Benzoylecgonine

DB01515ExperimentalIllicitSmall molecule

Benzoylecgonine is the major metabolite of cocaine. It is formed by hydrolysis of cocaine in the liver, catalysed by carboxylesterases. It is excreted in the urine of cocaine users after... It is the main pharmaceutical ingredient in the investigational drug Esterom, a topical solution used for the relief of muscle pain that is not FDA approved or on the market in the United States.

Chemical structure of Benzoylecgonine
Formula / weight
C16H19NO4 · 289.3264 g/mol (avg)
Also known as
Ecgonine benzoate · O-benzoylecgonine
Code names
DEA No. 9180

Resolves to

Clinical / RWD
Structure
InChIKeyGVGYEFKIHJTNQZ-RFQIPJPRSA-NSMILES[H][C@]12CC[C@]([H])([C@H]([C@H](C1)OC(=O)C1=CC=CC=C1)C(O)=O)N2C

What you can answer from here — as of September 12, 2026

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Which companies are running trials of Benzoylecgonine, in which indications and phases, and which of those programs are still active?

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