Dapivirine

DB08639InvestigationalSmall molecule

Dapivirine has been investigated for the prevention of HIV-1 Infections and Topical Penile Exposures.

Mechanism: Pharmacologically active on Gag-Pol polyprotein and Reverse transcriptase/RNaseH
Curator reviewed
Formula / weight: C₂₀H₁₉N₅ · 329.3984 g/mol (avg)
Code names: AIDS-105293 · R-147681 · TMC-120

Resolves to

Compound

Clinical / RWD

Structure

InChIKeyILAYIAGXTHKHNT-UHFFFAOYSA-NSMILESCC1=CC(C)=C(NC2=NC(NC3=CC=C(C=C3)C#N)=NC=C2)C(C)=C1

Targets

What you can answer from here — as of August 30, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

22Clinical trialsPhase, status and sponsor resolved per trial

1ATC codeIncluding every combination product, plus 7 drug categories

4+ReferencesStructured and connected to the statements they support

Which drugs share a target with Dapivirine, and which of those have an active Phase 3 trial?

Create a free account or log in to explore the full data card.