Ditazole

Identification

Name

Ditazole

Accession Number

DB08994

Description

Ditazole is a non-steroidal anti-inflammatory drug (NSAID). Ditazole's analgesic and antipyretic effects are similar to phenylbutazone. Additionally, ditazole is a platelet aggregation inhibitor marketed in Spain and Portugal with trade name Ageroplas.

Type

Small Molecule

Groups

Experimental, Withdrawn

Structure

3D

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MOLSDF3D-SDFPDBSMILESInChI

Similar Structures

Structure for Ditazole (DB08994)

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Weight

Average: 324.3737
Monoisotopic: 324.147392516

Chemical Formula

C₁₉H₂₀N₂O₃

Synonyms

• 2,2'-(4,5-Diphenyloxazol-2-ylazanediyl)diethanol
• Ditazole

External IDs

• S-222

Pharmacology

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Indication

Not Available

Contraindications & Blackbox Warnings

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Pharmacodynamics

Not Available

Mechanism of action

Not Available

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Not Available

Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects

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Toxicity

Not Available

Affected organisms

Not Available

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

• Approved
• Vet approved
• Nutraceutical
• Illicit
• Withdrawn
• Investigational
• Experimental
• All Drugs

Drug	Interaction
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Abciximab	The risk or severity of bleeding can be increased when Abciximab is combined with Ditazole.
Aceclofenac	The risk or severity of bleeding and hemorrhage can be increased when Aceclofenac is combined with Ditazole.
Acemetacin	The risk or severity of bleeding and hemorrhage can be increased when Acemetacin is combined with Ditazole.
Acenocoumarol	The risk or severity of bleeding can be increased when Acenocoumarol is combined with Ditazole.
Acetylsalicylic acid	Acetylsalicylic acid may increase the anticoagulant activities of Ditazole.
Albutrepenonacog alfa	The therapeutic efficacy of Albutrepenonacog alfa can be decreased when used in combination with Ditazole.
Alclofenac	The risk or severity of bleeding and hemorrhage can be increased when Alclofenac is combined with Ditazole.
Aldesleukin	The risk or severity of bleeding can be increased when Ditazole is combined with Aldesleukin.
Alemtuzumab	The risk or severity of bleeding can be increased when Ditazole is combined with Alemtuzumab.
Alteplase	The risk or severity of bleeding can be increased when Ditazole is combined with Alteplase.

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Food Interactions

• Avoid herbs and supplements with anticoagulant/antiplatelet activity. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.

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International/Other Brands

Ageroplas (Farma Lepori)

Categories

ATC Codes

B01AC01 — Ditazole

• B01AC — Platelet aggregation inhibitors excl. heparin
• B01A — ANTITHROMBOTIC AGENTS
• B01 — ANTITHROMBOTIC AGENTS
• B — BLOOD AND BLOOD FORMING ORGANS

Drug Categories

• Anticoagulants
• Blood and Blood Forming Organs
• Platelet Aggregation Inhibitors Excl. Heparin

Chemical TaxonomyProvided by Classyfire

Description

This compound belongs to the class of organic compounds known as phenyl-1,3-oxazoles. These are aromatic heterocyclic compounds containing a 1,3-oxazole substituted at one or more positions by a phenyl group.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Azoles

Sub Class

Oxazoles

Direct Parent

Phenyl-1,3-oxazoles

Alternative Parents

Dialkylarylamines / 2,4,5-trisubstituted oxazoles / Benzene and substituted derivatives / Heteroaromatic compounds / Oxacyclic compounds / Azacyclic compounds / Alkanolamines / Primary alcohols / Organopnictogen compounds / Hydrocarbon derivatives

Substituents

2,4,5-trisubstituted 1,3-oxazole / Alcohol / Alkanolamine / Aromatic heteromonocyclic compound / Azacycle / Benzenoid / Dialkylarylamine / Heteroaromatic compound / Hydrocarbon derivative / Monocyclic benzene moiety

Molecular Framework

Aromatic heteromonocyclic compounds

External Descriptors

Not Available

Chemical Identifiers

UNII

H2BQI5Z8FT

CAS number

18471-20-0

InChI Key

UUCMDZWCRNZCOY-UHFFFAOYSA-N

InChI

InChI=1S/C19H20N2O3/c22-13-11-21(12-14-23)19-20-17(15-7-3-1-4-8-15)18(24-19)16-9-5-2-6-10-16/h1-10,22-23H,11-14H2

IUPAC Name

2-[(diphenyl-1,3-oxazol-2-yl)(2-hydroxyethyl)amino]ethan-1-ol

SMILES

OCCN(CCO)C1=NC(=C(O1)C1=CC=CC=C1)C1=CC=CC=C1

References

General References

Not Available

External Links

KEGG Drug

D07138

PubChem Compound

29088

PubChem Substance

310264955

ChemSpider

27061

ChEBI

135383

ChEMBL

CHEMBL2104306

Drugs.com

Drugs.com Drug Page

Wikipedia

Ditazole

Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Not Available

Prices

Not Available

Patents

Not Available

Properties

State

Solid

Experimental Properties

Not Available

Predicted Properties

Property	Value	Source
Water Solubility	0.146 mg/mL	ALOGPS
logP	2.86	ALOGPS
logP	2.93	ChemAxon
logS	-3.4	ALOGPS
pKa (Strongest Acidic)	15.27	ChemAxon
pKa (Strongest Basic)	-0.12	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	69.73 Å2	ChemAxon
Rotatable Bond Count	7	ChemAxon
Refractivity	93.03 m3·mol-1	ChemAxon
Polarizability	35.89 Å3	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	1	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

Predicted ADMET Features

Not Available

Spectra

Mass Spec (NIST)

Not Available

Spectra

Spectrum	Spectrum Type	Splash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)	Predicted LC-MS/MS	Not Available

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Drug created on June 16, 2014 18:29 / Updated on February 21, 2021 18:52