Clostridium tetani toxoid antigen (formaldehyde inactivated)

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Brand Names
Adacel, Boostrix, Daptacel, Diphtheria and Tetanus Toxoids Adsorbed, Infanrix, Kinrix, Nimenrix, Pediarix, Pentacel, Quadracel, Td Adsorbed, Tdvax, Tenivac, Vaxelis
Generic Name
Clostridium tetani toxoid antigen (formaldehyde inactivated)
DrugBank Accession Number
DB10583
Background

Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus. The toxoid in the Clostridium tetani culture is grown and detoxified followed by purification via ammonium sulfate filtration and precipation.

Type
Biotech
Groups
Approved
Biologic Classification
Vaccines
Inactivated / Toxoid
Synonyms
  • Tetanus toxoid
  • Tetanus toxoid adsorbed
  • tetanus toxoid vaccine, inactivated

Pharmacology

Indication

Not Available

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Used in combination to preventDiphtheriaCombination Product in combination with: Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) (DB10584)•••••••••••••••••••••
Adjunct therapy in prevention ofDiphtheria••••••••••••
Adjunct therapy in prevention ofPertussis••••••••••••
Prevention ofTetanus•••••••••••••••••••••• ••••••••••
Used in combination to preventTetanusCombination Product in combination with: Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) (DB10584)•••••••••••••••••••••
Associated Therapies
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AbataceptThe therapeutic efficacy of Clostridium tetani toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Abatacept.
AdalimumabThe therapeutic efficacy of Clostridium tetani toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Adalimumab.
AldesleukinThe therapeutic efficacy of Clostridium tetani toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Aldesleukin.
AlefaceptThe therapeutic efficacy of Clostridium tetani toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Alefacept.
AlemtuzumabThe therapeutic efficacy of Clostridium tetani toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Alemtuzumab.
Food Interactions
Not Available

Products

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Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Tetanus Toxoid AdsorbedInjection, suspension5 [Lf]/0.5mLIntramuscularSanofi Pasteur Inc.2005-09-232016-04-14US flag
Tetanus Toxoid AdsorbedSuspension5 lf / 0.5 mLIntramuscularID Biomedical Corporation of Quebec1991-12-312005-08-03Canada flag
Tetanus Toxoid AdsorbedInjection, suspension5 [Lf]/0.5mLIntramuscularSanofi Pasteur Inc.2005-09-232016-04-14US flag
Tetanus Toxoid Adsorbed InjLiquid5 lf / 0.5 mLIntramuscularAventis Pasteur Limited1980-12-312006-07-17Canada flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
AdacelClostridium tetani toxoid antigen (formaldehyde inactivated) (5 lf / 0.5 mL) + Bordetella pertussis filamentous hemagglutinin antigen (formaldehyde inactivated) (5 mcg / 0.5 mL) + Bordetella pertussis fimbriae 2/3 antigen (5 mcg / 0.5 mL) + Bordetella pertussis pertactin antigen (3 mcg / 0.5 mL) + Bordetella pertussis toxoid antigen (formaldehyde, glutaraldehyde inactivated) (2.5 mcg / 0.5 mL) + Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) (2 lf / 0.5 mL)SuspensionIntramuscularSanofi Pasteur Limited1999-06-23Not applicableCanada flag
ADACELClostridium tetani toxoid antigen (formaldehyde inactivated) (1.5 mg/0.5ml) + Bordetella pertussis filamentous hemagglutinin antigen (formaldehyde inactivated) (5 mcg/0.5ml) + Bordetella pertussis pertactin antigen (formaldehyde inactivated) (3 mcg/0.5ml) + Bordetella pertussis toxoid antigen (formaldehyde inactivated) (2.5 mcg/0.5ml) + Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) (2 Lf/0.5ml)Injectionบริษัท ซาโนฟี่ ปาสเตอร์2012-06-27Not applicableThailand flag
ADACEL 0,5 ML IM ENJEKSİYONLUK SÜSPANSİYON İÇEREN FLAKON, 1 ADETClostridium tetani toxoid antigen (formaldehyde inactivated) (5 Lf/0.5mL) + Bordetella pertussis filamentous hemagglutinin antigen (formaldehyde inactivated) (5 mcg/0.5mL) + Bordetella pertussis fimbriae 2/3 antigen (5 mcg/0.5mL) + Bordetella pertussis pertactin antigen (3 mcg/0.5mL) + Bordetella pertussis toxoid antigen (formaldehyde, glutaraldehyde inactivated) (2.5 mcg/0.5mL) + Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) (2 Lf/0.5mL)Injection, solutionIntramuscularSANOFİ PASTEUR AŞI TİC. A.Ş.2017-08-17Not applicableTurkey flag
ADACEL 0,5 ML IM ENJEKSİYONLUK SÜSPANSİYON İÇEREN FLAKON, 5 ADETClostridium tetani toxoid antigen (formaldehyde inactivated) (5 Lf/0.5mL) + Bordetella pertussis filamentous hemagglutinin antigen (formaldehyde inactivated) (5 mcg/0.5mL) + Bordetella pertussis fimbriae 2/3 antigen (5 mcg/0.5mL) + Bordetella pertussis pertactin antigen (3 mcg/0.5mL) + Bordetella pertussis toxoid antigen (glutaraldehyde inactivated) (2.5 mcg/0.5mL) + Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) (2 Lf/0.5mL)Injection, solutionIntramuscularSANOFİ PASTEUR AŞI TİC. A.Ş.2017-08-17Not applicableTurkey flag
ADACEL POLIO 0,5 ML IM ENJEKSİYON İÇİN SÜSPANSİYON İÇEREN KULLANIMA HAZIR ENJEKTÖR, 1 ADETClostridium tetani toxoid antigen (formaldehyde inactivated) (5 Lf/0.5mL) + Bordetella pertussis filamentous hemagglutinin antigen (formaldehyde inactivated) (5 mcg/0.5mL) + Bordetella pertussis fimbriae 2/3 antigen (5 mcg/0.5mL) + Bordetella pertussis pertactin antigen (3 mcg/0.5mL) + Bordetella pertussis toxoid antigen (formaldehyde, glutaraldehyde inactivated) (2.5 mcg/0.5mL) + Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) (2 Lf/0.5mL) + Poliovirus type 1 antigen (formaldehyde inactivated) (40 DU/5mL) + Poliovirus type 2 antigen (formaldehyde inactivated) (8 DU/5mL) + Poliovirus type 3 antigen (formaldehyde inactivated) (32 DU/5mL)Injection, suspensionIntramuscularSANOFİ PASTEUR AŞI TİC. A.Ş.2008-12-302022-08-23Turkey flag

Categories

ATC Codes
J07AM51 — Tetanus toxoid, combinations with diphtheria toxoidJ07AM01 — Tetanus toxoidJ07AM52 — Tetanus toxoid, combinations with tetanus immunoglobulin
Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
K3W1N8YP13
CAS number
Not Available

References

General References
  1. TITCK Product Information: Tetadif (purified diphtheria/tetanus toxoid) for injection [Link]
PubChem Substance
347910742
RxNav
798306

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4Active Not RecruitingOtherCoronavirus Disease 2019 (COVID‑19) / Rheumatic Diseases1
4Active Not RecruitingPreventionCervical Carcinoma / Human Papillomavirus (HPV) Infections1
4Active Not RecruitingPreventionPertussis1
4CompletedBasic SciencePrevention of Infections With Bordetella Pertussis1
4CompletedPreventionAcellular Pertussis / Diphtheria / Diphtheria-Tetanus-acellular Pertussis Vaccines / Tetanus1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Injection, suspension40 iu/0.5ml
Injection, suspensionIntramuscular0.5 ml
Injection
SuspensionIntramuscular
Injection, suspensionIntramuscular
LiquidIntramuscular
Injection, suspensionParenteral
Injection, suspensionIntramuscular40 IU/0.5ml
Injection, powder, for suspensionIntramuscular
SolutionIntramuscular
Kit; powder, for solutionIntramuscular
Injection, powder, for solutionIntramuscular
Injection; injection, suspension; kitIntramuscular
Injection, solutionIntramuscular
Injection, solutionIntramuscular
SuspensionIntramuscular40 IU
Injection, suspensionIntramuscular5 [Lf]/0.5mL
SuspensionIntramuscular5 lf / 0.5 mL
LiquidIntramuscular5 lf / 0.5 mL
Injection, suspensionIntramuscular
Injection, suspensionIntramuscular; Subcutaneous40 IU
SuspensionIntramuscular; Subcutaneous40 I.U/ 0.5ml dose
Injection, suspensionIntramuscular30 iu/0.5ml
Injection, suspensionIntramuscular; Subcutaneous
InjectionIntramuscular30 iu/0.5ml
InjectionIntramuscular
SuspensionIntramuscular10 LfU
Injection
Injection, suspension
Injection40 iu/0.5ml
Injection, suspension10 Lf/0.5ml
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Drug created at December 01, 2015 20:04 / Updated at February 22, 2024 22:28