TNX-901
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Identification
- Generic Name
- TNX-901
- DrugBank Accession Number
- DB05797
- Background
TNX-901 is a therapeutic monoclonal antibodies designed to address significant unmet medical needs in the areas of asthma, allergy, inflammation and other diseases affecting the human immune system.
- Type
- Biotech
- Groups
- Investigational
- Synonyms
- Not Available
Pharmacology
- Indication
Investigated for use/treatment in allergic reaction.
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- Pharmacodynamics
Not Available
- Mechanism of action
TNX-901 is an anti-IgE antibody. IgE antibody is the receptor responsible for allergic reactions and severe asthma attacks. An anti-IgE antibody binds IgE and prevents it from initiating an allergic reaction.
Target Actions Organism UHigh affinity immunoglobulin epsilon receptor subunit alpha Not Available Humans - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAbciximab The risk or severity of adverse effects can be increased when Abciximab is combined with TNX-901. Adalimumab The risk or severity of adverse effects can be increased when Adalimumab is combined with TNX-901. Aducanumab The risk or severity of adverse effects can be increased when TNX-901 is combined with Aducanumab. Alemtuzumab The risk or severity of adverse effects can be increased when Alemtuzumab is combined with TNX-901. Alirocumab The risk or severity of adverse effects can be increased when TNX-901 is combined with Alirocumab. - Food Interactions
- Not Available
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 9591BL735Z
- CAS number
- Not Available
References
- General References
- Leung DY, Shanahan WR Jr, Li XM, Sampson HA: New approaches for the treatment of anaphylaxis. Novartis Found Symp. 2004;257:248-60; discussion 260-4, 276-85. [Article]
- External Links
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
Targets
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- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Ige receptor activity
- Specific Function
- Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and t...
- Gene Name
- FCER1A
- Uniprot ID
- P12319
- Uniprot Name
- High affinity immunoglobulin epsilon receptor subunit alpha
- Molecular Weight
- 29595.67 Da
Drug created at November 18, 2007 18:27 / Updated at June 12, 2020 16:52