Decongestants and Antiallergics

Decongestants and Antiallergics
Accession Number

Not Available

ATC Classification
DrugDrug Description
EpinastineAn H1 receptor antagonist used to prevent itching in allergic conjunctivitis.
OxymetazolineAn alpha-1A adrenoceptor agonist used to treat nasal congestion, allergic reactions of the eye, and facial erythema associated with rosacea.
EmedastineA selective H1-receptor antagonist used topically to manage symptoms of allergic conjunctivitis.
LevocabastineA selective histamine H1 receptor antagonist indicated for the management of seasonal allergic conjunctivitis symptoms.
XylometazolineA direct-acting alpha-adrenergic agonist used for the symptomatic treatment of nasal congestion and minor inflammation due to allergies or colds.
AlcaftadineA H1 histamine receptor antagonist for ophthalmic use to prevent itching associated with allergic conjunctivitis.
LodoxamideAn ophthalmic agent used for the treatment of the ocular disorders referred to by the terms vernal keratoconjunctivitis, vernal conjunctivitis, and vernal keratitis.
Spaglumic acidThe β-aspartyl isoform of N-Acetyl-l-aspartylglutamate, a naturally occurring neurotransmitter, used in allergic eye conditions due to its ability to stabilize mast cells.
SynephrineSynephrine, also referred to as, p-synephrine, is naturally occurring alkaloid. It is present in approved drug products as neo-synephrine, its m-substituted analog. p-synephrine and m-synephrine are known for their longer...
PhenylephrineAn alpha-1 adrenergic agonist used in the management of hypotension, generally in the surgical setting associated with the use of anesthetics.
NedocromilA pyrano quinoline used to treat allergic conjunctivitis.
OlopatadineA histamine H1 antagonist used to treat allergic conjunctivitis and rhinitis.
KetotifenA histamine H1 receptor blocker and mast cell stabilizer used to treat mild atopic asthma and allergic conjunctivitis.
AzelastineA histamine H1-receptor antagonist used intranasally to treat allergic and vasomotor rhinitis and in an ophthalmic solution to treat allergic conjunctivitis.
Cromoglicic acidA medication used to treat asthma, allergic reactions of the eyes and nose, as well as other mast cell reactions.
NaphazolineA sympathomimetic vasoconstrictor used for the symptomatic relief of redness and itching of the eye, and nasal congestion.
TetryzolineAn alpha-adrenergic agonist used in the temporary symptomatic relief of discomfort and redness of the eyes due to minor irritations, as well as alleviate nasal congestion.
CetirizineA selective Histamine-1 antagonist drug used in allergic rhinitis and chronic urticaria.
BrimonidineAn alpha-2 adrenergic agonist used to treat glaucoma and ocular hypertension, as well as facial erythema in rosacea.
BilastineA peripheral histamine H1-antagonist used to treat seasonal allergic rhinitis and chronic spontaneous urticaria.
Drugs & Drug Targets
EpinastineHistamine H1 receptortarget
EpinastineHistamine H2 receptortarget
EpinastineAlpha-1A adrenergic receptortarget
EpinastineAlpha-2A adrenergic receptortarget
Epinastine5-hydroxytryptamine receptor 2Atarget
Epinastine5-hydroxytryptamine receptor 7target
EpinastineP-glycoprotein 1transporter
EpinastineCytochrome P450 2B6enzyme
EpinastineCytochrome P450 2D6enzyme
EpinastineCytochrome P450 3A4enzyme
OxymetazolineAlpha-1A adrenergic receptortarget
OxymetazolineAlpha-2A adrenergic receptortarget
OxymetazolineAlpha-2C adrenergic receptortarget
OxymetazolineAlpha-2B adrenergic receptortarget
OxymetazolineAlpha-1B adrenergic receptortarget
OxymetazolineAlpha-1D adrenergic receptortarget
Oxymetazoline5-hydroxytryptamine receptor 1Atarget
Oxymetazoline5-hydroxytryptamine receptor 1Btarget
Oxymetazoline5-hydroxytryptamine receptor 1Dtarget
Oxymetazoline5-hydroxytryptamine receptor 1Ctarget
OxymetazolineUDP-glucuronosyltransferase 1-9enzyme
OxymetazolineCytochrome P450 2C19enzyme
EmedastineHistamine H1 receptortarget
LevocabastineNeurotensin receptor type 2target
LevocabastineHistamine H1 receptortarget
XylometazolineAlpha-2A adrenergic receptortarget
XylometazolineAlpha-1A adrenergic receptortarget
XylometazolineAlpha-1B adrenergic receptortarget
XylometazolineAlpha-1D adrenergic receptortarget
XylometazolineAlpha-2B adrenergic receptortarget
XylometazolineAlpha-2C adrenergic receptortarget
AlcaftadineHistamine H1 receptortarget
Spaglumic acidProton-coupled amino acid transporter 1transporter
Spaglumic acidGlutamate carboxypeptidase 2target
SynephrineAlpha-1 adrenergic receptorstarget
PhenylephrineAlpha-1A adrenergic receptortarget
PhenylephrineAlpha-1B adrenergic receptortarget
PhenylephrineAmine oxidase [flavin-containing] Aenzyme
PhenylephrineAlpha-1D adrenergic receptortarget
PhenylephrineCytochrome P450 1A2enzyme
PhenylephrineSulfotransferase 1A3/1A4enzyme
PhenylephrineAmine oxidase [flavin-containing] Benzyme
NedocromilCysteinyl leukotriene receptor 1target
NedocromilCysteinyl leukotriene receptor 2target
NedocromilProstaglandin D2 receptortarget
NedocromilfMet-Leu-Phe receptortarget
NedocromilHeat shock protein HSP 90-alphatarget
OlopatadineHistamine H1 receptortarget
OlopatadineProtein S100-A1target
OlopatadineProtein S100-A12target
OlopatadineProtein S100-Btarget
OlopatadineProtein S100-A13target
OlopatadineProtein S100-A2target
OlopatadineCytochrome P450 3A4enzyme
OlopatadineSerum albumincarrier
OlopatadineDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
OlopatadineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
OlopatadineP-glycoprotein 1transporter
OlopatadineHistamine H2 receptortarget
OlopatadineHistamine H3 receptortarget
KetotifenHistamine H1 receptortarget
Ketotifen6-phosphogluconate dehydrogenase, decarboxylatingtarget
KetotifenUDP-glucuronosyltransferase 1-3enzyme
KetotifenUDP-glucuronosyltransferase 1-4enzyme
KetotifenUDP-glucuronosyltransferase 2B10enzyme
AzelastineHistamine H1 receptortarget
AzelastineCytochrome P450 1A2enzyme
AzelastineCytochrome P450 2D6enzyme
AzelastineCytochrome P450 3A4enzyme
AzelastineCytochrome P450 2C19enzyme
AzelastineCytochrome P450 1A1enzyme
AzelastineCytochrome P450 3A5enzyme
AzelastineCytochrome P450 2C9enzyme
AzelastineCytochrome P450 2C8enzyme
AzelastineP-glycoprotein 1transporter
AzelastineCytochrome P450 2A6enzyme
AzelastineCytochrome P450 2E1enzyme
AzelastineHistamine H2 receptortarget
AzelastinePhospholipase A2target
AzelastineLeukotriene C4 synthasetarget
AzelastineCytochrome P450 2B6enzyme
Cromoglicic acidProtein S100-Ptarget
NaphazolineAlpha-1A adrenergic receptortarget
NaphazolineAlpha-2A adrenergic receptortarget
TetryzolineAlpha-1 adrenergic receptorstarget
TetryzolineAlpha-2 adrenergic receptorstarget
CetirizineHistamine H1 receptortarget
CetirizineP-glycoprotein 1transporter
BrimonidineAlpha-2A adrenergic receptortarget
BrimonidineAlpha-2B adrenergic receptortarget
BrimonidineAlpha-2C adrenergic receptortarget
BrimonidineAldehyde oxidaseenzyme
BilastineHistamine H1 receptortarget
BilastineATP-binding cassette sub-family B member 5transporter
BilastineSolute carrier organic anion transporter family member 1A2transporter
BilastineSolute carrier organic anion transporter family member 2B1transporter