- Accession Number
Cyclic esters of hydroxy carboxylic acids, containing a 1-oxacycloalkan-2-one structure. Large cyclic lactones of over a dozen atoms are MACROLIDES.
Drug Drug Description Erythromycin A macrolide antibiotic used to treat and prevent a variety of bacterial infections. Azithromycin A macrolide antibiotic used to treat a variety of bacterial infections. Pimecrolimus A topical calcineurin inhibitor used in the treatment of mild-moderate atopic dermatitis who are not candidates for other types of therapy due to previous lack of response or other reasons. Spironolactone An aldosterone receptor antagonist used for the treatment of hypertension, hyperaldosteronism, edema due to various conditions, hirsutism (off-label) and hypokalemia. Picrotoxin Used internally for relieving respiratory distress. Also for use as an antidote in poisoning by CNS depressants, especially barbiturates. Ivermectin An anti parasite medication used to treat head lice, onchocerciasis, strongyloidiasis, ascariasis, trichuriasis, and enterobiasis. Nystatin A polyene ionophore antifungal used to treat cutaneous, mucocutaneous, and gastrointestinal mycotic infections, particularly those caused by Candida species. Amphotericin B An antifungal used to treat fungal infections in neutropenic patients, cryptococcal meningitis in HIV infection, fungal infections, and leishmaniasis. Eplerenone An aldosterone receptor antagonist used to improve survival of patients with symptomatic heart failure and to reduce blood pressure. Roxithromycin An antibiotic used to treat a variety of susceptible bacterial infections. Natamycin A macrolide antifungal used to treat fungal infections of the eye. Tacrolimus A calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis. Sirolimus An immunosuppressant used to prevent organ transplant rejections and to treat lymphangioleiomyomatosis. Dirithromycin An antibiotic used to treat a variety of respiratory, skin, and other infections. Telithromycin An ketolide used to treat community acquired pneumonia of mild to moderate severity. Candicidin Used in the topical treatment of vulvovaginal candidiasis. Clarithromycin A macrolide antibiotic used for the treatment of a wide variety of bacterial infections such as acute otitis, pharyngitis, tonsillitis, respiratory tract infections, uncomplicated skin infections, and helicobacter pylori infection. Josamycin A macrolide antibiotic used for the treatment of various susceptible bacterial infections. Everolimus A mammalian target of rapamycin (mTOR) kinase inhibitor used to treat various types of malignancies. Epothilone D Investigated for use/treatment in colorectal cancer, lung cancer, breast cancer, solid tumors, and prostate cancer. Homoserine Lactone Not Available Soraphen A Not Available Patupilone Investigated for use/treatment in ovarian cancer, lung cancer, brain cancer, breast cancer, and gastric cancer. Radicicol Not Available 6-Deoxyerythronolide B Not Available Aplyronine A Not Available gamma-Butyrolactone One of the furans with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used... Reidispongiolide A Not Available Ixabepilone A microtubule inhibitor administered in combination with capecitabine or alone in the treatment of metastatic or locally advanced breast cancer that has shown inadequate response to taxanes and anthracyclines. Trastuzumab emtansine An antineoplastic agent and antibody-drug conjugate used to treat HER2-overexpressing breast cancer. GPI-1485 Investigated for use/treatment in erectile dysfunction and parkinson's disease. KOS-1584 Investigated for use/treatment in solid tumors. Spiramycin A macrolide antimicrobial agent used in the treatment of various bacterial infections. Ridaforolimus Investigated for use/treatment in solid tumors, sarcoma, cancer/tumors (unspecified), endometrial cancer, prostate cancer, and bone metastases. Temsirolimus A antineoplastic agent used in the treatment of renal cell carcinoma (RCC) that works by inhibiting mTOR. AVE9633 Investigated for use/treatment in leukemia (myeloid). Coltuximab ravtansine Investigated for use/treatment in lymphoma (non-hodgkin's). Cethromycin A ketolide antibiotic with broad-spectrum activity against Gram-positive, Gram-negative, and atypical bacteria that may be useful for treating several conditions including community-acquired pneumonia, inhalation anthrax, plague, and tularemia. Mitemcinal Investigated for use/treatment in gastroparesis and irritable bowel syndrome (IBS). Bafilomycin A1 The bafilomycins refer to a category of toxic macrolide antibiotics that are derivatives of Streptomyces griseus. These compounds all appear in the same fermentation and have similar biological activity. Bafilomycins... Bafilomycin B1 Not Available Brefeldin A A metabolite from Penicillium brefeldianum that exhibits a wide range of antibiotic activity. Spinosad A pediculicide used topically to treat head lice. Dehydroascorbic acid There is no approved indication for dehydroascorbic acid, but it has potential therapeutic use in patients with certain viruses and ischemic stroke. Firocoxib Used for the treatment of pain inflammation and fever in horses and dogs. Solithromycin Investigated for the treatment of community-acquired pneumonia (CAP). Kitasamycin Kitasamycin is a macrolide antibiotic derived from Streptomyces kitasatoensis. Propiolactone Propiolactone was used for vaccines, tissue grafts, surgical instruments, and enzymes, as a sterilant of blood plasma, water, milk and nutrient broth as a vapor-phase disinfectant in enclosed spaces. Its... Carbomycin Carbomycin, also called magnamycin, is crystalline macrolide antibiotic. This antibacterial is obtained from Streptomyces halstedii and it presents a large inhibitory effect against Gram-positive bacteria and some Mycoplasma strains. The... Doramectin Doramectin is a veterinary drug approved by the Food and Drug Administration for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in... Eprinomectin Not Annotated Gamithromycin Gamithromycin is an antibiotic used in cattle. Moxidectin Moxidectin is indicated for the treatment of river blindness, also called onchocerciasis, in patients aged 12 years and older. River blindness is caused by a parasitic worm Onchocerca volvulus and... Oleandomycin Oleandomycin is a macrolide antibiotic, though it is less effective than erythromycin. It is synthesized from strains of Streptomyces antibioticus. Selamectin Selamectin is a topical parasiticide and antihelminthic used on dogs and cats to treat and prevent infections of heartworms, fleas, ear mites, sarcoptic mange, and certain types of ticks in... Tildipirosin Tildipirosin is a veterinary antibiotic. Tilmicosin Tilmicosin is a macrolide antibiotic. It is used in veterinary medicine for the treatment of bovine respiratory disease and ovine respiratory disease associated with Mannheimia haemolytica. Tylosin Tylosin is a bacteriostatic macrolide antibiotic and feed additive used in veterinary medicine. It has a broad spectrum of activity against Gram-positive organisms and a limited range of Gram-negative organisms.... Zeranol Zeranol is a non-steroidal estrogen agonist. It is a mycotoxin, derived from fungi in the Fusarium family, and may be found as a contaminant in fungus-infected crops. It is 3-4x... Milbemycin oxime Not Annotated Tylvalosin Not Annotated Bryostatin 1 Bryostatin 1 has been investigated for the treatment of HIV Infection and Alzheimer's Disease. Lorvotuzumab mertansine Lorvotuzumab mertansine has been used in trials studying the treatment of SCLC, Leukemia, Ovarian Cancer, Multiple Myeloma, and Merkel Cell Carcinoma, among others. Epofolate Epofolate has been used in trials studying the treatment of Advanced Solid Tumors. Epofolate (BMS-753493) is a folate conjugate of the epothilone analog BMS-748285 that was designed to selectively target... Sagopilone Sagopilone has been used in trials studying the treatment of Melanoma, Neoplasms, CNS Disease, Breast Cancer, and Breast Neoplasms, among others. It is a so-called fully synthetic epothilone and is... Mirvetuximab Soravtansine Mirvetuximab Soravtansine has been used in trials studying the treatment of Ovarian cancer, Endometrial Cancer, Fallopian tube cancer, Epithelial Ovarian Cancer, and Primary Peritoneal Cancer, among others. PM-060184 PM060184 has been used in trials studying Solid Tumors. Troleandomycin For the treatment of bacterial infection. Miocamycin Miocamycin is a macrolide type antimicrobial . This drug may be marketed in Japan for clinical use as it is listed in the Japanese pharmacopeia . It has shown to... Flurithromycin Not Annotated Rokitamycin Not Annotated Midecamycin A macrolide antibiotic used to treat a variety of infections caused by susceptible bacteria. Pentamycin Not Annotated Mepartricin A medication indicated in the treatment of benign prostatic hyperplasia, vaginal candidiasis, or trichomoniasis. Concanamycin A Concanamycin A is an H+-ATPase (vacuolar) inhibitor. Anetumab ravtansine Anetumab ravtansine is under investigation in clinical trial NCT03455556 (Anetumab Ravtansine and Atezolizumab in Treating Participants With Advanced Non-small Cell Lung Cancer). Orlistat A reversible inhibitor of gastrointestinal lipases indicated for weight loss and weight maintenance. Fidaxomicin A macrolide antibiotic used to treat diarrhea associated with Clostridium difficile infection. Umirolimus Not Annotated Josamycin propionate Not Annotated Indatuximab ravtansine Indatuximab ravtansine is under investigation in clinical trial NCT01001442 (Safety and Dose Determining Multi-dose Study of BT062 in Patients With Relapsed or Refractory Multiple Myeloma). Modithromycin Modithromycin is under investigation in clinical trial NCT00270517 (Comparative Study of EDP-420 Versus Another Antibiotic in the Treatment of Community Acquired Pneumonia). Nafithromycin Nafithromycin is under investigation in clinical trial NCT02903836 (Phase II Study of Oral Nafithromycin in CABP). Carrimycin Not Available Hypothemycin Not Available
- Drugs & Drug Targets