Clostridium tetani toxoid antigen (formaldehyde inactivated)

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Clostridium tetani toxoid antigen (formaldehyde inactivated)
Accession Number
DB10583
Description

Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus. The toxoid in the Clostridium tetani culture is grown and detoxified followed by purification via ammonium sulfate filtration and precipation.

Type
Biotech
Groups
Approved
Biologic Classification
Vaccines
Inactivated / Toxoid
Synonyms
  • Tetanus toxoid
  • Tetanus toxoid adsorbed
  • tetanus toxoid vaccine, inactivated

Pharmacology

Indication
Not Available
Associated Conditions
Contraindications & Blackbox Warnings
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Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
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Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AbataceptThe therapeutic efficacy of Clostridium tetani toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Abatacept.
AdalimumabThe therapeutic efficacy of Clostridium tetani toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Adalimumab.
AldesleukinThe therapeutic efficacy of Clostridium tetani toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Aldesleukin.
AlefaceptThe therapeutic efficacy of Clostridium tetani toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Alefacept.
AlemtuzumabThe therapeutic efficacy of Clostridium tetani toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Alemtuzumab.
AltretamineThe therapeutic efficacy of Clostridium tetani toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Altretamine.
AmsacrineThe therapeutic efficacy of Clostridium tetani toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Amsacrine.
AnakinraThe therapeutic efficacy of Clostridium tetani toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Anakinra.
Antilymphocyte immunoglobulin (horse)The therapeutic efficacy of Clostridium tetani toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Antilymphocyte immunoglobulin (horse).
Antithymocyte immunoglobulin (rabbit)The therapeutic efficacy of Clostridium tetani toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Antithymocyte immunoglobulin (rabbit).
Additional Data Available
  • Extended Description
    Extended Description

    Extended description of the mechanism of action and particular properties of each drug interaction.

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  • Severity
    Severity

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  • Evidence Level
    Evidence Level

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  • Action
    Action

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Food Interactions
Not Available

Products

Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Tetanus Toxoid AdsorbedInjection, suspension5 [Lf]/0.5mLIntramuscularSanofi Pasteur Inc.2005-09-232016-04-14US flag
Tetanus Toxoid AdsorbedSuspension5 lfIntramuscularID Biomedical Corporation of Quebec1991-12-312005-08-03Canada flag
Tetanus Toxoid AdsorbedInjection, suspension5 [Lf]/0.5mLIntramuscularSanofi Pasteur Inc.2005-09-232016-04-14US flag
Tetanus Toxoid Adsorbed InjLiquidIntramuscularAventis Pasteur Limited1980-12-312006-07-17Canada flag
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Adacel TDaPClostridium tetani toxoid antigen (formaldehyde inactivated) (5 [Lf]/0.5mL) + Bordetella pertussis filamentous hemagglutinin antigen (formaldehyde inactivated) (5 ug/0.5mL) + Bordetella pertussis fimbriae 2/3 antigen (5 ug/0.5mL) + Bordetella pertussis pertactin antigen (3 ug/0.5mL) + Bordetella pertussis toxoid antigen (glutaraldehyde inactivated) (2.5 ug/0.5mL) + Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) (2 [Lf]/0.5mL)Injection, suspensionIntramuscularSanofi Pasteur Inc.2005-06-10Not applicableUS flag
Adacel TDaP TDaPClostridium tetani toxoid antigen (formaldehyde inactivated) (5 [Lf]/0.5mL) + Bordetella pertussis filamentous hemagglutinin antigen (formaldehyde inactivated) (5 ug/0.5mL) + Bordetella pertussis fimbriae 2/3 antigen (5 ug/0.5mL) + Bordetella pertussis pertactin antigen (3 ug/0.5mL) + Bordetella pertussis toxoid antigen (glutaraldehyde inactivated) (2.5 ug/0.5mL) + Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) (2 [Lf]/0.5mL)Injection, suspensionIntramuscularRemedy Repack2015-11-142016-03-29US flag
BoostrixClostridium tetani toxoid antigen (formaldehyde inactivated) (5 [iU]/0.5mL) + Bordetella pertussis filamentous hemagglutinin antigen (formaldehyde inactivated) (8 ug/0.5mL) + Bordetella pertussis pertactin antigen (formaldehyde inactivated) (2.5 ug/0.5mL) + Bordetella pertussis toxoid antigen (formaldehyde, glutaraldehyde inactivated) (8 ug/0.5mL) + Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) (2.5 [iU]/0.5mL)SuspensionIntramuscularGlaxoSmithKline Biologicals SA2009-07-24Not applicableUS flag
BoostrixClostridium tetani toxoid antigen (formaldehyde inactivated) (5 [iU]/0.5mL) + Bordetella pertussis filamentous hemagglutinin antigen (formaldehyde inactivated) (8 ug/0.5mL) + Bordetella pertussis pertactin antigen (formaldehyde inactivated) (2.5 ug/0.5mL) + Bordetella pertussis toxoid antigen (formaldehyde, glutaraldehyde inactivated) (8 ug/0.5mL) + Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) (2.5 [iU]/0.5mL)SuspensionIntramuscularA-S Medication Solutions2009-07-24Not applicableUS flag
BoostrixClostridium tetani toxoid antigen (formaldehyde inactivated) (5 [iU]/0.5mL) + Bordetella pertussis filamentous hemagglutinin antigen (formaldehyde inactivated) (8 ug/0.5mL) + Bordetella pertussis pertactin antigen (formaldehyde inactivated) (2.5 ug/0.5mL) + Bordetella pertussis toxoid antigen (formaldehyde, glutaraldehyde inactivated) (8 ug/0.5mL) + Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) (2.5 [iU]/0.5mL)SuspensionIntramuscularA-S Medication Solutions2009-07-24Not applicableUS flag
CLOSTRIDIUM TETANI TOXOID ANTIGEN (FORMALDEHYDE INACTIVATED), CORYNEBACTERIUM DIPHTHERIAE TOXOID ANTIGEN (FORMALDEHYDE INACTIVATED), BORDETELLA PERTUSSIS TOXOID ANTIGEN (GLUTARALDEHYDE INACTIVATED), BORDETELLA PERTUSSIS FILAMENTOUS HEMAGGLUTININ ANTIGEN (FORMALDEHYDE INACTIVATED), BORDETELLA PERTUSSIS PERTACTIN ANTIGEN, and BORDETELLA PERTUSSIS FIMBRIAE 2/3 ANTIGENClostridium tetani toxoid antigen (formaldehyde inactivated) (5 [Lf]/0.5mL) + Bordetella pertussis filamentous hemagglutinin antigen (formaldehyde inactivated) (5 ug/0.5mL) + Bordetella pertussis fimbriae 2/3 antigen (5 ug/0.5mL) + Bordetella pertussis pertactin antigen (3 ug/0.5mL) + Bordetella pertussis toxoid antigen (glutaraldehyde inactivated) (2.5 ug/0.5mL) + Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) (2 [Lf]/0.5mL)Injection, suspensionIntramuscularA-S Medication Solutions2005-06-10Not applicableUS flag
D2t5Clostridium tetani toxoid antigen (formaldehyde inactivated) (5 lf) + Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) (2 lf)SuspensionIntramuscularID Biomedical Corporation of Quebec1991-12-312005-08-03Canada flag
DaptacelClostridium tetani toxoid antigen (formaldehyde inactivated) (5 [Lf]/0.5mL) + Bordetella pertussis filamentous hemagglutinin antigen (formaldehyde inactivated) (5 ug/0.5mL) + Bordetella pertussis fimbriae 2/3 antigen (5 ug/0.5mL) + Bordetella pertussis pertactin antigen (3 ug/0.5mL) + Bordetella pertussis toxoid antigen (glutaraldehyde inactivated) (10 ug/0.5mL) + Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) (15 [Lf]/0.5mL)Injection, suspensionIntramuscularSanofi Pasteur Inc.2002-05-14Not applicableUS flag
DecavacClostridium tetani toxoid antigen (formaldehyde inactivated) (5 [Lf]/0.5mL) + Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) (2 [Lf]/0.5mL)SuspensionIntramuscularSanofi Pasteur Limited2004-03-242016-05-19US flag
Diphtheria and Tetanus Toxoids AdsorbedClostridium tetani toxoid antigen (formaldehyde inactivated) (5 [Lf]/0.5mL) + Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) (25 [Lf]/0.5mL)Injection, suspensionIntramuscularSanofi Pasteur Inc.2010-03-29Not applicableUS flag

Categories

ATC Codes
J07AM51 — Tetanus toxoid, combinations with diphtheria toxoidJ07AM01 — Tetanus toxoidJ07AM52 — Tetanus toxoid, combinations with tetanus immunoglobulin
Drug Categories
Classification
Not classified

Chemical Identifiers

UNII
K3W1N8YP13
CAS number
Not Available

References

General References
  1. TITCK Product Information: Tetadif (purified diphtheria/tetanus toxoid) for injection [Link]
PubChem Substance
347910742
RxNav
798306
AHFS Codes
  • 80:08.00 — Toxoids

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4Active Not RecruitingPreventionMeningococcal Disease, Invasive1
4Active Not RecruitingPreventionPertussis1
4CompletedPreventionAcellular Pertussis / Diphtheria / Diphtheria-Tetanus-acellular Pertussis Vaccines / Tetanus1
4CompletedPreventionAcellular Pertussis / Diphtheria / Diphtheria-Tetanus-aPertussis-Hepatitis B-Poliomyelitis-Haemophilus Influenzae Type b Vaccines / Haemophilus Influenzae Type B / Poliomyelitis / Tetanus / Viral Hepatitis B1
4CompletedPreventionAcellular Pertussis / Diphtheria / Diphtheria-Tetanus-aPertussis-Hepatitis B-Poliomyelitis-Haemophilus Influenzae Type b Vaccines / Poliomyelitis / Tetanus1
4CompletedPreventionAcellular Pertussis / Diphtheria / Haemophilus Influenzae Type B / Poliomyelitis / Tetanus / Viral Hepatitis B2
4CompletedPreventionAcellular Pertussis / Diphtheria / Poliomyelitis / Tetanus1
4CompletedPreventionAcellular Pertussis / Diphtheria / Poliomyelitis / Tetanus / Viral Hepatitis B1
4CompletedPreventionAcellular Pertussis / Diphtheria / Tetanus5
4CompletedPreventionBCG Infection / Immune Response / Reaction - Vaccine1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Injection, solutionIntramuscular2 Lf/0.5mL
Injection, suspensionIntramuscular2 Lf/0.5mL
Injection, suspension56 iu/1mL
Injection, suspensionIntramuscular0.5 ml
Injection, suspensionIntramuscular40 IU/0.5ml
Injection, suspensionIntramuscular8 ug/0.5mL
SuspensionIntramuscular2 IU/0.5ml
SuspensionIntramuscular8 cg
Injection, suspension5 iu/0.5mL
SuspensionIntramuscular
InjectionIntramuscular20 UI
Injection, suspensionIntramuscular
LiquidIntramuscular
Injection, suspensionIntramuscular20 UI
Injection, solutionIntramuscular20 IU
SuspensionIntramuscular2 IU
Injection, suspensionIntramuscular25 ug/0.5mL
Injection, powder, for suspensionIntramuscular25 mcg/0.5mL
Injection, powder, for suspensionIntramuscular25 mcg
Injection, powder, for suspensionIntramuscular30 UI
SuspensionIntramuscular30 UI
Injection, powder, for suspensionIntramuscular10 mcg
Kit; powder, for solutionIntramuscular
Injection, suspensionIntramuscular2 IU
Injection, suspensionIntramuscular2 IU/0.5ml
Injection, suspensionIntramuscular2 UI
SuspensionIntramuscular40 IU
Injection, suspension2 iu/0.5mL
InjectionIntramuscular40 IU
Injection, solutionIntramuscular40 IU/0.5mL
Injection, suspensionIntramuscular5 [Lf]/0.5mL
SuspensionIntramuscular5 lf
LiquidIntramuscular
Injection, suspension40 iu/0.5mL
Injection, suspensionIntramuscular; Subcutaneous40 IU
Injection, suspensionIntramuscular30 UI
Injection, suspensionIntramuscular30 IU/0.5mL
Injection, suspensionIntramuscular; Subcutaneous2 IU/0.5ml
InjectionIntramuscular
SuspensionIntramuscular10 LfU
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Drug created on December 01, 2015 13:04 / Updated on October 26, 2020 22:41

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