptamine receptor 1DProteinHumans
Yes
Agonist
Details
Dihydroergotamine5-hydroxytryptamine receptor 2BProteinHumans
Unknown
Agonist
Details
DihydrotachysterolVitamin D3 receptorProteinHumans
Yes
Agonist
Details
DimenhydrinateHistamine H1 receptorProteinHumans
Yes
Antagonist
Details
Dinoprost tromethamineProstacyclin receptorProteinHumans
Unknown
Antagonist
Details
DinoprostoneProstaglandin E2 receptor EP2 subtypeProteinHumans
Yes
Agonist
Details
DiphemanilMuscarinic acetylcholine receptor M3ProteinHumans
Yes
Antagonist
Details
DiphenhydramineHistamine H1 receptorProteinHumans
Yes
Antagonist
Details
DiphenoxylateMu-type opioid receptorProteinHumans
Yes
Agonist
Details
DiphenylpyralineHistamine H1 receptorProteinHumans
Yes
Antagonist
Details
DipivefrinBeta-2 adrenergic receptorProteinHumans
Yes
Agonist
Details
DipyridamoleAdenosine deaminaseProteinHumans
Yes
Inhibitor
Details
DipyridamolecAMP-specific 3',5'-cyclic phosphodiesterase 4AProteinHumans
Yes
Inhibitor
Details
DipyridamolecGMP-specific 3',5'-cyclic phosphodiesteraseProteinHumans
Yes
Inhibitor
Details
DisopyramideSodium channel protein type 5 subunit alphaProteinHumans
Yes
Inhibitor
Details
DobutamineBeta-1 adrenergic receptorProteinHumans
Yes
Agonist
Details
DofetilidePotassium voltage-gated channel subfamily H member 2ProteinHumans
Yes
Inhibitor
Details
Dolasetron5-hydroxytryptamine receptor 3AProteinHumans
Yes
Antagonist
Details
DomperidoneDopamine D2 receptorProteinHumans
Yes
Antagonist
Details
DonepezilAcetylcholinesteraseProteinHumans
Yes
Inhibitor
Details
DopamineDopamine D2 receptorProteinHumans
Yes
Agonist
Details
DorzolamideCarbonic anhydrase 2ProteinHumans
Yes
Inhibitor
Details
DoxacuriumNeuronal acetylcholine receptor subunit alpha-2ProteinHumans
Yes
Antagonist
Details
DoxepinHistamine H1 receptorProteinHumans
Yes
Antagonist
Details
DoxorubicinDNA topoisomerase 2-alphaProteinHumans
Yes
Inhibitor
Details
DoxylamineHistamine H1 receptorProteinHumans
Yes
Antagonist
Details
DronabinolCannabinoid receptor 1ProteinHumans
Yes
Agonist
Details
DrostanoloneAndrogen receptorProteinHumans
Yes
Agonist
Details
Drotrecogin alfaCoagulation factor VProteinHumans
Yes
Multitarget
Details
Drotrecogin alfaCoagulation factor VIIIProteinHumans
Yes
Multitarget
Details
DuloxetineSodium-dependent noradrenaline transporterProteinHumans
Yes
Inhibitor
Details
Dutasteride3-oxo-5-alpha-steroid 4-dehydrogenase 1ProteinHumans
Yes
Inhibitor
Details
Dutasteride3-oxo-5-alpha-steroid 4-dehydrogenase 2ProteinHumans
Yes
Inhibitor
Details
DydrogesteroneProgesterone receptorProteinHumans
Yes
Agonist
Details
DyphyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4AProteinHumans
Yes
Inhibitor
Details
EchothiophateCholinesteraseProteinHumans
Yes
Inhibitor
Details
EculizumabComplement C5ProteinHumans
Yes
Antibody
Details
EdrophoniumAcetylcholinesteraseProteinHumans
Yes
Inhibitor
Details
EfalizumabIntegrin alpha-LProteinHumans
Yes
Antibody
Details
Eletriptan5-hydroxytryptamine receptor 1BProteinHumans
Yes
Agonist
Details
Eletriptan5-hydroxytryptamine receptor 1DProteinHumans
Yes
Agonist
Details
EmedastineHistamine H1 receptorProteinHumans
Yes
Antagonist
Details
EnalaprilAngiotensin-converting enzymeProteinHumans
Yes
Inhibitor
Details
EnalkirenReninProteinHumans
Unknown
Inhibitor
Details
EncainideSodium channel protein type 5 subunit alphaProteinHumans
Yes
Inhibitor
Details
EnoxacinDNA topoisomerase 2-alphaProteinHumans
No
Inhibitor
Details
EnprofyllineAdenosine receptor A2bProteinHumans
Yes
Antagonist
Details
EnprofyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4AProteinHumans
Yes
Inhibitor
Details
EntacaponeCatechol O-methyltransferaseProteinHumans
Yes
Inhibitor
Details
EpinastineHistamine H1 receptorProteinHumans
Yes
Antagonist
Details
EpinephrineBeta-1 adrenergic receptorProteinHumans
Yes
Agonist
Details
EpinephrineBeta-2 adrenergic receptorProteinHumans
Yes
Agonist
Details
EplerenoneMineralocorticoid receptorProteinHumans
Yes
Antagonist
Details
EpoprostenolProstacyclin receptorProteinHumans
Yes
Agonist
Details
EprosartanType-1 angiotensin II receptorProteinHumans
Yes
Antagonist
Details
ErgocalciferolVitamin D3 receptorProteinHumans
Yes
Agonist
Details
Ergotamine5-hydroxytryptamine receptor 2AProteinHumans
Yes
Agonist
Details
ErlotinibEpidermal growth factor receptorProteinHumans
Yes
Antagonist
Details
ErythropoietinErythropoietin receptorProteinHumans
Yes
Agonist
Details
EsmololBeta-1 adrenergic receptorProteinHumans
Yes
Antagonist
Details
EsomeprazolePotassium-transporting ATPase alpha chain 1ProteinHumans
Yes
Inhibitor
Details
Estradiol acetateEstrogen receptor alphaProteinHumans
Yes
Agonist
Details
Estradiol benzoateEstrogen receptor alphaProteinHumans
Yes
Agonist
Details
Estradiol cypionateEstrogen receptor alphaProteinHumans
Yes
Agonist
Details
Estradiol dienanthateEstrogen receptor alphaProteinHumans
Yes
Agonist
Details
Estradiol valerateEstrogen receptor alphaProteinHumans
Yes
Agonist
Details
EstriolEstrogen receptor alphaProteinHumans
Yes
Agonist
Details
Estriol tripropionateEstrogen receptor alphaProteinHumans
Yes
Not AvailableDetails
EstroneEstrogen receptor alphaProteinHumans
Yes
Agonist
Details
Estrone sulfateEstrogen receptor alphaProteinHumans
Yes
Agonist
Details
Etacrynic acidSolute carrier family 12 member 1ProteinHumans
Yes
Inhibitor
Details
EtanerceptTumor necrosis factorProteinHumans
Yes
Antibody
Details
EthanolGamma-aminobutyric acid receptor subunit alpha-1ProteinHumans
Yes
Agonist
Details
EthinamateCarbonic anhydrase 2ProteinHumans
Yes
Inhibitor
Details
EthinylestradiolEstrogen receptor alphaProteinHumans
Yes
Agonist
Details
EthionamideEnoyl-[acyl-carrier-protein] reductase [NADH]ProteinMycobacterium tuberculosis
Yes
Adduct
Details
EthosuximideVoltage-dependent T-type calcium channel subunit alpha-1GProteinHumans
Yes
Inhibitor
Details
EthotoinSodium channel protein type 5 subunit alphaProteinHumans
Yes
Inhibitor
Details
EthylmorphineMu-type opioid receptorProteinHumans
Yes
Agonist
Details
Ethynodiol diacetateProgesterone receptorProteinHumans
Yes
Agonist
Details
Etidronic acidReceptor-type tyrosine-protein phosphatase SProteinHumans
Unknown
Inhibitor
Details
EtodolacProstaglandin G/H synthase 2ProteinHumans
Yes
Inhibitor
Details
EtomidateGamma-aminobutyric acid receptor subunit alpha-1ProteinHumans
Yes
Agonist
Details
EtonogestrelProgesterone receptorProteinHumans
Yes
Agonist
Details
EtoposideDNA topoisomerase 2-alphaProteinHumans
Yes
Inhibitor
Details
EtoricoxibProstaglandin G/H synthase 2ProteinHumans
Yes
Inhibitor
Details
EtorphineDelta-type opioid receptorProteinHumans
Yes
Agonist
Details
EtorphineMu-type opioid receptorProteinHumans
Yes
Agonist
Details
EverolimusSerine/threonine-protein kinase mTORProteinHumans
Yes
Inhibitor
Details
ExemestaneCytochrome P450 19A1ProteinHumans
Yes
Inhibitor
Details
ExenatideGlucagon-like peptide 1 receptorProteinHumans
Yes
Agonist
Details
EzetimibeNiemann-Pick C1-like protein 1ProteinHumans
Yes
Inhibitor
Details
FamotidineHistamine H2 receptorProteinHumans
Yes
Antagonist
Details
FelbamateGlutamate receptor ionotropic, NMDA 2AProteinHumans
Yes
Antagonist
Details
FelbamateGlutamate receptor ionotropic, NMDA 2BProteinHumans
Yes
Antagonist
Details
FelodipineVoltage-dependent calcium channel subunit alpha-2/delta-1ProteinHumans
Yes
Inhibitor
Details
FelodipineVoltage-dependent L-type calcium channel subunit alpha-1CProteinHumans
Yes
Inhibitor
Details
FelodipineVoltage-dependent L-type calcium channel subunit beta-2ProteinHumans
Yes
Inhibitor
Details
FelypressinVasopressin V1a receptorProteinHumans
Yes
Agonist
Details
FenofibratePeroxisome proliferator-activated receptor alphaProteinHumans
Yes
Agonist
Details
FenoldopamDopamine D1 receptorProteinHumans
Yes
Agonist
Details
FenoterolBeta-2 adrenergic receptorProteinHumans
Yes
Agonist
Details
FentanylMu-type opioid receptorProteinHumans
Yes
Agonist
Details
FesoterodineMuscarinic acetylcholine receptor M3ProteinHumans
Yes
Antagonist
Details
FidarestatAldose reductaseProteinHumans
Unknown
Inhibitor
Details
FlecainideSodium channel protein type 5 subunit alphaProteinHumans
Yes
Inhibitor
Details
FleroxacinDNA topoisomerase 2-alphaProteinHumans
Yes
Inhibitor
Details
FlunarizineVoltage-dependent T-type calcium channel subunit alpha-1HProteinHumans
Yes
Inhibitor
Details
FlunisolideGlucocorticoid receptorProteinHumans
Yes
Agonist
Details
FluorouracilThymidylate synthaseProteinHumans
Yes
Other/unknown
Details
FluoxetineSodium-dependent serotonin transporterProteinHumans
Yes
Inhibitor
Details
FluoxymesteroneAndrogen receptorProteinHumans
Yes
Agonist
Details
FlupentixolDopamine D2 receptorProteinHumans
Yes
Antagonist
Details
FluphenazineDopamine D1 receptorProteinHumans
Yes
Antagonist
Details
FluphenazineDopamine D2 receptorProteinHumans
Yes
Antagonist
Details
FluspirileneDopamine D2 receptorProteinHumans
Yes
Antagonist
Details
FlutamideAndrogen receptorProteinHumans
Yes
Antagonist
Details
Fluticasone propionateGlucocorticoid receptorProteinHumans
Yes
Agonist
Details
Fluvastatin3-hydroxy-3-methylglutaryl-coenzyme A reductaseProteinHumans
Yes
Inhibitor
Details
Folic acidFolate receptor betaProteinHumans
Unknown
Binder
Details
Folic acidFolate receptor gammaProteinHumans
Unknown
Binder
Details
FollitropinFollicle-stimulating hormone receptorProteinHumans
Yes
Agonist
Details
ForasartanType-1 angiotensin II receptorProteinHumans
Yes
Antagonist
Details
FosamprenavirHuman immunodeficiency virus type 1 proteaseProteinHuman immunodeficiency virus 1
Yes
Inhibitor
Details
FosinoprilAngiotensin-converting enzymeProteinHumans
Yes
Inhibitor
Details
FosphenytoinSodium channel protein type 5 subunit alphaProteinHumans
Yes
Inhibitor
Details
FreselestatNeutrophil elastaseProteinHumans
Unknown
Inhibitor
Details
Frovatriptan5-hydroxytryptamine receptor 1BProteinHumans
Yes
Agonist
Details
Frovatriptan5-hydroxytryptamine receptor 1DProteinHumans
Yes
Agonist
Details
FulvestrantEstrogen receptor alphaProteinHumans
Yes
Antagonist
Details
FumagillinMethionine aminopeptidase 2ProteinHumans
Unknown
Ligand
Details
FurosemideSolute carrier family 12 member 1ProteinHumans
Yes
Inhibitor
Details
Gallamine triethiodideMuscarinic acetylcholine receptor M2ProteinHumans
Yes
Antagonist
Details
GefitinibEpidermal growth factor receptorProteinHumans
Yes
Antagonist
Details
GemcitabineThymidylate synthaseProteinHumans
Unknown
Inhibitor
Details
Gemtuzumab ozogamicinMyeloid cell surface antigen CD33ProteinHumans
Yes
Antibody
Details
GlatiramerHLA class II histocompatibility antigen, DRB1-1 beta chainProteinHumans
Unknown
Binder
Details
GlucagonGlucagon receptorProteinHumans
Yes
Agonist
Details
GlycineGlutamate receptor ionotropic, NMDA 2AProteinHumans
Unknown
Antagonist
Details
GlycopyrroniumMuscarinic acetylcholine receptor M1ProteinHumans
Yes
Antagonist
Details
Glyphosate3-phosphoshikimate 1-carboxyvinyltransferaseProteinStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Unknown
Inhibitor
Details
GonadorelinGonadotropin-releasing hormone receptorProteinHumans
Yes
Agonist
Details
Granisetron5-hydroxytryptamine receptor 3AProteinHumans
Yes
Antagonist
Details
GuanineGTP cyclohydrolase 1ProteinHumans
Unknown
Inhibitor
Details
HadacidinAdenylosuccinate synthetaseProteinPlasmodium falciparum
Unknown
Inhibitor
Details
HaloperidolDopamine D1 receptorProteinHumans
Unknown
Antagonist
Details
HaloperidolDopamine D2 receptorProteinHumans
Yes
Antagonist
Details
HaloperidolGlutamate receptor ionotropic, NMDA 2BProteinHumans
Unknown
Antagonist
Details
HeparinAntithrombin-IIIProteinHumans
Yes
Potentiator
Details
HexafluroniumCholinesteraseProteinHumans
Yes
Inhibitor
Details
HexobarbitalGamma-aminobutyric acid receptor subunit alpha-1ProteinHumans
Yes
Potentiator
Details
HexylcaineSodium channel protein type 5 subunit alphaProteinHumans
Yes
Inhibitor
Details
HistamineHistamine H2 receptorProteinHumans
Yes
Agonist
Details
Homatropine methylbromideMuscarinic acetylcholine receptor M5ProteinHumans
Yes
Antagonist
Details
HydralazineProlyl 4-hydroxylase subunit alpha-1ProteinHumans
Unknown
Inhibitor
Details
HydrochlorothiazideSolute carrier family 12 member 3ProteinHumans
Yes
Inhibitor
Details
HydrocodoneMu-type opioid receptorProteinHumans
Yes
Agonist
Details
HydroflumethiazideSolute carrier family 12 member 1ProteinHumans
Yes
Inhibitor
Details
HydromorphoneDelta-type opioid receptorProteinHumans
Yes
Partial agonist
Details
HydroxocobalaminMethylmalonyl-CoA mutase, mitochondrialProteinHumans
Yes
Cofactor
Details
HydroxyfasudilRho-associated protein kinase 1ProteinHumans
Unknown
Inhibitor
Details
HymenialdisineCyclin-dependent kinase 1ProteinHumans
Unknown
Not AvailableDetails
HymenialdisineCyclin-dependent kinase 2ProteinHumans
Unknown
Inhibitor
Details
HymenialdisineCyclin-dependent kinase 5ProteinHumans
Unknown
Inhibitor
Details
HyperforinArachidonate 5-lipoxygenaseProteinHumans
Unknown
Inhibitor
Details
HyperforinProstaglandin G/H synthase 1ProteinHumans
Unknown
Inhibitor
Details
IbandronateFarnesyl pyrophosphate synthaseProteinHumans
Yes
Inhibitor
Details
Ibritumomab tiuxetanB-lymphocyte antigen CD20ProteinHumans
Yes
Antibody
Details
IbuprofenProstaglandin G/H synthase 1ProteinHumans
Yes
Inhibitor
Details
IbuprofenProstaglandin G/H synthase 2ProteinHumans
Yes
Inhibitor
Details
IbutilideVoltage-dependent L-type calcium channel subunit alpha-1CProteinHumans
Yes
Activator
Details
IcatibantB2 bradykinin receptorProteinHumans
Yes
Antagonist
Details
IdarubicinDNA topoisomerase 2-alphaProteinHumans
Yes
Inhibitor
Details
ImiquimodToll-like receptor 7ProteinHumans
Yes
Agonist
Details
Immucillin-GPurine nucleoside phosphorylaseProteinHumans
Unknown
Not AvailableDetails
IndecainideSodium channel protein type 5 subunit alphaProteinHumans
Yes
Inhibitor
Details
Indirubin-3'-monoximeCyclin-dependent kinase 1ProteinHumans
Unknown
Binder
Details
Indirubin-3'-monoximeCyclin-dependent kinase 2ProteinHumans
Unknown
Inhibitor
Details
Indirubin-3'-monoximeCyclin-dependent kinase 5ProteinHumans
Unknown
Inhibitor
Details
InfliximabTumor necrosis factorProteinHumans
Yes
Inhibitor
Details
Insulin detemirInsulin receptorProteinHumans
Yes
Agonist
Details
Insulin glargineInsulin receptorProteinHumans
Yes
Agonist
Details
Insulin humanInsulin receptorProteinHumans
Yes
Agonist
Details
Insulin lisproInsulin receptorProteinHumans
Yes
Agonist
Details
Insulin porkInsulin receptorProteinHumans
Yes
Binder
Details
Interferon alfa-2bInterferon alpha/beta receptor 1ProteinHumans
Yes
Binder
Details
Interferon alfa-2bInterferon alpha/beta receptor 2ProteinHumans
Yes
Binder
Details
Interferon alfa-n1Interferon alpha/beta receptor 1ProteinHumans
Yes
Agonist
Details
Interferon alfa-n1Interferon alpha/beta receptor 2ProteinHumans
Yes
Agonist
Details
Interferon alfa-n3Interferon alpha/beta receptor 1ProteinHumans
Yes
Agonist
Details
Interferon alfa-n3Interferon alpha/beta receptor 2ProteinHumans
Yes
Agonist
Details
Interferon alfacon-1Interferon alpha/beta receptor 1ProteinHumans
Yes
Binder
Details
Interferon alfacon-1Interferon alpha/beta receptor 2ProteinHumans
Yes
Binder
Details
Interferon beta-1bInterferon alpha/beta receptor 1ProteinHumans
Yes
Agonist
Details
Interferon beta-1bInterferon alpha/beta receptor 2ProteinHumans
Yes
Agonist
Details
Interferon gamma-1bInterferon gamma receptor 1ProteinHumans
Yes
Binder
Details
Interferon gamma-1bInterferon gamma receptor 2ProteinHumans
Yes
Binder
Details
InulinCycloinulo-oligosaccharide fructanotransferaseProteinPaenibacillus macerans
No
Binder
Details
IrbesartanType-1 angiotensin II receptorProteinHumans
Yes
Antagonist
Details
IrinotecanDNA topoisomerase 1ProteinHumans
Yes
Inhibitor
Details
IrinotecanDNA topoisomerase I, mitochondrialProteinHumans
Yes
Inhibitor
Details
Iron DextranHemoglobin subunit alphaProteinHumans
Yes
Activator
Details
Iron DextranHemoglobin subunit betaProteinHumans
Yes
Activator
Details
IsocarboxazidAmine oxidase [flavin-containing] AProteinHumans
Yes
Inhibitor
Details
IsoflurophateAcetylcholinesteraseProteinHumans
Yes
Inhibitor
Details
IsoniazidEnoyl-[acyl-carrier-protein] reductase [NADH]ProteinMycobacterium tuberculosis
Yes
Adduct
Details
IsoprenalineBeta-1 adrenergic receptorProteinHumans
Yes
Agonist
Details
IsoprenalineBeta-2 adrenergic receptorProteinHumans
Yes
Agonist
Binder
Details
IsradipineVoltage-dependent calcium channel subunit alpha-2/delta-1ProteinHumans
Yes
Inhibitor
Details
IsradipineVoltage-dependent L-type calcium channel subunit beta-2ProteinHumans
Yes
Inhibitor
Details
ItraconazoleLanosterol 14-alpha demethylaseProteinHumans
Yes
Inhibitor
Details
KetoprofenProstaglandin G/H synthase 2ProteinHumans
Yes
Inhibitor
Details
LabetalolBeta-1 adrenergic receptorProteinHumans
Yes
Antagonist
Details
LabetalolBeta-2 adrenergic receptorProteinHumans
Yes
Antagonist
Details
LansoprazolePotassium-transporting ATPase alpha chain 1ProteinHumans
Yes
Inhibitor
Details
LapatinibEpidermal growth factor receptorProteinHumans
Yes
Antagonist
Details
LapatinibReceptor tyrosine-protein kinase erbB-2ProteinHumans
Yes
Antagonist
Details
LeflunomideDihydroorotate dehydrogenase (quinone), mitochondrialProteinHumans
Yes
Inhibitor
Details
LepirudinProthrombinProteinHumans
Yes
Inhibitor
Details
LetrozoleCytochrome P450 19A1ProteinHumans
Yes
Antagonist
Details
LevacetylmethadolMu-type opioid receptorProteinHumans
Yes
Agonist
Details
LevobunololBeta-2 adrenergic receptorProteinHumans
Yes
Antagonist
Details
LevocabastineHistamine H1 receptorProteinHumans
Yes
Antagonist
Details
LevocarnitineCarnitine O-palmitoyltransferase 1, liver isoformProteinHumans
Unknown
Activator
Details
LevomentholTransient receptor potential cation channel subfamily A member 1ProteinHumans
Yes
Inducer
Details
LevomentholTransient receptor potential cation channel subfamily M member 8ProteinHumans
Yes
Inducer
Details
LevosimendanTroponin C, slow skeletal and cardiac musclesProteinHumans
Yes
Potentiator
Details
LevothyroxineThyroid hormone receptor alphaProteinHumans
Yes
Agonist
Details
LicofeloneArachidonate 5-lipoxygenaseProteinHumans
Unknown
Not AvailableDetails
LiothyronineThyroid hormone receptor alphaProteinHumans
Yes
Agonist
Details
LiotrixThyroid hormone receptor alphaProteinHumans
Yes
Agonist
Details
LisinoprilAngiotensin-converting enzymeProteinHumans
Yes
Inhibitor
Details
LisurideDopamine D2 receptorProteinHumans
Yes
Agonist
Details
LomefloxacinDNA topoisomerase 2-alphaProteinHumans
Unknown
Inhibitor
Details
LoperamideDelta-type opioid receptorProteinHumans
Yes
Agonist
Details
LoperamideMu-type opioid receptorProteinHumans
Yes
Agonist
Details
LopinavirHuman immunodeficiency virus type 1 proteaseProteinHuman immunodeficiency virus 1
Yes
Inhibitor
Details
LoratadineHistamine H1 receptorProteinHumans
Yes
Antagonist
Details
LosartanType-1 angiotensin II receptorProteinHumans
Yes
Antagonist
Details
Loteprednol etabonateGlucocorticoid receptorProteinHumans
Yes
Agonist
Details
Lovastatin3-hydroxy-3-methylglutaryl-coenzyme A reductaseProteinHumans
Yes
Inhibitor
Details
LoxapineDopamine D1 receptorProteinHumans
Unknown
Antagonist
Details
LoxapineDopamine D2 receptorProteinHumans
Yes
Antagonist
Details
LubiprostoneChloride channel protein 2ProteinHumans
Yes
Inducer
Details
LucanthoneDNA topoisomerase 2-alphaProteinHumans
Yes
Inhibitor
Details
LumiracoxibProstaglandin G/H synthase 2ProteinHumans
Yes
Inhibitor
Details
Lutropin alfaLutropin-choriogonadotropic hormone receptorProteinHumans
Yes
Agonist
Details
LypressinVasopressin V2 receptorProteinHumans
Yes
Not AvailableDetails
MaravirocC-C chemokine receptor type 5ProteinHumans
Yes
Antagonist
Details
Marimastat72 kDa type IV collagenaseProteinHumans
Yes
Inhibitor
Details
MarimastatInterstitial collagenaseProteinHumans
Yes
Inhibitor
Details
MarimastatMatrix metalloproteinase-9ProteinHumans
Yes
Inhibitor
Details
MarimastatStromelysin-1ProteinHumans
Yes
Antagonist
Details
MasoprocolArachidonate 5-lipoxygenaseProteinHumans
Yes
Inhibitor
Details
MecamylamineNeuronal acetylcholine receptor subunit alpha-2ProteinHumans
Yes
Antagonist
Details
Medroxyprogesterone acetateProgesterone receptorProteinHumans
Yes
Agonist
Details
MedrysoneGlucocorticoid receptorProteinHumans
Yes
Agonist
Details
Mefenamic acidProstaglandin G/H synthase 2ProteinHumans
Yes
Inhibitor
Details
Megestrol acetateProgesterone receptorProteinHumans
Yes
Agonist
Details
MelatoninMelatonin receptor type 1AProteinHumans
Yes
Agonist
Details
MenotropinsFollicle-stimulating hormone receptorProteinHumans
Yes
Binder
Details
MephenytoinSodium channel protein type 5 subunit alphaProteinHumans
Yes
Inhibitor
Details
MeprobamateGamma-aminobutyric acid receptor subunit alpha-1ProteinHumans
Yes
Agonist
Details
MequitazineHistamine H1 receptorProteinHumans
Yes
Antagonist
Details
MercaptopurineInosine-5'-monophosphate dehydrogenase (Protein Group)Protein groupHumans
Unknown
Inhibitor
Details
MesalazineProstaglandin G/H synthase 1ProteinHumans
Yes
Inhibitor
Details
MesoridazineDopamine D2 receptorProteinHumans
Yes
Antagonist
Details
MestranolEstrogen receptor alphaProteinHumans
Yes
Agonist
Details
MetamizoleProstaglandin G/H synthase 1ProteinHumans
Unknown
Not AvailableDetails
Methadyl acetateMu-type opioid receptorProteinHumans
Yes
Agonist
Details
MetharbitalGamma-aminobutyric acid receptor subunit alpha-1ProteinHumans
Yes
Potentiator
Details
MethdilazineHistamine H1 receptorProteinHumans
Yes
Antagonist
Details
MethimazoleThyroid peroxidaseProteinHumans
Yes
Substrate
Inhibitor
Details
MethohexitalGamma-aminobutyric acid receptor subunit alpha-1ProteinHumans
Yes
Antagonist
Details
MethotrexateDihydrofolate reductaseProteinHumans
Yes
Inhibitor
Details
MethoxamineAlpha-1B adrenergic receptorProteinHumans
Unknown
Agonist
Details
MethoxyfluraneGamma-aminobutyric acid receptor subunit alpha-1ProteinHumans
Yes
Agonist
Details
Methscopolamine bromideMuscarinic acetylcholine receptor M2ProteinHumans
Yes
Antagonist
Details
MethyclothiazideSolute carrier family 12 member 1ProteinHumans
Yes
Inhibitor
Details
MethylergometrineDopamine D1 receptorProteinHumans
Yes
Antagonist
Details
MethylphenidateSodium-dependent dopamine transporterProteinHumans
Yes
Inhibitor
Details
MethylphenobarbitalGamma-aminobutyric acid receptor subunit alpha-1ProteinHumans
Yes
Potentiator
Details
MethylprednisoloneGlucocorticoid receptorProteinHumans
Yes
Agonist
Details
MethyltestosteroneAndrogen receptorProteinHumans
Yes
Agonist
Details
MethyprylonGamma-aminobutyric acid receptor subunit alpha-1ProteinHumans
Yes
Agonist
Details
Methysergide5-hydroxytryptamine receptor 2CProteinHumans
Yes
Antagonist
Details
MetocurineNeuronal acetylcholine receptor subunit alpha-2ProteinHumans
Yes
Antagonist
Details
Metocurine iodideNeuronal acetylcholine receptor subunit alpha-2ProteinHumans
Yes
Antagonist
Details
MetolazoneSolute carrier family 12 member 3ProteinHumans
Yes
Inhibitor
Details
MetoprololBeta-1 adrenergic receptorProteinHumans
Yes
Antagonist
Details
MetyraponeCytochrome P450 11B1, mitochondrialProteinHumans
Yes
Inhibitor
Details
MetyrosineTyrosine 3-monooxygenaseProteinHumans
Yes
Binder
Details
Mevastatin3-hydroxy-3-methylglutaryl-coenzyme A reductaseProteinHumans
Yes
Inhibitor
Details
MexiletineSodium channel protein type 5 subunit alphaProteinHumans
Yes
Inhibitor
Details
MibefradilVoltage-dependent T-type calcium channel subunit alpha-1GProteinHumans
Yes
Inhibitor
Details
MifepristoneProgesterone receptorProteinHumans
Yes
Antagonist
Details
MiglitolMaltase-glucoamylase, intestinalProteinHumans
Yes
Antagonist
Inhibitor
Details
MiglustatCeramide glucosyltransferaseProteinHumans
Yes
Inhibitor
Details
MilrinonecGMP-inhibited 3',5'-cyclic phosphodiesterase AProteinHumans
Yes
Inhibitor
Details
Minaprine5-hydroxytryptamine receptor 2BProteinHumans
Yes
Antagonist
Details
MipomersenmRNA of ApoB-100NucleotideHumans
Yes
Binder
Details
MitoxantroneDNA topoisomerase 2-alphaProteinHumans
Yes
Inhibitor
Details
MivacuriumNeuronal acetylcholine receptor subunit alpha-2ProteinHumans
Yes
Antagonist
Details
MoclobemideAmine oxidase [flavin-containing] AProteinHumans
Yes
Antagonist
Inhibitor
Details
MoexiprilAngiotensin-converting enzymeProteinHumans
Yes
Inhibitor
Details
MolindoneDopamine D2 receptorProteinHumans
Yes
Antagonist
Details
MometasoneGlucocorticoid receptorProteinHumans
Yes
Agonist
Details
Mometasone furoateGlucocorticoid receptorProteinHumans
Yes
Not AvailableDetails
MontelukastCysteinyl leukotriene receptor 1ProteinHumans
Yes
Antagonist
Details
MoricizineSodium channel protein type 5 subunit alphaProteinHumans
Yes
Inhibitor
Details
MorphineDelta-type opioid receptorProteinHumans
Yes
Agonist
Details
MorphineMu-type opioid receptorProteinHumans
Yes
Agonist
Details
MoxifloxacinDNA topoisomerase 2-alphaProteinHumans
Unknown
Inhibitor
Details
MuromonabT-cell surface glycoprotein CD3 epsilon chainProteinHumans
Yes
Binder
Details
Mycophenolic acidInosine-5'-monophosphate dehydrogenase 2ProteinHumans
Yes
Inhibitor
Details
N-AcetylglucosamineAlpha-N-acetylglucosaminidaseProteinHumans
Unknown
Activator
Details
NabiloneCannabinoid receptor 1ProteinHumans
Yes
Partial agonist
Details
NabumetoneProstaglandin G/H synthase 2ProteinHumans
Yes
Inhibitor
Details
NADHNADH-ubiquinone oxidoreductase chain 1ProteinHumans
Unknown
Binder
Details
NADHNADH-ubiquinone oxidoreductase chain 2ProteinHumans
Unknown
Binder
Details
NADHNADH-ubiquinone oxidoreductase chain 3ProteinHumans
Unknown
Binder
Details
NadololBeta-1 adrenergic receptorProteinHumans
Yes
Antagonist
Details
NadololBeta-2 adrenergic receptorProteinHumans
Unknown
Antagonist
Details
NafarelinGonadotropin-releasing hormone receptorProteinHumans
Yes
Agonist
Details
NaftifineSqualene monooxygenaseProteinHumans
Yes
Inhibitor
Details
NalbuphineDelta-type opioid receptorProteinHumans
Yes
Antagonist
Details
NaloxoneMu-type opioid receptorProteinHumans
Yes
Antagonist
Details
NaltrexoneDelta-type opioid receptorProteinHumans
Yes
Antagonist
Details
NaltrexoneKappa-type opioid receptorProteinHumans
Yes
Antagonist
Details
NaltrexoneMu-type opioid receptorProteinHumans
Yes
Antagonist
Details
Nandrolone phenpropionateAndrogen receptorProteinHumans
Yes
Agonist
Details
Naratriptan5-hydroxytryptamine receptor 1BProteinHumans
Yes
Agonist
Details
Naratriptan5-hydroxytryptamine receptor 1DProteinHumans
Yes
Agonist
Details
Naratriptan5-hydroxytryptamine receptor 1FProteinHumans
Yes
Agonist
Details
NatalizumabIntegrin alpha-4ProteinHumans
Yes
Antibody
Details
NatalizumabIntercellular adhesion molecule 1ProteinHumans
Unknown
Not AvailableDetails
NebivololBeta-1 adrenergic receptorProteinHumans
Yes
Antagonist
Details
Nefazodone5-hydroxytryptamine receptor 2CProteinHumans
Yes
Antagonist
Details
NefazodoneAlpha-1B adrenergic receptorProteinHumans
Unknown
Other/unknown
Details
NelfinavirHIV-1 proteaseProteinHuman Immunodeficiency Virus
Yes
Inhibitor
Details
NeostigmineAcetylcholinesteraseProteinHumans
Yes
Inhibitor
Details
NesiritideAtrial natriuretic peptide receptor 1ProteinHumans
Unknown
Binder
Details
NicardipineVoltage-dependent calcium channel subunit alpha-2/delta-1ProteinHumans
Yes
Inhibitor
Details
NicardipineVoltage-dependent L-type calcium channel subunit alpha-1CProteinHumans
Yes
Inhibitor
Details
NicardipineVoltage-dependent L-type calcium channel subunit beta-2ProteinHumans
Yes
Inhibitor
Details
NicotinamidePoly [ADP-ribose] polymerase 1ProteinHumans
Unknown
Binder
Details
NifedipineVoltage-dependent L-type calcium channel subunit alpha-1CProteinHumans
Yes
Inhibitor
Details
NifedipineVoltage-dependent L-type calcium channel subunit beta-2ProteinHumans
Yes
Inhibitor
Details
NilutamideAndrogen receptorProteinHumans
Yes
Antagonist
Details
NilvadipineVoltage-dependent calcium channel subunit alpha-2/delta-1ProteinHumans
Yes
Inhibitor
Details
NimesulideProstaglandin G/H synthase 2ProteinHumans
Yes
Inhibitor
Details
NimodipineVoltage-dependent L-type calcium channel subunit alpha-1CProteinHumans
Yes
Inhibitor
Details
NimodipineVoltage-dependent L-type calcium channel subunit beta-2ProteinHumans
Yes
Inhibitor
Details
NisoldipineVoltage-dependent calcium channel subunit alpha-2/delta-1ProteinHumans
Yes
Inhibitor
Details
NisoldipineVoltage-dependent L-type calcium channel subunit alpha-1CProteinHumans
Yes
Inhibitor
Details
NisoldipineVoltage-dependent L-type calcium channel subunit beta-2ProteinHumans
Yes
Inhibitor
Details
Nitisinone4-hydroxyphenylpyruvate dioxygenaseProteinHumans
Yes
Inhibitor
Details
NitrendipineVoltage-dependent calcium channel subunit alpha-2/delta-1ProteinHumans
Yes
Inhibitor
Details
NitrendipineVoltage-dependent L-type calcium channel subunit alpha-1CProteinHumans
Yes
Inhibitor
Details
NitrendipineVoltage-dependent L-type calcium channel subunit beta-2ProteinHumans
Yes
Inhibitor
Details
NizatidineHistamine H2 receptorProteinHumans
Yes
Antagonist
Details
NorepinephrineBeta-1 adrenergic receptorProteinHumans
Yes
Agonist
Details
NorfloxacinDNA topoisomerase 2-alphaProteinHumans
Unknown
Inhibitor
Details
NorgestimateProgesterone receptorProteinHumans
Yes
Agonist
Details
Olanzapine5-hydroxytryptamine receptor 2AProteinHumans
Yes
Antagonist
Details
Olanzapine5-hydroxytryptamine receptor 2CProteinHumans
Unknown
Antagonist
Details
OlanzapineAlpha-1B adrenergic receptorProteinHumans
Unknown
Antagonist
Details
OlanzapineDopamine D1 receptorProteinHumans
Unknown
Antagonist
Details
OlanzapineDopamine D2 receptorProteinHumans
Yes
Antagonist
Details
OlanzapineDopamine D3 receptorProteinHumans
Unknown
Antagonist
Details
OlanzapineDopamine D4 receptorProteinHumans
Unknown
Antagonist
Details
OlanzapineHistamine H1 receptorProteinHumans
Unknown
Antagonist
Details
OlmesartanType-1 angiotensin II receptorProteinHumans
Yes
Antagonist
Details
OlomoucineCyclin-dependent kinase 1ProteinHumans
Unknown
Binder
Details
OlomoucineCyclin-dependent kinase 2ProteinHumans
Unknown
Inhibitor
Details
OlomoucineCyclin-dependent kinase 5ProteinHumans
Unknown
Inhibitor
Details
OlopatadineHistamine H1 receptorProteinHumans
Yes
Antagonist
Details
Ondansetron5-hydroxytryptamine receptor 3AProteinHumans
Yes
Antagonist
Details
OprelvekinInterleukin-11 receptor subunit alphaProteinHumans
Yes
Agonist
Details
OrciprenalineBeta-2 adrenergic receptorProteinHumans
Yes
Agonist
Details
Orotic acidDihydroorotaseProteinEscherichia coli (strain K12)
Unknown
Inhibitor
Details
OuabainSodium/potassium-transporting ATPase subunit alpha-1ProteinHumans
Yes
Inhibitor
Details
OxandroloneAndrogen receptorProteinHumans
Yes
Agonist
Details
OxprenololBeta-1 adrenergic receptorProteinHumans
Yes
Antagonist
Details
OxycodoneDelta-type opioid receptorProteinHumans
Yes
Agonist
Details
OxymorphoneMu-type opioid receptorProteinHumans
Yes
Agonist
Details
OxyphenoniumMuscarinic acetylcholine receptor M1ProteinHumans
Yes
Antagonist
Details
PaliferminFibroblast growth factor receptor 2ProteinHumans
Yes
Agonist
Binder
Details
PaliperidoneDopamine D2 receptorProteinHumans
Yes
Antagonist
Details
Palonosetron5-hydroxytryptamine receptor 3AProteinHumans
Yes
Antagonist
Details
Pamidronic acidFarnesyl pyrophosphate synthaseProteinHumans
Yes
Inhibitor
Details
PanitumumabEpidermal growth factor receptorProteinHumans
Yes
Suppressor
Details
ParicalcitolVitamin D3 receptorProteinHumans
Yes
Agonist
Details
PefloxacinDNA topoisomerase 2-alphaProteinHumans
Unknown
Inhibitor
Details
Peginterferon alfa-2aInterferon alpha/beta receptor 1ProteinHumans
Yes
Agonist
Details
Peginterferon alfa-2aInterferon alpha/beta receptor 2ProteinHumans
Yes
Agonist
Details
Peginterferon alfa-2bInterferon alpha/beta receptor 1ProteinHumans
Yes
Agonist
Details
Peginterferon alfa-2bInterferon alpha/beta receptor 2ProteinHumans
Yes
Agonist
Details
PegvisomantGrowth hormone receptorProteinHumans
Yes
Antagonist
Details
PemetrexedDihydrofolate reductaseProteinHumans
Yes
Inhibitor
Details
PemetrexedThymidylate synthaseProteinHumans
Yes
Inhibitor
Details
PenciclovirDNA polymerase catalytic subunitProteinHHV-1
Yes
Inhibitor
Details
PentagastrinGastrin/cholecystokinin type B receptorProteinHumans
Yes
Agonist
Details
PentobarbitalGamma-aminobutyric acid receptor subunit alpha-1ProteinHumans
Yes
Potentiator
Details
PentostatinAdenosine deaminaseProteinHumans
Yes
Inhibitor
Details
PerhexilineCarnitine O-palmitoyltransferase 1, liver isoformProteinHumans
Yes
Inhibitor
Details
PericiazineAlpha-1B adrenergic receptorProteinHumans
Unknown
Antagonist
Details
PerindoprilAngiotensin-converting enzymeProteinHumans
Yes
Inhibitor
Details
PerphenazineDopamine D2 receptorProteinHumans
Yes
Antagonist
Details
PhenacemideSodium channel protein type 1 subunit alphaProteinHumans
Yes
Inhibitor
Details
PhenacetinProstaglandin G/H synthase 1ProteinHumans
Unknown
Not AvailableDetails
PhendimetrazineAlpha-1B adrenergic receptorProteinHumans
Unknown
Agonist
Details
PhenelzineAmine oxidase [flavin-containing] AProteinHumans
Yes
Antagonist
Details
PhenelzineAmine oxidase [flavin-containing] BProteinHumans
Yes
Antagonist
Details
PhenindamineHistamine H1 receptorProteinHumans
Yes
Antagonist
Details
PhenindioneVitamin K epoxide reductase complex subunit 1ProteinHumans
Yes
Inhibitor
Details
PheniramineHistamine H1 receptorProteinHumans
Yes
Inverse agonist
Details
PhenprocoumonVitamin K epoxide reductase complex subunit 1ProteinHumans
Yes
Inhibitor
Details
PhenylalanineTyrosine 3-monooxygenaseProteinHumans
Unknown
Binder
Details
PhenylbutazoneProstaglandin G/H synthase 2ProteinHumans
Yes
Inhibitor
Details
PhenylephrineAlpha-1B adrenergic receptorProteinHumans
Yes
Agonist
Details
PhosphoramidonNeprilysinProteinHumans
Unknown
Inhibitor
Details
PhylloquinoneVitamin K-dependent gamma-carboxylaseProteinHumans
Yes
Substrate
Inducer
Cofactor
Details
PhysostigmineAcetylcholinesteraseProteinHumans
Yes
Inhibitor
Details
PicrotoxinGamma-aminobutyric acid receptor subunit alpha-1ProteinHumans
Yes
Antagonist
Details
PilocarpineMuscarinic acetylcholine receptor M2ProteinHumans
Yes
Agonist
Details
PimagedineNitric oxide synthase, inducibleProteinHumans
Unknown
Inhibitor
Details
PimozideDopamine D2 receptorProteinHumans
Yes
Antagonist
Details
Pindolol5-hydroxytryptamine receptor 1AProteinHumans
Unknown
Antagonist
Inhibitor
Ligand
Details
PindololBeta-1 adrenergic receptorProteinHumans
Yes
Partial agonist
Details
PindololBeta-2 adrenergic receptorProteinHumans
Yes
Partial agonist
Details
PipecuroniumNeuronal acetylcholine receptor subunit alpha-2ProteinHumans
Yes
Antagonist
Details
PipotiazineDopamine D2 receptorProteinHumans
Yes
Antagonist
Details
PirbuterolBeta-2 adrenergic receptorProteinHumans
Yes
Agonist
Details
PirenzepineMuscarinic acetylcholine receptor M1ProteinHumans
Yes
Antagonist
Details
PiretanideSolute carrier family 12 member 1ProteinHumans
Unknown
Inhibitor
Details
PiroxicamProstaglandin G/H synthase 2ProteinHumans
Yes
Inhibitor
Details
PodofiloxDNA topoisomerase 2-alphaProteinHumans
Yes
Inhibitor
Details
PolythiazideSolute carrier family 12 member 3ProteinHumans
Yes
Inhibitor
Details
Potassium chlorideSolute carrier family 12 member 1ProteinHumans
Unknown
Binder
Details
PractololBeta-1 adrenergic receptorProteinHumans
Yes
Antagonist
Details
PranlukastCysteinyl leukotriene receptor 1ProteinHumans
Yes
Antagonist
Details
Pravastatin3-hydroxy-3-methylglutaryl-coenzyme A reductaseProteinHumans
Yes
Inhibitor
Details
PrednisoneGlucocorticoid receptorProteinHumans
Yes
Agonist
Details
PrilocaineSodium channel protein type 5 subunit alphaProteinHumans
Yes
Inhibitor
Details
PrimidoneGamma-aminobutyric acid receptor subunit alpha-1ProteinHumans
Yes
Potentiator
Details
ProbenecidSolute carrier family 22 member 6ProteinHumans
Yes
Inhibitor
Details
ProcainamideSodium channel protein type 5 subunit alphaProteinHumans
Unknown
Inhibitor
Details
Procaine5-hydroxytryptamine receptor 3AProteinHumans
Yes
Antagonist
Details
ProcaterolBeta-2 adrenergic receptorProteinHumans
Yes
Agonist
Details
ProchlorperazineDopamine D2 receptorProteinHumans
Yes
Antagonist
Details
ProfenamineMuscarinic acetylcholine receptor M1ProteinHumans
Yes
Antagonist
Details
ProgabideGamma-aminobutyric acid type B receptor subunit 1ProteinHumans
Yes
Agonist
Details
ProguanilDihydrofolate reductaseProteinHumans
Yes
Inhibitor
Details
ProlinePeptidyl-prolyl cis-trans isomerase AProteinHumans
Unknown
Binder
Details
ProlinePeptidyl-prolyl cis-trans isomerase BProteinHumans
Unknown
Binder
Details
PromethazineHistamine H1 receptorProteinHumans
Yes
Antagonist
Details
PropafenonePotassium voltage-gated channel subfamily H member 2ProteinHumans
Yes
Inhibitor
Details
PropanthelineMuscarinic acetylcholine receptor M1ProteinHumans
Yes
Antagonist
Details
PropiomazineHistamine H1 receptorProteinHumans
Yes
Antagonist
Details
PropranololBeta-1 adrenergic receptorProteinHumans
Yes
Antagonist
Details
PropranololBeta-2 adrenergic receptorProteinHumans
Unknown
Antagonist
Details
PropranololBeta-3 adrenergic receptorProteinHumans
Unknown
Antagonist
Details
PropylthiouracilThyroid peroxidaseProteinHumans
Yes
Inhibitor
Details
PurvalanolCyclin-dependent kinase 4ProteinHumans
Unknown
Not AvailableDetails
PurvalanolMitogen-activated protein kinase 1ProteinHumans
Unknown
Inhibitor
Details
PurvalanolMitogen-activated protein kinase 3ProteinHumans
Unknown
Inhibitor
Details
PyridostigmineAcetylcholinesteraseProteinHumans
Yes
Inhibitor
Details
Pyridoxal phosphate4-aminobutyrate aminotransferase, mitochondrialProteinHumans
Unknown
Inhibitor
Details
Pyridoxal phosphateAspartate aminotransferase, cytoplasmicProteinHumans
Unknown
Activator
Details
PyrimethamineDihydrofolate reductaseProteinHumans
Yes
Inhibitor
Details
Pyruvic acid4-aminobutyrate aminotransferase, mitochondrialProteinHumans
Unknown
Inhibitor
Details
QuinaprilAngiotensin-converting enzymeProteinHumans
Yes
Inhibitor
Details
QuinestrolEstrogen receptor alphaProteinHumans
Yes
Agonist
Modulator
Details
QuinidineSodium channel protein type 5 subunit alphaProteinHumans
Yes
Inhibitor
Details
Quinidine barbiturateGamma-aminobutyric acid receptor subunit alpha-1ProteinHumans
Yes
Potentiator
Details
Quinidine barbiturateSodium channel protein type 5 subunit alphaProteinHumans
Yes
Inhibitor
Details
QuinineIntermediate conductance calcium-activated potassium channel protein 4ProteinHumans
Unknown
Inhibitor
Details
RabeprazolePotassium-transporting ATPase alpha chain 1ProteinHumans
Yes
Inhibitor
Details
RaloxifeneEstrogen receptor alphaProteinHumans
Yes
Agonist
Details
RaloxifeneEstrogen receptor betaProteinHumans
Yes
Agonist
Details
RaltitrexedThymidylate synthaseProteinHumans
Yes
Inhibitor
Details
RamelteonMelatonin receptor type 1AProteinHumans
Yes
Multitarget
Details
RamelteonMelatonin receptor type 1BProteinHumans
Yes
Multitarget
Details
RamiprilAngiotensin-converting enzymeProteinHumans
Yes
Inhibitor
Details
RasagilineAmine oxidase [flavin-containing] BProteinHumans
Yes
Inhibitor
Details
Rauwolfia serpentina rootSynaptic vesicular amine transporterProteinHumans
Yes
Inhibitor
Details
RemifentanilMu-type opioid receptorProteinHumans
Yes
Agonist
Details
RemikirenReninProteinHumans
Yes
Inhibitor
Details
RemoxiprideDopamine D2 receptorProteinHumans
Yes
Antagonist
Details
RescinnamineAngiotensin-converting enzymeProteinHumans
Yes
Inhibitor
Details
ReserpineSynaptic vesicular amine transporterProteinHumans
Yes
Inhibitor
Details
ResveratrolCasein kinase II subunit alphaProteinHumans
Unknown
Not AvailableDetails
ResveratrolProstaglandin G/H synthase 1ProteinHumans
Unknown
Inhibitor
Details
ResveratrolProstaglandin G/H synthase 2ProteinHumans
Unknown
Inhibitor
Details
ReteplasePlasminogenProteinHumans
Yes
Activator
Details
RibavirinInosine-5'-monophosphate dehydrogenase 1ProteinHumans
Yes
Inhibitor
Details
RidogrelThromboxane A2 receptorProteinHumans
Yes
Antagonist
Details
RifaximinDNA-directed RNA polymerase subunit betaProteinEscherichia coli (strain K12)
Yes
Inhibitor
Details
RimonabantCannabinoid receptor 1ProteinHumans
Yes
Antagonist
Details
Risedronic acidFarnesyl pyrophosphate synthaseProteinHumans
Yes
Inhibitor
Details
RitodrineBeta-2 adrenergic receptorProteinHumans
Yes
Agonist
Details
RituximabB-lymphocyte antigen CD20ProteinHumans
Yes
Antibody
Details
RivastigmineAcetylcholinesteraseProteinHumans
Yes
Inhibitor
Details
RivastigmineCholinesteraseProteinHumans
Yes
Inhibitor
Details
Rizatriptan5-hydroxytryptamine receptor 1BProteinHumans
Yes
Agonist
Details
Rizatriptan5-hydroxytryptamine receptor 1DProteinHumans
Yes
Agonist
Details
Rizatriptan5-hydroxytryptamine receptor 1FProteinHumans
Yes
Agonist
Details
RocuroniumNeuronal acetylcholine receptor subunit alpha-2ProteinHumans
Yes
Antagonist
Details
RofecoxibProstaglandin G/H synthase 2ProteinHumans
Yes
Inhibitor
Details
RopiniroleDopamine D4 receptorProteinHumans
Unknown
Agonist
Details
RosiglitazonePeroxisome proliferator-activated receptor gammaProteinHumans
Yes
Agonist
Details
RosoxacinDNA gyrase subunit BProteinEscherichia coli (strain K12)
Yes
Inhibitor
Details
Rosuvastatin3-hydroxy-3-methylglutaryl-coenzyme A reductaseProteinHumans
Yes
Inhibitor
Details
SalbutamolBeta-2 adrenergic receptorProteinHumans
Yes
Agonist
Details
Salicylic acidProstaglandin G/H synthase 1ProteinHumans
Yes
Inhibitor
Details
SalmeterolBeta-2 adrenergic receptorProteinHumans
Yes
Agonist
Details
Salmon calcitoninCalcitonin receptorProteinHumans
Unknown
Agonist
Details
SalsalateProstaglandin G/H synthase 1ProteinHumans
Yes
Inhibitor
Details
SaprisartanType-1 angiotensin II receptorProteinHumans
Yes
Antagonist
Details
SapropterinTyrosine 3-monooxygenaseProteinHumans
Yes
Cofactor
Details
SargramostimGranulocyte-macrophage colony-stimulating factor receptor subunit alphaProteinHumans
Yes
Agonist
Details
ScopolamineMuscarinic acetylcholine receptor M2ProteinHumans
Yes
Antagonist
Details
scyllo-inositolCDP-diacylglycerol--inositol 3-phosphatidyltransferaseProteinHumans
Unknown
Inhibitor
Details
SecobarbitalGamma-aminobutyric acid receptor subunit alpha-1ProteinHumans
Yes
Potentiator
Details
SelegilineAmine oxidase [flavin-containing] BProteinHumans
Yes
Inhibitor
Details
SermorelinGrowth hormone-releasing hormone receptorProteinHumans
Yes
Agonist
Details
SertindoleDopamine D2 receptorProteinHumans
Yes
Antagonist
Details
SibutramineSodium-dependent noradrenaline transporterProteinHumans
Yes
Inhibitor
Details
SildenafilcGMP-specific 3',5'-cyclic phosphodiesteraseProteinHumans
Yes
Inhibitor
Details
Simvastatin3-hydroxy-3-methylglutaryl-coenzyme A reductaseProteinHumans
Yes
Inhibitor
Details
SirolimusPeptidyl-prolyl cis-trans isomerase FKBP1AProteinHumans
Yes
Other
Details
SirolimusSerine/threonine-protein kinase mTORProteinHumans
Yes
Inhibitor
Details
SitagliptinDipeptidyl peptidase 4ProteinHumans
Yes
Inhibitor
Details
SitaxentanEndothelin B receptorProteinHumans
Unknown
Antagonist
Details
SitaxentanEndothelin-1 receptorProteinHumans
Yes
Antagonist
Details
Sodium tetradecyl sulfateVitamin K-dependent protein CProteinHumans
Yes
Inhibitor
Details
SolifenacinMuscarinic acetylcholine receptor M3ProteinHumans
Yes
Antagonist
Details
SomatotropinGrowth hormone receptorProteinHumans
Yes
Ligand
Details
SorafenibSerine/threonine-protein kinase B-rafProteinHumans
Yes
Inhibitor
Details
SorbinilAldose reductaseProteinHumans
Unknown
Inhibitor
Details
SotalolBeta-1 adrenergic receptorProteinHumans
Yes
Antagonist
Details
SparfloxacinDNA topoisomerase 2-alphaProteinHumans
Yes
Inhibitor
Details
SpiraprilAngiotensin-converting enzymeProteinHumans
Yes
Inhibitor
Details
SpironolactoneMineralocorticoid receptorProteinHumans
Yes
Antagonist
Details
StreptokinasePlasminogenProteinHumans
Yes
Activator
Details
SU9516Cyclin-dependent kinase 1ProteinHumans
Unknown
Binder
Details
SU9516Cyclin-dependent kinase 2ProteinHumans
Unknown
Inhibitor
Details
SU9516Cyclin-dependent kinase 5ProteinHumans
Unknown
Inhibitor
Details
Succinic acidSuccinate-semialdehyde dehydrogenase, mitochondrialProteinHumans
Unknown
Inhibitor
Details
SufentanilMu-type opioid receptorProteinHumans
Yes
Agonist
Details
SulfasalazineCystine/glutamate transporterProteinHumans
Unknown
Inhibitor
Details
SulfinpyrazoneMultidrug resistance-associated protein 1ProteinHumans
Yes
Inhibitor
Details
SulindacAldose reductaseProteinHumans
Unknown
Inhibitor
Details
SulodexideAntithrombin-IIIProteinHumans
Yes
Potentiator
Details
SulpirideDopamine D2 receptorProteinHumans
Yes
Antagonist
Details
Sumatriptan5-hydroxytryptamine receptor 1BProteinHumans
Yes
Agonist
Details
Sumatriptan5-hydroxytryptamine receptor 1DProteinHumans
Yes
Agonist
Details
Sumatriptan5-hydroxytryptamine receptor 1FProteinHumans
Yes
Agonist
Details
SunitinibMast/stem cell growth factor receptor KitProteinHumans
Yes
Inhibitor
Details
SunitinibReceptor-type tyrosine-protein kinase FLT3ProteinHumans
Yes
Inhibitor
Details
SunitinibVascular endothelial growth factor receptor 2ProteinHumans
Yes
Inhibitor
Details
TacrineAcetylcholinesteraseProteinHumans
Yes
Inhibitor
Details
TadalafilcGMP-specific 3',5'-cyclic phosphodiesteraseProteinHumans
Yes
Inhibitor
Details
TalbutalGamma-aminobutyric acid receptor subunit alpha-1ProteinHumans
Yes
Potentiator
Details
TamibaroteneRetinoic acid receptor alphaProteinHumans
Yes
Agonist
Details
TamoxifenEstrogen receptor alphaProteinHumans
Yes
Antagonist
Agonist
Details
TamoxifenEstrogen receptor betaProteinHumans
Yes
Antagonist
Agonist
Details
TamsulosinAlpha-1A adrenergic receptorProteinHumans
Yes
Antagonist
Details
TamsulosinAlpha-1B adrenergic receptorProteinHumans
Unknown
Antagonist
Details
TamsulosinAlpha-1D adrenergic receptorProteinHumans
Unknown
Antagonist
Details
TasosartanType-1 angiotensin II receptorProteinHumans
Yes
Antagonist
Details
TazaroteneRetinoic acid receptor gammaProteinHumans
Yes
Agonist
Details
Tegaserod5-hydroxytryptamine receptor 4ProteinHumans
Yes
Antagonist
Partial agonist
Details
TelmisartanType-1 angiotensin II receptorProteinHumans
Yes
Antagonist
Details
TemsirolimusSerine/threonine-protein kinase mTORProteinHumans
Yes
Inhibitor
Details
TenecteplasePlasminogenProteinHumans
Yes
Activator
Details
TeniposideDNA topoisomerase 2-alphaProteinHumans
Yes
Inhibitor
Details
TenoxicamProstaglandin G/H synthase 2ProteinHumans
Yes
Inhibitor
Details
TerazosinAlpha-1A adrenergic receptorProteinHumans
Yes
Antagonist
Details
TerazosinAlpha-1B adrenergic receptorProteinHumans
Yes
Antagonist
Details
TerazosinAlpha-1D adrenergic receptorProteinHumans
Yes
Antagonist
Details
TerbinafineSqualene monooxygenaseProteinHumans
No
Inhibitor
Details
TerbutalineBeta-2 adrenergic receptorProteinHumans
Yes
Agonist
Details
TerfenadineHistamine H1 receptorProteinHumans
Yes
Antagonist
Details
TerfenadinePotassium voltage-gated channel subfamily H member 2ProteinHumans
Unknown
Inhibitor
Details
TeriparatideParathyroid hormone/parathyroid hormone-related peptide receptorProteinHumans
Unknown
Binder
Details
TerlipressinVasopressin V1a receptorProteinHumans
Unknown
Stimulator
Details
TestolactoneCytochrome P450 19A1ProteinHumans
Yes
Inhibitor
Details
TestosteroneAndrogen receptorProteinHumans
Yes
Agonist
Details
Testosterone cypionateAndrogen receptorProteinHumans
Yes
Agonist
Details
Testosterone enanthateAndrogen receptorProteinHumans
Yes
Agonist
Details
Testosterone undecanoateAndrogen receptorProteinHumans
Yes
Agonist
Details
TetrabenazineSynaptic vesicular amine transporterProteinHumans
Yes
Inhibitor
Details
TetracosactideAdrenocorticotropic hormone receptorProteinHumans
Yes
Agonist
Details
TetracyclineMajor prion proteinProteinHumans
Unknown
Inhibitor
Details
ThalidomideNuclear factor NF-kappa-B p105 subunitProteinHumans
Yes
Antagonist
Details
ThalidomideTumor necrosis factorProteinHumans
Yes
Inhibitor
Details
TheophyllineAdenosine receptor A2bProteinHumans
Yes
Antagonist
Details
TheophyllinecGMP-specific 3',5'-cyclic phosphodiesteraseProteinHumans
Yes
Inhibitor
Details
ThiabendazoleFumarate reductase flavoprotein subunitProteinEscherichia coli (strain K12)
Yes
Inhibitor
Details
ThiopentalFatty-acid amide hydrolase 1ProteinHumans
Unknown
Inhibitor
Details
ThioproperazineDopamine D2 receptorProteinHumans
Yes
Antagonist
Details
ThiorphanNeprilysinProteinHumans
Unknown
Inhibitor
Details
ThiothixeneDopamine D2 receptorProteinHumans
Yes
Antagonist
Details
Thyrotropin alfaThyrotropin receptorProteinHumans
Yes
Agonist
Details
TiagabineSodium- and chloride-dependent GABA transporter 1ProteinHumans
Yes
Inhibitor
Details
Tiaprofenic acidProstaglandin G/H synthase 2ProteinHumans
Yes
Inhibitor
Details
TiclopidineP2Y purinoceptor 12ProteinHumans
Yes
Antagonist
Details
TiotropiumMuscarinic acetylcholine receptor M3ProteinHumans
Yes
Antagonist
Details
TipranavirHuman immunodeficiency virus type 1 proteaseProteinHuman immunodeficiency virus 1
Yes
Inhibitor
Details
TirofibanIntegrin beta-3ProteinHumans
Yes
Antagonist
Details
TocainideSodium channel protein type 5 subunit alphaProteinHumans
Yes
Inhibitor
Details
TolcaponeCatechol O-methyltransferaseProteinHumans
Yes
Inhibitor
Details
TolmetinProstaglandin G/H synthase 2ProteinHumans
Yes
Inhibitor
Details
TolrestatAldose reductaseProteinHumans
Unknown
Inhibitor
Details
TolterodineMuscarinic acetylcholine receptor M3ProteinHumans
Yes
Antagonist
Details
TopotecanDNA topoisomerase 1ProteinHumans
Yes
Inhibitor
Details
TorasemideSolute carrier family 12 member 1ProteinHumans
Yes
Inhibitor
Details
TorasemideSolute carrier family 12 member 2ProteinHumans
Yes
Inhibitor
Details
ToremifeneEstrogen receptor alphaProteinHumans
Yes
Modulator
Details
TositumomabB-lymphocyte antigen CD20ProteinHumans
Yes
Antibody
Details
TramadolMu-type opioid receptorProteinHumans
Yes
Agonist
Details
TramadolSodium-dependent noradrenaline transporterProteinHumans
Yes
Inhibitor
Details
TrandolaprilAngiotensin-converting enzymeProteinHumans
Yes
Inhibitor
Details
TranylcypromineAmine oxidase [flavin-containing] AProteinHumans
Yes
Inhibitor
Details
TranylcypromineAmine oxidase [flavin-containing] BProteinHumans
Yes
Inhibitor
Details
TrastuzumabReceptor tyrosine-protein kinase erbB-2ProteinHumans
Yes
Antibody
Details
Trastuzumab emtansineReceptor tyrosine-protein kinase erbB-2ProteinHumans
Yes
Antibody
Details
TravoprostProstaglandin F2-alpha receptorProteinHumans
Yes
Agonist
Details
TreprostinilProstacyclin receptorProteinHumans
Yes
Agonist
Details
TretinoinRetinoic acid receptor gammaProteinHumans
Yes
Agonist
Details
TriamtereneAmiloride-sensitive sodium channel subunit alphaProteinHumans
Yes
Inhibitor
Details
TrichlormethiazideSolute carrier family 12 member 3ProteinHumans
Yes
Inhibitor
Details
TrifluoperazineDopamine D2 receptorProteinHumans
Yes
Antagonist
Details
TrifluoperazineNeuron-specific vesicular protein calcyonProteinHumans
Yes
Antagonist
Details
Triflupromazine5-hydroxytryptamine receptor 2BProteinHumans
Yes
Antagonist
Details
TrifluridineThymidylate synthaseProteinHumans
Yes
Inhibitor
Details
TrihexyphenidylMuscarinic acetylcholine receptor M1ProteinHumans
Yes
Antagonist
Details
TrimethadioneVoltage-dependent T-type calcium channel subunit alpha-1GProteinHumans
Yes
Inhibitor
Details
Trimipramine5-hydroxytryptamine receptor 2CProteinHumans
Unknown
Antagonist
Details
TripelennamineHistamine H1 receptorProteinHumans
Yes
Antagonist
Details
TriprolidineHistamine H1 receptorProteinHumans
Yes
Antagonist
Details
TroglitazonePeroxisome proliferator-activated receptor gammaProteinHumans
Yes
Agonist
Details
TropicamideMuscarinic acetylcholine receptor M4ProteinHumans
Yes
Antagonist
Details
TrovafloxacinDNA topoisomerase 2-alphaProteinHumans
Unknown
Inhibitor
Details
TubocurarineNeuronal acetylcholine receptor subunit alpha-2ProteinHumans
Yes
Antagonist
Details
TyrosineTyrosine 3-monooxygenaseProteinHumans
Unknown
Binder
Details
UdenafilcGMP-specific 3',5'-cyclic phosphodiesteraseProteinHumans
Yes
Inhibitor
Details
UrofollitropinFollicle-stimulating hormone receptorProteinHumans
Yes
Agonist
Details
UrokinasePlasminogenProteinHumans
Yes
Activator
Details
ValdecoxibProstaglandin G/H synthase 2ProteinHumans
Yes
Inhibitor
Details
ValrubicinDNA topoisomerase 2-alphaProteinHumans
Yes
Inhibitor
Details
ValsartanType-1 angiotensin II receptorProteinHumans
Yes
Antagonist
Details
VapreotideNeurokinin 1 receptorProteinHumans
Unknown
Antagonist
Details
VardenafilcGMP-specific 3',5'-cyclic phosphodiesteraseProteinHumans
Yes
Inhibitor
Details
VareniclineNeuronal acetylcholine receptor subunit alpha-4ProteinHumans
Yes
Partial agonist
Details
VasopressinVasopressin V2 receptorProteinHumans
Yes
Agonist
Details
VogliboseMaltase-glucoamylase, intestinalProteinHumans
Yes
Inhibitor
Details
VorinostatHistone deacetylase 1ProteinHumans
Yes
Inhibitor
Details
WarfarinVitamin K epoxide reductase complex subunit 1ProteinHumans
Yes
Inhibitor
Details
XimelagatranProthrombinProteinHumans
Yes
Inhibitor
Details
ZafirlukastCysteinyl leukotriene receptor 1ProteinHumans
Yes
Antagonist
Details
ZanamivirNeuraminidaseProteinInfluenza A virus (strain A/Bangkok/1/1979 H3N2)
Yes
Inhibitor
Details
ZileutonArachidonate 5-lipoxygenaseProteinHumans
Yes
Inhibitor
Details
Zoledronic acidFarnesyl pyrophosphate synthaseProteinHumans
Yes
Inhibitor
Details
ZonisamideSodium channel protein type 1 subunit alphaProteinHumans
Yes
Inhibitor
Details
ZuclopenthixolDopamine D2 receptorProteinHumans
Yes
Antagonist
Details
Drug Enzymes
DrugEnzymeKindOrganismPharmacological ActionActions
EntacaponeCatechol O-methyltransferaseProteinHumans
Unknown
Inhibitor
Details
MenadioneAldehyde oxidaseProteinHumans
Unknown
Inhibitor
Details
MoclobemideAmine oxidase [flavin-containing] AProteinHumans
Unknown
Inhibitor
Details
PhenelzineAmine oxidase [flavin-containing] BProteinHumans
Unknown
Substrate
Details
TryptophanIndoleamine 2,3-dioxygenase 1ProteinHumans
Unknown
Substrate
Details
Drug Carriers
DrugCarrierKindOrganismPharmacological ActionActions
AlclometasoneCorticosteroid-binding globulinProteinHumans
Unknown
Binder
Details
Beclomethasone dipropionateCorticosteroid-binding globulinProteinHumans
Unknown
Binder
Details
Bismuth subsalicylateSerum albuminProteinHumans
No
Binder
Details
CiclesonideCorticosteroid-binding globulinProteinHumans
Yes
Binder
Details
FlumethasoneCorticosteroid-binding globulinProteinHumans
Unknown
Binder
Details
Fluocinolone acetonideCorticosteroid-binding globulinProteinHumans
Unknown
Binder
Details
FluocinonideCorticosteroid-binding globulinProteinHumans
Unknown
Binder
Details
FlurandrenolideCorticosteroid-binding globulinProteinHumans
Unknown
Binder
Details
Gadobenic acidSerum albuminProteinHumans
Unknown
Binder
Details
IodipamideSerum albuminProteinHumans
Unknown
Binder
Details
ParamethasoneCorticosteroid-binding globulinProteinHumans
Unknown
Binder
Details
PrednisoloneCorticosteroid-binding globulinProteinHumans
Unknown
Binder
Details
Prednisolone acetateCorticosteroid-binding globulinProteinHumans
Unknown
Binder
Details
RimexoloneCorticosteroid-binding globulinProteinHumans
Unknown
Binder
Details
Sodium lauryl sulfateSerum albuminProteinHumans
Unknown
Binder
Details
TriamcinoloneCorticosteroid-binding globulinProteinHumans
Unknown
Binder
Details
Drug Transporters
DrugTransporterKindOrganismPharmacological ActionActions
Potassium chlorideSolute carrier family 12 member 1ProteinHumans
Unknown
Substrate
Details