| Lepirudin | A protein-based direct thrombin inhibitor used to reverse and prevent thrombus formation in heparin-induced thrombocytopenia. |
| Bivalirudin | A direct thrombin inhibitor used to treat heparin-induced thrombocytopenia and to prevent thrombosis during percutaneous coronary intervention. |
| Alteplase | A recombinant form of human tissue plasminogen activator used in the emergency treatment of myocardial infarction, ischemic stroke, and pulmonary emboli. |
| Darbepoetin alfa | A recombinant form of human erythropoietin used to increase differentiation of progenitor cells to red blood cells in the treatment of anemia. |
| Urokinase | A low molecular weight form of human urokinase used to treat pulmonary embolism and myocardial infarction as well as to clear IV lines. |
| Reteplase | A purified form of human tissue plasminogen activator used in the emergency treatment of myocardial infarction, ischemic stroke, and pulmonary emboli. |
| Erythropoietin | A recombinant form of human erythropoietin used to increase differentiation of progenitor cells to red blood cells in the treatment of anemia. |
| Antihemophilic factor, human recombinant | A form of recombinant coagulation Factor VIII used to treat hemophilia A, von Willebrand disease, and Factor XIII deficiency. |
| Anistreplase | A form of recombinant human tissue plasminogen activator used in the emergency treatment of myocardial infarction and pulmonary emboli. |
| Tenecteplase | A modified form of recombinant human tissue plasminogen activator used in the emergency treatment of myocardial infarction and pulmonary emboli. |
| Coagulation factor VIIa Recombinant Human | A form of recombinant human coagulation Factor VII used to treat hemophilia A and B. |
| Abciximab | A monoclonal anti-glycoprotein IIb/IIIa receptor antibody used to prevent thrombosis during percutaneous coronary intervention. |
| Drotrecogin alfa | A form of recombinant activated human protein C used to reduce mortality in patients with severe sepsis by inhibiting coagulation Factors V and VIII. |
| Alpha-1-proteinase inhibitor | A purified form of human alpha-1 proteinase inhibitor used to treat emphysema patients with associated alpha-1 proteinase inhibitor deficiency. |
| Eptifibatide | A peptide-based antagonist for glycoprotein IIb/IIIa used in the medical management of myocardial infarction and as an adjunct to percutaneous coronary intervention. |
| Streptokinase | A purified fibrinolytic bacterial protein used to breakdown thrombosis in myocardial infarction, pulmonary embolism, and venous thromboembolism. |
| Cyanocobalamin | A vitamin available in many formulations to correct vitamin B12 deficiency. |
| L-Lysine | An amino acid commonly found as a component of total parenteral nutrition. |
| Arginine | An amino acid commonly found as a component of total parenteral nutrition. |
| Glycine | An amino acid commonly used as a component of total parenteral nutrition and is also used as irrigation during surgery. |
| Menadione | The primary known function of vitamin K is to assist in the normal clotting of blood, but it may also play a role in normal bone calcification. |
| Hydroxocobalamin | A synthetic form of vitamin B12 used to treat vitamin B12 associated disorders and cyanide poisoning. |
| Ticlopidine | A platelet aggregation inhibitor used in the prevention of conditions associated with thrombi, such as stroke and transient ischemic attacks (TIA). |
| Dicoumarol | For decreasing blood clotting. Often used along with heparin for treatment of deep vein thrombosis. |
| Argatroban | A synthetic direct thrombin inhibitor used for the prevention and treatment of thrombosis related to heparin use. |
| Tranexamic acid | An antifibrinolytic agent used for heavy menstrual bleeding. |
| Treprostinil | A prostacyclin vasodilator for the treatment of pulmonary arterial hypertension to relieve exercise associated symptoms and to prevent clinical deterioration after stopping epoprostenol. |
| Phenindione | For the treatment of pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, mural thrombosis, and thrombophili. Also used for anticoagulant prophylaxis. |
| Aminocaproic acid | An antifibrinolytic agent used to induce clotting postoperatively. |
| Magnesium sulfate | A drug used to treat convulsions during pregnancy, nephritis in children, magnesium deficiency, and tetany. |
| Warfarin | A vitamin K antagonist used to treat venous thromboembolism, pulmonary embolism, thromboembolism with atrial fibrillation, thromboembolism with cardiac valve replacement, and thromboembolic events post myocardial infarction. |
| Clopidogrel | An antiplatelet agent used to prevent blood clots in peripheral vascular disease, coronary artery disease, and cerebrovascular disease. |
| Tirofiban | A platelet aggregation inhibitor used to prevent thrombotic events in non-ST elevated acute coronary syndrome. |
| Phenprocoumon | Used for the prevention and treatment of thromboembolic disease including venous thrombosis, thromboembolism, and pulmonary embolism as well as for the prevention of ischemic stroke in patients with atrial fibrillation... |
| Dipyridamole | A phosphodiesterase inhibitor used to prevent postoperative thromboembolic events. |
| Phylloquinone | A fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses. |
| Iloprost | A synthetic prostacyclin analog indicated to treat pulmonary arterial hypertension (PAH). |
| Heparin | An anticoagulant indicated for thromboprophylaxis and to treat thrombosis associated with a variety of conditions such as pulmonary embolism and atrial fibrillation. |
| Cilostazol | An antiplatelet agent and vasodilator used for the symptomatic relief of intermittent claudication. |
| Enoxaparin | A low molecular weight heparin used for the prophylaxis of deep vein thrombosis and ischemic complications of unstable angina and non-Q-wave myocardial infarction, when concurrently administered with aspirin. |
| Epoprostenol | A vasodilator and platelet aggregation inhibitor used for the management of primary pulmonary hypertension and pulmonary hypertension in patients with heart failure. |
| Sodium bicarbonate | A compound used for the symptomatic treatment of heartburn, acid indigestion, and upset stomach as well as the treatment of metabolic acidosis associated with conditions such as severe renal disease and circulatory insufficiency due to shock. |
| Acenocoumarol | An anticoagulant drug used in the prevention of thromboembolic diseases in infarction and transient ischemic attacks, as well as management of deep vein thrombosis and myocardial infarction. |
| Iron | An essential element commonly used for the treatment of patients with documented iron deficiency. |
| Sorbitol | A product that can be used as a laxative to relieve constipation, and also as a urologic irrigating fluid. May also be used as a pharmaceutical sweetener. |
| Mecobalamin | Not Available |
| Tromethamine | A proton acceptor used for the prevention and correction of metabolic acidosis associated with various clinical conditions, such as cardiac bypass surgery. |
| Ximelagatran | For the treatment of acute deep vein thrombosis. |
| Defibrotide | A mixture of single-stranded oligonucleotides used in the treatment of severe hepatic veno-occlusive disease with renal or pulmonary dysfunction following hematopoietic stem-cell transplantation. |
| Ancrod | An anticoagulant purified from the venom of the Malayan pit viper that functions by inactivating circulating plasma fibrinogen. Not currently approved for use or marketed in any country. |
| Beraprost | For the treatment of pulmonary hypertension. |
| Fibrinolysin | Fibrinolysin assists with the healing of minor burns, superficial wounds, ulcers, surgical wounds, and superficial hematomas. |
| Ecallantide | A kallikrein inhibitor used to prevent and treat acute attacks caused by Hereditary Angioedema (HAE). |
| Romiplostim | A fusion protein thrombopoietin (TPO) peptide analog that increases platelet counts by binding to and activating the human TPO receptor. Used to treat thrombocytopenia associated with chronic immune thrombocytopenia (ITP). |
| Icatibant | A bradykinin B2 receptor antagonist used to treat acute episodes of swelling and inflammation associated with hereditary angioedema (HAE). |
| Prasugrel | A P2Y12 platelet inhibitor used to reduce risk of thrombotic cardiovascular events in unstable angina or non-ST-elevation myocardial infarction (NSTEMI), and in patients with STEMI when managed with either primary or delayed PCI. |
| Eltrombopag | A thrombopoietin receptor agonist used to treat thrombocytopenia or aplastic anemia associated with various etiologies. |
| Rivaroxaban | A factor Xa inhibitor used to treat deep vein thrombosis (DVT) and pulmonary embolism (PE). May also be used as thrombosis prophylaxis in specific situations. |
| Sulodexide | Sulodexide has been used clinically for the prophylaxis and treatment of vascular diseases with increased risk of thrombosis, including intermittent claudication, peripheral arterial occlusive disease and post-myocardial infarc-tion. Also investigated... |
| Human C1-esterase inhibitor | A C1 inhibitor used to prevent angioedema attacks associated with hereditary angioedema. |
| Cangrelor | A P2Y12 platelet receptor antagonist used during percutaneous coronary intervention to reduce the risk for periprocedural myocardial infarction (MI), repeat coronary revascularization, and stent thrombosis (ST). |
| Apixaban | An anticoagulant used for the prophylaxis of stroke and systemic embolism in nonvalvular atrial fibrillation, and deep vein thrombosis(DVT) leading to pulmonary embolism(PE), including in patients after a hip or knee replacement surgery. |
| Aprotinin | A serine protease inhibitor used to reduce the risk for perioperative blood loss and the need for blood transfusion in high-risk patients during cardiopulmonary bypass for coronary artery bypass graft surgery. |
| Dabigatran etexilate | An anticoagulant used for the prevention of venous thromboembolic events or stroke in patients with recent elective hip or knee replacement surgery and atrial fibrillation. |
| Danaparoid | A heparinoid with anticoagulant and antithrombotic activities used for the treatment of acute episode of Heparin-Induced Thrombocytopenia (HIT), and for prophylaxis in patients with a history of HIT. |
| Ammonium chloride | Expectorant in cough syrups.
The ammonium ion (NH4+) in the body plays an important role in the maintenance of acid-base balance. The kidney uses ammonium (NH4+) in place of sodium... |
| Dalteparin | A low molecular weight heparin used for the prophylaxis of thrombotic events in certain patients and prevent acute cardiac ischemic events in patients with unstable angina and non-Q-wave myocardial infarction. |
| Tinzaparin | A low molecular weight heparin used for the treatment of acute symptomatic deep vein thrombosis with or without pulmonary embolism when administered in conjunction with warfarin. |
| Ethyl biscoumacetate | Ethyl biscoumacetate is a courmarin that is used as an anticoagulant. It has actions similar to those of Warfarin. (From Martindale, The Extra Pharmacopoeia, 30th ed, p226) |
| Nadroparin | A low molecular weight heparin used for the prophylaxis of thrombotic events and deep vein thrombosis, and prevent unstable angina and non-Q-wave myocardial infarction. |
| Triflusal | Triflusal is indicated as prophylaxis of thromboembolic disorders. It has been registered in Spain and in other countries of Europe, South America and South Korea for the prevention of Stroke... |
| Ticagrelor | A P2Y12 platelet inhibitor used in patients with a history of myocardial infarction or with acute coronary syndrome (ACS) to prevent future myocardial infarction, stroke and cardiovascular death. |
| Peginesatide | Peginesatide is used for the treatment of anemia due to chronic kidney disease (CKD) in adult patients on dialysis |
| Ditazole | Ditazole is a non-steroidal anti-inflammatory drug (NSAID). Ditazole's analgesic and antipyretic effects are similar to phenylbutazone. Additionally, ditazole is a platelet aggregation inhibitor marketed in Spain and Portugal with trade... |
| Batroxobin | No approved indications. Batroxobin is a defibrongenating agent which has been observed to reduce fibrinogen levels and thus reduce clot risk when used intravenously. |
| Carbazochrome | Indicated for capillary and parenchymal hemorrhage (trauma, tonsillectomy, during surgery), intestinal bleeding, and thrombocytopenic purpura. |
| Vorapaxar | A platelet aggregation inhibitor used to reduce thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or peripheral arterial disease (PAD). |
| Hydroxyethyl Starch | A plasma volume substitute used to treat and prevent hypovolemia. |
| Methoxy polyethylene glycol-epoetin beta | A synthetic erythropoiesis stimulating agent (ESA) used to treat anemia associated with chronic kidney disease. |
| Sodium chloride | An ingredient found in a variety of nutritional products as a source of electrolytes and water. |
| Sodium citrate | An ingredient used for the anticoagulation of whole blood as part of automated apheresis procedures. |
| Fibrinogen human | A hemostatic agent used for the treatment of acute bleeding episodes in patients with congenital fibrinogen deficiency, including afibrinogenemia and hypofibrinogenemia. |
| Conestat alfa | A recombinant C1INH used for the treatment of acute attacks of hereditary angioedema (HAE) due to C1 esterase inhibitor deficiency in adults. |
| Dextran | A low molecular weight dextran used as an adjunctive treatment of shock or impending shock due to hemorrhage, burns, surgery or other trauma, as well as the prophylaxis of venous thrombosis and pulmonary embolism during high-risk medical procedures. |
| Bemiparin | Bemiparin is indicated in the following cases: To prevent blood clots in the veins after general abdominal surgery in patients with a moderate risk of venous thromboembolism; in the prevention... |
| Reviparin | By the FDA, reviparin is indicated for the treatment of deep vein which may lead to pulmonary embolism in pediatric patients. It is also indicated for the long-term treatment of... |
| Parnaparin | Used in the prevention and treatment of venous thromboembolism (deep vein thrombosis and pulmonary embolism) and in the treatment of myocardial infarction. |
| Catridecacog | A recombinant FXIII subunit‐A molecule evaluated for clotting factor replacement therapy in congenital FXIII deficiency. |
| Chymotrypsin | No therapeutic indications. |
| Amino acids | Mixture of amino acids ; used for parenteral nutrition in infants. |
| Sodium acetate | A compound used for electrolyte replenishment and total parenteral nutrition (TPN) therapy. |
| Magnesium chloride | An ionic compound and source of magnesium used for electrolyte replenishment and conditions associated with magnesium deficiencies. |
| Potassium lactate | Not Annotated |
| Desoxyribonuclease | Desoxyribonuclease is a crystalline enzyme that aids in the digestion of the thymus nucleic acid. The mechanism of action of the enzyme involves the splitting of thymus nucleic acid into... |
| Sodium glycerophosphate | A medication used to treat hypophosphatemia. |
| Desirudin | Indicated as prophylaxis of deep vein thrombosis for patients undergoing hip replacement surgery. |
| Cobamamide | An ingredient found in a variety of supplements and vitamins. |
| Thrombin | A coagulation factor used to stop bleeding during surgery. |
| Protein C | A medication used to treat protein C deficiency leading to purpura fulminans or coumarin-induced skin necrosis. |
| Selexipag | A non prostanoid IP prostacyclin receptor agonist used to treat pulmonary arterial hypertension. |
| Antithrombin III human | An alpha-2-glycoprotein used to prevent thromboembolisms in patients with hereditary antithrombin III deficiency. |
| Susoctocog alfa | A recombinant Factor VIII used to treat and prevent bleeding in hemophilia A. |
| Alanyl glutamine | Alanyl Glutamine is under investigation in clinical trial NCT00338221 (Clinical Trial of Alanyl-Glutamine or Glycine in Children With Persistent Diarrhea or Malnutrition). |
| Taurolidine | Taurolidine has been investigated for the prevention of Central Venous Catheter, Home Parenteral Nutrition, and Catheter-Related Infections. |
| Indobufen | Indobufen has been used in trials studying the supportive care and prevention of Atrial Fibrillation. |
| Von Willebrand Factor Human | A complex of von Willebrand Factor and Factor VIII used to treat bleeding episodes in von Willebrand disease. |
| Fluindione | Fluindione is under investigation for the treatment of Venous Thrombosis, Pulmonary Embolism, Permanent Atrial Fibrillation, and Anticoagulating Treatment on a Duration at Least 12-month-old Superior. Fluindione has been investigated for... |
| Coagulation factor X human | A coagulation factor used to treat Factor X deficiency to control bleeding. |
| Anti-inhibitor coagulant complex | A medication used to control bleeding episodes and prevent bleeding episodes in hemophilia A and B. |
| Antihemophilic factor human | A Factor VIII replacement therapy used to treat hemophilia A. |
| Brinase | Not Annotated |
| Mandelic acid | Mandelic acid is an approved aromatic, alpha hydroxy acid . Mandelic acid is used as an ingredient in cosmetics and drug products applied topically. |
| Ferrous aspartate | The use of ferrous acetate over ferrous sulfate is currently undergoing an investigation by a clinical trial . It is also used for dying of fabric or leather and as... |
| Aminomethylbenzoic acid | Aminomethylbenzoic acid may be useful as an antifibrinolytic agent . |
| Clorindione | Clorindione is a vitamin K antagonist, which may be useful to decrease prothrombin levels in humans. |
| Picotamide | Not Annotated |
| Diphenadione | Not Annotated |
| Cloricromen | Not Annotated |
| Calcium alginate | Not Annotated |
| Sodium feredetate | Not Annotated |
| Ferric hydroxide | Not Annotated |
| Tioclomarol | Not Annotated |
| Etamsylate | Not Annotated |
| Aloxiprin | Not Annotated |
| Ferrous chloride | Not Annotated |
| Oxidized cellulose | Not Annotated |
| Melagatran | Not Annotated |
| Tetragalacturonic acid hydroxymethylester | Not Annotated |
| Ferrous tartrate | Not Annotated |
| Saruplase | Not Annotated |
| Hemoglobin raffimer | Not Annotated |
| Ferrous carbonate | Not Annotated |
| Camostat | A serine protease indicated in Japan to treat chronic pancreatitis. |
| Ferric sodium citrate | Not Annotated |
| Noxytiolin | Local antibacterial that probably acts by releasing formaldehyde in aqueous solutions. It is used for THERAPEUTIC IRRIGATION of infected body cavities - bladder, peritoneum, etc. and as a spray for... |
| Magnesium phosphate | Not Annotated |
| Hemoglobin crosfumaril | Hemoglobin in which the alpha-subunit are cross-linked intramolecularly. |
| Nitrofural | For the treatment of bacterial skin infections including pyodermas, infected dermatoses and infections of cuts, wounds, burns and ulcers due to susceptible organisms. |
| Sulfamethizole | A sulfonamide antibiotic used to treat a wide variety of susceptible bacterial infections. |
| Mannitol | A sugar alcohol used to test for asthma, to reduce intracranial and intraocular pressure, to measure glomerular filtration rate, and to manage pulmonary symptoms associated with cystic fibrosis. |
| Potassium chloride | A potassium salt used to treat hypokalemia. |
| Neomycin | An aminoglycoside antibiotic agent used orally and topically to treat a wide variety of infections in the body. |
| Calcium chloride | An ionic compound used for the treatment of hypocalcemia and hyperkalemia, and as an antidote to magnesium intoxication due to overdosage of magnesium sulfate. |
| Cetylpyridinium | A compound used to reduce plaque and gingivitis, as well as whiten teeth. |
| Magnesium citrate | A laxative used in bowel preparation for colonoscopy or as a magnesium supplement. |
| Trypsin | Trypsin is a serine protease that plays an essential role in protein hydrolysis and absorption in mammals. When converted from its zymogen trypsinogen, trypsin is available as an active peptide... |
| Ethacridine | Not Annotated |
| Hydrochloric acid | Not Annotated |
| Adrenalone | Not Annotated |
| Carbaspirin calcium | Not Annotated |
| Fondaparinux | An anticoagulant used to prevent venous thromboembolism, to treat deep vein thrombosis, and to improve survival following myocardial infarction. |
| Ferrous gluconate | A medication used to treat iron-deficiency anemia. |
| Ferrous succinate | Used in preventing and treating iron-deficiency anemia. |
| Ferrous ascorbate | A medication used to treat iron-deficiency anemia. |
| Ferrous fumarate | A medication used to treat iron-deficiency anemia. |
| Potassium acetate | A medication used to treat hypokalemia. |
| Ferrous glycine sulfate | Used in preventing and treating iron-deficiency anemia. |
| Zinc chloride | A medication used to treat zinc deficiencies and associated symptoms and also in total parenteral nutrition. |
| Urea | A keratolytic emollient used to treat hyperkeratotic lesions and moisturize the skin. |
| Roxadustat | In clinical development for the treatment of anemia of chronic inflammatory disease. |
| Caplacizumab | A von Willebrand factor (vWF)-directed antibody fragment used to treat acquired thrombotic thrombocytopenic purpura (aTTP). |
| Edoxaban | A novel oral anticoagulant used for reducing the risk of stroke and systemic embolism (SE) in patients with nonvalvular atrial fibrillation (NVAF). |
| Avatrombopag | A thrombopoietin receptor agonist used to treat thrombocytopenia in patients with chronic liver disease who are scheduled to undergo a procedure. |
| Fostamatinib | A spleen tyrosine kinase inhibitor used to treat chronic immune thrombocytopenia after attempting one other treatment. |
| Lusutrombopag | A medication used to treat thrombocytopenia in patients with chronic liver disease scheduled to have a procedure. |
| Emicizumab | An antibody against Factor IXa and Factor X used to treat hemophilia A. |
| Lanadelumab | A plasma kallikrein inhibitor used to treat attacks of hereditary angioedema. |
| Hyaluronidase | An enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents. |
| Acetylsalicylic acid | A salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events. |
| Ferric maltol | A complexed iron supplement used to treat iron deficiency in adults. |
| Hyaluronidase (human recombinant) | An enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents. |
| Hemin | An iron-containing porphyrin injection used for the relief of recurrent attacks of acute intermittent porphyria (AIP) associated with the menstrual cycle when carbohydrate therapy is not effective. |
| Ulinastatin | Ulinastatin has been investigated for the prevention of Cardiovascular Disease and Adverse Reaction to Drug. |
| Luspatercept | An erythroid maturation agent used to treat anemia secondary to beta thalassemia in patients requiring regular red blood cell transfusions. |
| Betrixaban | A Factor Xa inhibitor used for prophylaxis of venous thromboembolism in hospitalized patients. |
| Crizanlizumab | A monoclonal antibody that targets selectin to reduce the frequency of vasooclusive crises in patients with sickle cell disease. |
| Dermatan sulfate | Not Annotated |