Diagnostic Uses of Chemicals

Name
Diagnostic Uses of Chemicals
Accession Number
DBCAT000559
Description

Chemicals administered to patients in order to diagnose or study the pathology of medical conditions, diseases, or syndromes.

Drugs
DrugDrug Description
FluoresceinA dye used in angiography or angioscopy of the iris and retina.
IohexolA contrast agent for intrathecal administration used in myelography and contrast enhancement for computerized tomography.
Technetium Tc-99m disofeninA radiopharmaceutical diagnostic agent used for hepatobiliary scans.
Ioflupane I-123A radiopharmaceutical used in single photon emission computed tomography (SPECT) brain imaging to help diagnose patients with suspected Parkinsonian syndromes.
InclisiranA PCSK9-targeting short interfering RNA (siRNA) that lowers plasma LDL-cholesterol levels.
Fluoroazomycin arabinoside F-18Fluoroazomycin arabinoside F-18 is under investigation in clinical trial NCT03257150 (A Study of the Use of Irreversible Electroporation in Pancreatic Ductal Cancer).
Flortaucipir F-18A small lipophilic tracer containing [18F]fluoride capable of crossing the blood-brain barrier and binding to aggregated tau protein; used in PET imaging for the diagnosis of Alzheimer's disease.
GadodiamideA gadolinium-based contrast agent used for the visualization of lesions with vascularity during magnetic resonance imaging (MRI) scans.
DiatrizoateAn injected contrast agent used in radiology.
GadoversetamideA gadolinium compound used as a contrast agent in MRI tests of the brain, spine, and liver.
PerflutrenA diagnostic medication to improve contrast during echocardiograms.
GadoteridolA medication used to improve the contrast of MRI scans for better visualization.
Gadobenic acidA gadolinium compound used as a contrast agent in MRIs.
Gadopentetic acidA gadolinium compound used as a contrast agent in MRIs.
Ethiodized oilA contrast agent used in imaging procedures.
IophendylateIophendylate is used as a contrast agent to locate spinal tumors.
IodixanolA contrast agent used during coronary angiography, particularly in patients with renal dysfunction.
MetrizamideMetrizamide is used for lumbar, thoracic, cervical, and total columnar myelography to determine the presence of abnormalities in the spinal column, spinal canal, and central nervous system (CNS) as well...
IodipamideA contrast agent used in cholangiography and cholecystography.
Motexafin gadoliniumInvestigated for use/treatment in brain cancer, cancer/tumors (unspecified), lung cancer, and lymphoma (non-hodgkin's).
PerflubronInvestigated for use/treatment in cardiac surgery, hemorrhage, and ileus.
GadobutrolA contrast agent used during diagnostic procedures to visualize disrupted areas of blood brain barrier (BBB) and/or abnormal vascularity of the central nervous system.
IobenguaneA radiopharmaceutical agent used for the diagnosis of primary and metastatic pheochromocytoma or neuroblastoma.
Gadofosveset trisodiumAn intravenous contrast agent used during magnetic resonance angiography (MRA) to evaluate aortoiliac occlusive disease (AIOD) in adults with peripheral vascular disease.
MangafodipirAn organ-specific paramagnetic contrast agent indicated for the imaging of the hepatobiliary system and detecting lesions in the liver and pancreas.
Gadoxetic acidA gadolinium-based contrast agent used in magnetic resonance imaging (MRI) to help characterize lesions in the liver.
Iotroxic acidIotroxic acid is a contrast medium molecule.
Iopanoic acidIopanoic acid contains iodine and is useful as a contrast medium in cholecystography.
IopamidolA diagnostic imaging agent used for angiography throughout the cardiovascular system.
IodamideIodamide is a contrast medium molecule that is no longer marketed in the United States.
Gadoteric acidA diagnostic contrast agent used with magnetic resonance imaging to provide contrast enhancement for intracranial and spinal lesions with abnormal blood brain barrier or abnormal vascularity, and for whole body imaging.
Iothalamic acidA diagnostic contrast agent used in various medical imaging procedures, such as angiography, arthrography, and computed tomographic scans.
IoversolA diagnostic contrast agent used in various medical imaging procedures, such as angiography, urography, and computed tomographic scans.
IoxilanA diagnostic contrast agent used in various medical imaging procedures, such as angiography, urography, and computed tomographic scans.
Technetium Tc-99m mebrofeninA diagnostic radiopharmaceutical agent used during hepatobiliary imaging tests.
Technetium Tc-99m medronateA diagnostic radiopharmaceutical agent used as a bone imaging agent to delineate areas of altered osteogenesis.
Flutemetamol (18F)A radiopharmaceutical diagnostic agent used during Positron Emission Tomography (PET) imaging of the brain to estimate β-amyloid neuritic plaque density in adult patients to diagnose the causes of cognitive impairment.
IopromideAn X-ray contrast agent used during various types of imaging tests such as angiography and contrast computed tomography (CT) imaging tests.
Technetium Tc-99m tetrofosminTechnetium-99m tetrofosmin is indicated for the diagnosis of heart abnormalities by exercise myocardial scintigraphy. The exercise myocardial scintigraphy is an established method for the diagnosis of the severity of coronary...
Technetium Tc-99m sestamibiA radiopharmaceutical diagnostic agent used in nuclear medicine imaging tests to detect coronary artery disease and evaluate myocardial function.
Technetium Tc-99m exametazimeA radiopharmaceutical diagnostic agent used as an adjunct for scintigraphy in the detection of altered regional cerebral perfusion in stroke.
Technetium Tc-99m pyrophosphateA radiopharmaceutical diagnostic agent used for diagnostic imaging scans for the bones, heart, and gastrointestinal tract.
Ioxaglic acidA tri-iodinated benzoate contrast agent used in various radiological procedures including angiography, phlebography, urography, computed tomography (CT), and hysterosalpingography.
Technetium Tc-99m pertechnetateA radiocontrast agent used for the identification of various organs, including but not limited to the brain, thyroid, placenta, and bladder.
Iopodic acidAn iodine containing cholecystography agent.
Tyropanoic acidFor use in cholecystography (X-ray diagnosis/imaging of gallstones).
Metrizoic acidFor use as a contrast medium .
Acetrizoic acidAcetrizoic acid indication was to be used as a contrast agent for X-ray. Some information indicates its nephrotropic property as one of the characteristics for the utilization of acetrizoic acid....
PropyliodoneRadiopaque medium usually in oil; used in bronchography.
Technetium Tc-99m sulfur colloidA radiopharmaceutical diagnostic agent used for the localization of lymph nodes, evaluation of peritoneovenous (LeVeen) shunt patency, imaging areas of functioning reticuloendothelial cells, and gastrointestinal imaging.
Technetium Tc-99m etidronateNot Annotated
MeglumineAn amino sugar found in iodinated contrast media.
Technetium Tc-99m succimerA radioactive diagnostic agent used as an aid in the scintigraphic evaluation of renal parenchymal disorders.
Iofetamine I-123Not Annotated
IotrolanNonionic, isotonic contrast medium designed for intrathecal use.
Fludeoxyglucose (18F)A radiopharmaceutical agent used for positron emission tomography (PET) imaging in oncology, cardiology, and neurology.
FerumoxidesNot Annotated
Barium sulfateA contrast agent used for CT scans of the gastrointestinal tract.
PerflenapentDodecafluoropentane is an ingredient in the EMA-withdrawn product EchoGen.
IomeprolAn iodine-based X-ray contrast agent.
GadoliniumGadolinium is under investigation in Hypertension, ACUTE KIDNEY INJURY, and Chronic Kidney Disease. Gadolinium has been investigated for the basic science of CAD, Multiple Sclerosis, and Coronary Artery Disease.
IobitridolAn iodine-based contrast agent used with X-ray or CT imaging.
PentetreotideA somatostatin receptor inhibitor, available in a kit with Indium-111, used as a contrast agent in the visualization of somatostatin receptor-positive neuroendocrine tumours.
PerflubutanePerflubutane has been used in trials studying the diagnostic of Liver Mass, Liver Diseases, Liver Metastasis, Portal Hypertension, and Peripheral Artery Disease. It is a cardiovascular drug designed to enable...
Iobenzamic acidNot Annotated
Ioxitalamic acidA contrast agent used for CT scans of the abdomen and pelvis.
Iodoxamic acidRadiopaque medium used in the diagnosis of gall bladder & bile duct diseases, usually as meglumine salt.
DiodoneNot Annotated
Ioglycamic acidNot Annotated
Iocarmic acidNot Annotated
IopentolIopentol is used as a contrast medium.
Lutetium Lu 177 dotatateA radiolabeled somatostatin analog used to treat somatostatin receptor positive gastroenteropancreatic neuroendocrine tumors.
Bevacizumab zirconium Zr-89Bevacizumab zirconium Zr-89 is under investigation in clinical trial NCT01338090 (89Zr-bevacizumab PET Imaging in Patients With Neuroendocrine Tumors).
FlortaucipirFlortaucipir is under investigation in clinical trial NCT03507257 (Longitudinal Early-onset Alzheimer's Disease Study Protocol).
FlutemetamolFlutemetamol is under investigation in clinical trial NCT02353949 (Investigating the Clinical Consequences of Flutemetamol-PET-scanning).
TozuleristideTozuleristide is under investigation in clinical trial NCT02464332 (Safety Study of BLZ-100 in Adult Subjects With Sarcoma Undergoing Surgery).
PafolacianineAn optical imaging agent indicated in adult patients with ovarian cancer as an adjunct for intraoperative identification of malignant lesions.
Iodohippuric acidIodohippuric acid is under investigation in clinical trial NCT02599844 (Impact of Pediatric Acute Renal Injury in Severe Sepsis in Young Adults).
Gallium Ga-68 gozetotideA radiopharmaceutical agent used in the diagnosis of prostate-specific membrane antigen (PSMA) positive lesions in male patients during positron emission tomography.
Lutetium Lu-177 vipivotide tetraxetanA radioligand therapeutic agent used to treat prostate-specific membrane antigen (PSMA)-positive metastatic castration-resistant prostate cancer in adults.
Drugs & Drug Targets
DrugTargetType
FluoresceinIg kappa chain V-II region RPMI 6410target
FluoresceinDNAtarget
FluoresceinSolute carrier family 22 member 6transporter
FluoresceinBile salt export pumptransporter
FluoresceinMultidrug resistance-associated protein 1transporter
Ioflupane I-123Sodium-dependent dopamine transportertransporter
InclisiranProprotein convertase subtilisin/kexin type 9target
Flortaucipir F-18Microtubule-associated protein tautarget
Flortaucipir F-18Amine oxidase [flavin-containing] Atarget
Flortaucipir F-18Amine oxidase [flavin-containing] Btarget
Gadobenic acidSerum albumincarrier
Gadopentetic acid6-phosphogluconate dehydrogenase, decarboxylatingtarget
IodipamideSerum albumincarrier
Motexafin gadoliniumThioredoxin reductase 1, cytoplasmictarget
Motexafin gadoliniumThioredoxin reductase 2, mitochondrialtarget
Motexafin gadoliniumRibonucleoside-diphosphate reductase subunit M2target
IobenguaneSodium-dependent noradrenaline transportertransporter
Gadofosveset trisodiumSerum albumincarrier
MangafodipirAlpha-2-macroglobulincarrier
MangafodipirSerum albumincarrier
MangafodipirSuperoxide dismutase [Mn], mitochondrialenzyme
MangafodipirNatural resistance-associated macrophage protein 2transporter
Gadoxetic acidSolute carrier organic anion transporter family member 1B1transporter
Gadoxetic acidSolute carrier organic anion transporter family member 1B3transporter
Gadoxetic acidCanalicular multispecific organic anion transporter 2transporter
Gadoxetic acidCanalicular multispecific organic anion transporter 1transporter
Gadoxetic acidMultidrug resistance-associated protein 4transporter
Technetium Tc-99m mebrofeninSolute carrier organic anion transporter family member 1B1transporter
Technetium Tc-99m mebrofeninSolute carrier organic anion transporter family member 1B3transporter
Flutemetamol (18F)Amyloid beta A4 proteintarget
Technetium Tc-99m tetrofosminP-glycoprotein 1carrier
Technetium Tc-99m sestamibiP-glycoprotein 1transporter
Technetium Tc-99m sestamibiMultidrug resistance-associated protein 1transporter
Technetium Tc-99m pyrophosphateHydroxyapatitetarget
Technetium Tc-99m pyrophosphateAmorphous calcium phosphatetarget
Iopodic acidThyroxine 5-deiodinasetarget
Iopodic acidSerum albumincarrier
Tyropanoic acidBeta-glucuronidaseenzyme
Acetrizoic acidSerum albumincarrier
Technetium Tc-99m succimerSodium-dependent phosphate transporter 1transporter
Technetium Tc-99m succimerSodium-dependent phosphate transporter 2transporter
Fludeoxyglucose (18F)Hexokinase-1enzyme
Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 4transporter
Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 2transporter
Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 1transporter
Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 3transporter
Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 9transporter
Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 5transporter
Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 6transporter
Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 7transporter
Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 8transporter
Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 10transporter
Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 11transporter
Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 12transporter
Lutetium Lu 177 dotatateSomatostatin receptor type 2target
Lutetium Lu 177 dotatateSomatostatin receptor type 1target
Lutetium Lu 177 dotatateSomatostatin receptor type 3target
Lutetium Lu 177 dotatateSomatostatin receptor type 4target
Lutetium Lu 177 dotatateSomatostatin receptor type 5target
PafolacianineFolate receptor alphatarget
PafolacianineSolute carrier organic anion transporter family member 1B1transporter
PafolacianineSolute carrier organic anion transporter family member 1B3transporter
PafolacianineSolute carrier family 22 member 6transporter
Gallium Ga-68 gozetotideProstate-specific antigentarget
Lutetium Lu-177 vipivotide tetraxetanProstate-specific antigentarget