ETC-588, or LUV (large unilamellar vesicles), is made of naturally occurring lipids that circulate through arteries to facilitate the role of high-density lipoprotein (HDL) in removing accumulated cholesterol and other... LUV are capable of transporting excess cholesterol from the vasculature to the liver for eventual elimination as part of the reverse lipid transport (RLT) pathway.
- Mechanism
- Curator reviewed
ETC-588 is a phospholipid bilayer that can sequester cholesterol. Once the HDL particle, which is small enough to enter the arterial wall, pulls the cholesterol out of the plaque, it readily hands the cholesterol over to the LUV. The LUV then transports the cholesterol to the liver for processing.
- Primary indication
- Investigated for use/treatment in atherosclerosis, coronary artery disease, and vascular diseases.Curator reviewed
- Formula / weight
- C42H82NO8P · 760.0761 g/mol (avg)
- Code names
- ETC-588
Resolves to
RRVPPYNAZJRZFR-MRCUWXFGSA-NSMILESCCCCCCCCCCCCCCCC(=O)OC(COC(=O)CCCCCCC\C=C/CCCCCCCC)COP([O-])(=O)OCC[N+](C)(C)CWhat you can answer from here — as of April 02, 2025
Which companies are running trials of ETC-588, in which indications and phases, and which of those programs are still active?
Create a free account or log in to explore the full data card.
Create Account